• Journal of the korean academy of Pediatric Dentistry
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• v.30 no.3
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• pp.341-347
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• 2003

Smith-Magenis syndrome (SMS) is a clinically recognizable multiple congenital anomaly and mental retardation syndrome caused by an interstitial deletion of chromosome 17 p11.2. Physical features include short stature, characteristic facial appearance: flattened mid-face, down-turned mouth, prominent and often rosy cheeks; prominent jaw in older children and adults, chronic ear infections, hearing impairment, eye problems, including: strabismus (an eye which turns in or out) and myopia (nearsightedness), hoarse voice, short fingers and toes, heart defects or murmurs, problems related to the urinary system, scoliosis (curvature of the spine), an unusual gait (walking pattern), and decreased sensitivity to pain. Behavioral and developmental characteristics include speech delay and articulation problems, developmental delay, learning disability, mental retardation, hyperactivity, self-injury, including: head banging; hand biting; picking at skin, sores and nails; pulling off finger- and toenails; inserting foreign objects into ears, nose, or other body orifices, explosive outbursts, prolonged tantrums, destructive and aggressive behavior, excitability, arm hugging or hand squeezing when excited. This report is the case of a Korean 3-year-3-month old male with Smith-Magenis syndrome referred from local clinic for the treatment of dental caries. The patient was treated by physical restraint after prophylatic administration of antibiotic(Amoxacillin 50mg/kg).

• Journal of Korean Ophthalmic Optics Society
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• v.8 no.2
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• pp.47-52
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• 2003

117 undergraduate ophthalmic optics students volunteered to participate in this study. They ranged in age from 19 to 26 years. Subject, had best corrected visual acuity of at least 1.0 in both eyes, no strabismus, no amblyopia, and no history of ocular surgery. 37 subjects are esphoria and 25 subjects are $3{\Delta}$ and less, and the rest of 12 subjects show more $4{\Delta}$. Average phoria amount is $2.96{\Delta}$ at far distance and $1.08{\Delta}$ at near distance, respectively. The variation of phoria amount in far and near distance, unchanging subjects are 3, 8 subjects are increase esophoria amount, and 26 subjects are phoria amount decreasing or appear exophoria. The reason of esophoria amount is decreasing in near distance, and the results are convergence burden decreases. At positive relative convergence, the expected value in far distance, blurred point is 7, break point is 16, and recovery point is 12. And negative relative convergence, break point is 7 and recovery point is 13, respectively. Moreover, at positive relative convergence, the expected value in near distance is blurred point is 8, break point is 7 and recovery point is 22. And negative relative convergence, blurred point is 2, break point is 8 and recovery point is 12, respectively.

• Journal of Korean Ophthalmic Optics Society
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• v.15 no.3
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• pp.287-291
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• 2010

Purpose: The aim of this study was to compare binocular functions such as near point of convergence (NPC), AC/A ratios, heterophoria, accommodation, accommodation lag, positive relative accommodation (PRA), negative relative accommodation (NRA), positive relative convergence (PRC), negative relative convergence (NRC) in normal subjects and convergence insufficiency. Methods: 86 subject (male n=45, female n=41, mean $age{\pm}SD=23.27{\pm}2.85$ years) without amblyopia, strabismus, and ocular pathology were studied. Forty three patients each group were classified as normal subjects and convergence insufficiency group based on AC/A ratio and far and near phoria. Binocular function of the two groups was measured using phoropter. r. Results: The values between normal subjects and convergence insufficiency were 5.71 cm and 7.07 cm for NPC, 5.28 and 2.81 for Heterophria AC/A, 0.92 exo/3.36 exo and 2.17 exo/10.84 exo for far and near phoria, 15.49/23.30/13.30 and 13.50/20.02/9.09 for PRC, respectively. However, there were no significant differences between normal subjects and convergence insufficiency for accommodative amplitude, accommodative lag, PRA, NRA, BI vergence test, BO vergence test, NRC. Conclusions: Both groups were a significant difference for cover test, NPC, Heterophria AC/A, far and near phoria, break point of PRC, and recovery point of PRC.

• Journal of Korean Ophthalmic Optics Society
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• v.15 no.4
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• pp.367-372
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• 2010

Purpose: The purpose of this study was to provide useful information for evaluating the sensory function of patients with strabismus by identifying the distribution of anomalous retinal correspondence (ARC) and normal retinal correspondence (NRC) by the degree of refractive errors and deviation angles. Methods: Objective refraction (AR/K, Cannon RK-F1, Japan) and subjective refraction tests were performed on 56 subjects (male: 26, female: 30) by an examiner; objective deviation angle was measured using synoptophore (OCULUS Synoptophore, Germany) with subject' eyes fully corrected for distance, and then subjective deviation angle was measured. Results: In all groups with refractive errors, the number of ARC was larger than that of NRC(67%). Particularly, it was largest in groups with myopia (71%), and in all groups, the number of UARC was larger than that of HARC. In groups with anisometropia, although the numbers of NRC and ARC were same, the number of UARC was larger than that of HARC as in other groups. In the distribution of NRC and ARC by deviation angle, the number of NRC was larger than that of ARC (46%) only at microstrabismus (0 ~ ${\pm}10{\triangle}$). Conclusions: Normal retinal correspondence were the most emmetropia in the retinal response were much higher than in the more hyperopia than the retinal correspondence were more myopia. In addition, the smaller the angle of retinal correspondence Normal over many, but overall, respectively.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.18
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• pp.7863-7867
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• 2014

Background: Retinoblastoma is a rare type of cancer that usually develops in early childhood. If left untreated it can cause blindness and even death. The aim of this study is to determine sociodemographic and clinical features of retinoblastoma patients and also to determine the treatment pattern and outcome in Malaysia. Materials and Methods: Data for this study were retrieved from the Retinoblastoma Registry of the National Eye Database (NED) in Malaysia. Hospital Kuala Lumpur, Hospital Umum Kuching, Sarawak and Hospital Queen Elizabeth, Kota Kinabalu were the major source data providers for this study. Data collected in the registry cover demography, clinical presentation, modes of treatment, outcomes and complications. Results: The study group consisted of 119 patients (162 eyes) diagnosed with retinoblastoma between 2004 and 2012. There were 68 male (57.1%) and 51 (42.9%) female. The median age at presentation was 22 months. A majority of patients were Malays (54.6%), followed by Chinese (18, 5%), Indians (8.4%), and indigenous races (15.9%). Seventy six (63.8%) patients had unilateral involvement whereas 43 patients had bilateral disease (36.1%). It was found that most children presented with leukocoria (110 patients), followed by strabismus (19), and protopsis (12). Among the 76 with unilateral involvement (76 eyes), enucleation was performed for a majority (79%). More than half of these patients had extraocular extension. Of the 40 who received chemotherapy, 95% were given drugs systemically. Furthermore, in 43 patients with bilateral involvement (86 eyes), 35 (41%) eyes were enucleated and 17 (49%) showed extraocular extension. Seventy-two percent of these patients received systemic chemotherapy. The patients were followed up 1 year after diagnosis, whereby 66 were found to be alive and 4 dead. Sixteen patients defaulted treatment and were lost to follow-up, whereas follow-up data were not available in 33 patients. Conclusions: Patients with retinoblastoma in this middle-income Asian setting are presenting at late stages. As a result, a high proportion of patients warrant aggressive management such as enucleation. We also showed that a high number of patients default follow-up. Therefore, reduction in refusal or delay to initial treatment, and follow-up should be emphasized in order to improve the survival rates of retinoblastoma in this part of the world.

• Journal of Yeungnam Medical Science
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• v.8 no.2
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• pp.24-34
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• 1991

Delayed emergence of speech or language are frequent causes for concern about development during early childhood. Dealy in evaluation and proper management until school entry in more likely to result in frustration, anxiety and school failure. Many language disturbances and their attendant behavior disorders respond to intensive language therapy. Authors analyzed the medical recoreds of 52 children with delayed language development evaluated during 30 months from January 1986 through June 1988. The results were as follows : 1. The majority of cases were evaluated at the age of 2-2.9 year old(16 cases, 30.8%) and 3-3.9 year old(11 cases, 21.2%) 2. Male to female ratio was 3 : 1 3. The most common cause was mental retardation(53.8%), followed by developmental language disorder(23.1%) and autism(13.5%) 4. The most common associated condition was dysarticulation(17.3%), followed by strabismus(9.6%) and seizures(7.7%) 5. Special education was recommended in cases of 23(44.2%), speech therapy in 12 cases(23.1%) and consultation to child psychiatry in 7 cases (13.5%). Making diagnosis of underlying disorders is not simple because assessment of intelligence in young children is difficult and only a few tests are standardized. More detailed study on children with delayed language development and development of psychometric tests for the handicapped children are necessary, especially in Korea.

• Journal of Korean Ophthalmic Optics Society
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• v.11 no.4
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• pp.329-335
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• 2006

The aim of this study was to evaluate the relation between Asthenopia of near lateral phoria and fusional reserve and also to provide fundamental clinical data. A total of 97 subjects, aged between 17 and 35 years old, who had no strabismus, an eye trouble or whole body disease, were examined nacked visual acuity, corrected visual acuity, corrected diopter, phoria, fusional reserve tests from October of 2005 to July of 2006. We excluded 8 subjects for the following reasons: if they had an amblyopia affecting binocular vision or inaccurate data. After these exclusions, 87 subjects remained. The results were as follow. According to interview results was that in near works, exophoria and esophoria with asthenopia was 59.6%, 64.7%, and 52.6% respectively. The subjects who have exophoria of $0-6{\Delta}$ in the range of normal state was 19.1%. The subjects who have exophoria of $7{\Delta}$ over in the range of abnormal state was 80.9%. The fusional reserve was in inverse proportion to phoria. The fusional reserve was twice over of phoria were 30.3%, and twice under were 69.7%. The asthenopia complain persons were 33.9% with the twice over fusional reserve of phoria. The asthenopia no complain persons were 66.1% with the twice under fusional reserve of phoria. In conclusion, our research has shown conclusively that there is a link between asthenopia of lateral phoria and fusional reserve and we also find that fusional reserve must be examined when we prescribe for a patient who has phoria.

• Journal of Korean Ophthalmic Optics Society
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• v.12 no.4
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• pp.95-99
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• 2007

This study performed apreliminary test with male high school students in Gwangju metropolitan city in order to determine visual function information of high school students. For the items in this preliminary test, there were inquiry, test for long distance unaided visual acuity, pinhole visual acuity test, colour vision test, cover test and stereo test. Most complaint related to eye was about blurred vision (28.4%) and over 90% of subjects had one or more, and among them, over 50% appealed two or more complaints. 76.1% of all subjects showed less than 0.7 in unaided distance visual acuity. In pinhole visual acuity test, 98% had an improved unaided pinhole visual acuity and most of them experienced an improvement and 2% had no change or dropped. The students with normal stereoscopic vision test were 85.6% and the students under normal range were 14.4%. In colour vision test, 7.9% of them were protanomaly and deuteranomaly and none of them had trichromasy and total color blindness. In cover test, it showed 30.2% of orthophoria, 8.2% of esophoria and 61.5% of exophoria, and none of them had strabismus.

• Clinical and Experimental Pediatrics
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• v.51 no.11
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• pp.1211-1216
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• 2008

Purpose : Diamond-Blackfan anemia (DBA) is a rare heterogeneous genetic disorder of infancy and early childhood. It is characterized by red cell aplasia, congenital anomalies, and a predisposition to cancer. Corticosteroids and red cell transfusions are the mainstays of therapy. We describe our experience of 6 cases of DBA that were encountered over a period of 16 years. Methods : Medical records of 6 patients diagnosed to have DBA and admitted to the Chonnam National University Hospital between 1992 and 2008 were retrospectively reviewed. Results : Three patients were males. The age at diagnosis ranged from 3 to 18 months (median, 5.5 months). Heart defects were observed in 4, polydactyly in 2, and strabismus in 1 patient. The median number of transfusions was 3 (range, 2-8). All patients responded to initial treatment with steroids and had a hemoglobin level ${\geq}9g/dL$ with a median of 12.5 days (range, 7-22 days). Three patients are currently not receiving steroid therapy. A minimum dose of oral prednisolone (<5 mg per day) was required to maintain hemoglobin ${\geq}9mg/dL$ in 3 cases. Red cell transfusion was infrequently required in 1 patient. In the median follow-up of 14 years, there was no development of malignancy. No significant side effects of steroids were found, except for short stature in 2. Conclusion : The majority of DBA patients achieved complete response and under maintenance therapy with low dose of steroids. Close observation is needed to monitor steroid side effects, cardiac function, and development of malignancy. A nation-wide survey is necessary to further characterize this rare disease in Korean children.

• Journal of Korean Ophthalmic Optics Society
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• v.20 no.2
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• pp.219-228
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• 2015

Purpose: The current study was performed to compare the difference in binocular visual function depending on variable background colors at near work. Method: Fifty four adults (18 males, 34 females) who consented to the present study and had no ocular disease, ocular surgery history, strabismus and amblyopia with normal binocular vision were participated into this study. The subjects were asked to read the novels with black letter printed on white, red, green and blue background for 15 min. Then, their heterophoria, AC/A ratio, near point of convergence, accommodation facility, relative accommodation and vergence were measured before and after reading. The difference of measurements were compared. Result: Overall heterophoria was tended to decrease with regardless of background color. AC/A ratio showed a tendency of increase after reading the novels with all backgrounds except white background. Near point of convergence was significantly increased compared to before reading at all background color. Accommodative facility of dominant and non-dominant eyes were also significantly increased after reading however, binocular accommodative facility showed a tendency of decrease. Negative relative accommodation also decreased at all background colors however, the change of positive relative accommodation was not significantly different. In case of vergence, there was significant difference in break point of far BO and recovery point of far BI by the wavelength of background color. Conclusions: From the results, it was known there is convergence change depending on the wavelength of light even though same amount of accommodation and convergence is required when doing near work for certain period. Thus, it can be suggested that the adjustment of the near working environment which perception of various color was required, should be conducted according to the main wavelength.