통합 검색 | Korea Science

Cho, Myung-A;Han, Songhee;Lim, Young-Ran;Kim, Vitchan;Kim, Harim;Kim, Donghak
- Biomolecules & Therapeutics
- /
- 제27권2호
- /
- pp.127-133
- /
- 2019
The study of the genus Streptomyces is of particular interest because it produces a wide array of clinically important bioactive molecules. The genomic sequencing of many Streptomyces species has revealed unusually large numbers of cytochrome P450 genes, which are involved in the biosynthesis of secondary metabolites. Many macrolide biosynthetic pathways are catalyzed by a series of enzymes in gene clusters including polyketide and non-ribosomal peptide synthesis. In general, Streptomyces P450 enzymes accelerate the final, post-polyketide synthesis steps to enhance the structural architecture of macrolide chemistry. In this review, we discuss the major Streptomyces P450 enzymes research focused on the biosynthetic processing of macrolide therapeutic agents, with an emphasis on their biochemical mechanisms and structural insights.
https://doi.org/10.4062/biomolther.2018.183 인용 PDF KSCI

Koh, Dongsoo;Park, Jongmin;Lim, Yoongho
- Journal of Applied Biological Chemistry
- /
- 제44권1호
- /
- pp.20-22
- /
- 2001
We have attempted to synthesize polyhydroxy stilbene compounds through the benzyl thioether moiety. During synthesis, we unexpectedly observed that demethylation of the compound under $AlCl_3$ in ethanethiol resulted in a regioselective addition of thiol to the double bond as well as complete demethylation. We report on the regioselective short synthesis for general structure and its structural identification.
PDF

Kwon, Nam-Koong;Choi, Byung-Gil;Lee, Hee-Soon
- 대한약학회:학술대회논문집
- /
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
- /
- pp.347.1-347.1
- /
- 2002
In cancer chemotherapy. it is becoming increasingly clear that the DNA topoisomerases play an active role in the expression of the cytotoxic action of drugs. The amino substituted azaanthraquinones have attracted much interest due to their possible role as topoisomerase inhibitors. In connection with our interests in the design and synthesis of potent topoisomerase inhibitor. we herein described the preparation of a series of benzoquinoxalinedione derivatives. These were designed based on the SAR of azaanthraquinones and structural analysis of products which are fitted with doxorubicin.
PDF