• Journal of the Korean Geotechnical Society
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• v.25 no.6
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• pp.5-16
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• 2009

The is study is to evaluate the small strain shear modulus ($G_{max}$) of Busan clay using in-situ penetration tests. A series of dilatometer tests (DMT) and piezocone penetration tests (CPTu) are performed at Busan newport and Noksan sites, and hybrid oedometer tests are also carried out on the specimens obtained from both sites. The $G_{max}$ is evaluated from the shear wave velocity ($V_s$) measured by the bender elements installed at the boundary of oedometer cell. By analyzing these data, the relationship of $G_{max}$ and state variables, such as confined stress and void ratio, is developed. The analysis of lab and in-situ test results reveals that the ratio of $G_{max}$ to $q_t$ is inversely proportional to the plasticity index while the ratio of $G_{max}$ to $E_D$ has a linear relationship with ($I/I_D$)$(p_a/{\sigma}'_v)^{0.5}$. Two correlations suggested in this study, based on CPT and DMT results, appear to provide reasonable predictions of the small strain shear modulus.

• The Journal of Korean Medicine
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• v.43 no.3
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• pp.122-138
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• 2022

Objectives: This study was conducted to develop a Korean Medicine(KM) Clinical Practice Guidelines(CPG) of female infertility. We conducted this questionnaire survey to reflect the experiences of Korean Medicine doctors(KMD) and clinical field in Korea. Method: We sent a questionnaire survey to KMD belonging to the Association of Korean Medicine by e-mail. We received 665 responds, and analyzed the answers. Results: 51.2% of respondents knew the previously developed CPG of female infertility, and 18.3% actually used. 83.3% agreed about the necessity of CPG of female infertility, and 80.3% had practical use plan. 90.2% of respondents treated less than 5 infertility woman for a month. 22.7% of respondents treated 50% of patients with collaborative treatment of KM and Western medical treatments. The main age group of patients was '35~40 years'(54.7%), and the most common cause was unexplained infertility(61.7%). The most common pattern identification of female infertility patients was Kidney deficiency(55.4%). KMD used 'a combination of decoction of herbal medicine, acupuncture and moxibustion treatment' the most(43%), and 'a decoction of herbal medicine treatment alone' was next(35%). 84.2% conducted lifestyle modification education about diet, stress, exercise etc. Conclusion: We figured out Korean Medicine doctors' recognition about CPG of female infertility, preference of treatments, and also characteristics of patients visiting Korean Medical clinics to make a practical CPG reflecting clinical situation.

• 한국체육학회지인문사회과학편
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• v.55 no.2
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• pp.35-46
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• 2016

This study aims to observe the operation aspect of physical education during before class and further, to search for the utmost improvement direction using IPA (Importance-Performance Analysis). 500 middle & high school students have chosen through a purposeful sampling method, and 430 was used for analysis. The results were as follows. The quadrant I is "the keep up the good work" part. And the quadrant I includes "de-stress", "the pleasure of school life", "improvement in performance", "peer relationship", "help for P.E.", "health promotion", "sport facility surroundings", "rules", "teacher leadership", "passionate coaching", "fair coaching", "improvement in exercise ability", "understanding P.E." The quadrant II is "the concentrate here" part. And the quadrant II includes "develop talent", "excercise time", "safety management for exercise facility", "new sports event", "consider needs and interests", "consider level" "consider gender". The quadrant III is "the low priority" part. And the quadrant III includes "change of personality", "ability to do various sports event", "develope thinking ability". "communication with peer" "an intelligible explanation" In order to improve the quality of before classes, first, "safety connected program" second, "emotional and intellectual development program", third, "divided classes per level and gender", and the last, "professional manpower for developing the quality of class" are needed.

• Journal of Marine Life Science
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• v.3 no.2
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• pp.51-58
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• 2018

Variations in water temperature are known to affect almost every part of fish physiology. The rise in water temperature due to climate change can physically damage fish. This study was conducted to evaluate the health status of the Atlantic salmon (Salmo salar) at high water temperature (20℃) than the optimum water temperature (15℃). Liver tissue exerts important metabolic functions in thermal adaptation. Therefore, liver tissue was used in this study. The evaluation method is to develop the biomarker gene using NGS RNAseq analysis and to examine the expression pattern using RT-qPCR analysis. The NGS RNAseq analysis revealed 1,366 differentially expressed genes, among which 880 genes were increase expressed and 486 genes were decrease expressed. The biomarker genes are such as heat shock protein 90 alpha (Hsp90α), heat shock protein 90 beta (Hsp90β) and cytochrome P450 1A (CYP1A). The selected genes are sensitive to changes in water temperature through NGS RNAseq analysis. Expression patterns of these genes through RT-qPCR were similar to those of NGS RNAseq analysis. The results of this study can be applied to other fish species and it is considered to be useful industrially.

• Journal of Marine Life Science
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• v.3 no.2
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• pp.59-66
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• 2018

The assessment of level of health of the tidal flats can be evaluate by health of organisms inhabit the tidal flats. It is possible to evaluate the precise health level of organisms inhabit the tidal flats using analysis of expression of biomarker genes. The purpose of this research is to evaluate the health of the tidal flats on the west coast using biomarker genes such as heat shock protein 70 (Hsp70), heat shock protein 90 (Hsp90), glutathione S-transferases (GST) and thioredoxin (TRX). These genes are stress, immune, and antioxidant related genes that can be used to look at the health of an organism through gene expression. In this study, we collected manila clam (Ruditapes philippinarum) in 8 analysis areas on the west coast. Expression of the genes was analyzed by RT-qPCR method. Results showed that, the expression of Hsp70, Hsp90, GST and TRX genes were differentially expressed in the 8 analysis areas. In particular, the expression of Hsp90 and GST or the expression of Hsp70 and TRX were similar. This means that there is a substance that reacts specifically to each gene. Therefore, I think suggest that the based on the results of physicochemical analysis, it can be selected genes suitable for analysis. These results suggest that Hsp70, Hsp90, GST and TRX were played roles in biomarker for assessment of the health of tidal flats.

• Nutrition Research and Practice
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• v.17 no.4
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• pp.682-697
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• 2023

BACKGROUND/OBJECTIVES: Tibetan tea is a kind of dark tea, due to the inherent complexity of natural products, the chemical composition and beneficial effects of Tibetan tea are not fully understood. The objective of this study was to unravel the composition of Tibetan tea using knowledge-guided multilayer network (KGMN) techniques and explore its potential antioxidant and hypolipidemic mechanisms in mice. MATERIALS/METHODS: The C57BL/6J mice were continuously gavaged with Tibetan tea extract (T group), green tea extract (G group) and ddH2O (H group) for 15 days. The activity of total antioxidant capacity (T-AOC) and superoxide dismutase (SOD) in mice was detected. Transcriptome sequencing technology was used to investigate the molecular mechanisms underlying the antioxidant and lipid-lowering effects of Tibetan tea in mice. Furthermore, the expression levels of liver antioxidant and lipid metabolism related genes in various groups were detected by the real-time quantitative polymerase chain reaction (qPCR) method. RESULTS: The results showed that a total of 42 flavonoids are provisionally annotated in Tibetan tea using KGMN strategies. Tibetan tea significantly reduced body weight gain and increased T-AOC and SOD activities in mice compared with the H group. Based on the results of transcriptome and qPCR, it was confirmed that Tibetan tea could play a key role in antioxidant and lipid lowering by regulating oxidative stress and lipid metabolism related pathways such as insulin resistance, P53 signaling pathway, insulin signaling pathway, fatty acid elongation and fatty acid metabolism. CONCLUSIONS: This study was the first to use computational tools to deeply explore the composition of Tibetan tea and revealed its potential antioxidant and hypolipidemic mechanisms, and it provides new insights into the composition and bioactivity of Tibetan tea.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.28 no.3C
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• pp.179-186
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• 2008

Pressuremeter test estimates the deformational properties of soil from the relationship between applied pressure and the displacement of cavity wall. It is general to utilize the reloading curve for the estimation of deformational properties of soil because the initial loading curve can be affected by the disturbance caused by boring. On the other hand, the instrumental resolution or the variation of measured data makes it hard to estimate the maximum shear modulus from pressuremeter test results. This study suggested the methodology estimating the maximum shear modulus from pressuremeter test directly, based on the curve fitting of reloading curve. In addition, the difference was taken into account between the stress state around the probe in reloading and that of the in-situ state. Pressuremeter tests were conducted for 15 cases using a large calibration chamber, together with a number of reference tests. The maximum shear moduli taken from suggested method were compared with those from empirical correlation and bender element test.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.30 no.6A
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• pp.513-523
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• 2010

For continuous I-girder bridges, a large negative bending moment is generated near pier region so that plastic hinge is first formed at this point. Then, the bending moment is redistributed when the I-girder has enough flexural ductility (or rotational capacity). However, for I-girder with high strength steel, it is known that the flexural ductility is considerably decreased by increasing the yield strength of material. Thus, it is necessary to conduct a study for guaranteeing proper flexural ductility of I-girder with high-strength steel. In this study, the evaluation of flexural ductility of negative moment region of I-girder with high strength steel where yield stress of steel is 680 MPa is presented based on the results of finite element analysis and experiment. From the results, it is found that the flexural ductility of the I-girder is significantly reduced due to the increase of elastic deformation and the decrease of plastic deformation ability of the material when the yield strength increases. In this study, the method to improve the flexural ductility of I-girder with high strength steel is proposed by an unequal installation of cross beam and an optimal position of cross beam is also suggested. Finally, the effects of the unequal installation of cross beam on the flexural ductility are discussed based on the experimental results.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.29 no.4A
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• pp.329-335
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• 2009

The purpose of this study is to provide the efficient method and guideline of controlling the cracking in bridge deck concrete due to differential drying shrinkage. Drying shrinkage cracking is mainly influenced by the moisture diffusion coefficient that determines moisture diffusion rate inside concrete structures. In addition to the diffusion coefficient, surface coefficient of concrete surface and relative humidity of ambient air simultaneously affect the moisture evaporation from concrete inside to external air outside. Within the framework of cracking shrinkage cracking mechanism, it is necessary to conceive the numerical analysis, which involves these three influencing factors to predict and control the shrinkage cracking of concrete. In this study, moisture diffusion and stress analysis corresponding to drying shrinkage on bridge deck are performed with consideration of diffusion coefficient, surface coefficient, and relative humidity of ambient air. From the numerical results, it is found that cracking behavior due to differential drying shrinkage of bridge deck concrete shows different feature according to three influencing factors and the methodology of controlling of drying shrinkage cracks can be suggested from this study.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.30 no.6C
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• pp.255-263
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• 2010

This paper investigates the effects of tunnelling-induced ground movements on nearby structures, considering soil-structure interactions of different construction (ground loss) and soil characteristics. The response of four-story block structures, which are subjected to tunnelling-induced ground movements, has been investigated in different construction (ground loss) and soil conditions using numerical analysis. The structures for numerical analysis has been modelled using Discrete Element Method (DEM) to have real cracks when the shear and tensile stress exceed the maximum shear and tensile strength. The response of four-story block structures has been investigated with a ground movement magnitude and compared in terms of construction (ground loss) and soil conditions considering the magnitude of deformations and cracks in structures. In addition, the damage levels, which are possibly induced in structures, has been provided in terms of construction (ground loss) and soil conditions using the state of strain damage estimation criterion (Son and Cording, 2005). The results of this study will provide a background for better understandings for controlling and minimizing building damage on nearby structures due to tunnelling-induced ground movements.