• Molecules and Cells
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• v.42 no.7
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• pp.512-522
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• 2019

Chromosomes located in the nucleus form discrete units of genetic material composed of DNA and protein complexes. The genetic information is encoded in linear DNA sequences, but its interpretation requires an understanding of three-dimensional (3D) structure of the chromosome, in which distant DNA sequences can be juxtaposed by highly condensed chromatin packing in the space of nucleus to precisely control gene expression. Recent technological innovations in exploring higher-order chromatin structure have uncovered organizational principles of the 3D genome and its various biological implications. Very recently, it has been reported that large-scale genomic variations may disrupt higher-order chromatin organization and as a consequence, greatly contribute to disease-specific gene regulation for a range of human diseases. Here, we review recent developments in studying the effect of structural variation in gene regulation, and the detection and the interpretation of structural variations in the context of 3D chromatin structure.

• Geomechanics and Engineering
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• v.18 no.3
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• pp.329-337
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• 2019

This paper presents an experimental investigation about visualization of bulging development of geosynthetic-encased stone column (GESC) based on the digital image correlation (DIC) technique and transparent soil. Visual model tests on GESC and ordinary stone column (OSC) were carried out. In order to delete the warping effect resulting from transparent soil and experiment setup, a modification for experiment results was performed. The bulging development process of the GESC and the displacement field of the surrounding soil were measured. By comparing with the existing experimental and theoretical results, it demonstrates that the model test system developed for studying the continuous bulging development of GESC is suitable. The current test results show that the bulging depth of GESC ranges from 1.05 to 1.40 times the diameter of GESC. The influence depth of GESC bulging on surrounding soil displacement is 0~3 the times diameter of GESC.

• Advances in concrete construction
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• v.7 no.4
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• pp.231-239
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• 2019

The present study deals with the development of metakaolin-based geopolymer concrete (GPC) and thereafter studying the effects of adding ultra-fine slag on its mechanical and permeability characteristics. The mechanical characteristics including compressive, split tensile, flexural strengths and elastic modulus were studied. In addition, permeability characteristics including water absorption, porosity, sorptivity and chloride permeability were studied up to 90 days. The results showed the effective utilization of metakaolin for the development of elevated temperature cured geopolymer concrete having high 3-day compressive strength of 42.6 MPa. The addition of ultra-fine slag up to 15%, as partial replacement of metakaolin resulted in an increase in strength characteristics. Similar improvement in durability properties was also observed with the inclusion of ultra-fine slag up to 15%. Beyond this optimum content of 15%, further increase in ultra-fine slag content affected the mechanical as well as permeability parameters in a negative way. In addition, the relationship between various properties of GPC was also derived.

• The Bulletin of The Korean Astronomical Society
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• v.44 no.1
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• pp.73.3-73.3
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• 2019

A Korean VLBI Network $1^{st}$ generation key science program, the Interferometric Monitoring of Gamma-ray Bright AGNs (iMOGABA) program has revealed various natures of gamma-ray flares in active galactic nuclei (AGNs). Here in this presentation, we would like to introduce a new candidate of KVN $2^{nd}$ generation key science program, so called, the AiMOGABA (Astrometric iMOGABA), aiming at studying a wondering radio core effect of relativistic jets from AGNs with high resolution VLBI astrometric monitoring of high-energy bursting AGNs with KVN as well as a Australian millimeter radio telescope MOPRA. The introduction will include the current scientific highlights of the iMOGABA, and the overview of the AiMOGABA.

• The Bulletin of The Korean Astronomical Society
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• v.44 no.1
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• pp.73.5-73.5
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• 2019

Studying the amount and kinematics of circumand intergalactic medium (CGM and IGM) is key to understanding the role of feedback and environment (cold streams and galactic winds) in the evolution of galaxies. In particular, $Ly{\alpha}$ emission line has been utilized to investigate the density structure and kinematics of the (most abundant) H I gas in the CGM and IGM around galaxies. Therefore, modeling $Ly{\alpha}$ radiative transfer through multiphase interstellar medium (ISM), CGM and IGM is crucial in understanding the galaxy evolution. As discussed in Kakiichi & Dijkstra (2018), most $Ly{\alpha}$ RT effects would occur on interstellar scales. This is because the main source of $Ly{\alpha}$ photons would be H II regions, which are in most cases, if not all, surrounded by "cold" photo-dissociation regions. However, most $Ly{\alpha}$ RT studies have been performed in the CGM and IGM environments with T ~ 10,000K. In this talk, we present how the $Ly{\alpha}$ RT effect in the cold ISM with T ~ 100 K regulates the $Ly{\alpha}$ spectral properties.

• International Journal of Computer Science & Network Security
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• v.22 no.4
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• pp.229-236
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• 2022

This study investigates the impact of flipped classroom strategy in developing students' achievement and acquisition of life skills. The study employed a quasi-experimental design where students were divided into two groups: an experimental (N=22) and a control (N=22). The randomly selected and assigned sample consisted of sixth-year elementary school students studying English as a basic course. The findings revealed statistically significant differences between the two group's means in both achievement and life skills tests in favor of the experimental group. Students of the experimental group who studied using the flipped classroom strategy outperformed the control group who studied in the standard way in achieving the English language and in the life situations test, where the effect size of the use of the strategy was large in both dependent variables. The study is concluded with some recommendations to facilitate the use of flipped classroom strategy for EFL teachers. This can be achieved by training teachers on using the strategy and providing technological resources at schools to implement the strategy efficiently.

• Journal of Platform Technology
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• v.10 no.3
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• pp.3-10
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• 2022

The effectiveness of an innovative skin treatment system that delivers an anti-aging solution deep into the skin without invasiveness and pain using a non-invasive air technology was investigated. In addition, an effective change using a non-invasive technique for delivering a solution for skin improvement was confirmed. The equipment named Cellre Jet is an effective skin care and drug delivery equipment that instantly opens the skin epidermis by using a maximum output pressure of 6 bars and high-pressure purified oxygen of 75-90% purity to deliver various nano-sized vital substances deep into the skin, and it uses the method of precisely controlling the equipment through an 8-inch digital touch display to accurately dispense the prescribed dosage. In this study, changes in skin condition were analyzed using this equipment and nano ampoules on subjects with actual skin problems through a related comparison and effectiveness judgment program. Through this study, skin care and drug delivery are possible, which will contribute to verifying the effectiveness of this non-invasive drug delivery equipment in the future, and is expected to establish the systematic effect in observing and studying changes in the skin.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2020.06a
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• pp.117-118
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• 2020

The masonry structure is constructed by cement mortar binding material of brick objects and uses reinforced hardware (connected hardware or wall tie) together when building. However, over time, the corrosion of reinforced steel and the deterioration of joint mortar as well as bricks cause the risk of collapse. In particular, when the externally decorated brick wall is installed on the concrete girder for each floor, the angle bracket is not constructed or corroded, the full-layer weight load is applied to the wall of 0.5B, which is an example of full-scale or collapse. The purpose of this study is to provide numerical information on the reinforcement design by experimentally studying the structural performance of concrete reinforcement brackets that reinforce the vertical load of the exterior wall.

• Steel and Composite Structures
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• v.47 no.6
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• pp.795-811
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• 2023

When studying the resonance problem of nanoplates, the existing papers do not consider the influences of geometric nonlinearity and initial geometric imperfection, so this paper is to fill this gap. In this paper, based on the nonlocal strain gradient theory (NSGT), the nonlinear resonances of functionally graded (FG) nanoplates with initial geometric imperfection under different boundary conditions are established. In order to consider the small size effect of plates, nonlocal parameters and strain gradient parameters are introduced to expand the assumptions of the first-order shear deformation theory. Subsequently, the equations of motion are derived using the Euler-Lagrange principle and solved with the help of perturbation method. In addition, the effects of initial geometrical imperfection, functionally graded index, strain gradient parameter, nonlocal parameter and porosity on the nonlinear forced vibration behavior of nanoplates under different boundary conditions are discussed.

• Journal of Information Technology Applications and Management
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• v.30 no.3
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• pp.15-35
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• 2023

Considerable agreement exists about the importance of promoting entrepreneurship in both developed and developing countries. In less developed countries, governments see entrepreneurship as a way to stimulate economic development and tackle serious economic and social challenges. So how can countries encourage young people to become entrepreneurs? Research confirms that intentions play an important role in the decision to start a new firm and many factors influence that intentions. The purpose of the study was to investigate the antecedents to entrepreneurship behavior with particular attention to moderating role of social support and entrepreneur self-efficacy. The study covered 116 business students of undergraduate and post graduate level studying under different universities in Kathmandu, Nepal. The questionnaire for data collection was distributed in college groups via WhatsApp and viber with the support and permission from the college administration. The study design used was correlational with a sampling procedure of convenience. The study only showed the impact of attitude to entrepreneurship behavior as well as moderating effect of social support was also observed.