• Molecules and Cells
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• v.44 no.7
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• pp.458-467
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• 2021

GPR43 (also known as FFAR2 or FFA2) is a G-protein-coupled receptor primarily expressed in immune cells, enteroendocrine cells and adipocytes that recognizes short-chain fatty acids, such as acetate, propionate, and butyrate, likely to be implicated in innate immunity and host energy homeostasis. Activated GPR43 suppresses the cAMP level and induces Ca²⁺ flux via coupling to Gα_i and Gα_q families, respectively. Additionally, GPR43 is reported to facilitate phosphorylation of ERK through G-protein-dependent pathways and interacts with β-arrestin 2 to inhibit NF-κB signaling. However, other G-protein-dependent and independent signaling pathways involving GPR43 remain to be established. Here, we have demonstrated that GPR43 augments Rho GTPase signaling. Acetate and a synthetic agonist effectively activated RhoA and stabilized YAP/TAZ transcriptional coactivators through interactions of GPR43 with Gα_q/11 and Gα_12/13. Acetate-induced nuclear accumulation of YAP was blocked by a GPR43-specific inverse agonist. The target genes induced by YAP/TAZ were further regulated by GPR43. Moreover, in THP-1-derived M1-like macrophage cells, the Rho-YAP/TAZ pathway was activated by acetate and a synthetic agonist. Our collective findings suggest that GPR43 acts as a mediator of the Rho-YAP/TAZ pathway.

• Bulletin of the Korean Mathematical Society
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• v.60 no.4
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• pp.915-931
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• 2023

Let F_n be the Farey sequence of order n. For S ⊆ F_n, let 𝓠(S) be the set of rational numbers x/y with x, y ∈ S, x ≤ y and y ≠ 0. Recently, Wang found all subsets S of F_n with |S| = n + 1 for which 𝓠(S) ⊆ F_n. Motivated by this work, we try to determine the structure of S ⊆ F_n such that |S| = n and 𝓠(S) ⊆ F_n. In this paper, we determine all sets S ⊆ F_n satisfying these conditions for n ∈ {p, 2p}, where p is prime.

• Korean Journal of Materials Research
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• v.25 no.8
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• pp.423-428
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• 2015

Impedancemetric $NO_x$ (NO and $NO_2$) gas sensors were designed with a stacked-layer structure and fabricated using $LaCr_xCo_{1-x}O_3$ (x = 0, 0.2, 0.5, 0.8 and 1) as the receptor material and $Li_{1.3}Al_{0.3}Ti_{1.7}(PO_4)_3$ plates as the solid-electrolyte transducer material. The $LaCr_xCo_{1-x}O_3$ layers were prepared with a polymeric precursor method that used ethylene glycol as the solvent, acetyl acetone as the chelating agent, and polyvinylpyrrolidone as the polymer additive. The effects of the Co concentration on the structural, morphological, and $NO_x$ sensing properties of the $LaCr_xCo_{1-x}O_3$ powders were investigated with powder X-ray diffraction, field emission scanning electron microscopy, and its response to 20~250 ppm of $NO_x$ at $400^{\circ}C$ (for 1 kHz and 0.5 V), respectively. When the as-prepared precursors were calcined at $700^{\circ}C$, only a single phase was detected, which corresponded to a perovskite-type structure. The XRD results showed that as the Co concentration of the $LaCr_xCo_{1-x}O_3$powders increased, the crystal structure was transformed from an orthorhombic phase to a rhombohedral phase. Moreover, the $LaCr_xCo_{1-x}O_3$ powders with $0{\leq}x<0.8$ had a rhombohedral symmetry. The size of the particles in the $LaCr_xCo_{1-x}O_3$powders increased from 0.1 to $0.5{\mu}m$ as the Co concentration increased. The sensing performance of the stack-structured $LaCr_xCo_{1-x}O_3/Li_{1.3}Al_{0.3}Ti_{1.7}(PO_4)_3$ sensors was found to divide the impedance component between the resistance and capacitance. The response of these sensors to NO gas was more sensitive than that to $NO_2$ gas. Compared to other impedancemetric sensors, the $LaCr_{0.8}Co_{0.2}O_3/Li_{1.3}Al_{0.3}Ti_{1.7}(PO_4)_3$ sensor exhibited good reversibility and reliable sensingresponse properties for $NO_x$ gases.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.29 no.10C
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• pp.1451-1459
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• 2004

In this paper, a low-power 32-point IMDCT structure is proposed for MP3. Through re-odering of IMDCT matrices, we propose the systolic structure operating with 16, 8, 4, 2, and 1 cycle, respectively. To reduce power consumption, multiplication of each sub blocks are implemented by add and shift operation with CSD(Canrmic sigled digit) form coefficients. To reduce, furthermore, the number of adders, we utilize the common sub-expression sharing techniques. With these techniques, the relative power consumption of the proposed structure is reduced by 58.4% comparison to the conventional structure using only 2's complement form coefficient. Validity of the proposed structure is proved through Verilog-HDL coding.

• Korean Journal of Materials Research
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• v.34 no.8
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• pp.377-386
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• 2024

The surface of titanium (Ti) dental implants was modified by applying a zinc (Zn)-doped titanium dioxide (TiO₂) coating. Initially, the Ti surfaces were etched with NaOH, followed by a hydrolysis co-condensation using tetrabutyl titanate (TBT, Ti(OC₄H₉)₄) and zinc nitrate hexahydrate (Zn(NO₃)₂·6H₂O), with ammonia water (NH₃·H₂O) acting as a hydroxide anion source. The morphology and chemical composition of the Zn-doped TiO₂-coated Ti plates were characterized using X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), Raman spectroscopy, and scanning electron microscopy (SEM). Synthesis temperatures were carefully adjusted to produce anatase Zn-doped TiO₂ nanoparticles with a bipyramidal structure and approximate sizes of 100 nm. Wettability tests and cell viability assays demonstrated the biomedical potential of these modified surfaces, which showed high biocompatibility with a survival rate of over 95 % (p < 0.05) and improved wettability. Corrosion resistance tests using potentiodynamic polarization reveal that Zn-TiO₂-treated samples with an anatase crystal structure exhibited a lower corrosion current density and more noble corrosion potential compared to samples coated with a rutile structure. This method offers a scalable approach that could be adapted by the biomaterial industry to improve the functionality and longevity of various biomedical implants.

• ETRI Journal
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• v.44 no.2
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• pp.260-273
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• 2022

This study presents a novel multilayer structure of parallel coupled-line bandpass filtercentered at 2.42 GHz with a fractional bandwidth value of approximately 19.4%. The designed filter can suppress harmonics with an appropriate frequency response by incorporating different techniques based on the multilayer technique. A combination of different techniques such as radial microstrip stubs and defected ground structure (DGS) and defected microstrip structure techniques are employed to suppress harmonics up to 5f₀. These techniques are used in two layers to suppress up to 5f₀. In addition, in this study, the effects of different parameters, such as the width of slot-line DGS, the angle of diagonal line slots in the upper layer, and the air gap between the two layers on the filter performance, are investigated. To verify the correct circuit operation, the designed filter is implemented and tested. The measurement results of the proposed filter are compared with the simulation results.

• Journal of the Korean Mathematical Society
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• v.61 no.2
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• pp.309-339
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• 2024

Let M be a real hypersurface in the complex hyperbolic quadric Q^m*, m ≥ 3. The Riemannian curvature tensor field R of M allows us to define a symmetric Jacobi operator with respect to the Reeb vector field ξ, which is called the structure Jacobi operator R_ξ = R( · , ξ)ξ ∈ End(TM). On the other hand, in [20], Semmelmann showed that the cyclic parallelism is equivalent to the Killing property regarding any symmetric tensor. Motivated by his result above, in this paper we consider the cyclic parallelism of the structure Jacobi operator R_ξ for a real hypersurface M in the complex hyperbolic quadric Q^m*. Furthermore, we give a complete classification of Hopf real hypersurfaces in Q^m* with such a property.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.35 no.1
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• pp.27-32
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• 2003

To understand the chemical structure of sewer sludge in comparison with commercial compost and charcoal used as a soil improver, it was carried out to analyse their ash contents and metal ions, and to elucidate the chemical structure of their residuals after a sequential treatment of alcohol-benzene(1:2) extraction in Soxhlet, 3% HCl reflux and 79% H₂SO₄ hydrolysis, using CHNS analyzer and solid C-13 NMR spectrometer. The results obtained were as follows: 1. Ash content of sludge was about 46% that is higher than those of compost (17%) and charcoal (4%). 2. The residual of sludge after a sequential treatment of HCl and H₂SO₄ hydrolyses had high ash content about 23%, too. 3. The sludge seems to be suitable to the soil improver because the content of heavy metal ions in sludge was near the compost and below the organic fertilizer standard. 4. Elemental composition of sludge residual after HCl-H₂SO₄ hydrolyes was C/sub 56/H/sub 91/O/sub 12/N₂S = (C/sub 6/H/sub 10/O/sub 5/)/sub 7/(C/sub 6/H₄)/sub 7/C₂H/sub 43/O₂N₂S, similar to C/sub 103/H/sub 122/O/sub 33/N/sub 6/S = (C/sub 6/H/sub 10/O/sub 5/)/sub 6/(C/sub 6/H₄)/sub 10/C/sub 7/H/sub 22/O₃N/sub 6/S of compost. 5. The sludge residual had proved to have both considerable aliphatic and aromatic groups, but the compost residual to have mainly aliphatic groups and the charcoal to have mainly aromatic groups, through the peak analysis of solid C-13 NMR charts. 6. So, the sewer sludge is proved to have a considerable amount of aromaticity like in woody biomass containing lignin.

• Bulletin of the Korean Chemical Society
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• v.26 no.9
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• pp.1447-1449
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• 2005

• Journal of IKEEE
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• v.26 no.1
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• pp.129-132
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• 2022

In this paper, a technique for optimizing the sub-array system structure that can minimize the side lobe level of the phased-array antenna is proposed. Optimization of the proposed array antenna structure is to adjust the spacing between sub-arrays and sub-arrays by using a hexagonal array structure of one sub-array and a hexagonal sub-array for six hexagonal arrays, and thus the entire phased array antenna system of the radiation pattern was optimized. Compared to the 2-dimensional planar antenna system, the proposed technique maintains a gain of 24.3 dBi and a half-power beam-width of 8.46 degrees without change, and only reduces -3.4 dB and -6.5 dB in the x-axis and y-axis directions, respectively.