• 제목/요약/키워드: Structural Synthesis

검색결과 793건 처리시간 0.027초

5-(2'-(N-(1-메틸-3-(3'-카바밀페닐)-n-프로필))아미노에틸)-8-히드록시-4- 메틸카보스티릴 유도체의 합성 및 안정성 연구 (Synthesis and in Vitro Stability Evaluations of 5-(2'-(N-(1-methyl-3'-carbamylphenyl)-n-propyl))aminoethyl)-8-hydroxy-4-methylcarbostyril Derivatives)

  • 윤성화;박규순
    • 약학회지
    • /
    • 제39권5호
    • /
    • pp.506-510
    • /
    • 1995

  • The 5-(2'-(N-(1-methyl-3'-carbamylphenyl)-n-propyl))aminoethyl)-8- hydroxy-4-methyl-carbostyril derivatives which have isoelectronic and isosteric structural similarity with dobutamine without having the Catechol-O-Methyltransferase (COMT) vulnerable m-hydroxy group were synthesized via 7 synthetic steps, and their stabilities in phosphate buffer solution(pH=7.4), human blood. 80% human plasma and 20% rat liver homogenate were determined in vitro condition.

  • PDF