• The Korean Journal of Physiology and Pharmacology
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• v.17 no.2
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• pp.111-120
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• 2013

Prolyl 4 hydroxylases (P4H) are iron- and 2-oxoglutamate-dependent dioxygenase enzymes and hypoxia-inducible transcription factor (HIF)-P4Hs play a critical role in the regulating oxygen homeostasis in the local tissues as well in the systemic circulation. Over a period of time, a number of prolyl hydroxylase inhibitors and activators have been developed. By employing the pharmacological tools and transgenic knock out animals, the critical role of these enzymes has been established in the pathophysiology of number of diseases including myocardial infarction, congestive heart failure, stroke, neurodegeneration, inflammatory disease, respiratory diseases, retinopathy and others. The present review discusses the different aspects of these enzymes including their pathophysiological role in disease development.

• International Journal of Internet, Broadcasting and Communication
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• v.12 no.2
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• pp.15-20
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• 2020

The objectives of this study were to compare unimanual, symmetrical and reciprocal movement of transportation. Nineteen participants with post-stroke hemiparesis were involved in this study. We used the Fitmeter accelerometer to measure the dependent variables: signal vector magnitude, peak acceleration and peak deceleration. With respect to the hand and arm, intensity of unimanual movement was higher than that of symmetrical movement, and reciprocal movement was greater than that of symmetrical movement. With regard to the trunk, intensity of unimanual movement was lower than that of symmetrical movement, and within bimanual movement, reciprocal movement was greater than that of symmetrical movement. In conclusion, reciprocal movement would facilitate upper extremity movement and decrease the compensatory movement of trunk more than would symmetrical movement.

• Transactions of the Korean Society of Machine Tool Engineers
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• v.16 no.4
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• pp.51-56
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• 2007

Precision positioning system with magnetostrictive actuator(MA) has widely used in manufacturing devices to control the positioning accuracy to meet the high load and stroke requirements. It has many advantage in comparison with piezoelectric actuator; high force, high strain, high efficient etc. But, the performance of Terfenol-D, the commercially available magnetostrictive material, is highly dependent on the prestress, magnetic field intensity and temperature. This paper present an experimental investigation of the temperature effect on displacement characteristics of magnetostrictive actuator. In this paper, compressed cold air is proposed to improve of positioning accuracy of magnetostrictive actuator. The compressed cold air cooling system has good cooling effect Experimental results confirming the effectiveness of the proposed cooling system as high precision positioning system are also has presented in this paper.

• Proceedings of the KSMRM Conference
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• 2003.10a
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• pp.85-85
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• 2003

Purpose： To investigate whether or not acupuncture of GB34 produces a significant response of the modulation of somatomotor areas by functional magnetic resonance imaging (fMRI) study. Materials and methods： The acupoint, GB34, located in the back of the knee, is known to be effective in recovering motor function after stroke. Using 3T MRI scanner, functional MR imaging of the whole brain was peformed in 12 normal healthy subjects during two stimulation paradigms; acupuncture manipulation on GB34 and sham points. This study investigates the activation of the motor cortex elicited by a soft and an intensified stimulation of GB 34.Three different paradigms were carried out to detect any possible modulation of the Blood Oxygenation Level Dependent (BOLD) response in the somatomortor area to motor stimulation through acupuncture.

• Environmental Engineering Research
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• v.14 no.2
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• pp.95-101
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• 2009

Natural gas is a promising alternative fuel of internal combustion engines. In this paper, the combustion and emission characteristics were investigated on a natural gas engine at two different fuel injection timings during the intake stroke. The results show that fuel injection timing affects combustion processes. The optimum spark timing (MBT) achieving the maximum indicated mean effective pressure (IMEP) is related to fuel injection timing and air fuel ratio. At MBT spark timing, late fuel injection timing delays ignition timing and prolongs combustion duration in most cases. But fuel injection timing has little effect on IMEP at fixed lambdas. The coefficient of variation (COV) of IMEP is dependent on air fuel ratio, throttle positions and fuel injection timings at MBT spark timing. The COV of IMEP increases with lambda in most cases. Late fuel injection timings can reduce the COV of IMEP at part loads. Moreover, engine-out CO and total hydrocarbon (THC) emissions can be reduced at late fuel injection timing.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.18 no.4
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• pp.388-394
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• 2009

Precision positioning system with magnetostrictive actuator(MA) has widely used in manufacturing devices to control the positioning accuracy to meet the high load and stroke requirements. It has many advantage in comparison with piezoelectic actuator; high force, high strain, high efficient etc. But, the performance of Terfenol-D, the commercially available magnetostrictive material, is highly dependent on the prestress, magnetic field intensity and temperature. Therefore, thermal strain of magnetostrictive material obstructs precision position control of magnetostrictive actuator, magnetostrictive actuator is need of cooling system. In this paper, cooling system using compressed cold air is developed and proper temperature and velocity of compressed cold air is studied by thermal analysis according to applied current.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2002.05a
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• pp.104-108
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• 2002

In this study, the dynamic absorbing system for the shoulder-fired system with high-level-impact force has been investigated. for this purpose, firstly, mathematical model based on the short recoil system has been constructed. In order to design the dynamic absorbing system, parameter sensitivity analysis and parameter optimization process have been performed under constraints of moving displacement and transmitted force. In order to enhance the efficiency of energy dissipation, the stroke-dependent variable damping system has been analyzed. finally, the performance of the designed dynamic absorbing system has been evaluated by simulation with respect to the benchmark system.

• Natural Product Sciences
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• v.8 no.2
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• pp.71-75
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• 2002

As apart of our continuing search for antistroke agents from the herbal medicinal resources, we examined in vitro, ex vivo and in vivo the possibility of Sunghyangjunggisan and its ingradients as a novel antithrombotic agent. In vitro ADP- and collagen-induced rat platelet aggregations were potently inhibited by Arisaematis Rhizoma, Cinnamomi Cortex and Zingiberis Rhizoma in a dose-dependent manner, but not by Sunghyangjunggisan. However, Sunghyangjunggisan significantly inhibited ex vivo rat platelet aggregation. Arisaematis Rhizoma, Atractylodis Rhizoma Alba, and Pinelliae Rhizoma also significantly inhibited ex vivo rat platelet aggregation. Sunghyangjunggisan, Alpiniae Fructus and Zingiberis Rhizoma showed significant protection from death due to pulmonary thrombosis in mice. Therefore, Sunghyangjunggisan can express the antithrombotic action, when it is orally administered.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2002.10a
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• pp.431-434
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• 2002

In this study, the dynamic absorbing system using MR damper for the multiple structure system with high-level-impact force has been investigated. Based on the experiment and analysis of short recoil system, the dynamic absorbing system has been constructed by using MR damper and stroke-dependent variable damper. Through a series of experimental works with the devised test bench, the absorbing system with MR damper using reverse control is effective for reduction of the transmitted force, furthermore, for implementation to the multi-structure impulsive force system.

• Animal cells and systems
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• v.10 no.2
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• pp.79-83
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• 2006

Tissue plasminogen activator (tPA) is used to lyse clots and reperfuse brain in ischemic stroke. However, sideeffects of intracerebral hemorrhage (ICH) and edema limit their clinical application. In part, these phenomena has been linked with elevations in matrix metalloproteinase-9 (MMP-9) in neurovascular unit. However little is known about their regulatory signaling pathways in brain cells. Here, I examine the role of MAP kinase pathways in tPA-induced MMP-9 regulation in rat cortical astrocytes. tPA $(1-10\;{\mu}g/ml)$ induced dose-dependent elevations in MMP-9 and MMP-2 in conditioned media. Although tPA increased phosphorylation in two MAP kinases (ERK, JNK), only inhibition of the JNK pathway by the JNK inhibitor SP600126 significantly reduced MMP-9 upregulation. Neither ERK inhibition with U0126 nor p38 inhibition with SB203580 had any significant effects. Taken together, these results suggest that c-jun N-terminal kinase (JNK) plays an essential role for tPA-induced MMP-9 upregulation.