• The Korean Journal of Physiology and Pharmacology
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• 제4권3호
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• pp.253-261
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• 2000

Head-out water immersion induces marked increase in the cardiac stroke volume. The present study was undertaken to characterize the stroke volume change by analyzing the aortic blood flow and left ventricular systolic time intervals. Ten men rested on a siting position in the air and in the water at $34.5^{circ}C$ for 30 min each. Their stroke volume, heart rate, ventricular systolic time intervals, and aortic blood flow indices were assessed by impedance cardiography. During immersion, the stroke volume increased 56%, with a slight (4%) decrease in heart rate, thus cardiac output increased ${\sim}50%.$ The slight increase in R-R interval was due to an equivalent increase in the systolic and diastolic time intervals. The ventricular ejection time was 20% increased, and this was mainly due to a decrease in pre-ejection period (28%). The mean arterial pressure increased 5 mmHg, indicating that the cardiac afterload was slightly elevated by immersion. The left ventricular end-diastolic volume index increased 24%, indicating that the cardiac preload was markedly elevated during immersion. The mean velocity and the indices of peak velocity and peak acceleration of aortic blood flow were all increased by ${\sim}30%,$ indicating that the left ventricular contractile force was enhanced by immersion. These results suggest that the increase in stroke volume during immersion is characterized by an increase in ventricular ejection time and aortic blood flow velocity, which may be primarily attributed to the increased cardiac preload and the muscle length-dependent increase in myocardial contractile force.

• 감성과학
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• 제20권1호
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• pp.115-132
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• 2017

본 연구는 운전자 연령대와 뇌손상 여부에 따라 다양한 반응시간 과제에서의 반응시간과 반응정확성에서 어떠한 차별성이 있는지 살펴볼 목적으로 수행되었다. 이를 위해 30-50대의 중년운전자, 65세 고령운전자, 그리고 65세 이상의 뇌졸중 고령운전자들을 대상으로 단순반응, 2-선택반응, 자극 이심률을 달리한 4-선택반응, 탐색반응 및 동적자극 탐지 과제에 대한 수행을 비교하였다. 본 연구의 결과를 정리하면 다음과 같다. 첫째, 전반적으로 중년, 고령 및 뇌졸중 고령운전자 순으로 느린 반응시간을 보였으나 자극 이심률이 작은 조건($5^{\circ}$)에 비해 큰 조건($10^{\circ}$)에서 뇌졸중 고령운전자의 반응시간이 다른 집단에 비해 더 두드러지게 지연되었다. 둘째, 전체 반응시간에서 단순 반응시간을 감산한 반응시간을 분석한 결과, 2-선택반응 과제와 동적자극 탐지과제에서의 집단간 반응시간 차이는 유의하지 않았는데, 이것은 이러한 과제들에서의 반응시간 차이가 단순 반응시간에 의해 주로 결정된다는 것을 시사한다. 셋째, 일시적 기억을 요구하는 탐색과제에서는 두 고령운전자 집단이 중년운전자 집단에 비해 유의하게 느리고 부정확한 수행을 보였다. 넷째, 집단간 반응정확성에서의 차이는 선택 대안이 많은 과제와 기억을 요구하는 과제에서 두드러졌다. 이러한 결과는 기억 요구를 수반하는 탐색과제는 중년과 고령운전자 사이의 수행을, 반면 자극 이심률 조건은 뇌졸중 여부에 따른 고령운전자 집단에서의 수행 차이를 민감하게 반영할 수 있음을 시사한다.

• 대한한방내과학회지
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• 제23권1호
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• pp.5-13
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• 2002

Purpose : Studies on stroke were conducted by using the scaling system to estimate, compare severity and to predict prognosis. National Institute of Health Stroke Scale is widely used for this purpose due to its accuracy in predicting clinical symptoms. According to previous studies, neurologic symptoms in acute stage of ischemic stroke did not disappear, and approximately 27% to 43% of them were aggravated, We conducted this study to define clinical aggravation and to improve ischemic stroke in its acute stage by using NIHSS. Methods and Subjects : Due to their acute ischemic stroke, twenty five patients visited Wonkwang Oriental Medicine in Cheonju within forty eight hours from its beginning stage. Two oriental medicine doctors checked NIHSS every six hours during the first ninety six hours and later every twenty four hours for twelve days from the beginning of the disease. Results : The Aggravated group consisted of nineteen out of twenty five cases, which is seventy six % and NIHSS on admissions were $5.88{\pm}0.63$ and it increased linearly over time by the equation of NIHSS on admissions was $8.50{\pm}2.02$ and it decreased linearly over time by the equation of NIHSS=-0.01 one hour+7.91. Conclusion : During the study, we defined the clinical courses of acute ischemic stroke. There have been no reports on this so far. Therefore, we hope that this study will be beneficial to expand the scope of oriental medicine in dealing with aggravating ischemic stroke in the acute stage.

• 대한물리의학회지
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• 제9권1호
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• pp.101-106
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• 2014

PURPOSE: This study was to provide reference data and examine stroke and healty older differences in sit-to-stand test. This study were to determine utility of the 5 repetition sit to stand for discriminating between fallers and non-fallers, identifying an appropriate cutoff score to delineate between the groups. METHODS: Ninety-five participants were recruited. Seventy-two individuals with stroke and twenty-three healthy older agreed to participate in the study. Falls were recorded using a self-administered questionnaire. The 5 repetition sit to stand test measured the time taken to complete t repetitions of the sit to stand maneuver. The time from the initial seated position to the final seated position after completing five stands was the test measure. A cutoff score regarding 5 repetition sit to stand performance in fallers vs. non-fallers, stroke patients vs. healthy older and <60 vs. $$\geq_-$$ age groups was determined using and ROC curve. RESULTS: Cutoff score of 9.9 seconds were found to be discriminatory between healthy older and subjects with stroke. Cutoff score of 15.5 seconds were found to be discriminatory between fallers and non-fallers. Cutoff score of 18.3 seconds were found to be discriminatory between <60 and $$\geq_-$$ age groups. CONCLUSION: The 5-repetition sit-to stand test is quick, easily administered measure useful for gross determination of fall risk in people with stroke.

• Biomolecules & Therapeutics
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• 제28권6호
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• pp.512-518
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• 2020

Stroke is a leading cause of long-term disability in ischemic survivors who are suffering from motor, cognitive, and memory impairment. Previously, we have reported suppressing LPA₅ activity with its specific antagonist can attenuate acute brain injuries after ischemic stroke. However, it is unclear whether suppressing LPA₅ activity can also attenuate chronic brain injuries after ischemic stroke. Here, we explored whether effects of LPA₅ antagonist, TCLPA5, could persist a longer time after brain ischemic stroke using a mouse model challenged with tMCAO. TCLPA5 was administered to mice every day for 3 days, starting from the time immediately after reperfusion. TCLPA5 administration improved neurological function up to 21 days after tMCAO challenge. It also reduced brain tissue loss and cell apoptosis in mice at 21 days after tMCAO challenge. Such long-term neuroprotection of TCLPA5 was associated with enhanced neurogenesis and angiogenesis in post-ischemic brain, along with upregulated expression levels of vascular endothelial growth factor. Collectively, results of the current study indicates that suppressing LPA₅ activity can provide long-term neuroprotection to mice with brain ischemic stroke.

• 대한물리의학회지
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• 제5권1호
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• pp.25-34
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• 2010

Purpose : The purpose of this study is to assess the effect for gait, balance, and depression for stroke patients by group task-related program training based motor learning theory. Methods : The subjects of this study were administrated to the 11 stroke patients (9 male, 2 female) by 5 weeks, 3 times per week, 15 times. The group task-related program training were performed gait, balance, treadmill, muscle strengthening, and game program. Each program took 7~10 minutes and total time took 60 minutes including moving time. The difference of program training were compared using the paired t-test. Results : The results of this study revealed that Fugl-Meyer motor assessment, Chedoke-McMaster Stroke assessment of lower extremity and Berg balance scale were significantly correlated. However, impairment item of Chedoke-McMaster Stroke assessment, spatio-temporal gait parameters, Timed up and go test, and depression item of Minnesota Multiphasic Personality Inventory were not significantly correlated. Conclusion : These results support that group task-related program could be a useful treatment to improve the balance skills and motor function of lower extremity for the chronic stroke patients.

• 대한한의학회지
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• 제23권4호
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• pp.196-202
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• 2002

Aphasia is frequent in stroke patients and most patients with aphasia exhibit spontaneous progressive improvement in language abilities over time, but few recover completely. Neurological variables, especially initial severity of aphasia and time post-onset, appear to have influence on improvement. Effect of speech therapy and pharmacotherapy has been studied and some drugs, like amphetamine are proved to be benefit for recovery of aphasia following stroke. But there has been few evidence to facilitate recovery from aphasia by acupuncture or herbal medication therapy. So we report two cases of aphasic stroke patients who treated by combination therapy of acupuncture, herbal medication(Cheongsinhaeo-tang) and speech therapy over 6 months and improved in language abilities. Further clinical studies will be needed to explore the effects of acupuncture and herbal medication therapy for aphasia. Researchers should examine the long term effect of these treatment, and whether it is more effective than speech therapy and western pharmacotherapy or not..

• 한국신뢰성학회지:신뢰성응용연구
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• 제16권1호
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• pp.64-70
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• 2016

Purpose: The purpose of this study was to evaluate performance reliability of stroke patients using kinematic analysis. Methods: A protocol to evaluate performance reliability was performed for three tasks on 20 stroke patients and 10 normal people. The tasks include hand to head (HH) task, hand to mouth (HM) task, and hand to target (HT) task. Results: The affected arms showed smaller joint angle, slower peak velocity, longer time to peak velocity for task performances than control group. Also, slower peak velocity and longer movement time for task performance in unaffected arm of stroke patients were obtained compared with the control group. Conclusion: Kinematic analysis is very useful quantitative tool to provide understanding on upper extremity function of stroke patients.

• 동서간호학연구지
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• 제1권1호
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• pp.82-98
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• 1997

The purpose of this study was to determine pattern of the stress perceived by stroke patients over time. The ultimate goal of the research is to provide data to help nurses to design the plan of nursing care of the stroke patients both in the hospital and at home. A total of 57 admitted stroke patients were collected from one general hospital in Seoul from June, 12 to September, la, 1993. The data were collected for three phases(within one week after leaving the hospital). The tools for this study, three scales were used ; Stress scale developed by the investigator. Constitution classifing scale designed by Kho(1984), and Self-care measuring scale by Kang(1984). Data were analyzed in four steps using statistical analysis. First, demographic data were determined by descriptive statistics. Second. the pattern of stress perceived by stroke patients across three phases was measured using repeated measures ANOVA. Third, stress of stroke patients classified by constitution, paralyzed area. and attack frequency were measured using ANOVA or t-test, and the pattern of stress by group over time was determined using paired t-test in post hoc test. Fourth. Pearson correlation coefficients were calculated to determine the relationship between the stress and self-care activities. The results of this study are ; 1. The pattern of stress across three phases ; There was a decrease of the stress across three phases. In general. psychological stress as the highest among three phases(F=36.92. P=.000). There was a statistically significant difference of the physical stress(F=34.55, p=.000), the psychological stress (F=15.49, p=.0005) and the social stress (F=24.71. p=.000) among three phases. There was a statistically significant difference of the stress between the first phase (on admission) and the second phase(before leaving the hospital) and was a decrease of the stress (t =6.36. p=.000). 2. The pattern of stress of stroke patients classified by constitution across three phases ; Stroke patients classified as So-Eum perceived the highest stress among three groups(Tae-Eum, So-Eum. So-Yang). There was no statistically significant difference of stress according to the constitution of stroke patients among three phases. Hence. stress was not influenced by the constitution of stroke patients, but there was a statistically significant difference of stress over time. 3. The pattern of stress of stroke patients classified by the paralyzed area across three phases ; Right paralyzed stroke patients perceived higher stress than left paralyzed stroke patients. There was, however, no statistically significant difference of stress between two groups except 2nd phase. There was no statistically significant difference of the perception of stress bet ween the right and left paralyzed stroke patients. 4. The pattern of stress of stroke patients classified by the frequency of the relapse of the disease across three phases ; Stress was higher in stroke patients who had the relapse of the disease twice more than the first time. There was, however, no statistically significant difference of stress between two groups. There was no statistically significant difference of stress of stroke patients according to the relapse of the disease among three phases. Hence, stress was no influenced by the relapse of the disease. 5. The relationship between the stress and self-care activities ; There was a negative relationship between the stress and self-care activities each phase(on admission, r= -.1563 ; before leaving the hospital, r= -.4030 ; after leaving the hospital, r= -.5291). Hence, the higher the self-care activities, the lower the stress. This study has three important findings. First finding was that psychological stress perceived by stroke patients was the highest among three phases. The second finding was that factors such as the constitution, the paralyzed area, and the relapse of the disease did not have an influence on the stress perceived by stroke patients across three phases(on admission, before leaving the hospital, after leaving the hospital). There was a statistically significant decrease of the stress perceived by stroke patients across three phases. The third finding was that there was a negative relationship between the self-care ability and stress. In this study, these findings have implications for nursing care for the rehabilitation of stroke patients and suggest the need of nursing intervention to promote the self-care ability and to support the psychological self-esteem of stroke patients.

• 대한한방내과학회지
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• 제27권4호
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• pp.905-914
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• 2006

Background and Purpose : The purpose of this study was to classify according to the TOAST classification (Trial of Org 10172 in Acute Stroke Treatment) acute stroke patients (first-ever stroke) treated at the Department of Internal Medicine of Kyungwon University In-cheon Oriental Medical Hospital. Methods : In the time period Oct. 2005 to Oct. 2006. 101 patients with a first-ever stroke admitted to the Department of Internal Medicine of Kyungwon University In-cheon Oriental Medical Hospital were included. Patients were hospitalized within 14 days after the onset of stroke. They had neurological deficits for a time more than 24 hours. We classified patients according to the original TOAST classification (Trial of Org 10172 in Acute Stroke Treatment) Results : The incidence in males was 54.4%, in females was 45.6%. Ischemic stroke (86.l%) was more common than hemorrhagic stroke (13.9%). The results of TOAST classification in this study were as follows: small-vessel occlusion, 72.4% large-artery atherosclerosis. 14.9 % cardioembolism, 4.6% stroke of other determined etiology, 4.6%: stroke of undetermined etiology, 3.5%. Patients in the small-vessel occlusion subgroup in this study were the most frequent. The result of this study is that Korean stroke registry is not in accordance with western medicine. Conclusions : The TOAST classification system is the most widely accepted tool to categorize stroke subtypes in western medicine, but in oriental medicine, it is not yet widely accepted. The authors suggest the general use of the TOAST classification to determine adequate management for stroke patients, to predict the prognosis and recurrence of stroke and to develop a Korean standard of stroke in oriental medicine.