• Genomics & Informatics
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• v.19 no.3
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• pp.29.1-29.10
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• 2021

In our previous studies, we have demonstrated the association of certain variants of the thyroid-stimulating hormone receptor (TSHR), thyroid peroxidase (TPO), and thyroglobulin (TG) genes with congenital hypothyroidism. Herein, we explored the mechanistic basis for this association using different in silico tools. The mRNA 3'-untranslated region (3'-UTR) plays key roles in gene expression at the post-transcriptional level. In TSHR variants (rs2268477, rs7144481, and rs17630128), the binding affinity of microRNAs (miRs) (hsa-miR-154-5p, hsa-miR-376a-2-5p, hsa-miR-3935, hsa-miR-4280, and hsa-miR-6858-3p) to the 3'-UTR is disrupted, affecting post-transcriptional gene regulation. TPO and TG are the two key proteins necessary for the biosynthesis of thyroid hormones in the presence of iodide and H₂O₂. Reduced stability of these proteins leads to aberrant biosynthesis of thyroid hormones. Compared to the wild-type TPO protein, the p.S398T variant was found to exhibit less stability and significant rearrangements of intra-atomic bonds affecting the stoichiometry and substrate binding (binding energies, ΔG of wild-type vs. mutant: -15 vs. -13.8 kcal/mol; and dissociation constant, K_d of wild-type vs. mutant: 7.2E^-12 vs. 7.0E^-11 M). The missense mutations p.G653D and p.R1999W on the TG protein showed altered ΔG(0.24 kcal/mol and 0.79 kcal/mol, respectively). In conclusion, an in silico analysis of TSHR genetic variants in the 3'-UTR showed that they alter the binding affinities of different miRs. The TPO protein structure and mutant protein complex (p.S398T) are less stable, with potentially deleterious effects. A structural and energy analysis showed that TG mutations (p.G653D and p.R1999W) reduce the stability of the TG protein and affect its structure-functional relationship.

• Steel and Composite Structures
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• v.42 no.4
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• pp.539-552
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• 2022

Concentrically braced frames (CBFs) possess high stiffness and strength against lateral loads; however, they suffer from low energy absorption capacity against seismic loads due to the susceptibility of CBF diagonal elements to bucking under compression loading. To address this problem, in this study, an innovative damper was proposed and investigated experimentally and numerically. The proposed damper comprises main plates and includes a flange plate angled at θ and a trapezius-shaped web plate surrounded by the plate at the top and bottom sections. To investigate the damper behaviour, dampers with θ = 0°, 30°, 45°, 60°, and 90° were evaluated with different flange plate thicknesses of 10, 15, 20, 25 and 30 mm. Dampers with θ = 0° and 90° create rectangular-shaped and I-shaped shear links, respectively. The results indicate that the damper with θ = 30° exhibits better performance in terms of ultimate strength, stiffness, overstrength, and distribution stress over the damper as compared to dampers with other angles. The hysteresis curves of the dampers confirm that the proposed damper acts as a ductile fuse. Furthermore, the web and flange plates contribute to the shear resistance, with the flange carrying approximately 80% and 10% of the shear force for dampers with θ = 30° and 90°, respectively. Moreover, dampers that have a larger flange-plate shear strength than the shear strength of the web exhibit behaviours in linear and nonlinear zones. In addition, the over-strength obtained for the damper was greater than 1.5 (proposed by AISC for shear links). Relevant relationships are determined to predict and design the damper and the elements outside it.

• Nuclear Engineering and Technology
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• v.53 no.7
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• pp.2387-2395
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• 2021

Seismic qualifications of electrical equipment, such as cabinet systems, have been emerging as the key area of nuclear power plants in Korea since the 2016 Gyeongju earthquake, including the high-frequency domain. In addition, electrical equipment was sensitive to the high-frequency ground motions during the past earthquake. Therefore, this paper presents the rocking behavior of the electrical cabinet system subjected to Reg. 1.60 and UHS. The high fidelity finite element (FE) model of the cabinet related to the shaking table test data was developed. In particular, the first two global modes of the cabinet from the experimental test were 16 Hz and 24 Hz, respectively. In addition, 30.05 Hz and 37.5 Hz were determined to be the first two local modes in the cabinet. The high fidelity FE model of the cabinet using the ABAQUS platform was extremely reconciled with shaking table tests. As a result, the dynamic properties of the cabinet were sensitive to electrical instruments, such as relays and switchboards, during the shaking table test. In addition, the amplification with respect to the vibration transfer function of the cabinet was observed on the third floor in the cabinet due to localized impact corresponding to the rocking phenomenon of the cabinet under Reg.1.60 and UHS. Overall, the rocking of the cabinet system can be caused by the low-frequency oscillations and higher peak horizontal acceleration.

• Structural Monitoring and Maintenance
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• v.8 no.4
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• pp.345-360
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• 2021

This paper presents an analytical approach to calculate the buckling load of the cylindrical ring structures subjected to both hydrostatic and hydrodynamic pressures. Based on the conservative law of energy and Timoshenko beam theory, a theoretical formula, which can be used to evaluate the critical pressure of buckling, is first derived for the simplified cylindrical ring structures. It is assumed that the hydrodynamic pressure can be treated as an equivalent hydrostatic pressure as a cosine function along the perimeter while the thickness ratio is limited to 0.2. Note that this paper limits the deformed shape of the cylindrical ring structures to an elliptical shape. The proposed analytical solutions are then compared with the numerical simulations. The critical pressure is evaluated in this study considering two possible failure modes: ultimate failure and buckling failure. The results show that the proposed analytical solutions can correctly predict the critical pressure for both failure modes. However, it is not recommended to be used when the hydrostatic pressure is low or medium (less than 80% of the critical pressure) as the analytical solutions underestimate the critical pressure especially when the ultimate failure mode occurs. This implies that the proposed solutions can still be used properly when the subsea vehicles are located in the deep parts of the ocean where the hydrostatic pressure is high. The finding will further help improve the geometric design of subsea vehicles against both hydrostatic and hydrodynamic pressures to enhance its strength and stability when it moves underwater. It will also help to control the speed of the subsea vehicles especially they move close to the sea bottom to prevent a catastrophic failure.

• Advances in aircraft and spacecraft science
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• v.8 no.4
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• pp.345-372
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• 2021

The analysis of nonlinear vibrations, buckling, post-buckling, flutter boundary determination and post-flutter behavior of a homogeneous curved plate assuming cylindrical bending is conducted in this article. Other assumptions include simply-supported boundary conditions, supersonic aerodynamic flow at the top of the plate, constant pressure conditions below the plate, non-viscous flow model (using first- and third-order piston theory), nonlinear structural model with large deformations, and application of mechanical and thermal loads on the curved plate. The analysis is performed with constant environmental indicators (flow density, heat, Reynolds number and Mach number). The material properties (i.e., coefficient of thermal expansion and modulus of elasticity) are temperature-dependent. The equations are derived using the principle of virtual displacement. Furthermore, based on the definitions of virtual work, the potential and kinetic energy of the final relations in the integral form, and the governing nonlinear differential equations are obtained after fractional integration. This problem is solved using two approaches. The frequency analysis and flutter are studied in the first approach by transferring the handle of ordinary differential equations to the state space, calculating the system Jacobin matrix and analyzing the eigenvalue to determine the instability conditions. The second approach discusses the nonlinear frequency analysis and nonlinear flutter using the semi-analytical solution of governing differential equations based on the weighted residual method. The partial differential equations are converted to ordinary differential equations, after which they are solved based on the Runge-Kutta fourth- and fifth-order methods. The comparison between the results of frequency and flutter analysis of curved plate is linearly and nonlinearly performed for the first time. The results show that the plate curvature has a profound impact on the instability boundary of the plate under supersonic aerodynamic loading. The flutter boundary decreases with growing thermal load and increases with growing curvature.

• Wind and Structures
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• v.34 no.5
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• pp.437-450
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• 2022

Vortex-induced vibration (VIV) is a significant concern when designing slender structures with square cross sections. VIV strongly depends on structural dynamics and flow states, which depend on the conditions of the approaching flow and shape of a structure. Therefore, the effects of the angle of attack on the coupling effects of VIV for a square cylinder are expected to be significant in practice. In this study, the aerodynamic forces for a fixed and elastically mounted square cylinder were measured using wind pressure tests. Aerodynamic forces on the stationary cylinder are firstly discussed by comparisons of variation of statistical aerodynamic force and wind pressure coefficient with wind angle of attack. The coupling effect between the aerodynamic forces and the motion of the oscillating square cylinder by VIV is subsequently investigated in detail at typical wind angels of attack with occurrence of three typical flow regimes, i.e., leading-edge separation, separation bubble (reattachment), and attached flow. The coupling effect are illustrated by discussing the onset of VIV, characteristics of aerodynamic forces during VIV, and interaction between motion and aerodynamic forces. The results demonstrate that flow states can be classified based on final separation points or the occurrence of reattachment. These states significantly influence coupling effects of the oscillating cylinder. Vibration enhances vortex shedding, which creates strong fluctuations in aerodynamic forces. However, differences in the lock-in range, aerodynamic force, and interaction process for angles of attack smaller and larger than the critical angle of attack revealed noteworthy characteristics in the VIV of a square cylinder.

• Advances in nano research
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• v.12 no.5
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• pp.529-547
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• 2022

Graphene is one of the strongest, stiffest, and lightest nanoscale materials known to date, making it a potentially viable and attractive candidate for developing lightweight structural composites to prevent high-velocity ballistic impact, as commonly encountered in defense and space sectors. In-plane twist in bilayer graphene has recently revealed unprecedented electronic properties like superconductivity, which has now started attracting the attention for other multi-physical properties of such twisted structures. For example, the latest studies show that twisting can enhance the strength and stiffness of graphene by many folds, which in turn creates a strong rationale for their prospective exploitation in high-velocity impact. The present article investigates the ballistic performance of twisted bilayer graphene (tBLG) nanostructures. We have employed molecular dynamics (MD) simulations, augmented further by coupling gaussian process-based machine learning, for the nanoscale characterization of various tBLG structures with varying relative rotation angle (RRA). Spherical diamond impactors (with a diameter of 25Å) are enforced with high initial velocity (V_i) in the range of 1 km/s to 6.5 km/s to observe the ballistic performance of tBLG nanostructures. The specific penetration energy (E_p^*) of the impacted nanostructures and residual velocity (V_r) of the impactor are considered as the quantities of interest, wherein the effect of stochastic system parameters is computationally captured based on an efficient Gaussian process regression (GPR) based Monte Carlo simulation approach. A data-driven sensitivity analysis is carried out to quantify the relative importance of different critical system parameters. As an integral part of this study, we have deterministically investigated the resonant behaviour of graphene nanostructures, wherein the high-velocity impact is used as the initial actuation mechanism. The comprehensive dynamic investigation of bilayer graphene under the ballistic impact, as presented in this paper including the effect of twisting and random disorder for their prospective exploitation, would lead to the development of improved impact-resistant lightweight materials.

• Advances in nano research
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• v.12 no.5
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• pp.515-527
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• 2022

The application of fibers in concrete obviously enhances the properties of concrete, also the application of natural fibers in concrete is raising due to the availability, low cost and environmentally friendly. Besides, predicting the mechanical properties of concrete in general and shear strength in particular is highly significant in concrete mixture with fiber nanocomposite reinforced concrete (FRC) in construction projects. Despite numerous studies in shear strength, determining this strength still needs more investigations. In this research, Adaptive Neuro-Fuzzy Inference System (ANFIS) have been employed to determine the strength of reinforced concrete with fiber. 180 empirical data were gathered from reliable literature to develop the methods. Models were developed, validated and their statistical results were compared through the root mean squared error (RMSE), determination coefficient (R²), mean absolute error (MAE) and Pearson correlation coefficient (r). Comparing the RMSE of PSO (0.8859) and ANFIS (0.6047) have emphasized the significant role of structural parameters on the shear strength of concrete, also effective depth, web width, and a clear depth rate are essential parameters in modeling the shear capacity of FRC. Considering the accuracy of our models in determining the shear strength of FRC, the outcomes have shown that the R² values of PSO (0.7487) was better than ANFIS (2.4048). Thus, in this research, PSO has demonstrated better performance than ANFIS in predicting the shear strength of FRC in case of accuracy and the least error ratio. Thus, PSO could be applied as a proper tool to maximum accuracy predict the shear strength of FRC.

• International Journal of Computer Science & Network Security
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• v.21 no.12
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• pp.309-315
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• 2021

The purpose of the article is to analyze the functioning of economic systems in the context of the development of their potential in a circular economy. It is determined that the functioning of economic systems to ensure their sustainability should meet modern challenges and provide for the formation of competitive institutional architecture, the introduction of structural and regulatory innovations, the transition to an innovative model of development. The specific principles of functioning of economic systems include openness, nonlinearity, multivectority, dynamism, emergence, uncertainty about the development of economic processes. It is substantiated that the linear nature of development and equilibrium are not dominant in the functioning of economic systems, and increasing the level of economic efficiency should go hand in hand with minimizing the activities of enterprises, which necessitates the use of circular economy. The main prerequisites for the transition to a circular economy are analyzed. It is determined that the basic concept of the circular economy involves the development of a system of production and consumption, which is based on processing, reuse, repair, product sharing, change of consumption patterns and new business models and systems. The main elements of the circular economy include: a closed cycle, the use of renewable energy sources, systems thinking. The correlation of the principles of sustainable development and the peculiarities of the application of the circular economy is analyzed. It is determined that the circular economy contrasts with the traditional linear economic model, which is based on the model of "take-do-consume-throw away". The advantages and disadvantages due to the use of the principles of circular economy are given. Based on the study, steps are identified to accelerate the transition from a linear economy to a circular economy.

• Journal of Korean Library and Information Science Society
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• v.53 no.2
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• pp.333-353
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• 2022

This study analyzed the relevance of the curriculum by applying topic modeling to book reports written as content area reading activities in the 'physics' class. In order to carry out the research, 332 physics book reports were collected to analyze the relevance among keywords and topics were extracted using STM. The result of the analysis showed that the main keywords of the physics book reports were 'thought', 'content', 'explain', 'theory', 'person', 'understanding'. To examine the influence and connection relationship of the derived keywords, the study presented degree centrality, between centrality, and eigenvetor centrality. As a result of the topic modeling analysis, eleven topics related to the physics curriculum were extracted, and the curriculum linkage could be drawn in three subjects (Physics I, Physics II, Science History), and six areas (force and motion, modern physics, wave, heat and energy, Western science history, and What is science). The analyzed results can be used as evidence for a more systematic implementation of content area reading activities which reflect the subject characteristics in the future.