• Steel and Composite Structures
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• v.34 no.1
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• pp.91-105
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• 2020

Steel-concrete composite beam with profiled steel sheet has gained its popularity in the last two decades. Due to the ageing of these structures, retrofitting in terms of flexural strength is necessary to ensure that the aged structures can carry the increased traffic load throughout their design life. The steel ribs, which presented in the profiled steel deck, limit the use of shear connectors. This leads to a poor degree of composite action between the concrete slab and steel beam compared to the solid slab situation. As a result, the shear connectors that connects the slab and beam will be subjected to higher shear stress which may also require strengthening to increase the load carrying capacity of an existing composite structure. While most of the available studies focus on the strengthening of longitudinal shear and flexural strength separately, the present work investigates the effect of both flexural and longitudinal shear strengthening of steel-concrete composite beam with composite slab in terms of failure modes, ultimate load carrying capacity, ductility, end-slip, strain profile and interface differential strain. The flexural strengthening was conducted using carbon fibre reinforced polymer (CFRP) or steel plate on the soffit of the steel I-beam, while longitudinal shear capacity was enhanced using post-installed high strength bolts. Moreover, a combination of both the longitudinal shear and flexural strengthening techniques was also implemented (hybrid strengthening). It is concluded that hybrid strengthening improved the ultimate load carrying capacity and reduce slip and interface differential strain that lead to improved composite action. However, hybrid strengthening resulted in brittle failure mode that decreased ductility of the beam.

• Genomics & Informatics
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• v.11 no.4
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• pp.245-253
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• 2013

A radioresistant cell line was established by fractionated ionizing radiation (IR) and assessed by a clonogenic assay, flow cytometry, and Western blot analysis, as well as zymography and a wound healing assay. Microarray was performed to profile global expression and to search for differentially expressed genes (DEGs) in response to IR. H460R cells demonstrated increased cell scattering and acidic vesicular organelles compared with parental cells. Concomitantly, H460R cells showed characteristics of increased migration and matrix metalloproteinase activity. In addition, H460R cells were resistant to IR, exhibiting reduced expression levels of ionizing responsive proteins (p-p53 and ${\gamma}$-H2AX); apoptosis-related molecules, such as cleaved poly(ADP ribose) polymerase; and endoplasmic reticulum stress-related molecules, such as glucose-regulated protein (GRP78) and C/EBP-homologous protein compared with parental cells, whereas the expression of anti-apoptotic X-linked inhibitor of apoptosis protein was increased. Among DEGs, syntrophin beta 2 (SNTB2) significantly increased in H460R cells in response to IR. Knockdown of SNTB2 by siRNA was more sensitive than the control after IR exposure in H460, H460R, and H1299 cells. Our study suggests that H460R cells have differential properties, including cell morphology, potential for metastasis, and resistance to IR, compared with parental cells. In addition, SNTB2 may play an important role in radioresistance. H460R cells could be helpful in in vitro systems for elucidating the molecular mechanisms of and discovering drugs to overcome radioresistance in lung cancer therapy.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.8 no.1
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• pp.28-36
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• 1996

The influence of vertical eddy viscosity to the nonlinear interaction of tidal current and wind-induced current is examined using a point model. A zero-equation turbulence model is derived by simplifying the q$^2$-q$^2$1 turbulence model under the assumption that the generation of turbulence kinetic energy is balanced with its dissipation and is further modified to include the depth of frictional influence properly The zero-equation turbulence model is derived and the possibility of resonance in the presence of Coriolis effect is suggested. The amplitudes of tidal currents remain the same regardless of the applied wind stress, but the over-tide component is generated due to the nonlinear interaction of tidal current and wind-induced current. Significant changes in the vertical profile of wind-induced currents can occur according to tide-induced background turbulence. The turbulence model can give rise to misleading results when applied to the wind-driven circulation in the tide-dominated sea such as Yellow Sea unless the tide-induced background turbulence is adequately included in the parameterization of vertical eddy viscosity.

• Development and Reproduction
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• v.24 no.3
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• pp.197-205
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• 2020

Diabetes mellitus is a common heterogeneous metabolic disorder, characterized by deposition of extracellular matrix, oxidative stress, and vascular dysfunction, thereby leading to gradual loss of function in multiple organs. However, little attention has been paid to gene expression changes in the lung under hyperglycemic conditions. In this study, we found that diabetes inuced histological changes in the lung of streptozotocin-induced diabetic mice. Global gene expression profiling revealed a set of genes that are up- and down-regulated in the lung of diabetic mice. Among these, expression of Amigo2, Adrb2, and Zbtb16 were confirmed at the transcript level to correlate significantly with hyperglycemia in the lung. We further evaluated the effect of human umbilical cord-derived perivascular stem cells (PVCs) on these gene expression in the lung of diabetic mice. Our results show that administration of PVC-conditioned medium significantly suppressed Amig2, Adrb2, and Zbtb16 upregulation in these mice, suggesting that these genes may be useful indicators of lung injury during hyperglycemia. Furthermore, PVCs offer a promising alternative cell therapy for treating diabetic complications via regulation of gene expression.

• Molecular & Cellular Toxicology
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• v.2 no.1
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• pp.21-28
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• 2006

Gadolinium chloride ($GdCl_{3}$) was known to block Kupffer cells and generally its toxicity study based on blocking these cells. Therefore, $GdCl_{3}$ frequently used to study toxic mechanisms of hepatotoxicants inducing injury through Kupffer cells. We also tried to investigate the effect of $GdCl_{3}\;on\;CCl_{4}$ toxicity, typical hepatotoxicants. Administration of $GdCl_{3}$ to mice significantly suppressed AST (asparatate amino transferase), ALT (alanine amino transferase) levels which were increased by $CCl_{4}$ treatment. However, $GdCl_{3}$ didn't inhibit the phagocytotic activity of Kupffer cells. Malondialdehyde (MDA) is a good indicator of the degree of lipid peroxidation. In this study, MDA increased by $GdCl_{3}$ administration not by $CCl_{4}$. To understand the toxicity of $GdCl_{3}$, we analyzed global gene expression profile of mice liver after acute $GdCl_{3}$ injection. Four hundred fifty two genes were differentially expressed with more than 2-fold in at least one time point among 3 hr, 6 hr, and 24 hr. Several genes involved in fibrogenesis regulation. Several types of pro-collagens (Col1a2, Col5a2, Col6a3, and Col13a1) and tissue inhibitor of metal-loproteinase1 (TIMP1) were up regulated during all the time points. Genes related to growth factors, chemokines, and oxidative stress, which were known to control fibrogenesis, were significantly changed. In addition, $GdCl_{3}$ induced abnormal regulation between lipid synthesis and degradation related genes. These data will provide the information about influence of $GdCl_{3}$ to hepatotoxicity.

• KOREAN JOURNAL OF PACKAGING SCIENCE & TECHNOLOGY
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• v.27 no.3
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• pp.175-180
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• 2021

Although it has recently been regulated for use as an eco-friendly policy in Korea, the use of EPS (Expanded Polystyrene) cooling boxes, which are used as cold chain delivery insulation boxes for fresh agricultural and livestock products, is also increasing rapidly as e-commerce logistics such as delivery have increased rapidly due to COVID-19. Studies were conducted to optimize the EPS cooling container through internal air heat flow of CFD (Computational Fluid Dynamics) analysis and FEM (Finite Element Method) random vibration analysis using domestic PSD (Power Spectral Density) profile of the EPS cooling box to which the refrigerant is applied in this study. In the analysis of the internal air heat flow by the refrigerant in the EPS cooling box, the application of vertical protrusions inside was excellent in volume heat flow and internal air temperature distribution. In addition, as a result of random vibration analysis, the internal vertical protrusion gives the rigid effect of the cooling box, so that displacement and stress generation due to vibration during transport are smaller than that of a general cooling container without protrusion. By utilizing the resonance point (frequency) of the EPS cooling box derived by the Model analysis of ANSYS Software, it can be applied to the insulation and cushion packaging design of the EPS product line, which is widely used as insulation and cushion materials.

• Journal of the Korean Society of Industry Convergence
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• v.25 no.2_2
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• pp.263-269
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• 2022

In this study, the optimal support position determination and stability determination of the wedge wire screen were performed for the production of the wedge wire filter screen with improved mesh screen. In order to manufacture a filter screen using a wedge wire, the support rod wedge wire is first installed according to the filtering capacity, and then spot welding is performed while rotating the profile wire. In the existing manufacturing method, it was manufactured using a 3m rod wedge wire and then cut according to dimensions, but it required the manufacture of a 6m cylindrical screen. Due to the increase in wedge wire length, it is difficult to manufacture stress concentration at sagging and fixed positions. In order to shorten the time of analysis, a single wedge wire was applied instead of a plurality of wedge wires. The reliability and validity of the interpretation were presented and the results were derived. After selecting the support point at the 2m position, structural analysis was performed on the entire filter screen to confirm stability.The purpose of this study is to identify the maximum deflection of the wire for the production of a 6m wedge wire screen and secure design basic data so that it can work safely through optimal support.

• Journal of Preventive Medicine and Public Health
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• v.54 no.4
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• pp.275-283
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• 2021

Objectives: The workplace is an ideal place for encouraging health-promoting behaviors. Therefore, the aim of the present study was to determine the effect of an empowerment program on the health-promoting behaviors of women workers. Methods: This randomized clinical trial was conducted with 80 women workers employed at a food packaging facility in 2020. The subjects were selected using convenience sampling and were classified into intervention and control groups using block randomization. An empowerment program for women workers was conducted across 6 sessions based on an empowerment model. Data collection tools included a demographic questionnaire and the Health Promoting Lifestyle Profile-II, which participants completed both before the program and 8 weeks after the last session. Data analysis was performed in SPSS version 16 using descriptive analysis and inferential statistics. Results: There were no significant differences between the 2 groups in various health-promoting behaviors before the program. However, the intervention group's scores for nutrition (34.92±1.09 vs. 27.87±4.23), physical activity (24.40±2.94 vs. 17.40±5.03), stress management (26.35±2.60 vs. 23.05±4.27), spiritual growth (34.02±3.00 vs. 30.22±5.40), interpersonal relationships (30.82±2.38 vs. 27.60±4.61), and health responsibility (31.60±2.71 vs. 28.22±4.59) were significantly higher than the control group's 8 weeks after the program had ended. Moreover, there was a significant difference in the total score of health-promoting behaviors for the intervention group compared to the control group (179.00±9.22 vs. 151.42±20.25, p=0.001). Conclusions: An empowerment program for women workers led to significant improvements in the health-promoting behaviors of the participants. Similar programs can ultimately improve women's health in the workplace.

• Journal of People, Plants, and Environment
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• v.24 no.5
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• pp.545-550
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• 2021

Background and objective: With increasing land use intensity in urban areas, apartment buildings have been recognized as a typical type of urban residence. In this study, the impacts of different views through a window on health-related responses were investigated using psychological and physiological parameters. Methods: Photos of three different types of views taken on low (2-12 m), middle (28-35 m), and high (over 54 m) floors of dense apartment building areas were used as visual stimuli. Twenty-two healthy adults participated in the indoor experiment. Semantic differential methods and profile of mood states were used as psychological tools. Autonomic nervous activity was evaluated using blood pressures, pulse rate and heart rate variability (HRV). Results: Analytic data showed different characteristics of psychological and physiological outcomes in three different apartment views. In the analysis of psychological parameters, significantly negative responses to the views on middle floors were found in the subscales of tension-anxiety and anger-hostility, compared to low floors. Significantly positive scores in the subscale of vigor were found on low floors with abundance of vegetation and high floors with a view of the sky. A significantly increased value of HF was found on low floors (2,294.96 ± 169.79), compared to the middle(1,553.45 ± 84.66) and high (1,523.02 ± 70.49) floors. Despite the high scores in openness and vigor, high floor views showed significantly higher LF/HF values (1.83 ± 0.09), the indicator of the sympathetic nervous system, than low (1.30 ± 0.07) and middle floor views (1.34 ± 0.06), which might be related to the unconscious fear of heights. Conclusion: Views from different heights in an apartment building can affect the psychological states of residents. Green space through the window may have a positive health outcome by reducing physiological stress.

• Korean Journal of Exercise Nutrition
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• v.24 no.3
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• pp.25-31
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• 2020

[Purpose] Epidemiological evidence has shown that leisure-time physical activity and structured exercise before and after breast cancer diagnosis contribute to reducing the risk of breast cancer recurrence and mortality. Thus, in this review, we aimed to summarize the physical activity-dependent regulation of systemic factors to understand the biological and molecular mechanisms involved in the initiation, progression, and survival of breast cancer. [Methods] We systematically reviewed the studies on 1) the relationship between physical activity and the risk of breast cancer, and 2) various systemic factors induced by physical activity and exercise that are potentially linked to breast cancer outcomes. To perform this literature review, PubMed database was searched using the terms "Physical activity OR exercise" and "breast cancer", until August 5th, 2020; then, we reviewed those articles related to biological mechanisms after examining the resulting search list. [Results] There is strong evidence that physical activity reduces the risk of breast cancer, and the protective effect of physical activity on breast cancer has been achieved by long-term regulation of various circulatory factors, such as sex hormones, metabolic hormones, inflammatory factors, adipokines, and myokines. In addition, physical activity substantially alters wholebody homeostasis by affecting numerous other factors, including plasma metabolites, reactive oxygen species, and microRNAs as well as exosomes and gut microbiota profile, and thereby every cell and organ in the whole body might be ultimately affected by the biological perturbation induced by physical activity and exercise. [Conclusion] The understanding of integrative mechanisms will enhance how physical activity can ultimately influence the risk and prognosis of various cancers, including breast cancer. Furthermore, physical activity could be considered an efficacious non-pharmacological therapy, and the promotion of physical activity is probably an effective strategy in primary cancer prevention.