• Title/Summary/Keyword: Strong solution

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Anti-cancer effects of Salicornia herbacea extract in OVCAR-3 cells by induction of apoptosis pathway (함초 추출물의 세포사멸 유도에 의한 난소암세포에서 항암 효과)

  • La, Yu Ri;Lee, You Rim;Lee, Dong Seok;Kim, Soo Hwan;Lee, Hyeong Seon
    • Korean Journal of Food Science and Technology
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    • v.53 no.1
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    • pp.34-39
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    • 2021
  • This study investigated the anti-cancer effects of Salicornia herbacea L. fractions in human ovarian cancer cells (OVCAR-3). S. herbacea powder was extracted with 95% EtOH and sequentially fractionated with hexane, dichloromethane (DCM), ethyl acetate, butanol, and H2O. Further, the growth inhibitory effects of the six fractions were determined using the MTS assay. The DCM fraction dramatically decreased cell viability. Similarly, the cell cycle was arrested at the subG1 phase in DCM-treated cells. To confirm apoptosis, the cells were stained with annexin V/FITC-PI solution. Total, early, and late apoptotic cells were significantly increased in the DCM fraction. The mRNA expression of Bcl-2 was reduced, whereas the pro-apoptotic factors Bax and Bak were increased in DCM fraction-treated cells. These results indicated that the DCM fraction in S. herbacea exhibited strong apoptotic effects through the p53-dependent signaling pathway.

Identity of thermogenic reaction to Korean ginseng through bibliography - Focusing on oriental medicine interpretation (서지학적 고증을 통한 인삼 승열작용의 정체성 - 한의학적 해석을 중심으로)

  • Ko, Sungkwon
    • Journal of Ginseng Culture
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    • v.3
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    • pp.119-131
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    • 2021
  • The purpose of this study was to explore the characteristics of and solution to thermogenic reactions to Korean ginseng through bibliographic research. A review of bibliography on the thermogenic reaction induced by ginseng indicated that people who lack fluids, have fever in lungs, a stuffy chest, coughing up sputum, a strong pulse, and constipation due to fever in the stomach may exhibit such a reaction. In the herbal medicine book of the Qing Dynasty, Bon-Cho-Jeong-Ui (本草正義) recorded that wild simulated ginseng is slightly cold and replenishes the body's liquid reserves. The book also describes the field cultivated ginseng is slightly warm and enhancing stamina. Bon-Kyung-Bong-Won (本經逢源), Bon-Cho-Pyon-Dok (本草便讀), and Bon-Cho-Jeong-Ui were published authors in the Qing Dynasty, and they explained that ginseng fine root is bitter, supplements bodily fluids, and can be easily ingested because it is cold. Wol-Ji-In-Sam-Jeon (月池人蔘傳) and Bon-Cho-Bi-Yo (本草備要) described fresh ginseng assweet, bitter, and slightly cold in the Ming and Qing Dynasties, respectively. On the basis of this bibliographic description, the thermogenic reaction induced by Korean ginseng can be overcome by using ginseng fine root, fresh ginseng, or wild simulated ginseng. These ginseng radices are slightly cool, replenish human bodily fluids, and show the physiological effects of easy ingestion properties.

A Study on Estimation of Road and Transportation Facility Improvement Direction Using Random Forest (랜덤 포레스트를 활용한 도로 및 교통시설 개선방향 추정 연구)

  • Hwang, Jae-seong;Kim, Do-kyeong;Kim, Nam-sun;Lee, Choul-ki
    • The Journal of The Korea Institute of Intelligent Transport Systems
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    • v.20 no.6
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    • pp.37-46
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    • 2021
  • Government agencies, such as police and local governments, strive to prevent traffic hazards and create a comfortable road environment by pormoting transportation and road facilities. To this end, roads and transportation facilities are enhanced and adjusted, and improvement projects in areas with frequent traffic accidents are carried out. Usually, improvement projects in areas with frequent traffic accidents vary by projects and region. Moreover, these projects are carried out under the supervision of a person in charge and related parties. Hence, civil complaints and subjectivity are reflected in deriving priorities for the improvement projects, limiting the efficiency of the project. To this end, a study was conducted to estimate the direction of improvement of the project target site. This study comprehensively considered road, traffic, and accident conditions of representative projects with high effectiveness in handling traffic accidents. The results of the study state that the accuracy of estimating the improvement project was around 88%. In addition, the study found that there was a strong relationship between traffic volume, accident rate, and accident severity in estimating the improvement direction.

Carbonation Resistance Property of Mortar using Electrolysis Aqueous (전기분해수를 배합수로 활용한 모르타르의 탄산화 저항 특성)

  • Jeong, Su-Mi;Park, Sun-Gyu
    • Journal of the Korean Recycled Construction Resources Institute
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    • v.10 no.3
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    • pp.204-210
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    • 2022
  • Cement is pointed out as the main cause of carbon dioxide emission in the construction industry. Many researchs are underway to use blast furnace slag, an industrial by-product, as a substitute for cement to reduce carbon dioxide emitted during the manufacturing the cement. When blast furnace slag is used as a substitute for cement, it has advantages such as long-term strength and chemical resistance improvement. However, blast furnace slag has a problem that makes initial strength low. This is due to the impermeable film on the surface created during the production of blast furnace slag. The created film is known to be destroyed in an alkaline environment, and based on this, previous studies have suggested a solution using various alkali activators. But, alkali activator is dangerous product since it is a strong alkaline material. And it has the disadvantage in price competitiveness. In this study, an experiment was conducted to improve the initial hydration reactivity of the blast furnace slag to secure the initial strength of the mortar substituted with the blast furnace slag and to check whether the carbonation resistance was increased. As a result of the experiment, it was confirmed that the mortar using alkaline water showed higher strength than the mortar using tap water, and there were more hydration products generated inside. In addition, it was confirmed that the mortar using alkaline water as a compounding water had high carbonation resistance.

A Study on the Application Method of Artificial Injection Test according to the Hydraulic Conductivity of Aquifer (대수층 수리지질특성에 따른 인공함양시험 적용 방법에 관한 연구)

  • Chae, Dong-Seok;Choi, Jin-O;Jeong, Hyeon-Cheol;Kim, Chang-Yong
    • The Journal of Engineering Geology
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    • v.31 no.4
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    • pp.589-601
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    • 2021
  • Artificial recharge technology is a method for solving problems such as groundwater level drop and ground subsidence caused by groundwater withdrawal. This study investigated the applicability of using the hydraulic conductivity of an aquifer to predict injection test results for aquifer restoration. Pumping and injection tests were performed under the same conditions as those for the artificial injection facility located in Icheon, Gyeonggi-do. The hydraulic conductivity of the aquifer, which plays a decisive role in restoring the groundwater level, was derived from the pumping test. A numerical model of a simplified on-site aquifer was constructed, and a transient analysis was applied with the same conditions as the pumping test. The correlation between the measured and the resulting model values is strong (R2 = 0.78). The injection test was performed in a sedimentary layer composed of silt sand and clay sand. From the results of the injection test, an empirical formula was derived using Theim's formula, which is a common well analysis solution to determine the parameters of the aquifer from time-level data. The model values from the empirical formula have a high degree of correlation (R2 = 0.99) with measured values. Under specific conditions, for areas where it is difficult to conduct an injection test, the formula from this study, which relies on the hydraulic conductivity of the aquifer determined through the pumping test, may be used to predict reliable injection rates for groundwater restoration.

Characteristics of Fluoride-based Anti-stain Chemicals Made from Industrial By-product (II) -Fungicidal Effectiveness against Isolated Fungi Through Laboratory Evaluation and Field Evaluation- (산업 부산물을 이용하여 제조한 플루오르화합물계 목재 방미제의 특성 (II) - 분리 균주에 대한 목재 방미효력 및 야외 효력 평가 -)

  • Lee, Jong-Shin
    • Journal of the Korean Wood Science and Technology
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    • v.32 no.2
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    • pp.82-89
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    • 2004
  • Two kinds of chemicals (RNF-3 and RNF-4) with high anti-mold effectiveness against stored fungi causing fungal discoloration was selected from among the six kinds of fluoride-based chemicals in the preceding study. In this study, the anti-mold test using 16 species fungi isolated from the softwood lumbers which were fungal discolored and field test in the sawmill was carried out to prove the feasibility for practical using of selected chemicals.For the isolated fungi, the RNF-3 consist of F and Cu showed high mycelial growth control in the PDA medium and fungicidal effectiveness in the japanese red pine (Pinus densiflora), korean pine (Pinus koraiensis) and radiata pine (Pinus radiata) when the concentration was 2% or more. However the RNF-4 consist of F only was not effective compared with RNF-3 because of mycelial growth in the PDA medium and wood treated with 2% or more chemical solution. The RNF-3 also showed a strong anti-mold effectiveness because there was no fungal discoloration for the radiata pine boards treated by 2% and 10 min. soaking in the field test. These results mean that RNF-3 can be used as domestic anti-stain chemicals for prevention of fungal discoloration of the softwood lumber

Ru-based Activated Carbon-MgO Mixed Catalyst for Depolymerization of Alginic Acid (루테늄 담지 활성탄-마그네시아 혼합 촉매 상에서 알긴산의 저분자화 연구)

  • Yang, Seungdo;Kim, Hyungjoo;Park, Jae Hyun;Kim, Do Heui
    • Clean Technology
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    • v.28 no.3
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    • pp.232-237
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    • 2022
  • Biorefineries, in which renewable resources are utilized, are an eco-friendly alternative based on biomass feedstocks. Alginic acid, a major component of brown algae, which is a type of marine biomass, is widely used in various industries and can be converted into value-added chemicals such as sugars, sugar alcohols, furans, and organic acids via catalytic hydrothermal decomposition under certain conditions. In this study, ruthenium-supported activated carbon and magnesium oxide were mixed and applied to the depolymerization of alginic acid in a batch reactor. The addition of magnesium oxide as a basic promoter had a strong influence on product distribution. In this heterogeneous catalytic system, the separation and purification processes are also simplified. After the reaction, low molecular weight alcohols and organic acids with 5 or fewer carbons were produced. Specifically, under the optimal reaction conditions of 30 mL of 1 wt% alginic acid aqueous solution, 100 mg of ruthenium-supported activated carbon, 100 mg of magnesium oxide, 210 ℃ of reaction temperature, and 1 h of reaction time, total carbon yields of 29.8% for alcohols and 43.8% for a liquid product were obtained. Hence, it is suggested that this catalytic system results in the enhanced hydrogenolysis of alginic acid to value-added chemicals.

Synthesis of Linear 1,2-Alkylaminopropanediols as Preservatives and Antimicrobial Activity (보존제로서 선형 1,2-알킬아미노프로판디올의 합성과 항균활성)

  • Cha, Kyung-On;Kwak, Sang-Woon;Jeong, Kook-In;Kim, Young-Ho
    • Applied Chemistry for Engineering
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    • v.33 no.4
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    • pp.394-401
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    • 2022
  • The synthesis of 1,2-alkylaminopropanediols (1,2-AAPs) was designed to improve the hydrophilicity of linear 1,2-alkanediols having 10, 12, 14, and 16 carbon atoms in the alkyl chain. 1,2-AAPs were synthesized by reacting 3-monochloro-1,2-propanediol (3-MCPD) with linear alkylamines having 10, 12, 14 or 16 carbon atoms in an ethanol solvent at 40℃ for 2 h. The yield and purity of four types of 1,2-AAPs synthesized were found to be in the range of 51-58% and 85-99%, respectively. The amine salts of four types of 1,2-AAPs were prepared from a purified paste or solid compound by adding an acidic solution (HCl) to pH 7, and then their solubilities and antibacterial effects were tested. 1,2-decylaminopropanediol, 1,2-dodecylaminopropanediol, and 1,2-tetradecylaminopropanediol were all dissolved in water at concentrations of 100%, 50%, and 0.1%, respectively, however 1,2-hexadecylaminopropanediol was not. The antibacterial effect was improved as the length of the alkyl chain increased. As a result of confirming the preservative effect of the lotion (cosmetic formulation) applied with 1,2-AAP for application, it showed very strong antibacterial activity at low concentrations ranging from 0.005% to 0.2%.

The Role of Tolerance to Promote the Improving the Quality of Training the Specialists in the Information Society

  • Oleksandr, Makarenko;Inna, Levenok;Valentyna, Shakhrai;Liudmyla, Koval;Tetiana, Tyulpa;Andrii, Shevchuk;Olena, Bida
    • International Journal of Computer Science & Network Security
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    • v.22 no.12
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    • pp.63-70
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    • 2022
  • The essence of the definition of "tolerance" is analyzed. Motivational, knowledge and behavioral criteria for tolerance of future teachers are highlighted. Indicators of the motivational criterion are the formation of value orientations, motivational orientation, and the development of empathy. Originality and productivity of thoughts and judgments, tact of dialogue, pedagogical ethics and tact are confirmed as indicators of the knowledge criterion. The behavioral criterion includes social activity as a life position, emotional and volitional endurance, and self-control of one's own position. The formation of tolerance is influenced by a number of factors: the social environment, the information society, existing stereotypes and ideas in society, the system of education and relationships between people, and the system of values. The main factors that contribute to the education of tolerance in future teachers are highlighted. Analyzing the structure of tolerance, it is necessary to distinguish the following functions of tolerance: - motivational (determines the composition and strength of motivation for social activity and behavior, promotes the development of life experience, because it allows the individual to accept other points of view and vision of the solution; - informational (understanding the situation, the personality of another person); - regulatory (tolerance has a close connection with the strong - willed qualities of a person: endurance, selfcontrol, self-regulation, which were formed in the process of Education); - adaptive (allows the individual to develop in the process of joint activity a positive, emotional, stable attitude to the activity itself, which the individual carries out, to the object and subject of joint relations). The implementation of pedagogical functions in the information society: educational, organizational, predictive, informational, communicative, controlling, etc. provides grounds to consider pedagogical tolerance as an integrative personal quality of a representative of any profession in the field of "person-person". The positions that should become conditions for the formation of tolerance of the future teacher in the information society are listed.

The analysis for the HCl modification effect and formation of TiO2 on activated carbon fiber surface (활성탄소섬유 표면의 염산처리효과와 TiO2 형성에 관한 분석)

  • Oh, Won-Chun;Han, Sang-Bum;Bae, Jang-Soon
    • Analytical Science and Technology
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    • v.20 no.4
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    • pp.279-288
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    • 2007
  • We have studied a method for the preparation of $ACF/TiO_2$ composites involving the penetrationof titanium n-butoxide (TNB) solution into activated carbon fiber. It was focused on the characterization of $TiO_2$ formed in prorous carbon was which increased with surface functional groups by hydrochloric acid treatment. The conversion of TNB to $TiO_2$ for the acid treatment effect must be important for the preparationof $ACF/TiO_2$ composites. From the characterization of surface properties, both the BET surface area and the total pore volume decreased as the distribution of $TiO_2$ on the activated carbon fiber surfaces after acid treatments.The changes in XRD pattern showed the typical anatase type on $ACF/TiO_2$ composite for the sample named FT, FT1 and FT2 treated with 0.05, 0.1 and 0.5 M, respectively. However, XRD patern of FT3 treated with 0.5M showed mixed amatase-rutile structure. According to the results of SEM micrographs, the titanium complexe particles were irregularly distributed around carbon. And some large clusters were found when an amount of acid treatment increased. The EDX results of $ACF/TiO_2$ composites showed the presence of C, O and P with strong Ti peaks. Finally, the excellent photocatalytic activity of the $ACF/TiO_2$ composites between relative concentration($c/c_o$) of MB (methylene blue) and UV irradiation time could be attributed to the both effects between photocatalysis of the formation of titania complexes and adsorptivity of the activated carbon fiber.