• Asian Pacific Journal of Cancer Prevention
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• v.13 no.3
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• pp.945-951
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• 2012

Objective: FAS/FASL gene promoter polymorphisms have been repeatedly associated with gastric cancer risk, but findings are inconclusive across studies. To address a more precise estimation of the relationship, a meta-analysis was performed. Methods: Data were collected from the Pubmed, Medline and EMBASE databases, with the last report up to 1 December, 2011. Crude ORs with 95% CIs were used to assess the strength of the association by (1) the additive, (2) the codominant, (3) the dominant, and (4) the recessive models. Results: A total of seven studies, including six studies on FAS -1377G>A polymorphism, five studies on FAS -670A>G polymorphism, and six studies on FASL -844T>C polymorphism, were identified in the current meta-analysis. Overall, an association of FAS -1377G>A (AA versus GG: OR = 1.313, 95% CI = 1.045-1.650, Ph = 0.347, $I^2$ = 10.8) and FASL -844T>C (CC versus TT: OR = 1.352, 95% CI = 1.043-1.752, Ph = 0.461, $I^2$ = 0.0) polymorphisms with gastric cancer was found in the codominant model. However, we did not detect any association between gastric cancer and the FAS -670A>G polymorphism. In the subgroup analysis by ethnicity, similar elevated risks were also observed in Asian population for FAS -1377G>A (AA versus GG: OR = 1.309, 95% CI = 1.041-1.646, Ph = 0.240, $I^2$ = 27.3) and FASL -844T>C (CC versus TT: OR = 1.420, 95% CI = 1.081-1.865, Ph = 0.524, $I^2$ = 0.0) polymorphisms. Conclusions: This meta-analysis indicated that FAS -1377G>A and FASL -844T>C polymorphisms might be associated with gastric cancer risk.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.2349-2354
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• 2012

Objective: Individual studies of the associations between P53 codon 72 polymorphism (rs1042522) and bladder cancer susceptibility have shown inconclusive results. To derive a more precise estimation of the relationship, we performed this systemic review and meta-analysis based on 15 publications. Methods: We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. Results: We found that there was no association between P53 codon 72 polymorphism and bladder cancer risk in the comparisons of Pro/Pro vs Arg/Arg; Pro/Arg vs. Arg/Arg; Pro/Pro plus Pro/Arg vs. Arg/Arg; Arg/Arg vs. Pro/Arg plus Arg/Arg (OR=1.06 95%CI 0.81-1.39; OR=1.06 95%CI 0.83-1.36; OR=0.98 95%CI 0.78-1.23; OR=1.06 95%CI 0.84-1.32). However, a significantly increased risk of bladder cancer was found among Asians in the homozygote comparison (Pro/Pro vs. Arg/Arg, OR=1.36 95%CI 1.05-1.75, P=0.790 for heterogeneity) and the dominant model (Arg/Pro plus Pro/Pro vs. Arg/Arg, OR=1.26 95%CI 1.05-1.52, P=0.564 for heterogeneity). In contrast, no evidence of an association between bladder cancer risk and P53 genotype was observed among Caucasian population in any genetic model. When stratifying for the stage of bladder, no statistical association were found (Pro/Pro vs. Arg/Arg, OR=0.45 95%CI 0.17-1.21; Pro/Arg vs. Arg/Arg, OR=0.60 95%CI 0.28-1.27; Dominant model, OR=0.56 95%CI 0.26-1.20; Recessive model, OR=0.62 95%CI0.35-1.08) between P53 codon 72 polymorphism and bladder cancer in all comparisons. Conclusions: Despite the limitations, the results of the present meta-analysis suggest that, in the P53 codon 72, Pro/Pro type and dominant mode might increase the susceptibility to bladder cancer in Asians; and there are no association between genotype distribution and the stage of bladder cancer.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.29 no.4
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• pp.180-188
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• 2017

Recently, as the strength of winds and waves increases due to the climate change, abnormal waves such as swells have been also increased, which results in the increase of downtime events of loading/unloading in a harbour. To reduce the downtime events, breakwaters were constructed in a harbour to improve the tranquility. However, it is also important and useful for efficient port operation by predicting accurately and also quickly the downtime events when the harbour operation is in a limiting condition. In this study, numerical simulations were carried out to calculate the wave conditions based on the forecasted wind data in offshore area/outside harbour and also the long-term observation was carried out to obtain the wave data in a harbour. A forecasting method was designed using an auto-regressive (AR) and artificial neural networks (ANN) models in order to establish the relationship between the wave conditions calculated by wave model (SWAN) in offshore area and observed ones in a harbour. To evaluate the applicability of the proposed method, this method was applied to predict wave heights in a harbour and to forecast the downtime events in Pohang New Harbour with highly complex topography were compared. From the verification study, it was observed that the ANN model was more accurate than the AR model.

• Journal of the Korea Concrete Institute
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• v.18 no.4 s.94
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• pp.535-542
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• 2006

In Seoul, more than 80 percent of residential buildings are constructed with unreinforced masonry(URM) buildings in early 1970 to 1990. In general, URM buildings have the advantages of reducing the construction time and easy to construction. However, URM buildings do not have enough strength against the lateral force. Moreover, low rise buildings have not adopted seismic designs, and for that reason a critical damage is expected with an earthquake. And also, the necessity of the seismic performance evaluation of existing building structures is raised through the Taiwan earthquake in 1999. The purpose of this study is to provide basic information for unreinforced masonry building in Korea by application of the proposed seismic evaluation method. In this study, seismic capacities of 50 existing unreinforced masonry buildings are evaluated based on the proposed method. Also, relationships of seismic capacities between Korean earthquake damage ratios of korean unreinforced masonry buildings are estimated. Results of this study were as follows; 1)Seismic retrofit was needed $8{\sim}48%$ in Korean unreinforced masonry buildings. 2)Korean unreinforced masonry buildings were expected to have severe damage under the earthquake intensity level experienced in Japan.

• Tunnel and Underground Space
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• v.18 no.5
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• pp.343-354
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• 2008

A new method is suggested herein to measure the virgin earth stresses by means of a borehole. This novel concept is basically a combination of borehole stress relieving and borehole fracturing techniques. The destressing of the borehole is achieved by means of inducing thermal tensile stresses at the borehole periphery by using a cryogenic fluid such as Liquid Nitrogen($LN_2$). The borehole wall eventually develops fractures when the induced thermal stresses exceed the existing compressive stresses at the borehole periphery in addition to the tensile strength of the rock. The above concept is theoretically analyzed for its potential applicability to interpret in situ stress levels from the tensile fracture stresses and the corresponding borehole wall temperatures. Coupled thermo-mechanical numerical simulations are also conducted using FLAC3D, with thermal option, to check the validity of the proposed techniques. From the preliminary theoretical and numerical analysis, the method suggested for the measurement of in situ stresses appears to be capable of accurate estimation of the virgin stresses by monitoring tensile crack formation at a borehole wall and recording the wall temperatures at the time of crack initiation.

• Journal of the Korean Wood Science and Technology
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• v.43 no.4
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• pp.456-462
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• 2015

365 pieces of domestic $38{\times}140{\times}3600mm$ Red pine structural lumber were machine graded conforming to a softwood structural lumber standard (KS F 3020). The allowable bending stresses calculated for each grade were compared with the values currently tabulated in the standard. Four calculation methods for lower $5^{th}$ percentile bending stress were non-parametric estimation with 75% confidence level, 2-parameter and 3-parameter Weibull distribution fit, and bending modulus of rupture (MOR)-modulus of elasticity (MOE) regression based method. Only the data set of Grades E8, E9, and E10 were statistically eligible for the $5^{th}$ percentile calculation. The MOR-MOE regression based method only was able to estimate the lower $5^{th}$ percentile values theoretically for the full range of grades. The results showed that all allowable bending stresses calculated were lower than the design values tabulated in the standard. This implies that the current machine grading system has the pitfall of structural safety. Improvement in current machine grading system could be achieved by introducing the bending strength and stiffness combination grade system.

• The Journal of Engineering Geology
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• v.25 no.3
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• pp.413-420
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• 2015

Streambed hydraulic conductivity along the upper reaches of the Gongdo stage of Anseong Stream was estimated through measurements of stream-aquifer exchange rates (using a seepage meter) and vertical hydraulic gradients (using a manually driven piezometer). From the measured data, it was found out that the stream-aquifer exchange rates varied from -1.55 × 10^-6 to 1.77 × 10^-5 m/s, the corresponding vertical hydraulic gradient varied from -0.122 to 0.030, and the values of the streambed vertical hydraulic conductivity were estimated from 1.77 × 10^-5 to 1.97 × 10^-3 m/s, with variations representing local differences. The results are within the general range of streambed hydraulic conductivity values suggested by Calver (2001) and are slightly higher than values previously measured at other stream sites in Korea. The combined use of a drive-point piezometer and seepage meter (both constructed of high-strength stainless steel) is expected to be of practical use in the estimation of streambed hydraulic conductance, given the durability and portability of the instruments.

• The Journal of Engineering Geology
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• v.17 no.3
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• pp.471-481
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• 2007

The Landslide in natural slope is occurred mostly by a heavy rain of the summer. This landslide is influenced in soil property of the surface than the rock mass. Soils in natural slope are created by weathering phenomena of the bedrock. These soils differed to the geological conditions such as sedimentary rock, metamorphic rock and volcanic rock. Therefore, estimation of landslide in natural slope is the most important analysis of the bedrock distributions and soil characteristics. This study analyzed the soil property to the natural slopes of Busan area where is distributed to volcanic rock, granite and sedimentary rock. Soil sample conducted various soil tests for estimate the soil physical property and soil engineering characteristics, and analysis of the correlation of geological conditions. In the experiment result, soils were mainly classified by a clayey sand. It is also established that $1.07{\sim}1.99kg/cm^3$ for wet density, $28.2{\sim}39.6^{\circ}$ for angle of shearing resistance, and $8.10{\times}10^{-5}{\sim}8.38{\times}10^{-2}cm/sec$ for coefficient of permeability. From the physical parameter, the soils are estimated to the permeable ground with good shear strength, and soil properties are showed a differential tendency for each geological condition.

• Journal of the Korean Geotechnical Society
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• v.30 no.7
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• pp.17-26
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• 2014

Tunneling-induced displacement in a jointed rock mass is an important factor to control tunnel stability and to secure a demanded space and construction quality. The magnitude of the inducible displacements is significantly affected by an elastic modulus and therefore, in a rock mass where a joint controls tunnel behavior, it is very important to estimate an elastic modulus of jointed rock mass reliably. Elastic modulus of jointed rock mass is affected by many factors such as rock type, joint condition, and loading condition. Nevertheless, most existing studies were focused on rough empirical relationships based on compressive loading conditions, which are different from tunnel excavation loading conditions, without a systematic approach of rock, joint, and loading conditions together. Therefore, this study considered rock and joint conditions systematically to estimate an elastic modulus of jointed rock mass under tunnel excavation loading. The controlled factors considered in this study are rock types and joint conditions (joint shear strength, joint inclination angle, number of joint sets, and joint spacing). Numerical parametric studies have been carried out with a consideration of different rock and joint conditions; the results have been compared with existing empirical relationships; and charts of elastic modulus change of different rock and joint conditions have been provided. The results are expected to have a great practical use for estimating the convergence induced by tunnel excavation in jointed rockmass.

• Journal of the Korean GEO-environmental Society
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• v.16 no.9
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• pp.23-32
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• 2015

This study examined blast testing measurement data which had been obtained from 97 field sites in Korea to investigate the comprehensive characteristics of rock blasting-induced vibration focusing on the effect of excavation types (tunnel, bench) and rock types. The measurement data was from the testing sites mostly in Kangwon province and Kyungsang province and rock types were granite, gneiss, limestone, sand stone, and shale in the order of number of data. The study indicated that the blasting-induced vibration velocity was affected by the excavation types (tunnel, bench) and bench blasting induced higher velocity than tunnel blasting. In addition, the vibration velocity was also highly affected by the rock types and therefore, it can be concluded that rock types should be considered in the future to estimate a blasting-induced vibration velocity. Furthermore, the pre-existing criteria was compared with the results of this study and the comparison indicated that there was a discernable difference except for tunnel blasting results based on the square root scaling and therefore, further studies and interests, which include the effects of rock strength, joint characteristics, geological formation, excavation type, power type, measurement equipment and method, might be necessarily in relation to the estimation of blasting-induced vibration velocity in rock mass.