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A Development of Fusion Processor Architecture for Efficient Main Memory Access in CPU-GPU Environment (CPU-GPU환경에서 효율적인 메인메모리 접근을 위한 융합 프로세서 구조 개발)

  • Park, Hyun-Moon;Kwon, Jin-San;Hwang, Tae-Ho;Kim, Dong-Sun
    • The Journal of the Korea institute of electronic communication sciences
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    • v.11 no.2
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    • pp.151-158
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    • 2016
  • The HSA resolves an old problem with existing CPU and GPU architectures by allowing both units to directly access each other's memory pools via unified virtual memory. In a physically realized system, however, frequent data exchanges between CPU and GPU for a virtual memory block result bottlenecks and coherence request overheads. In this paper, we propose Fusion Processor Architecture for efficient access of main memory from both CPU and GPU. It consists of Job Manager, Re-mapper, and Pre-fetcher to control, organize, and distribute work loads and working areas for GPU cores. These components help on reducing memory exchanges between the two processors and improving overall efficiency by eliminating faulty page table requests. To verify proposed algorithm architectures, we develop an emulator based on QEMU, and compare several architectures such as CUDA(Compute Unified Device Architecture), OpenMP, OpenCL. As a result, Proposed fusion processor architectures show 198% faster than others by removing unnecessary memory copies and cache-miss overheads.

Prostaglandin A2-induced Apoptosis is Not Inhibited by Heme Oygenase-1 in U2OS Cells (U2OS 세포에서 prostaglandin A2에 의한 apoptosis는 heme oxygenase-1에 의하여 저해되지 않는다)

  • Ko, Kyoung-Won;Lee, Sun-Young;Ahn, Ji-Hyun;Kim, Jae-Taek;Kim, In-Kyung;Kim, Ho-Shik
    • Journal of Life Science
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    • v.18 no.11
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    • pp.1485-1492
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    • 2008
  • Prostaglandin $A_2$ ($PGA_2$), one of cyclopentenone PGs, induced both apoptosis and heme oxygenase (HO)-1 expression in U2OS cells. $PGA_2$-induced apoptosis was not perturbed by either over-expression or knock-down of HO-1, whereas $H_2O_2$-induced cell death was inversely modulated by the expression level of HO-1. In addition, N-acetyl-L-cysteine (NAC), a thiol antioxidant, blocked both apoptosis and HO-1 expression induced by $PGA_2$. But, non-thiol antioxidants like butylated hydorxyanisole (BHA) and ascorbic acid did not block either apoptosis or HO-1-induction. Taken together, these results suggest that $PGA_2$ induces both apoptosis and HO-1 expression, which are critically related to the thiol- reactivity of $PGA_2$, but not oxidative stress, and HO-1 expression may be independent or functionally located downstream of apoptosis by $PGA_2$ without contribution to apoptosis progression.

Feeding of Cassava Hay for Lactating Dairy Cows

  • Wanapat, M.;Puramongkon, T.;Siphuak, W.
    • Asian-Australasian Journal of Animal Sciences
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    • v.13 no.4
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    • pp.478-482
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    • 2000
  • Whole cassava (Manihot esculenta, Crantz) crop was harvested about 10-15 cm above ground at 3 months after planting and sun dried for 1-3 days or until the leaves were crispy-dried and the branches and stems were mostly wilted to produce cassava hay. Cassava hay (CH) contained 86.3% DM, 8.9% ash, 23.6% CP, 44.3% NDF, 30.0% ADF, 5.8% ADL, 0.257% condensed tannin and 0.35 mg % HCN, respectively. In addition, CH contained relatively higher amino acid than alfalfa hay especially methionine, isoleucine, leucine and lysine. Ruminal fermentation of CH resulted in high concentrations of $C_2$, $C_3$, and $C_4$ at 72, 17 and 7 mol/100 mole, respectively. A feeding trial was conducted to study on effect of feeding of cassava hay in late lactating dairy cows fed on urea-treated rice straw during the dry season on their intake, ruminal pH, $NH_3$-N, milk yield and compositions. Thirty, Holstein-Friesian crossbred cows in their first lactation were randomly assigned in a randomized complete block design to receive five different dietary treatments: T1=supplementation of concentrate to milk yield at 1:2, T2=supplementation of concentrate to milk yield at 1:2+0.56 kg DM, T3=supplementation of concentrate to milk yield at 1:3+1.3 kg DM CH, T4=supplementation of concentrate to milk yield at 1:4+1.70 kg DM CH, T5=CH fed on ad libitum+small concentrate supplement. All cows received urea-treated rice straw as a roughage source throughout a 80 d feeding trial. The experiment revealed that cassava hay contained high level of protein and minimal level of tannin at 3 months of harvest. Tannin intake ranged from 1.44 to 13.36 g/hd/d and did not affect on urea-treated rice straw intake. Milk yield across treatments were similar (5.4-6.3 kg/hd/d) (p>0.05) but 3.5% FCM was highest in cows received CH at 1.70 kg/hd/d. Feeding of cassava hay resulted in increasing milk fat (4.0 to 4.6%) (p<0.05) and milk protein (3.8 to 5.3%) (p<0.05). Moreover, the use of CH could reduce concentrate supplementation to milk yield from 1:2 to 1:4, respectively, thus resulted in more milk income return.

The Crystal Structure of Thiourea of Derivatives(I) (Thiourea Deirvatives의 결정과 분자구조 (제1보))

  • Park Young Ja;Suh Chung Sun;Koo, Chung Hoe
    • Journal of the Korean Chemical Society
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    • v.21 no.5
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    • pp.307-319
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    • 1977
  • The crystal structure of $N-({\alpha}-dimethyl\;{\beta}-hydroxy)ethyl\;N'-cyclohexyl\;thiourea,\;C_{ll}H_{22}N_2OS)$, has been determined by X-ray diffraction method. The compound crystallizes in the orthorhombic space group Pbca with a = 10.33(3), b = 11.82(3), c = 22.57(4)${\AA}$ and Z = 8. A total of 1414 observed reflections collected by the Weissenberg photographs and was solved by heavy atom method and refined by block diagonal least-squares methods to the R value of 0.13. The cyclohexane ring has a normal chair conformation and the thiourea unit is planar. The primary alcoholic group O-H bonded to C(l) makes an intramolecular hydrogen bond with N(2), which leads to stablize the molecule. There are two independent hydrogen bonds in the structure. One of them is of the type N-H${\cdot}{\cdot}{\cdot}$O intramolecular hydrogen bond with the length 2.71${\AA}$, another is of the type O-H${\cdot}{\cdot}{\cdot}$S intermolecular hydrogen bond with the length 3.21${\AA}$ parallel to the b axis. Apart from the hydrogen bonding system the molecules are held together by van der Waals forces in the crystal.

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Titanium Hemostatic Clip Tailoring Method to Overcome Vessel Caliber Discrepancy in Interposition Saphenous Vein Graft for Carotid Artery Resection (경동맥 절제술 후 재건에 사용된 복재정맥의 혈관구경 불일치를 극복하기 위한 Titanium Hemostatic Clip 봉합방법)

  • Kim Sun-Ho;Lim Young-Chang;Lee Sei-Young;Lim Jae-Yol;Choi Eun-Chang
    • Korean Journal of Head & Neck Oncology
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    • v.20 no.2
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    • pp.177-180
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    • 2004
  • Objectives: To completely excise a malignant tumor which invades carotid artery walls, the resection and reconstruction of the carotid artery is essentially required. In most of the cases, interposition graft using a saphenous vein has been performed, however the vessel caliber discrepancy between a common carotid artery and the saphenous vein can result in a problem on surgical technique. We have introduced and evaluated a new titanium hemoclip tailing method to overcome vessel caliber discrepancy in interposition saphenous vein graft for carotid artery resection in the treatment of head and neck cancers. Method: After carotid artery resection, the calibers of the proximal common carotid artery and the vein were compared, and an orifice of the common carotid artery was gradually reduced to a little larger than or the same size as the orifice of the vein by using the titanium hemostatic clip. Subsequently, the common carotid artery was connected to the vein through anastomosis. The same method was also applied to the distal anastomosis site. There after, the vessels were connected through the anastomosis, and a circulation was restored by releasing a vascular clamp. Then, a titanium hemostatic clip-applied redundant portion on the outside of carotid artery was sutured by the blanket edge suture method, using 6-0 Prolene. Results: We have experienced this method in two patients with recurrent squamous cell carcinoma and neuroblostoma, respectively. The interposition saphenous vein graft of these patients was found to maintain good patency on the follow up angiography after one year, and they had no specific vascular complication, such as atherosclerosis. Conclusion: This method made it possible to simply perform the interposition saphenous vein graft (ISVG) within a short time and, therefore, was very useful for shortening the duration to block circulation.

Reliability Analysis on Safety Instrumented System by Using Safety Integrity Level for Fire.Explosion Prevention in the Ethyl Benzene Processes (Ethyl Benzene 공정에서 화재.폭발방지를 위하여 안전건전성수준을 이용한 안전장치시스템의 신뢰도 분석)

  • Ko, Jae-Sun;Kim, Hyo;Lee, Su-Kyoung
    • Fire Science and Engineering
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    • v.20 no.3 s.63
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    • pp.1-8
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    • 2006
  • The purpose of this work is to analyze quantitatively if the safety instrumented system(SIS) like the pressure safety valves(PSV) in the processes of ethyl benzene plant have been designed relevantly to the safety integrity level because overpressure in the benzene or ethyl benzene columns causes the explosive reactions, fires and reactor explosions. The safety integrity level(SIL) 3 has been adopted as a target level of SIS based on the general data of the Probability of Failure on Demand of PSV, $1.00E-4{\sim}1.00E-3$. The standard model of the reliability has been set up and then the fault tree analysis of it has been carried out to get the PFD of SIS, and the results show 8.97E-04, 5.37E-04, 5.37E-04 for benzene prefractionator column, benzene column and EB column, respectively. Thus, we conclude that the SIS is designed to fulfill the condition of SIL3, and when the partial stroke test for the control valve are carried out every sixth month, the SIS of each column is expected to increase its reliability up to $22{\sim}27%$.

Association of UDP-galactose-4-epimerase with milk protein concentration in the Chinese Holstein population

  • Li, Cong;Cai, Wentao;Liu, Shuli;Zhou, Chenghao;Cao, Mingyue;Yin, Hongwei;Sun, Dongxiao;Zhang, Shengli;Loor, Juan J.
    • Asian-Australasian Journal of Animal Sciences
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    • v.33 no.11
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    • pp.1725-1731
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    • 2020
  • Objective: An initial RNA-Sequencing study revealed that UDP-galactose-4-epimerase (GALE) was one of the most promising candidates for milk protein concentration in Chinese Holstein cattle. This enzyme catalyzes the interconversion of UDP-galactose and UDP-glucose, an important step in galactose catabolism. To further validate the genetic effect of GALE on milk protein traits, genetic variations were identified, and genotypes-phenotypes associations were performed. Methods: The entire coding region and the 5'-regulatory region (5'-UTR) of GALE were re-sequenced using pooled DNA of 17 unrelated sires. Association studies for five milk production traits were performed using a mixed linear animal model with a population encompassing 1,027 Chinese Holstein cows. Results: A total of three variants in GALE were identified, including two novel variants (g.2114 A>G and g.2037 G>A) in the 5'-UTR and one previously reported variant (g.3836 G>C) in an intron. All three single nucleotide polymorphisms (SNPs) were associated with milk yield (p<0.0001), fat yield (p = 0.0006 to <0.0001), protein yield (p = 0.0232 to <0.0001) and protein percentage (p<0.0001), while no significant associations were detected between the SNPs and fat percentage. A strong linkage disequilibrium (D' = 0.96 to 1.00) was observed among all three SNPs, and a 5 Kb haplotype block involving three main haplotypes with GAG, AGC, and AGG was formed. The results of haplotype association analyses were consistent with the results of single locus association analysis (p<0.0001). The phenotypic variance ratio above 3.00% was observed for milk protein yield that was explained by SNP-g.3836G >C. Conclusion: Overall, our findings provided new insights into the polymorphic variations in bovine GALE gene and their associations with milk protein concentration. The data indicate their potential uses for marker-assisted breeding or genetic selection schemes.

Design of e-Learning System for Spectral Analysis of High-Order Pulse (고차원펄스 스펙트럼 분석을 위한 이러닝 시스템의 설계)

  • Oh, Yong-Sun
    • The Journal of the Korea Contents Association
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    • v.11 no.8
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    • pp.475-487
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    • 2011
  • In this paper, we present a systematic method to derive spectrum of high-order pulse and a novel design of e-Learning system that deals with deriving the spectrum using concept-based branching method. Spectrum of high-order pulse can be derived using conventional methods including 'Consecutive Differentiations' or 'Convolutions', however, their complexity of calculation should be too high to be used as the order of the pulse increase. We develop a recursive algorithm according to the order of pulse, and then derive the formula of spectrum connected to the order with a newly designed look-up table. Moving along, we design an e-Learning content for studying the procedure of deriving high-order pulse spectrum described above. In this authoring, we use the concept-based object branching method including conventional page or title-type branching in sequential playing. We design all four Content-pages divided into 'Modeling', 'Impulse Response and Transfer Function', 'Parameters' and 'Look-up Table' by these conceptual objects. And modules and sub-modules are constructed hierarchically as conceptual elements from the Content-pages. Students can easily approach to the core concepts of the analysis because of the effects of our new teaching method. We offer step-by-step processes of the e-Learning content through unit-based branching scheme for difficult modules and sub-modules in our system. In addition we can offer repetitive learning processes for necessary block of given learning objects. Moreover, this method of constructing content will be considered as an advanced effectiveness of content itself.

Optimal Scheduling of SAD Algorithm on VLIW-Based High Performance DSP (VLIW 기반 고성능 DSP에서의 SAD 알고리즘 최적화 스케줄링)

  • Yu, Hui-Jae;Jung, Sou-Hwan;Chung, Sun-Tae
    • The Journal of the Korea Contents Association
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    • v.7 no.12
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    • pp.262-272
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    • 2007
  • SAD (Sum of Absolute Difference) algorithm is the most frequently executing routine in motion estimation, which is the most demanding process in motion picture encoding. To enhance the performance of motion picture encoding on a VLIW processor, an optimal implementation of SAD algorithm on VLIW processor should be accomplished. In this paper, we propose an implementation of optimal scheduling of SAD algorithm with conditional branch on a VLIW-based high performance DSP. We first transform the nested loop with conditional branch of SAD algorithm into a single loop with conditional branch which has a large enough loop body to utilize fully the ILP capability of VLIW DSP and has a conditional branch to make the escape from loop to be achieved as soon as possible. And then we apply a modulo scheduling technique to the transformed single loop. We test the proposed implementation on TMS320C6713, and analyze the code size and performance with respect to processing time. Through experiments, it is shown that the SAD implementation proposed in this paper has small code size appropriate for embedded applications, and the H.263 encoder with the proposed SAD implementation performs better than other H.263 encoder with other SAD implementations.

The Nutritive Values in Different Varieties of Corn Planted in One Location Fed to Growing Pigs over Three Consecutive Years

  • Zhang, L.;Li, Y.K.;Li, Z.C.;Li, Q.F.;Lyu, M.B.;Li, D.F.;Lai, C.H.
    • Asian-Australasian Journal of Animal Sciences
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    • v.29 no.12
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    • pp.1768-1773
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    • 2016
  • This experiment was conducted to determine the effect of variety and planting year on the nutritive values of corn fed to growing pigs. Four corn varieties examined in this experiment were planted in the same village located in Longhua County, Heibei Province, China, in 2012, 2013, and 2014, respectively. During each year, corn was hand-harvested in early October and sun dried to about 14% moisture content. Three batches of twenty-four barrows ($33.27{\pm}4.30$, $31.88{\pm}2.93$, $34.21{\pm}3.81kg$ body wight [BW] in 2012, 2013, and 2014, respectively) were used and allotted to a complete block design with 4 diets and 6 replicate pigs per diet. Pigs were individually placed in metabolic crates. The four experimental diets were formulated by mixing each variety of corn and vitamins and minerals, respectively. A five-day collection period followed a seven-day diet acclimation period. The results indicated that variety of corn significantly influenced the available energy content (digestible energy [DE] on dry matter basis, p<0.05; metabolizable energy (ME) on dry matter basis, p<0.05, respectively), and the apparent total tract digestibility (ATTD) of organic matter (p<0.01), dry matter (p<0.05), gross energy (p<0.05), neutral detergent fiber (p<0.01), acid detergent fiber and ether extract (p<0.05). The planting year also significantly influenced the available energy contents (DE on dry matter basis, p<0.05; ME on dry matter basis, p<0.01, respectively) and the ATTD of neutral detergent fiber (p<0.01), acid detergent fiber (p<0.01), crude protein (p<0.01), and ether extract (p<0.01). No interaction was observed between the variety and planting year in DE and ME contents in corn. In conclusion, the variety and planting year significantly influenced the available energy and nutrient digestibility of corn fed to growing pigs.