• Journal of Korean Neurosurgical Society
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• 제57권2호
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• pp.94-99
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• 2015

Objective : The purpose of our study was to assess prevalence of carotid intraplaque hemorrhage (IPH) and associations between territorial acute infarction and IPH on magnetization-prepared rapid acquisition with gradient-echo (MPRAGE) in patients with acute neurologic symptoms. Methods : 83 patients with suspected acute neurologic symptoms were evaluated with both brain diffusion weighted imaging (DWI) and carotid MPRAGE sequences. Carotid plaque with high signal intensity on MPRAGE of >200% that of adjacent muscle was categorized as IPH. We analyzed the prevalence of IPH and its correlation with territorial acute infarction. Results : Of 166 arteries, 39 had a carotid artery plaque. Of these arteries, 26 had carotid artery stenosis less than 50%. In all carotid arteries, MR-depicted IPH was found in 7.2% (12/166). High-signal intensity on DWI was found in 17.5% (29/166). Combined lesion with ipsilateral high-signal intensity on DWI and IPH on carotid MPRAGE sequence was found in 6 lesions (6/166, 3.6%). Of patients with carotid artery plaque, MR-predicted IPH was found in 30.8% (12/39) and match lesions with high-signal intensity on DWI and MPRAGE was found in 15.4% (6/39). MR-predicted IPH was significantly higher prevalence in high-grade stenosis group (p=0.010). Relative risk between carotid MPRAGE-positive signal and ipsilateral high-signal intensity on DWI in arteries with carotid artery plaques was 6.8 (p=0.010). Conclusion : Carotid MPRAGE-positive signal in patients was associated with an increased risk of territorial acute infarction as detected objectively by brain DWI. The relative risk of stroke was increased in high-grade stenosis categories.

• Journal of Korean Neurosurgical Society
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• 제63권6호
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• pp.717-722
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• 2020

Objective : Dissection of the middle cerebral artery (MCA) is less common than dissection of vessels in the vertebrobasilar system or carotid artery. Acute complete occlusion related to MCA dissection is extremely rare. We report an endovascular approach in patients with acute complete occlusion due to MCA dissection. Methods : We reviewed retrospectively the endovascular procedure and clinical results for acute-stroke patients who underwent recanalization from October 2014 through December 2018. Initial imaging findings and the endovascular procedure were analyzed for patients with acute complete occlusion due to MCA dissection. Results : We undertook first-line aspiration thrombectomy using a Penumbra catheter in 294 patients with acute occlusion of the M1 segment. Of these patients, seven were confirmed to have acute complete occlusion due to MCA dissection. All patients had angiographic findings of an intimal flap at the proximal occlusion site of the MCA. One patient complained of severe headache during microcatheter passage through the occluded lesion and died due to massive bleeding caused by rupture of the false lumen. The remaining patients underwent initial contact aspiration thrombectomy without microcatheter passage. After aspiration thrombectomy, six patients had delayed flow through the MCA. One patient underwent stenting of the MCA because of progressive symptoms. Conclusion : An intimal flap at the proximal portion of an occluded MCA can suggest the possibility of MCA dissection. Contrast aspiration thrombectomy without microcatheter passage can reduce the risk of false lumen rupture in cases of MCA dissection.

• 한국의학물리학회지:의학물리
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• 제18권3호
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• pp.149-160
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• 2007

초급성 허혈성 뇌졸중 환자를 대상으로 관류 전산화단층촬영(CT)의 임상적 적용을 평가하였다. 뇌졸중 증상 발현 62명의 환자를 대상으로 하였고, 관류 CT는 소뇌 기저부위에서 8 cm 상방으로 스캔하여 후처리 과정을 거쳐 뇌혈용적(cerebral blood volume, CBV), 뇌혈류량(cerebral blood flow, CBF), 평균 조영제 통과시간(mean transit time, MTT) 및 조영제 최고 도달시간(time to peak, TTP) 등의 네 가지 지도의 영상을 얻었다. 관류 CT의 CBV, CBF, MTT, TTP 지도에서 병변을 평가하였으며, 병변 부위와 정상측 대칭부위에서 MTT와 TTP를 측정하여 차이를 비교하였다. 관류 CT의 네 가지 지도 모두에서 관류결손을 인지할 수 있었고, 관류 결손이 인지되는 부위에서 MTT와 TTP의 현저한 지연이 있었다. 관류 CT의 MTT와 TTP영상이 초급성 허혈성 경계부위의 페넘브라를 반영하였다. 관류 CT의 네 가지 지도를 이용하면 뇌졸중의 조기 진단, 허혈 중심부, 허혈 페넘브라를 알 수 있게 되어 관류결손 부위의 혈류역동학적 평가가 가능함으로써, 허혈성 뇌졸중 환자의 진단 및 효과적인 치료를 위해 관류 CT가 유용하여 임상적 적용이 가능하다.

• 대한한의진단학회지
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• 제13권2호
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• pp.24-33
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• 2009

Objectives : This study was aimed to clarify the relationship between the tongue diagnosis of dampness-phlegm and hyperlipidemia in acute stroke patients. Methods : We analyzed the data of 1405 patients with acute stroke in 10 oriental medical hospitals from November 2006 to December 2008. We classified patients into two groups, dampness-phlegm and non dampness-phlegm by tongue diagnosis such as the white coating of the tongue, thick coating of the tongue, swollen tongue and teeth printed tongue which is oriental medical diagnosis. And We analyzed their characteristics with type of stroke and lipid blood level. Results : 1. There was no significant difference of stroke type between the dampness-phlegm tongue diagnosis group and the non dampness-phlegm tongue diagnosis group. 2. The ratio of SVO was higher in dampness-phlegm tongue diagnosis group (76.06%) than the non dampness-phlegm tongue diagnosis group (61.26%). 3. According to the blood test, the dampness-phlegm tongue diagnosis group showed higher in total cholesterol, HDL cholesterol, LDL cholesterol and triglyceride than the control group. 4. Total cholesterol and HDL cholesterol were significant higher in dampness-phlegm tongue diagnosis than the control group. Conclusion : According to the analysis, the relationship between the tongue diagnosis of dampness-phlegm and hyperlipidemia in acute stroke patients were more clarified. Based on these results, more prospective studies are to be done with more clinical data.

• Nutrition Research and Practice
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• 제10권5호
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• pp.516-523
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• 2016

BACKGROUND/OBJECTIVES: This study was conducted to examine relationships between dietary habits and intakes of antioxidants and B vitamins and the risk of ischemic stroke, and to compare dietary factors according to the presence of cerebral artery atherosclerosis and stroke subtypes. SUBJECTS/METHODS: A total of 147 patients and 144 control subjects were recruited consecutively in the metropolitan area of Seoul, Korea. Sixty participants each in the case and control groups were included in analyses after 1:1 frequency matching. In addition, 117 acute ischemic stroke patients were classified into subtypes according to the Trial of Org 10172 in Acute Stroke Treatment (TOAST) guidelines. Dietary intake was measured using a semi-quantitative food frequency questionnaire composed of 111 food items and plasma lipid and homocysteine levels were analyzed. RESULTS: When compared with control subjects, stroke patients had unfavorable dietary behaviors and lower intakes of fruits ($73.1{\pm}83.2g$ vs. $230.9{\pm}202.1g$, P < 0.001), vegetables ($221.1{\pm}209.0g$ vs. $561.7{\pm}306.6g$, P < 0.001), and antioxidants, including vitamins C, E, $B_6$, ${\beta}$-carotene, and folate. The intakes of fruits, vegetables, vitamin C, and folate were inversely associated with the risk of ischemic stroke after adjusting for confounding factors. Intakes of vegetables, vitamins C, $B_6$, $B_{12}$, and folate per 1,000 kcal were lower in ischemic stroke with cerebral atherosclerosis than in those without. Overall vitamin $B_{12}$ intake per 1,000 kcal differed according to the TOAST classification (P = 0.004), but no differences among groups existed based on the post-hoc test. CONCLUSIONS: When compared with control subjects, ischemic stroke patients, particularly those with cerebral atherosclerosis, had unfavorable dietary intake, which may have contributed to the development of ischemic stroke. These results indicate that proper dietary recommendations are important for the prevention of ischemic stroke.

• Journal of Korean Neurosurgical Society
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• 제50권2호
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• pp.75-80
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• 2011

Objective : Leukoaraiosis (LA) has been suggested to be related to the poor outcome or the occurrence of symptomatic intracerebral hemorrhage (sICH) after acute ischemic stroke. We retrospectively investigated the influences of LA on long-term outcome and the occurrence of sICH after thrombolysis in acute ischemic stroke (AIS). Methods : In this study, we recruited 164 patients with AIS and magnetic resonance image (MRI)-detected thrombolysis. The presence and extent of LA were assessed using the Fazekas grading system. The National Institutes of Health Stroke Scale score was used to assess the baseline measure of neurologic severity, and the modified Rankin Scale score assessment was used up to 1 year after thrombolysis. Results : Of 164 subjects, 56 (34.2%) showed LA on MRI. Compared to the 108 patients without LA, the patients with LA were of much older age (p<0.01), had a higher prevalence of hypertension (p<0.01), and had a much poorer outcome at 90 days (p=0.05) and 1 yr (p=0.01) after thrombolysis. There were no significant differences in sICH between patients with and without LA on MRI. In univariate analysis for the occurrence of poor outcome at 90 days after thrombolysis, the size of ischemic lesion on diffusion weighted images (DWI), [odds ratio (OR), 1.03; 95% confidence interval (95% CI), 1.01-1.04; p<0.01], recanalization (OR, 0.03; 95% CI, 0.01-0.10; p<0.01), sICH (OR, 12.2; 95% CI, 1.54-95.8), neurologic severity (OR, 1.17; 95% CI, 1.09-1.25; p<0.01), blood glucose level (OR, 1.01; 95% CI, 1.00-1.02; p=0.03), and the presence of LA on MRI (OR, 2.01; 95% CI, 1.04-3.01; p=0.04) were statistically significant. In multivariate analysis, neurologic severity (OR, 1.14; 95% CI, 1.04-1.24; p<0.01), recanalization (OR, 0.03; 95% CI, 0.01-0.11; p<0.01), lesion size on DWI (OR, 1.02; 95% CI, 1.01-1.03; p=0.02), serum glucose level (OR, 1.01; 95% CI; 1.01-1.02; p=0.03), and the presence of LA on MRI (OR, 3.2; 95% CI, 1.22-8.48; p<0.01) showed statistically significant differences. These trends persisted up to 1 yr after thrombolysis. Conclusion : In this study, we demonstrated that the presence of LA on MRI might be related to poor outcome after use of intravenous tissue plasminogen activator in AIS.

• 한국전자통신학회논문지
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• 제11권10호
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• pp.995-1002
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• 2016

본 연구의 목적은 스마트폰을 사용한 구강안면 운동 프로그램이 삼킴장애가 있는 급성 뇌졸중 환자의 삼킴기능과 혀 근력에 미치는 효과를 알고자 하였다. 본 연구는 삼킴장애가 있는 급성 뇌졸중 환자 16명을 대상으로 하였다. 연구에 참가한 모든 대상자들은 실험군과 대조군으로 8명씩 무작위 배정되었다. 두 그룹의 대상자들은 4주간 주 5회, 하루 30분의 보편적인 삼킴장애 치료를 받았다. 실험군은 스마트폰을 사용한 구강안면 운동 프로그램을 보호자의 감독 하에 추가적으로 30분씩 더 수행하였다. 결과측정은 흡인-침습 척도, 후두계곡 잔여물, 조롱박오목 잔여물, 혀의 최대 등척성 압력을 측정하였다. 연구 결과, 두 그룹은 중재 전과 후에 모든 평가에서 유의한 향상을 보였다(p<.05). 두 그룹 간 변화량 비교에서 실험군은 대조군보다 후두계곡 잔여물과 혀의 최대 등척성 압력에서 유의한 향상을 보였다(p<.05). 스마트폰을 사용한 구강안면 운동 프로그램은 삼킴장애가 있는 급성 뇌졸중 환자의 인두 내 잔여물 감소와 혀 근력 향상에 긍정적인 효과를 기대할 수 있는 중재방법으로 사료된다.

• 한국전자통신학회논문지
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• 제12권2호
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• pp.391-400
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• 2017

본 연구의 목적은 스마트 기기를 활용한 구강안면 훈련 영상 프로그램이 마비말장애가 있는 급성 뇌졸중 환자의 구강 구조 및 기능과 조음교대운동속도에 미치는 효과를 알고자 하였다. 본 연구는 마비말장애가 있는 급성 뇌졸중 환자 14명을 대상으로 하였다. 연구에 참가한 모든 대상자들은 실험군과 대조군으로 7명씩 무작위 할당되었다. 두 그룹의 대상자들은 4주 동안 모두 동일하게 보편적인 재활치료를 받았다. 실험군은 스마트 기기를을 활용한 구강안면 훈련 영상 프로그램을 보호자의 감독 하에 추가적으로 30분씩 더 수행하였다. 구강 구조와 기능을 측정하기 위하여 조음기관 구조 및 기능선별검사의 하위항목인 구강 구조와 기능을 평가하였다. 조음교대운동속도를 측정하기 위하여 교대운동속도와 연속운동속도를 평가하였다. 연구 결과, 그룹 내 비교에서 실험군과 대조군은 구강 구조 및 기능, 교대운동속도, 연속운동속도에서 유의한 향상을 보였다(p<.05). 두 그룹 간 변화량 비교에서 실험군은 대조군보다 구강기능과 교대운동속도의 /퍼/와 /터/에서 유의한 향상을 보였다(p<.05). 스마트 기기를 활용한 구강안면 훈련 영상 프로그램은 마비말장애가 있는 급성 뇌졸중 환자의 구강 기능과 조음기관 기능에 긍정적인 효과를 기대할 수 있는 중재방법으로 사료된다.

• 디지털융복합연구
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• 제17권9호
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• pp.271-278
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• 2019

본 연구의 목적은 가상현실 훈련이 아급성 뇌졸중 환자의 상지기능과 일상생활활동에 미치는 효과를 규명하는 것이다. 아급성기 뇌졸중 환자 18명이 본 연구에 참여하였다. 모든 대상자는 실험군 9명과 대조군 9명으로 배정되었다. 두 군은 하루 30분, 주 5회, 4주 동안 보편적인 작업치료를 받았다. 실험군은 가상현실 훈련을 회기 마다 30분 더 받았으며, 대조군은 보편적인 작업치료를 회기 마다 30분 더 받았다. 결과 측정은 중재 전과 후에 Fugl-Meyer 평가와 한국판 수정바델지수에 의해 수행되었다. 연구 결과, 실험군은 중재 후 Fugl-Meyer 평가 점수와 한국판 수정바델지수 점수에서 유의한 향상을 보였다(p<.05). 대조군은 Fugl-Meyer 평가의 어깨/팔꿈치/전완, 손목, 손 하위항목과 한국판 수정바델지수에서 유의한 향상을 보였다(p<.05). 중재 후 실험군은 대조군보다 Fugl-Meyer 평가의 총점, 손목과 손하위항목에서 유의하게 더 큰 향상을 보였다(p<.05). 이러한 결과들은 가상현실 훈련이 아급성기 뇌졸중 환자의 상지기능 향상에 긍정적인 효과를 나타낼 수 있음을 시사한다.

• 대한한방내과학회지
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• 제29권1호
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• pp.285-298
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• 2008

Objective : This study was aimed to investigated the correlation between the stroke incidence by day of the week and risk factors in acute stroke patients. Methods : From October in 2005 to October in 2007, 673 acute stroke patients wereincluded. Patients were hospitalized within 14 days after the onset of stroke in DongGuk University International Hospital, Kyungwon University In-cheon Oriental Medical Hospital or the Department of Cardiovascular and Neurologic Diseases (Stroke Center), Kyung Hee University Oriental hospital. We investigated general characteristics, stroke types, age group, educational backgrounds, medical history, lifestyle (the impact of stress, exercise, smoking and drinking) and Sasang constitution according to the stroke incidence by day of the week. Results : After examining each participants with day of the week, the order of days by incidence was Monday, Wednesday, Sunday, Saturday, Tuesday, Thursday and Friday respectively. Monday and Tuesday showed the highest ratio. As the aspect of demographic data of subjects, the group under 55 years and from 55 years to 70 years showed the highest ratio on Monday. In the group between 25 years to 55 years, the ratio, by the classification of actual productive age, was statistically higheron Monday. In addition, the ratio showed statistically higherby educational background, from elementary school to high school and over high school. In regard tothe medical aspect, incidence of cerebral hemorrhage showed higher ratio on Sunday, and incidence of brain infarction was higheron Monday. However, there was no difference of the past history between the two groups. With regard tothe aspect of lifestyle of subjects, the group with huge stress before the incidence of stroke showed a higher ratio of stroke incidence on Monday. Participants who didn't exercise regularly and participants who didn't smoke or drink showed higher ratio of stroke incidence on Monday. However, this was not important statistically. In regard to the aspect of Sasang constitution, Soeumin showed the highest ratio of stroke incidence on Wednesday, Taeuminon Monday, and Soyangin on Saturday and Monday. Conclusion : According to these results, several cardiovascular risk factors affect stroke incidences on Monday. Further studies will be needed to help understand the correlation between stroke incidence by day of the week and risk factors in acute stroke patients.