• Annals of Rehabilitation Medicine
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• v.41 no.6
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• pp.924-934
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• 2017

Objective To investigate the anatomical correlates of the neuropsychological deficits in patients with the cerebellar stroke. Methods We screened patients who were admitted to the National Rehabilitation Center with the cerebellar stroke between October 2012 and November 2016. The patients with the cerebellar stroke who underwent neuropsychological testing for which the Seoul Neuropsychological Screening Battery (SNSB) or the SNSB-II were enrolled. The neuropsychological function capacities were compared in accordance with the stroke type (hemorrhagic vs. ischemic) and the location (right/left anterior, right/left posterior intermediate, right/left posterior lateral lobe, and vermis). Mean z-scores were computed to compare the patient performances with the population averages. Results Twenty-six patients (15 with ischemic stroke and 11 with hemorrhagic stroke) with a mean age of $54.8{\pm}16.6$ years were assessed $8.8{\pm}9.2$ months after the stroke. Differences in the neuropsychological functioning according to the stroke type were not observed. All of the numerical subtests of the stroke patients showed significantly poorer performances compared with the population averages (mean z-score <0), and some of the subtests revealed abnormal performances in attention-, visuospatial function-, memory-, and frontal/executive function-related tasks (mean z-score <-1). The patients with the presence of a lesion in the right posterior intermediate lobe of the cerebellum showed a poorer performance in the subtests evaluating the executive function including the Korean-version Stroop Test (p=0.04), the Digit Symbol Coding Test (p=0.01), and the Korean-version Trail Making Test (p=0.02) compared with the patients without that lesion. Conclusion The present study confirms that the cerebellar stroke affects the neuropsychological functioning which is associated with the anatomical site of stroke.

• Journal of Convergence for Information Technology
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• v.9 no.7
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• pp.145-152
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• 2019

The aim of this study was to evaluation the effect of Interactive Metronome(IM) training on executive function for stroke patients. Twenty patients with stroke were randomly assigned to experimental group(n=10) or control group(n=10). The patients in the experimental group received IM training with basic rehabilitation and those in the control group received traditional rehabilitation with basic rehabilitation. The patients were assessed before and after intervention using Kims frontal-executive function neuropsychology test II to evaluate executive function. The result of the present study was experimental group demonstrated more increased than control group in stroop interference, word fluency, delayed recall, executive function quotient(EFQ). Therefore, IM training was effective in improving the executive function. It is deemed that IM training can be usefully applied to improve executive function.

• Anxiety and mood
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• v.15 no.2
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• pp.68-76
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• 2019

Objective : The goal of this study was to investigate the characteristics of early maladaptive schemas (EMSs), and associated neurocognitive functions as seen in visitors for military designation process. Methods : This retrospective study included 111 males aged 18 to 24 years among three groups: 41 visitors for military designation process (VMD), 21 patients with obsessive-compulsive disorder (OCD), and 49 healthy subjects. We collected the results of the Young Schema Questionnaire, Symptom Checklist-90-Revised, three neurocognitive tests as well as their clinicodemographic data. We analyzed the differences in EMSs between these three groups, and the correlations among the identified EMSs and neurocognitive performances within the VMD group. Results : Compared with both the OCD and healthy groups, the evaluation of the VMD group showed significantly higher scores in mistrust/abuse (F=6.4, p=0.002), vulnerability to harm (F=6.6, p<0.0001) and negativity/pessimism schema (F=7.3, p<0.0001), even when controlling for depression scores and levels of education. These three schemas also exhibited significant negative correlations with the score of Stroop test with r ranging from -0.34 to -0.44. Conclusion : These findings suggest that people who are likely to have difficulties adjusting to living in a military life may have psychological vulnerabilities related to certain EMSs. Further studies are warranted to test the clinical potentials of these findings, such as a treatment target and a predictor factor.

• Journal of Convergence for Information Technology
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• v.9 no.10
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• pp.133-143
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• 2019

The purpose of this paper was to analyze the differences in executive function according to type of early English learning experience. The subjects were 75 5-years-old who had immersive early English learning in language school, and daycare center. The measurement tools were stroop, DCCST, memorize numbers, pattern fluency, and maze. We conducted covariance analysis with total intelligence as the covariates. In the results, there were significant differences in attention control and cognitive flexibility, but weren't significant differences in information processing and goal setting according to type of early English learning experience. This study suggests that experience of immersive early English learning positively affected attention control and cognitive flexibility, and didn't affect information processing and goal setting.

• Journal of the Korea Convergence Society
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• v.12 no.2
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• pp.233-246
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• 2021

The present study aimed to investigate whether there would be differences in the severity of PTSD symptoms, self and others concepts between trauma types. Among 166 university students, 61 (simple trauma's n = 31, complex trauma's n = 30) finally met the criteria and completed the Life Events Checklist, Impact of the Event Scale-Revised, and the emotional Stroop task. The results were as follows: firstly, PTSD symptoms were higher in complex trauma group than single trauma group. Secondly, response time in the complex trauma group was longer in the condition that the negative word related to 'self' was presented for 2 seconds compared to the single trauma group. These results suggest that the complex trauma group has different features at least in the severity of PTSD symptoms and the concept of the self, compared with the single trauma group. Finally, the therapeutic implications and limitations of the study were discussed.

• Science of Emotion and Sensibility
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• v.25 no.1
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• pp.55-66
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• 2022

Many studies have shown that musical dissonance generally evokes negative affect, but few studies detail how distinct dissonant intervals, ranging in various roughness, influence emotions and cognition. This research entailed two experiments to confirm whether varying musical intervals of dissonance trigger particular negative emotions and increase cognitive interference. Experiment 1 assumed that different dissonant intervals would elicit distinct negative emotions. In a survey involving 131 participants, there was an overwhelming consensus that dissonant intervals elicited stronger high arousal negative affect than low arousal negative affect. The major 7th degree was found to evoke a significantly stronger feeling of scared. Experiment 2 investigated whether emotions-affecting dissonance would have an enhancing effect on cognitive interference. According to a color-word Stroop task conducted on 81 participants, the presence of any dissonant sound caused significantly higher reaction times and error rates than in the absence of sound. In particular, the minor 2nd degree was cognitively the most disruptive and associated with the slowest reaction times. This paper shows how different ranges of dissonance can effectively influence negative affect and heighten cognitive interference.

• Korean Journal of Exercise Nutrition
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• v.24 no.4
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• pp.15-23
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• 2020

[Purpose] Lactate is a principal energy substrate for the brain during exercise. A single bout of high-intensity interval exercise (HIIE) can increase the blood lactate level, brain lactate uptake, and executive function (EF). However, repeated HIIE can attenuate exercise-induced increases in lactate level and EF. The lactate levels in the brain and blood are reported to be correlated with exercise-enhanced EF. However, research is yet to explain the cause-and-effect relationship between lactate and EF. This study examined whether lactate consumption improves the attenuated exercise-enhanced EF caused by repeated HIIE. [Methods] Eleven healthy men performed two sets of HIIE, and after each set, 30 min were given for rest and examination. In the 2^nd set, the subjects consumed experimental beverages containing (n = 6) and not containing (n = 5) lactate. Blood, cardiovascular, and psychological variables were measured, and EF was evaluated by the computerized color-word Stroop test. [Results] The lactate group had a higher EF (P < 0.05) and tended to have a higher blood lactate level (P = 0.082) than the control group in the 2^nd set of HIIE. Moreover, blood lactate concentration was correlated with the interference score (i.e., reverse score of EF) (r = -0.394; P < 0.05). [Conclusion] Our results suggest that the attenuated exercise-enhanced EF after repeated HIIE can be improved through lactate consumption. However, the role of lactate needs to be elucidated in future studies, as it can be used for improving athletes' performance and also in cognitive decline-related clinical studies.

• Journal of Home Health Care Nursing
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• v.30 no.3
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• pp.252-263
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• 2023

Purpose: To assess the feasibility, safety, and preliminary estimates of effectiveness of Tai Chi on the functional outcomes of older adults in the community. Methods: This was a mixed-method study that employed a single-group repeated measure design and in-depth interviews. Nine older adults were recruited from the community were recruited to participate in a Tai Chi program, conducted twice weekly for 6 months. Research outcomes included physical function, cognitive function, and quality of life, measured at intervals of 3 and 6 months. Findings: Tai Chi exercises were gradually conducted based on the health status of the older adults. All participants actively participated in the program with an average attendance of 90%. Consequently, the participants showed significant improvements in mobility and their memory recall ability at both 3 and 6 months. Additionally, the results of the Stroop test exhibited improvement 3 months after the commencement of the study program. Quality of life of the participants improved according to the mild cognitive impairment questionnaire, but it did not show significant improvement in health-related quality of life. Conclusion: The Tai Chi exercise program was a safe and, feasible program to improve the physical function, cognitive function, quality of life among the older adults in the community.

• Journal of Ginseng Research
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• v.47 no.6
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• pp.735-742
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• 2023

Background: Gintonin is a new material of ginseng that acts through the ginseng-derived lysophosphatidic acid (LPA) receptor ligand. The gintonin-enriched fraction (GEF) inhibits amyloid plaque accumulation in the cortex and hippocampus, improves cognitive dysfunction by increasing acetylcholine levels, and promoted hippocampal neurogenesis in an animal model of Alzheimer's disease. We evaluated the effect of the GEF on the cognitive performance of subjects with subjective memory impairment (SMI). Methods: In this eight-week, randomized, assessor- and participant-blinded, placebo-controlled study, participants with SMI were assigned to three groups receiving placebo, GEF 300 mg/day or GEF 600 mg/day. The Korean versions of the Alzheimer's Disease Assessment Scale (K-ADAS), Mini-Mental State Examination (K-MMSE), and Stroop color-word test (K-SCWT) were also evaluated along with the safety profiles. Results: One hundred thirty-six participants completed the study. After eight weeks, we analyzed intergroup differences in primary or secondary outcome score changes. When we compared the GEF group with the placebo group, we observed significant improvements in the K-ADAS and K-SCWT scores. The GEF group did not show a significant improvement in K-MMSE and BDI scores compared to the placebo group. No adverse events were observed in the gintonin and placebo groups for eight weeks. Conclusion: The GEF is safe and effective in improving subjective cognitive impairment related to both the K-ADAS and K-SCWT in this study. However, further large-scale and randomized controlled studies are warranted to secure other cognitive function tests besides the K-ADAS and K-SCWT, and to confirm the findings of the current study.

• Sleep Medicine and Psychophysiology
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• v.12 no.2
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• pp.122-132
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• 2005

Objectives: The objective of this study is to assess cognitive functions and their relationship with sleep symptoms in young narcoleptic patients. Methods: Eighteen young narcolepsy patients and 18 normal controls (age: 17-35 years old) were recruited. All narcolepsy patients had HLA $DQB_1$ *0602 allele and cataplexy. Several important areas of cognition were assessed by a battery of neuropsychological tests consisting of 13 tests: executive functions (e.g. cognitive set shifting, inhibition, and selective attention) through Wisconsin card sorting test, Trail Making A/B, Stroop test, Ruff test, Digit Symbol, Controlled Oral Word Association and Boston Naming Test; alertness and sustained attention through paced auditory serial addition test; verbal/nonverbal short-term memory and working memory through Digit Span and Spatial Span; visuospatial memory through Rey-Osterrieth complex figure test; verbal learning and memory through California verbal learning test; and fine motor activity through grooved pegboard test. Sleep symptoms in narcolepsy patients were assessed with Epworth sleepiness scale, Ullanlinna narcolepsy scale, multiple sleep latency test, and nocturnal polysomnography. Relationship between cognitive functions and sleep symptoms in narcolepsy patients was also explored. Results: Compared with normal controls, narcolepsy patients showed poor performance in paced auditory serial addition (2.0 s and 2.4 s), digit symbol tests, and spatial span (forward)(t=3.86, p<0.01; t=-2.47, p=0.02; t=-3.95, p<0.01; t=-2.22, p=0.03, respectively). There were no significant between-group differences in other neuropsychological tests. In addition, results of neuropsychological test in narcolepsy patients were not correlated with Epworth sleepiness scale score, Ullanlinna narcolepsy scale score and sleep variables in multiple sleep latency test or nocturnal polysomnography. Conclusion: The current findings suggest that young narcolepsy patients have impaired attention. In addition, impairment of attention in narcolepsy might not be solely due to sleep symptoms such as excessive daytime sleepiness.