• Communications for Statistical Applications and Methods
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• v.11 no.2
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• pp.297-311
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• 2004

In the sample survey for a highly skewed population, stratum jumpers often occur. Stratum jumpers are units having large discrepancies between a stratification variable and a study variable. We propose two models for stratum jumpers: a multiplicative model and a random replacement model. We also consider the modification of the L-H stratification algorithm such that we apply the previous models to L-H algorithm in determination of the sample sizes and the stratum boundaries. We evaluate the performances of the new stratification algorithms using real data. The result shows that L-H algorithm for the random replacement model outperforms other algorithms since the estimator has the least coefficient of variation.

• Journal of Pharmaceutical Investigation
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• v.19 no.1
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• pp.39-46
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• 1989

The clonidine transport mechanism through the skin was investigated with assumptions that epidermis is heterogeneous and two-layer membrane. Immobilization of clonidine was not found in stratum corneum but in viable epidermis. The sorption in the viable epidermis agreed with the dual sorption theory. Diffusion coefficient in stratum corneum was five order magnitude less than that in viable epidermis. In viable epidermis, the ratio of true diffusivity to apparent diffusivity increased initially then decreased as a function of clonidine concentration, and the true diffusivity was always larger than the apparent diffusivity.

• The Korean Journal of Applied Statistics
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• v.34 no.5
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• pp.671-683
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• 2021

Power allocation is a technique that evenly allocates samples for each stratum, although the overall efficiency of the allocation is less than that of optimal allocation, and it is often used as a square root proportional allocation in real survey. Also, considering the non-response that occurs in real survey, a larger sample size is used than that in the theoretical formula. In this study, in determining the sample size for each stratum, we study the new methods of allocating by adding information on the response rate per each stratum to power allocation method. The proposed allocation methods are compare with proportional, optimal, and square root proportional allocation in simulation. In addition, the comparison with the proportional and optimal allocation to which the response rate was added is examined through simulation. As a result, we examine the advantages and disadvantages of the allocation methods.

• Archives of Pharmacal Research
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• v.12 no.2
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• pp.143-147
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• 1989

The urea effect on skin permeation of clonidine was investigated to reduce a log time and to increase a permeability. ICR mouse skin and human skin were used and were assumed to be a two-layer membrane consisted of stratum corneum and viable epidermis. The urea acted as a skin denaturant and humectant in the whole epidermis. Also it enhanced the skin permeability of clonidine about 3.5 times. On the other hand, it enhanced the skin permeability by acting as a humectant in the viable epidermis. But the urea effect on the whole epidermis was shown to be greater than that on the viable epidermis. Therefore, it was found that the effect of urea was greater on the stratum corneum than the viable epidermis. Variation of enhancing effect according to the concentration of urea was not found in the range of 1% to 20%.

• Biotechnology and Bioprocess Engineering:BBE
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• v.3 no.1
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• pp.1-5
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• 1998

One cervical cancer cell line, C9, carrying human papillomavirus type 18 (HPV18) genes that is one of the major etiologic concoviruses for cervical cancer was characterized. This cell line was further characterized for its capacity related to the epithelial cell proliferation, stratification and differentiation in reconstituted artificial epithelial tissue. The in vitro construction of three dimensional artificial cervical opithelial tissue has been engineered using C9 epithelial cancer cells, human foreskin fibroblasts and a matrix made of type I collagen by organotypic culture of epithelial cells. The morphology of paraffin embedded artificial tissue was examined by histochemical staining. The artificial epithelial tissues were well developed having multilayer. However, the tissue morphology was similar to the cervical tissus having displasia induced by HPV infection. The characteristics of the artificial tissues were examined by determinining the expression of specific marker proteins. In the C9 derived artificial tissues, the expression of EGF receptor, as epithelial proliferation marker proteins for stratum basale was observed up to the stratum spinosum. Another epithelial proliferation marker for stratum spinosum, cytokerations 5/6/18, were observed well over the stratum spinosum. For the differentiation markers, the expression of involucrin and filaggrin were observed while the terminal differentiation marker, cytokeratins 10/13 was not detected at all. Therefore the reconstituted artificial epithelial tissues expressed the same types of differentiation marker proteins that are expressed in normal human cervical epithelial tissues but lacked the final differentiation capacity representing characteristics of C9 cell line as a cancer tissue devived cell line. Expression of HPV18 E6 oncoprotein was also observed in this artifical cervical opithelial tissue though the intensity of the staining was weak. Thus this artificial epithelial tissue could be used as a useful model system to examine the relationship between HPV-induced cervical oncogenesis and epithelial cell differentiation.

• Journal of the Korean Geosynthetics Society
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• v.11 no.2
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• pp.49-54
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• 2012

The final consolidation settlement is important factor in soft ground improvement because of settlement management and completion time. The compression index, which is slope of primary consolidation curve, is commonly used for the calculation of final consolidation settlement in clay layer. The existing final consolidation settlement is calculated in total consolidation layer that is assumed as one layer. This paper describes analysis result of the acquired settlement, when the consolidation layer is divided as several layer. The consolidation settlement increased according to increase of the divided layer and then it is converged. This result was unrelated to surcharge load. The division effect of layer is very high when the surcharge load is less than the consolidation layer thickness. The division effect of layer is 1.2 to 1.4 in the general surcharge load, and this value can be apply as safety factor in the calculation of final consolidation settlement.

• Journal of Pharmaceutical Investigation
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• v.36 no.5
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• pp.305-308
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• 2006

Poloxamer-based hydrogel formulation for the topical delivery of ascorbic acid(AsA) was prepared and the effect of limonene on AsA skin permeation and localization was evaluated. In vitro rat skin permeation study, the AsA skin permeation of limonene-containing hydrogel was about 3 to 5 fold higher than control hydrogel. However the amount of permeated AsA was independent to the concentration of limonene. On the other hand the localized amount of AsA after 2 h increased proportion to the content of limonene. The increase in the ratio of localized AsA($Q_L$) to permeated AsA($Q_P$) was attributed to the limonene's ability of making polar pathway within stratum corneum by interacting on lipid domain of the skin and the AsA's hydration effect on the stratum corneum and effect on the protein domain of the skin.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.44 no.4
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• pp.455-463
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• 2018

Skin elasticity has been known to be influenced by the change of dermal components such as collagen, elastic fiber, and glycosaminoglycans. However, it is unclear whether the uppermost epidermis may affect the mechanical characteristics of elasticity. In present study we tried to find the role of stratum corneum when determining the elastic property under skin bioengineering measurement with $Cutometer^{(R)}$. A total of 10 healthy volunteers aged 25-40 years were investigated by the parameters reflecting the skin elasticity from face and volar forearm. Within various ranges of suction pressure, R0 (=Uf), R7 (=Ur/Uf) and R8 (=Ua) were obtained to explore the depth-associated elasticity. In addition, these parameters were re-measured after the skin was fully hydrated. As results, we found that the measurement of depth-associated elasticity was possible as using various suction pressure. And the R7 parameter was significantly lower from face than those from forearm in before hydration (p < 0.05). Also, we found that the hydration of stratum corneum could affect skin elasticity. Especially, the R7 parameter at 300 mbar suction pressure of face skin showed significantly increased values than that of before hydration (p < 0.05). Interestingly, measured data from the face before and after hydration manifested relatively higher variation than from the forearm. These results suggest that it is possible to evaluate the skin elasticity considering the changes of stratum corneum and epidermis by using various suction pressure and skin hydration.

• Journal of Korean Society of Forest Science
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• v.99 no.3
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• pp.285-291
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• 2010

Since 2006, the $5^{th}$ National Forest Inventory (NFI) has been implemented to provide forest resources statistics at the national level and at the county level as well. However, it needs a small-area estimator for estimating forest statistics at the county-level due to a small number of samples collected within a county. This study was conducted to evaluate the applicability of a geographical-based synthetic estimator for estimating forest growing stock volumes at the county level. The NFI-field plots surveyed were post-stratified into three forest cover types. In the synthetic estimator, field plots within a geographical-based super-county for each county were used to estimate stratum weights and stratum mean volumes. It was resulted that estimated stratum weights using the synthetic estimation were significantly differ from forest cover maps. The standard errors of estimated mean by the synthetic estimation that ranged from ${\pm}3.5\;m^3$/ha to ${\pm}7.7\;m^3$/ha were more smaller than those (${\pm}7.8\;m^3/ha{\sim}{\pm}24.7\;m^3/ha$) by the direct estimation. This means that the synthetic estimation is possible to provide more precise estimates of mean volumes.

• Toxicological Research
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• v.7 no.2
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• pp.129-139
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• 1991

Preventive effect of red ginseng saponin on experimentally-induced hyperkeratosis was investigated by ultrastructural observation, skin weight and epidermal lipid analysis. Hexadecane increased skin weight per unit area and epidermal lipids, free fatty acids, cholesterol and triglyceride in guinea pig skin. Topical application of ginseng saponin reduced these hyperkeratotic responses regradless of the concentration and the purity of ginseng saponin. Ultrastructurally, lipids and empty space-containing multiple horny cells were piled and nuclear remnants, desmosome, desmosomal bodies, tight junction were shown in the stratum corneum of hexadecane-treated skin.