• Asian Pacific Journal of Cancer Prevention
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• 제14권1호
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• pp.523-528
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• 2013

Background: The possibility that electromagnetic fields (EMF) exposure may increase male breast cancer risk has been discussed for a long time. However, arguments have been presented that studies limited by poor quality could have led to statistically significant results by chance or bias. Moreover, data fo the last 10 years have not been systematically summarized. Methods and Results: To confirm any possible association, a meta-analysis was performed by a systematic search strategy. Totals of 7 case-control and 11 cohort studies was identified and pooled ORs with 95% CIs were used as the principal outcome measures. Data from these studies were extracted with a standard meta-analysis procedure and grouped in relation to study design, cut-off point, exposure assessment method, adjustment and exposure model. A statistical significant increased risk of male breast cancer with EMF exposure was defined (pooled ORs = 1.32, 95% CI = 1.14-1.52, P < 0.001), and subgroup analyses also showed similar results. Conclusions: This meta-analysis suggests that EMF exposure may be associated with the increase risk of male breast cancer despite the arguments raised.

• 한국융합학회논문지
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• 제11권2호
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• pp.361-373
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• 2020

본 연구의 목적은 국내에서 혈액투석환자를 대상으로 적용된 스트레스 중재프로그램을 메타분석하여 스트레스 중재프로그램의 효과를 확인하고, 스트레스 중재 방법의 특성과 경향을 파악하기 위함이다. 분석대상연구는 총 10편으로 MINORS를 사용하여 문헌의 질평가를 실시하였으며, Comprehen sive Meta Analysis Version 3.0 및 Review manager version 5.3을 활용하여 자료를 분석하였다. 연구의 질 평가 점수는 21.2점이었으며, 중재프로그램의 심리적 스트레스에 대한 효과크기는 -.72, 생리적 스트레스 중 코티졸의 효과크기는 -.52로 보통의 효과를 보였다. 하위그룹 분석에서 음악요법, 아로마요법, 투석 중 중재, 개인중재, 1회당 60분 이상의 중재, 총 10~20회기 중재의 효과가 더 컸다. 본 연구 결과를 활용하여 추후 효과적인 스트레스 중재프로그램을 구성할 수 있을 것이며, 추후 혈액투석환자를 대상으로 한 무작위배정 실험연구가 더 필요하다.

• 대한인간공학회지
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• 제34권5호
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• pp.501-517
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• 2015

Objective: The aim of this study was to investigate the technology trend on developing helmets based on the analysis of Korean, US, European and PCT patents. Background: The usage of the personal protective equipment such as the safety helmet would be essential for preventing injuries and reducing the severity of injuries depending on the type of activity and the exposed environment. Method: Database of WIPSON was used for searching the patents. The objects were the Korean, US, European and PCT patents registered or opened from January 2011 to December 2014. The keyword to investigate was helmet, and International Patent Classification (IPC) was used for investigating the technology trend of the patents. Results: The cases of US patents annually increased, but the cases of European patents decreased. US patents belonged to all sections but Korean and European patents and PCT patents did not. The largest number of IPC, to which four areas' patents belonged, was 'Headwear' and the second largest one was 'Hygiene'. In the subgroup level, the most common largest subgroups were 'Parts, details or accessories of helmets' and 'Masks, shields, or hoods for welders'. Korean patents had the lowest ratio of single_IPC at 11%, but the ratios of single_IPC for US and European patents were 52%, respectively. 'Human necessities', 'Mechanical engineering', 'Physics', and 'Electricity' were used as a single_IPC, but lower levels of 'Performing operations', 'Chemistry', 'Textiles' and 'Fixed constructions' were used as multi_IPC. Most main applicants had patents which belonged to 'Human necessities'. Conclusion: The cases of US patents annually increased unlike others. The common technologies for creating the helmet were Parts of helmets under Headwear and Shields for welders under Hygiene. Many Korean patents tended to be categorized as multi_IPC, different from others. Application: To know the technological characteristic of patents would be helpful to initial stage developers.

• Journal of Gastric Cancer
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• 제18권2호
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• pp.182-188
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• 2018

Purpose: Despite the fact that there are several reports of single-port laparoscopic distal gastrectomy (SPDG), no analysis of its learning curve has been described in the literature. The aim of this study was to investigate the favorable factors for SPDG and to analyze the learning curve of SPDG. Materials and Methods: A total of 125 cases of SPDG performed from November 2011 to December 2015 were enrolled. All operations were performed by 2 surgeons (surgeon A and surgeon B). The moving average method was used for defining the learning curve. All cases were divided into 10 cases in a sequence, and the mean operative time and estimated blood loss data were extracted from each group. Results: Surgeon A performed 68 cases (female-to-male sex ratio, 91.1%:8.82%), and surgeon B performed 57 cases (female-to-male sex ratio, 61.4%:38.5%). The operative time of surgeon B significantly decreased after 30 cases ($157.8{\pm}38.4$ minutes vs. $118.1{\pm}34.5$ minutes, P=0.003); that of surgeon A did not significantly decrease before and after around 30 cases ($160.8{\pm}51.6$ minutes vs. $173.3{\pm}35.2$ minutes, P=0.6). The subgroup analysis showed that the operative time significantly decreased in the patients with body mass index (BMI) of <$25kg/m^2$ (<$25kg/m^2$:${\geq}25kg/m^2$, $159.3{\pm}41.7$ minutes: $194.25{\pm}81.1$ minutes; P=0.001). Conclusions: Although there was no significant decrease in the operative time for surgeon A, surgeon B reached the learning curve upon conducting 30 cases of SPDG. BMI of <$25kg/m^2$ was found to be a favorable factor for SPDG.

• Asian Pacific Journal of Cancer Prevention
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• 제14권7호
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• pp.4107-4113
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• 2013

Objective: Matrix metalloproteinase-9(MMP-9) plays an important role in tumor cell invasion. Although it has been studied frequently in ovarian cancer, its prognostic impact is still equivocal. The aim of this study was to more precisely estimate its prognostic significance. Method:We searched Pubmed, Embase, OVID, Sciencedirect and CBM databases to identify eligible studies. Hazard ratios (HRs) or odds ratios (ORs) with 95% confidence intervals (95% CIs) were pooled across studies using fixed-effects or random-effects models. We also performed subgroup analysis. Results: 30 studies (n=2552 patients) focusing on prognosis or expression of MM-9 were included. Increased expression of MMP-9 was associated with poor prognosis in ovarian cancer patients (HR=1.68, 95%CI 1.09-2.59, p=0.02). Besides, MMP-9 expression in ovarian cancer was significantly higher than non-malignant tumors (OR=11.46, 95%CI 8.47-15.50, P<0.00001). Moreover, increased expression of MMP-9 was significantly associated with FIGO stage (OR=4.85, 95%CI 2.60-9.04, P<0.00001), grade of differentiation (OR=3.34, 95%CI 2.46-4.54, P<0.00001), lymph node metastasis (OR=5.75, 95%CI 3.71-8.92, P<0.00001) and there was no association with histological type of ovarian cancer. Conclusions: Increased expression of MMP-9 was associated with poor prognosis in ovarian cancer patients. Down-regulation of MMP-9 is an attractive therapeutic approach which might improve outcome of ovarian cancer.

• Asian Pacific Journal of Cancer Prevention
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• 제13권7호
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• pp.3143-3147
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• 2012

Background: Previous studies investigating the association of physical activity with risk of lung cancer reported conflicting results. In order to update and improve available evidence on any link, a meta-analysis was performed. Method: We searched the PubMed database for prospective cohort studies investigating the relation of physical activity with risk of lung cancer. The pooled relative risk (RR) with its 95% confidence intervals (95%CI) was used to assess the association. Results: We included 14 prospective studies with a total of 1,644,305 participants, with 14,074 incident lung cancer cases documented during follow-up. Meta-analysis of all 14 studies suggested both high and medium levels of physical activity to be associated with decreased risk of lung cancer compared to the reference group with low level of physical activity (for high level, RR = 0.77, 95%CI 0.73-0.81, P < 0.001; for medium level, RR = 0.87, 95%CI 0.83-0.90, P < 0.001). Subgroup analyses by gender found obvious associations in both men and women. No publication bias was observed. Conclusion: Our findings suggest that high and medium levels of physical activity have a beneficial effect on lung cancer by reducing the overall risk of tumour development among both men and women.

• 대한지역사회영양학회지
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• 제11권4호
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• pp.534-540
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• 2006

Recent studies have shown that environmental, biochemical, nutritional or genetic factors affect bone mineral density (BMD). The purpose of the present study was to investigate the effect of vitamin D receptor (VDR) gentotype and nutritional status on BMD of elderly women living in a rural area. Three hundred thirty five elderly women over 65 years in Asan participated the study. Data for demographic and nutrient intakes were obtained by survey with a two day 24 hr recall method. BMD was measured by broadband ultrasound attenuation (BUA) using quantitative ultrasound (QUS). VDR genotypes of the subjects analyzed with Bsm I restriction enzyme were bb (92%), Bb (7%) and BB (1%). No differences were found between genotypes bb and Bb/BB in age, menopausal age, body mass index and body fat. BUA of bb genotype was higher (62.5 $\pm$ 15.6 dB/MHz) than Bb/BB genotype (56.1 $\pm$ 17.6 dB/MHz) by Student's t-tests. Correlation analyses showed strong negative correlation of BMD and age, but positive correlation with BMI, energy and calcium intake. When subgroup analyses were conducted after stratification by the median calcium intake level (412.9 mg/d), the above median calcium intake group showed significant difference in BUA by VDR genotype while the lower median calcium intake group did not show significant difference. The current study confirmed interaction of calcium intake and VDR genotype in association with BMD. Further nutritional intervention will be needed to improve calcium status of the elderly women living in rural areas.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제23권4호
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• pp.388-396
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• 2020

Purpose: Impaired intestinal mucosal integrity may affect the gastrointestinal function, especially in relation to nutrition, absorption, and barrier function. The purpose of this study was to measure the prevalence of impaired intestinal mucosal integrity in presumed healthy children aged 1-3 years and assess the effects of zinc, glutamine, fiber, and prebiotic supplementation in them. Methods: A cross-sectional study was conducted in 200 children aged 1-3 years in Pasar Minggu, South Jakarta, Indonesia. A randomized double-blind parallel group method clinical trial was then performed to assess the effects of zinc, glutamine, fiber, and prebiotic supplementation. Results: Elevated calprotectin was found in 91/200 subjects (45.5%) at the onset of the study. After 10 months, 144 subjects completed the study: 72 subjects received the trial formula, whereas the other 72 received the standard formula. A transitory decrease in fecal calprotectin (FC) was observed after 6 months in the subgroup with normal FC levels, who were fed the test formula (p=0.012). Conclusion: The prevalence of impaired intestinal mucosal integrity in this group of Indonesian children aged 1-3 years was high. Supplementation with zinc, glutamine, fiber, and prebiotics during 6 months reduced FC only in those who had low levels at baseline but not in those with impaired integrity.

• 인터넷정보학회논문지
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• 제3권2호
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• pp.79-85
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• 2002

개방형 통신망 구조에서 어플리케이션 시스템은 다수의 컴퓨팅 노드에 분산되어 있는 객체들의 집합으로 구성된다. 이러한 분산된 환경에서 복잡한 분산 소프트웨어의 개발 및 관리의 복잡성을 줄이고 분산된 객체들을 효율적으로 관리하면서 객체들의 실시간 서비스를 제공하기 위해서는 객체 그룹 관리 및 통신 기법이 필요하다. 본 연구에서는 CORBA를 기반으로 하여 기존의 시스템에 큰 변환 얼이 새로운 서비스를 적용시킬 수 있도록 객체그룹을 구성하고 신뢰성 있는 그룹통신 기법을 제공한다. 그룹관리의 효율향상을 위해 그룹을 서브그룹으로 나누고 서브그룹 관리자를 두어 서브그룹을 관리하도록 하였으며, 시퀀서를 두어 메시지의 순서성을 유지시킨다. 그룹간의 통신방법은 IP 멀티캐스트와 일대일 통신을 기반으로 한 멀티캐스트 기법을 혼용하여 사용하며 메시지 저장소를 두어 오류 발생 시 선택적으로 메시지를 재 전송할 수 있도록 함으로서 성능을 향상시켰다. 제안된 기법을 분산환경에서 시뮬레이션을 통하여 성능을 평가하였다.

• 동아시아식생활학회지
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• 제16권1호
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• pp.23-28
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• 2006

The purpose of this paper was to clarify the actual conditions of the 'Dietary externalization' mainly by using the economic and nutrition-related data, accompanied by the economic development in Korea and Japan. 'Modernization of food style' and other modernization have taken place, among which 'Dietary externalization' in particular has recently drawn interest. At the time this paper clarified with econometric analysis whether there are differences between the two countries in term of the modernization of food style and dietary externalization trend. The trends of Dietary externalization of both Korea and Japan were studied using Principal Component Analysis method. The food subgroup were investigated based on the annual report on the household income and expenditure survey of Korea and the annual report on the family income and expenditure survey of Japan. The statistical data from both country were analyzed by SAS program. The results are as follows; 1. In Korea, the ratio of carbohydrates in the total calorie intake is quite high and animal protein is rather low compared to those in Japan. 2. Traditional food such as grains and vegetables are consumed much more in Korea than in Japan. 3. The Principal Component 1, 2 were extracted in both countries during the whole analysis period, which suggested the 'Dietary externalization' 4. Principal Component 1 has a positive factor loaded in all food items including meals outside the home and process food. In other words, it is apparent that the 'Dietary externalization' tread in Korea has a simple pattern suggesting that all externalization related items are on the rise. 5. Principal component 1, 2 which indicated the dietary externalization, were detected in Japan.