• International Journal of Naval Architecture and Ocean Engineering
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• v.3 no.4
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• pp.274-285
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• 2011

The supercavitating vehicle is an underwater vehicle that is surrounded almost completely by a supercavity to reduce hydrodynamic drag substantially. Since the cruise speed of the vehicle is much higher than that of conventional submarines, the drag force is huge and a buckling may occur. The buckling phenomenon is analyzed in this study through static and dynamic approaches. Critical buckling load and pressure as well as buckling mode shapes are calculated using static buckling analysis and a stability map is obtained from dynamic buckling analysis. When the finite element method (FEM) is used for the buckling analysis, the solver requires a linear static solver and an eigenvalue solver. In this study, these two solvers are integrated and a consolidated buckling analysis module is constructed. Furthermore, Particle Swarm Optimization (PSO) algorithm is combined in the buckling analysis module to perform a design optimization computation of a simplified supercavitating vehicle. The simplified configuration includes cylindrical shell structure with three stiffeners. The target for the design optimization process is to minimize total weight while maintaining the given structure buckling-free.

• Journal of Auto-vehicle Safety Association
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• v.11 no.4
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• pp.6-15
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• 2019

Since introducing the offset frontal impact test in EuroNCAP in 1997, the vehicle has been constantly changing according to its usage and purpose. As of 2019, many vehicles have been released to the public, which has led to a large structural mass difference between small, medium and large vehicles. Also, the geometry of the front of the vehicle is completely different for each vehicle and tends not to be perfectly aligned at frontal collisions. The difference in mass of each of these vehicles and less performing structures for offset crashes have led to dramatically worse outcome in a car to car offset frontal impact tests. Even though a decade later passenger cars have become much safer due to consumer test programs and regulatory requirements, the aggressiveness and compatibility that can cause damage to the opponent car in the event of car to car collision is not considered in the above-mentioned section, and therefore much improvement is needed. After many years of study to solve this problem, EuroNCAP has developed a new mode MPDB offset front test that considers the aggressiveness and compatibility that can affect the opponent cars that have collided. This paper introduces the development process of aggressiveness and compatibility evaluation method of MPDB in EuroNCAP which will be implemented from 2020. Several impact tests have been conducted at different test conditions to rate the vehicle structure performance only focused on aggressiveness and compatibility of MPDB.

• Molecules and Cells
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• v.41 no.9
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• pp.842-852
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• 2018

Notch signaling is an evolutionarily conserved pathway and involves in the regulation of various cellular and developmental processes. Ligand binding releases the intracellular domain of Notch receptor (NICD), which interacts with DNA-bound CSL [CBF1/Su(H)/Lag-1] to activate transcription of target genes. In the absence of NICD binding, CSL down-regulates target gene expression through the recruitment of various corepressor proteins including SMRT/NCoR (silencing mediator of retinoid and thyroid receptors/nuclear receptor corepressor), SHARP (SMRT/HDAC1-associated repressor protein), and KyoT2. Structural and functional studies revealed the molecular basis of these interactions, in which NICD coactivator and corepressor proteins competitively bind to ${\beta}-trefoil$ domain (BTD) of CSL using a conserved ${\varphi}W{\varphi}P$ motif (${\varphi}$ denotes any hydrophobic residues). To date, there are conflicting ideas regarding the molecular mechanism of SMRT-mediated repression of CSL as to whether CSL-SMRT interaction is direct or indirect (via the bridge factor SHARP). To solve this issue, we mapped the CSL-binding region of SMRT and employed a 'one- plus two-hybrid system' to obtain CSL interaction-defective mutants for this region. We identified the CSL-interaction module of SMRT (CIMS; amino acid 1816-1846) as the molecular determinant of its direct interaction with CSL. Notably, CIMS contains a canonical ${\varphi}W{\varphi}P$ sequence (APIWRP, amino acids 1832-1837) and directly interacts with CSL-BTD in a mode similar to other BTD-binding corepressors. Finally, we showed that CSL-interaction motif, rather than SHARP-interaction motif, of SMRT is involved in transcriptional repression of NICD in a cell-based assay. These results strongly suggest that SMRT participates in CSL-mediated repression via direct binding to CSL.

• Journal of Korean Society of Steel Construction
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• v.11 no.2 s.39
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• pp.201-212
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• 1999

A beam supported by a flexible elastic support is commonly used as structural elements, e.g., braced beam, railway track, etc. The elastic support can be located in arbitrary point in the cross-section. This paper investigates the effects of support eccentricity on the elastic buckling of beams with elastic supports. The effects of stiffness of the elastic support are also studied. A beam element with elastic supports and the analysis program are developed for elastic buckling analysis using finite element formulation. The elastic support is modeled by elastic spring element. Using the offset technique, the eccentricity of support is taken into account. A beam element having 14 degrees of freedom including the warping degree of freedom is used. Various numerical example analyses show that the present formulation and analysis program accurately and effectively compute the buckling load and mode of beams with elastic supports.

• Proceedings of the Korean Society for Applied Microbiology Conference
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• 2004.06a
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• pp.215-218
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• 2004

Dextrans make up a class of polysaccharides that are D-glucans of various structures with contiguous $\alpha$-1longrightarrow6 ~6 glycosidic linkages in the main chains and $\alpha$-1longrightarrow2, $\alpha$-1longrightarrow3, or $\alpha$-1longrightarrow4 branch glycosidic linkages, depending on the specificity of the particular dextransucrase. Glucansucrases that catalyze glucans synthesis from sucrose. When other carbohydrates, in addition to sucrose, are present in the enzyme digest, the enzyme transfers glucose to the carbohydrate acceptors in the secondary reaction that diverts some of the glucose from incorporation into glucan. Many carbohydrate acceptors have been recognized and the products that result are dependent on the particular enzyme and the structure of the particular acceptor. Because of these unique catalytic characteristics, various dextransucrases have many important industrial and medical uses. To improve the understanding of their action mode and extend their applications, this study describes mechanism of glucan synthesis and potential industrial uses of dextransucrases, and our recent findings on the structural, functional organization and directed evolution of the glucansucrases to offer for designing glucansucrases with improved properties.

• Composites Research
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• v.16 no.6
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• pp.23-32
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• 2003

Applications of advanced composite material in construction field are tending upwards and development of all composite material bridges is making progress rapidly in home and abroad due to their high strength to weight ratio. This paper formulated the dynamic responses of the laminated composite structures subjected to moving load and analyzed the various dynamic behaviors using the finite element method. The nondimensionalized natural frequencies of a simply supported square-laminated composite plate are considered for verifications. Mode superposition and Newmark direct integration method are applied for moving load analysis. For structural models, dynamic magnification factor calculated for various velocities of the moving load and displacements characteristics of laminated composite structures due to the moving load are investigated theoretically Numerical results are presented to study the effects of lamination scheme, stacking sequence, and fiber angle for laminated composite structures during moving load. The various results on moving load and lamination through numerical analysis will present an important basic data for development and grasp the behavior of all composite material bridges.

• The Journal of Information Systems
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• v.29 no.1
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• pp.93-111
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• 2020

Purpose The purpose of this paper is to observe the relative priorities of importances among the modified versions of Block chain system, being based on AHP decision support model which should be also proposed in this paper. Design/methodology/approach Four versions modified from the beginning of Block chain were divided into Public& Permissionless, Private&Permissionless, Public&Permissioned and Private&Permissioned types. Five criteria for evaluating the four versions whether the version were suitable for Medical information system were introduced from five factors of Technologies Accept Model, which were Security, Availability, Variety, Reliability and Economical efficiency. We designed Decision support model based on AHP which would select the best alternative version suitable for introducing the Block chain technology into the medical information systems. We established the objective of the AHP model into finding the best choice among the four modified versions. First low layer of the model contains the five factors which consisted of Security, Availability, Variety, Reliability and Economical efficiency. Second low layer of the model contains the four modified versions which consisted Public&Permissionless, Private&Permissionless, Public&Permissioned and Private& Permissioned types. The structural questionnaire based on the AHP decision support model was designed and used to survey experts of medical areas. The collected data by the question investigation was analyzed by AHP analysis technique. Findings The importance priority of Security was highest among five factors of Technologies Accept Mode in the first layer. The importance priority of Private&Permissioned type was highest among four modified versions of Block chain technologies in second low layer. The second importance priority was Private&Permissionless type. The strong point of Private&Permissioned type is to be able to protect personal information and have faster processing speeds. The advantage of Private& Permissionless type is to be also able to protect personal information as well as from forging and altering transaction data. We recognized that it should be necessary to develop new Block chain technologies that would enable to have faster processing speeds as well as from forging and altering transaction data.

• BMB Reports
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• v.37 no.2
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• pp.153-158
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• 2004

The acid-labile subunit (ALS) is known to interact with the IGF binding protein (IGFBP) in the presence of insulin-like growth factors (IGFs). Studies, however, indicate that ALS forms a doublet with IGFBP3, independent of IGFs. To characterize the structural domain required for the IGF-free ALS-IGFBP3 interaction, seven recombinant human IGFBP3 mutants were generated: three deletion mutants and four site-specific mutants that had altering N-terminal regions of IGFBP3. ALS and IGFBP3 mRNAs were co-injected into Xenopus oocytes, and their products were cross-linked and immunoprecipitated using antisera against ALS or IGFBP3. Among the deletion mutants, the mutant of D40 (deleted in 11-40th amino acids) exerted no effect in the interaction with ALS, while D60 (${\Delta}11$-60) demonstrated a moderate reduction. D88 (${\Delta}11$-88), however, showed a significant decrease. In the case of site-specific mutants, the mutation that alterated the IGF binding site (codons 56 or 80) exerted a significant reduction in the interaction, whereas codons 72 or 87 showed no significant change in the interaction with ALS. The stability of the ALS-IGFBP3 interaction was analyzed according to a time-dependent mode. Consistent with the binding study, mutants on the IGF binding sites (56 or 80) consistently show a weakness in the ALS-IGFBP3 interaction when compared to the mutants that covered the non-IGF binding sites (72 or 87). This study suggests that the N-terminal of IGFBP3, especially the IGF binding site, plays an important role in interacting with ALS as well as in stabilizing the dual complex, independent of IGFs.

• Computers and Concrete
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• v.2 no.1
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• pp.79-96
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• 2005

The use of high-strength concrete (HSC) has significantly increased over the last decade, especially in offshore structures, long-span bridges, and tall buildings. The behavior of such concrete is noticeably different from that of normal-strength concrete (NSC) due to its different microstructure and mode of failure. In particular, the shear capacity of structural members made of HSC is a concern and must be carefully evaluated. The shear fracture surface in HSC members is usually trans-granular (propagates across coarse aggregates) and is therefore smoother than that in NSC members, which reduces the effect of shear transfer mechanisms through aggregate interlock across cracks, thus reducing the ultimate shear strength. Current code provisions for shear design are mainly based on experimental results obtained on NSC members having compressive strength of up to 50MPa. The validity of such methods to calculate the shear strength of HSC members is still questionable. In this study, a new approach based on artificial neural networks (ANNs) was used to predict the shear capacity of NSC and HSC beams without shear reinforcement. Shear capacities predicted by the ANN model were compared to those of five other methods commonly used in shear investigations: the ACI method, the CSA simplified method, Response 2000, Eurocode-2, and Zsutty's method. A sensitivity analysis was conducted to evaluate the ability of ANNs to capture the effect of main shear design parameters (concrete compressive strength, amount of longitudinal reinforcement, beam size, and shear span to depth ratio) on the shear capacity of reinforced NSC and HSC beams. It was found that the ANN model outperformed all other considered methods, providing more accurate results of shear capacity, and better capturing the effect of basic shear design parameters. Therefore, it offers an efficient alternative to evaluate the shear capacity of NSC and HSC members without stirrups.

• Structural Engineering and Mechanics
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• v.52 no.3
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• pp.485-505
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• 2014

This study aimed to develop an approach to accurately predict the wind models and wind effects of large wind turbines. The wind-induced vibration characteristics of a 5 MW tower-blade coupled wind turbine system have been investigated in this paper. First, the blade-tower integration model was established, which included blades, nacelle, tower and the base of the wind turbine system. The harmonic superposition method and modified blade element momentum theory were then applied to simulate the fluctuating wind field for the rotor blades and tower. Finally, wind-induced responses and equivalent static wind loads (ESWL) of the system were studied based on the modified consistent coupling method, which took into account coupling effects of resonant modes, cross terms of resonant and background responses. Furthermore, useful suggestions were proposed to instruct the wind resistance design of large wind turbines. Based on obtained results, it is shown from the obtained results that wind-induced responses and ESWL were characterized with complicated modal responses, multi-mode coupling effects, and multiple equivalent objectives. Compared with the background component, the resonant component made more contribution to wind-induced responses and equivalent static wind loads at the middle-upper part of the tower and blades, and cross terms between background and resonant components affected the total fluctuation responses, while the background responses were similar with the resonant responses at the bottom of tower.