• Bulletin of the Korean Chemical Society
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• v.23 no.11
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• pp.1503-1504
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• 2002

• Macromolecular Research
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• v.15 no.1
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• pp.82-85
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• 2007

• Proceedings of the Optical Society of Korea Conference
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• 2001.08a
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• pp.248-249
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• 2001

• Proceedings of the Korean Institute of Surface Engineering Conference
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• 1999.05a
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• pp.86-87
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• 1999

• Bulletin of the Korean Chemical Society
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• v.27 no.12
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• pp.2067-2070
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• 2006

• Proceedings of the Korean Institute of Surface Engineering Conference
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• 1998.05a
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• pp.93-94
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• 1998

• Proceedings of the Korean Institute of Surface Engineering Conference
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• 1998.11a
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• pp.13-14
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• 1998

• Proceedings of the Korean Radioactive Waste Society Conference
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• 2017.05a
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• pp.333-333
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• 2017

• Archives of Pharmacal Research
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• v.21 no.6
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• pp.677-682
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• 1998

The present study was designed to examine the metabolism of 1-anilino-8-naphthalene sulfonate (ANS), an anionic compound which is transported into liver via "multispecific organ ic anion transporter", with rat hepatic microsomes. TLC analysis indicated that the fluorescent metabolites were not produced to a measurable extent, which made it possible to assess the ANS metabolism by measuring the fluorescence disappearance. The metabolism of ANS was remarkably inhibited by the presence of SKF-525A as well as by the substitution of 02 by CO gas. ANS metabolism by microsomes also required NADPH as a cofactor. These results indicated that the microsomal monooxygenase system might be mainly responsible for the ANS metabolism. The maximum velocity ($V_{max}$) and Michaelis constant ($K_m$) were calculated to be $4.3{\pm}0.2$ nmol/min/mg protein and $42.1{\pm}2.0\;{\mu}M$, respectively. Assuming that 1g of liver contains 32mg of microsomal protein, the $V_{max}$ value was extrapolated to that per g of liver ($V_{max}^I$). The intrinsic metabolic clearance ($CL_{int}$) under linear conditions calculated from this in vitro metabolic study was 3.3ml/min/g liver, being comparable with that (3.0ml/min/g liver) calculated by analyzing the in vivo plasma disappearance curve in a previous study. Furthermore, the effects of other organic anions on the metabolism of ANS were examined. Bromophenolblue (BPB) and rose bengal (RB) competitively inhibited the metabolism of ANS, while BSP inhibited it only slightly. The inhibition constant ($K_i$) of BPB ($6\;{\mu}M$) was much smaller than that of RB ($200\;{\mu}M$). In conclusion, the microsomal monooxygenase system plays a major role in the metabolism of ANS, and other unmetabolizable organic anions (BPB and RB) compete for this metabolism.

• Applied Chemistry for Engineering
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• v.26 no.4
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• pp.458-462
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• 2015

It is essential to employ a binder to prepare transparent films from conductive polymer such as poly(3,4-ethylenedioxythiophene)-poly(styrene sulfonate) (PEDOT/PSS). In this paper, poly(vinyl alcohol) (PVA), poly(vinyl pyrrolidone) (PVP), and PSS were selected as a binder, and their effects were investigated. The formation of the film was found to be primarily dependent on the surface tension of coating solution including PEDOT/PSS and a binder. When PSS was used as a binder, the film was not formed. In case of using PVP, it was easily peeled off from the substrate. However, when using the PVA or the mixtures of PVA and PSS or PVA and PVP as a binder, films with good transparency and uniform surface resistances were produced. Based on adhesion and long-term stability tests, we concluded that the mixture of PVA and PSS is the best binder for preparing antistatic films of PEDOT/PSS.