• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제21권3호
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• pp.147-152
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• 2010

Objectives : The purpose of this study was to investigate the deficits in executive function in children with ADHD and anxiety disorder, and further, to characterize executive function deficits among the two groups. Methods : Subjects consisted of 60 children between the ages of 5 and 14 (16 Normal, 24 ADHD, 20 Anxiety Disorder). Neuropsychological tests (KEDI-WISC, CCTT, STROOP, WCST, ROCF) for assessing cognitive and executive function were individually administered to all subjects. Results : There were no significant differences in FSIQ or PIQ among the three groups. However, the ADHD group tended to score lower on the VIQ and subtest of similarity, vocabulary, and digit span tests. The three groups did not significantly differ with respect to CCTT test results. On the STROOP test, the ADHD group showed poor performance on the word, color, and color-word subtests. The three groups did not exhibit significant differences in WCST test results ; however, the anxiety group performed poorly belonging to below 25 percentile rank on perseverative response. On the ROCF test, the ADHD group performed poorly with respect to their organization score and in particular, regarding copy and immediate recall. The anxiety group also performed poorly with regard to organization ; however, this was limited only to immediate recall. Conclusion : Children with ADHD displayed poor inhibition and organizational abilities compared to children with anxiety and normal controls. Further, children with anxiety disorder exhibited low cognitive flexibility and voluntary problem-solving abilities compared to ADHD children and normal controls. Based on these results, we suggest that the characteristics of executive dysfunction in ADHD and anxiety disorder in children are different.

• 한국전문물리치료학회지
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• 제21권3호
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• pp.80-88
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• 2014

Previous studies have reported that decreased cognitive ability has been consistently associated with significant declines in performance of one or both tasks under a dual-task walking condition. This study examined the relationship between specific cognitive abilities and the dual-task costs (DTCs) of spatio-temporal gait parameters in stroke patients. The spatio-temporal gait parameters were measured among 30 stroke patients while walking with and without a cognitive task (Stroop Word-Color Task) at the study participant's preferred walking speed. Cognitive abilities were measured using Computerized Neuropsychological Testing. Pearson's correlation coefficients (r) were calculated to quantify the associations between the neuropsychological measures and the DTCs in the spatio-temporal gait parameters. Moderate to strong correlations were found between the Auditory Continuous Performance test (ACPT) and the DTCs of the Single Support Time of Non-paretic (r=.37), the Trail Making A (TMA) test and the DTCs of Velocity (r=.71), TMA test and the DTCs of the Step Length of Paretic (r=.37), TMA test and the DTCs of the Step Length Non-paretic (r=.36), the Trail Making B (TMB) test and the DTCs of Velocity (r=.70), the Stroop Word-Color test and the DTCs of Velocity (r=-.40), Visual-span Backward (V-span B) test and the DTCs of Velocity (r=-.41), V-span B test and the DTCs of the Double Support Time of Non-paretic (r=.38), Digit-span Forward test and the DTCs of the Step Time of Non-paretic (r=-.39), and Digit-span Backward test and the DTCs of the Single Support Time of Paretic (r=.36). Especially TMA test and TMB test were found to be more strongly correlated to the DTCs of gait velocity than the other correlations. Understanding these cognitive features will provide guidance for identifying dual- task walking ability.

• 생물정신의학
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• 제23권4호
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• pp.193-198
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• 2016

Objectives Obsessive-compulsive disorder (OCD) and schizophrenia have many common clinical and neurocognitive features. However, not all of them share the same underlying mechanism. The aim of this study was to discover evidences that indicate a pathophysiological mechanism specific to OCD by comparing correlations of quantitative electroencephalography (QEEG) patterns and neurocognitive function in patients with OCD and schizophrenia. Methods Resting-state QEEG data of total 265 patients were acquired retrospectively and parameters such as absolute power, relative power and peak frequency were analyzed from the data. Stroop test and Trail Making Test results as well as demographic features were reviewed for this study. The correlation of neurocognitive functions and brain electrical activities in each group were assessed and compared by correlation analysis. Results Compared with the OCD group, the schizophrenia group performed poorly in neurocognitive tests. Mean values of QEEG parameters in patients with OCD and schizophrenia did not show significant differences. Both absolute and relative power of alpha rhythm in central and frontal regions showed significant positive correlation with Stroop test results in OCD patients. Conclusions Findings in this study shows distinctive correlations between frontal executive dysfunction and frontal alpha rhythm in the OCD patients, both of which might be a candidate for endophenotype underlying obsessive rumination.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제27권1호
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• pp.72-81
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• 2016

Objectives: The purpose of this study was to evaluate anti-depressive effects of exercise on child and adolescent and its association with brain derived neurotrophic factor (BDNF). Methods: Twenty nine middle school boys (age $13.3{\pm}0.7$) were divided into two groups, 15 boys for control group and 14 in the experimental group. The control group participated in a regular exercise program, 3 times a week for 15 weeks. During the same period, the experimental group participated in an aerobic exercise program specifically designed to enhance anti-depressive effect of exercise. Serum BDNF level and its performance of each group on the Beck Depression Index (BDI), Children's Depression Inventory (CDI), Screen for Child Anxiety Related Emotional Disorders (SCARED), Aggression Questionnaire (AK-Q), and Stroop task were compared before and after the exercise program. Results: Scores of BDI, CDI, SCARED, and AK-Q were significantly lower in both groups after the exercise programs compared to those before the programs. The Stroop task performances were significantly improved after the programs. However, there were no significant differences between two exercise programs, except SCARED separation anxiety, AK-Q physical, and verbal aggression scores. Also, no association was found between serum BDNF level and anti-depressive effects of exercise. Conclusion: Our preliminary results suggest a possible effect of exercise on depression, anxiety, aggression, and cognition of child and adolescents.

• 한국산학기술학회논문지
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• 제14권5호
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• pp.2329-2337
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• 2013

본 연구는 만성 뇌졸중 환자를 대상으로 뉴로피드백(Neurofeedback) 훈련이 뇌파활성도와 인지수행력 변화에 미치는 효과를 알아보고자 하였다. 6개월 이상이 지난 만성 뇌졸중 환자들 중 사전 검사를 통해 선별된 20명을 각 군당 10명씩을 무작위 배치하였다. 대조군(n=10)은 일반 물리치료군, 실험군(n=10)은 일반 물리치료와 뉴로피드백 훈련군으로 나누어 총 4주간 실시하였다. 일반 물리치료는 1회 30분씩, 주 5회 적용하였고, 뉴로피드백 훈련은 일반 물리치료와 동일하게 적용하여 총 20회를 실시하였다. 효과를 알아보기 위해 중재 전, 중재 후, 중재가 끝난 2주 후 뇌의 전기 생리학적 측정방법인 뇌전도(EEG) 검사로 과제 시 절대 스펙트럼 파워를 산출하여, 기준뇌파에 대한 증감률(%)을 비교하였고, 인지수행력 변화는 임상적 평가도구인 MMSE-K, Stroop Test, Digit Span Test를 실시하였다. 뇌전도를 통한 뇌파 변화를 비교한 결과, 중재 후와 중재가 끝난 2주 후에서 대조군에 비해 실험군에서 절대 ${\alpha}$ 파와 절대 ${\beta}$-SMR파는 유의하게 증가되었고, 절대 ${\theta}$ 파는 유의하게 감소하였다. 또한, 임상평가에서 MMSE-K 점수는 유의하게 증가하였고, Stroop Test와 Digit Span Test에서는 오류의 수가 유의하게 감소하였다. 이상의 결과로 볼 때 뉴로피드백 훈련은 만성 뇌졸중 환자의 뇌파 조절을 통해 인지수행력을 개선시키는 효과가 있음을 확인할 수 있었고, 본 연구는 뇌파 조절을 통한 뇌를 직접 훈련하는 뉴로피드백 훈련 효과를 규명함으로서 뇌졸중 환자의 새로운 훈련가능성을 제시하고자 하였다.

• 아동학회지
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• 제24권4호
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• pp.15-27
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• 2003

The subjects were individually presented with the Maxi-doll task to examine false belief and with the flower-star (Stroop-like day-night) test to examine inhibitory control skill. In the $1^{st}$ session, the subjects were tested with both the Maxi tesk and the flower-star test. Three days later, subjects were retested with the Maxi task, including an inhibitory cue. Data were analyzed by 3-way ANOVA, age(2) $\times$ inhibitory level(2) $\times$ task type(Maxi-task or Maxi-including cue). All the main effects were significant and the interaction effect between inhibitory level and task type was also significant. Thus, their understanding of the mind and inhibitory control skill both influence children's performance on a typical false belief task.

• PNF and Movement
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• 제21권2호
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• pp.193-202
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• 2023

Purpose: We investigated the effects of transcranial stimulation and task-oriented training on upper extremity and cognitive function in chronic stroke patients. Methods: A total of 30 patients were randomly divided into transcranial stimulation and task-oriented training groups (TT) and task-oriented training groups (TO). The TT group performed 30 min 5 times a week for 4 weeks in task-oriented training combined with transcranial direct current stimulation. The TO group performed 30 min 5 times a week for 4 weeks in task-oriented training. To measure upper extremity function, the Jebsen-Taylor Hand Function Test, Manual Function Test, and Cognitive Function Test were performed using the Stroop Test and the Trail Making Test. Results: There was a significant difference (P < 0.05) before and after training in both groups, and the TT group showed significant improvement in both groups. Conclusion: In this study, we confirmed transcranial stimulation and task-oriented training in upper extremity function and cognitive function in patients with chronic strokes.

• 대한치매학회지
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• 제22권4호
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• pp.139-147
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• 2023

Background and Purpose: Dual walking task such as crossing over an obstacle may serve as an excellent tool for predicting early cognitive decline. Thus, this study aimed to investigate correlation between walking while crossing over an obstacle and executive functions under different gait phases to validate the use of walking with an obstacle for predicting early cognitive decline. Methods: A cross-sectional study was conducted on 48 elderly individuals from 2 day-care centers and 3 welfare-centers in Seoul and Gyeonggi, Korea. Executive function tests (Trail Making Test, Stroop test) and dual walking tests (gait speed, cadence, stance time, gait cycle time) were performed and compared using partial correlation analysis. Results: There were significant correlations between executive function and most of the gait variables (stance time, cadence, and gait cycle time) (p<0.05) when crossing over an obstacle while walking. Especially, stance time exhibited significant correlations with most executive functions (p<0.05). Conclusions: When evaluating executive function during walking with an obstacle, post-obstacle-crossing phase and stance time need to be observed.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제13권1호
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• pp.76-84
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• 2002

목 적：독일의 신경심리학자인 Moss 등의 1996년에서 1999년까지의 일련의 연구들에서 정상기압의 산소공급 후 정상 성인에서의 기억능력이 뚜렷하게 호전된다는 보고가 있었다. 그러나 아직까지 10대 청소년을 대상으로 한 연구는 없는 상황이다. 이에, 본 연구팀에서는 새롭게 개발된 산소흡입장치(Oxygen administration device)를 가지고 산소흡입이 청소년의 인지능력 향상에 도움이 되는지를 알아보기 위해 실험집단-위약집단-이중맹검법으로 평가하였다. 방 법：14세에서 17세까지의 청소년 23명을 대상으로 하였다. 학급성적 백분위 20%이상 50%미만에 해당하는 중-고등학생들을 대상으로 하였고, 정신과전문의가 평가하여 특정한 정신병리가 없고, 실험에 자발적 참여의지를 보인 청소년만을 연구에 참여시켰다. 주의력평가를 위해 사용 한 검사는 스트룹(stroop) 검사와 선로잇기(trail-making)검사, 연속수행검사(continuous performance test)였고, 기억능력의 측정을 위해서는 표준화된 기억평가척도(Memory Assessment Scale：MAS)를 사용하였다. 23명의 청소년을 무작위 배정하여 12명은 주의력검사와 기억능력 검사 10분전에 5분에 걸쳐 $O_2$를 공급하였고, 11명은 대조군으로 똑같은 기기에서 $O_2$ 공급원을 제거하여, 실내공기를 흡입하는 효과를 갖도록 하였다. 실험자나 피실험자 모두 실험군과 대조군 여부를 알지 못하도록 이중맹검 디자인으로 실시하였다. 결 과：1) 주의력평가：산소흡입 전후의 평균값 차이를 윌콕슨 순위 검사(Wilcoxon Signed Rank)로 평가한 결과, 흡입 전보다 4가지 주의력 평가 소검사들에서 통계적으로 유의한 호전 양상을 보여주었고, 공기흡입 전후의 평가에서는 3가지 소검사에서 호전된 양상을 보여 주었다. 단순주의력 평가에서는 산소흡입군과 공기흡입군 모두 능력의 향상을 보였으나, 간섭이 있는 주의력 검사에서는 산소흡입군만이 유의한 호전을 보였다. 또한 처치 전후의 변화율((치료후값-치료전값)/치료전값 *100)을 계산하여, 산소군과 공기군 간의 통계적 유의성을 평가한 결과, 공기 흡입군에 비해 산소흡입군이 스트룹 검사의 간섭시행, 그리고, 선로잇기검사의 B부분의 수행에서 유의한 차이를 보여, 산소흡입이 전두엽의 수행능력과 관련된 주의력의 호전에 보다 유의한 기여를 할 가능성이 있음을 보여주었다. 2) 기억능력평가：16가지의 기억능력 평가 도구 소척도값 중에서, 산소흡입군은 흡입 전에 비해 11개의 소검사 항목들에서 보다 우수한 수행을 보여 주었고, 공기흡입군은 7개 영역에서 유의한 호전이 있었다. 처치전후의 각 소척도 값의 변화율을 계산하여, 산소군과 공기군 간의 통계적 유의성을 평가한 결과, 단기기억소척도의 점수에서만, 두 군간에 유의한 통계적 차이가 발견되었다. 결 론：주의력과 기억능력에 미치는 산소효과를 검증하기 위해, 대조군비교-이중맹검 임상실험을 실시하여, 반복검사로 인한 효과, 위약효과 등을 배제하였다. 그 결과 양쪽 검사 모두에서 어느 정도의 반복검사 및 위약효과가 확인되었으나, 주의력에서는 전두엽의 실행능력(executive function)과 관련되는 검사들에서 산소흡입이 특이한 효과를 보여준다는 것이 확인되었고, 기억능력에서는 단기기억능력 평가에서 산소흡입군이 대조군보다 유의한 효과를 보여주는 것으로 평가되었다. 이러한 연구결과는 산소흡입이 전두엽과 관련된 수행능력, 작동기억능력 향상에 도움이 될 가능성이 있음을 시사하는 결과라고 생각된다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제24권4호
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• pp.220-227
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• 2013

Objectives : This study aims to investigate the clinical characteristics and neuropsychological profiles of children with attention-deficit hyperactivity disorder (ADHD) and their siblings. Methods : Eighteen children (age $8.2{\pm}1.7$ years, 12 boys) with ADHD and their 18 siblings (age $7.8{\pm}1.6$ years, 8 boys) completed Continuous Performance (CPT), Stroop, Children's Trail Making, Rey-Kim Memory, and Kim's Frontal Executive Function tasks. The parents of these subjects underwent the Attention-Deficit/Hyperactivity Disorder Rating Scale (ARS), 10-item Parent General Behavior Inventory (P-GBI), and the Social Responsiveness Scale (SRS). Paired t-tests were used. Results : The inattention (p=.020), and hyperactivity-impulsivity (p=.001), scores of the ARS and the P-GBI score (p=.004) were significantly higher in children with ADHD than in their siblings. Deficits in social communication and motivation on SRS were higher in children with ADHD than in their siblings (p=.017 and p=.011, respectively). Z-scores of omission and commission errors as well as response time variability on visual CPT and omission errors on auditory CPT were in clinically significant range, and z-score of omission errors on auditory CPT was in borderline range in siblings. Omission (p=.018) and commission errors on Visual CPT (p=.007) were significantly higher in children with ADHD compared to their siblings. Recognition efficiency on Kim's Frontal Executive Function Task was lower in children with ADHD compared to their siblings, but in normal range in both groups. Stroop interference and figure fluency on Kims Frontal Executive Function Task were in borderline range in ADHD group, and figure fluency was in borderline range in siblings. Conclusion : Our results support a preliminary evidence for mild degree of attention deficit in ADHD siblings. Further studies are needed to examine the cognitive functions of siblings with ADHD in larger samples.