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Differences of EEG and autonomic responses between olfactory stimuli with orange and valeric acid in human (오렌지향과 valeric acid향에 대한 뇌파와 자율신경계반응에 나타난 후각 감성)

  • 백은주;이윤영;이배환;문창현;이수환
    • Proceedings of the Korean Society for Emotion and Sensibility Conference
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    • 1997.11a
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    • pp.75-79
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    • 1997
  • The present study was designed to investigate whether there is a consistint changes in the signals from the central and autonomic nervous systim due to olfactory stimulation. The olfactory stimuli were 0.6% orange and 2.5% valeric acid and the stimuli through the olfactory stimulator soth controlled consistint flow, controlled concentration, and saturated with vapour to prevent drying the nasal mucosa. A room air blunk served as the control stimulus, EEG was recorede from 4channels according to the international 10-20 systim. Additionally, ECG, EOG, heart rate, skin conductance and resputation were recorded comtinuously. The fast Fourier transform analysis of EEG waves was analysed with the power spectra. Averaged power spectra were computed for the following frequency bands ; delta(0-4.5Hz), theta (4.5-7Hz), alphal(7-9.5Hz), alpha2 (9.5-12.5Hz) and beta(12.5-30Hz). Withthe results of the subjective sensibility test for the ordor, the orange was related to pleasant and familiar and the valeric acid was realted to snpleasant and bothersome. There is the difference between orange and valeric acid in alphal at PG2-A2 channel. While the unpleasant stimuli seem to be increased in alphal, alpha2 and beta waves at all channels. Also, the heart rate, galvaric skin resistance seem to be decreased by pleasant stimuli and thd unpleasant stimuli shdwed the opposite. In respiration, respiration rate had been declinig tendency, and input/output ampoitued and duration showed an upward trend by olfactory stimulation with orange, while opposite by valeric acid. In conclusion, the consistent EEG changes and the autonomic responses suggests the possibilities of the subjective signal of human sensibility.

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Pregnancy Rate by Intrauterine Insemination (IUI) with Controlled Ovarian Hyperstimulation (COH) (자궁강내 인공수정에 의한 임신율)

  • Hong, Jeong-Eui;Lee, Ji-Sam
    • Clinical and Experimental Reproductive Medicine
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    • v.25 no.2
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    • pp.217-231
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    • 1998
  • The effectiveness of intrauterine insemination (IUI) combined with controlled ovanan hyperstimulation (COH) in the treatment of infertility with various etiologies was compared in a total of 152 cycles. Patients received a maximum of three IUI cycles for the treatment. Severe male ($<2\times10^6$ motile sperm) or age factor (> 39 y) patients were excluded in this study. Pregnancy was classified as clinical if a gestational sac was seen on ultrasound. The overall clinical pregnancy rate was 7.9% per cycle (12/152) and 9.7% per patient (12/124). The pregnancy rates were 0% in unstimulated natural (0/18), 7.5% in CC (3/40), 8.2% in CC+hMG (4/49), 5.9% in GnRH-a ultrashort (1/17), 5.9% in GnRH-a long (1/17) and 27.3% in dual suppression cycles (3/11), respectively. The pregnancy rate was higher in dual suppression cycle than other stimulated cycles, but this was not significant. The multiple pregnancy rates were 25.0% (2 twins and 1 triplet). No patient developed ovarian hyperstimulation. Abortion rates were 66.7% in CC (2/3) and 100% in ultrashort cycles (1/1). The livebirth rate was 5.9% per cycle (9/152) and 7.3% per patient (9/124). There were no differences in age, duration of infertility, follicle size, total ampules of gonadotropins and days of stimulation between pregnant and non-pregnant groups. However, significant(P<0.05) differences were observed in the level of estradiol $(E_2)$ on the day of hCG injection ($3,266.6{\pm}214.2$ vs $2,202.7{\pm}139.4$ pg/ml) and total motile sperm count ($212.1{\pm}63.4$ vs $105.1{\pm}9.9\times10^6$) between pregnant group and non-pregnant group. These results suggest that IUI combined with successful ovarian stimulation tends to improve the chance of pregnancy as compared to IUI without COH and a total motile sperm count may be considered predictive of the success for pregnancy.

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Cessation of gonadotropin-releasing hormone antagonist on triggering day in flexible multiple-dose protocol: A randomized controlled study

  • Chang, Hye Jin;Lee, Jung Ryeol;Jee, Byung Chul;Suh, Chang Suk;Lee, Won Don;Kim, Seok Hyun
    • Clinical and Experimental Reproductive Medicine
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    • v.40 no.2
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    • pp.83-89
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    • 2013
  • Objective: To investigate outcomes of stimulated IVF cycles in which GnRH antagonist was omitted on the ovulation triggering day. Methods: A total of 86 women who underwent controlled ovarian hyperstimulation with recombinant FSH and GnRH antagonist flexible multiple-dose protocols were recruited and prospectively randomized into the conventional group (group A) or cessation group (group B). The GnRH antagonist, 0.25 mg/day of cetrorelix, was started when the leading follicle reached 14 mm in diameter and was continuously administered until the hCG triggering day (group A, 43 cycles) or until the day before hCG administration (group B, 43 cycles). The maturity of oocytes, fertilization rate, embryo quality, and implantation and clinical pregnancy rates were evaluated. Results: The duration of ovarian stimulation, total dose of gonadotropins, serum estradiol levels on hCG administration day, and number of oocytes retrieved were not significantly different between the two groups. The total dose of GnRH antagonist was significantly lower in group B than group A ($2.5{\pm}0.9$ vs. $3.2{\pm}0.8$ ampoules, p<0.05). There was no premature luteinization in any of the subjects. The proportion of mature oocytes and fertilization rate were not significantly different in group B than group A (70.7% vs. 66.7%; 71.1% vs. 66.4%, respectively). There were no significant differences in the implantation or clinical pregnancy rates. Conclusion: Our prospective randomized study suggested that cessation of GnRH antagonist on the hCG administration day during a flexible multiple-dose protocol could reduce the total dose of GnRH antagonist without compromising its effects on pregnancy rates.

A Comparative Study of External & Central Temperature Characteristics during the Moxibustion Period (애주 연소 과정에서 발생하는 애주의 표면 및 중심부의 온도변화 특성 연구)

  • Hong, Deok;Kwon, Oh-Sang;Kim, Young-Jin;Kim, Yu-Lee;Kim, Jae-Hyo;Ahn, Seong-Hun;Sohn, In-Chul
    • Korean Journal of Acupuncture
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    • v.27 no.3
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    • pp.47-56
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    • 2010
  • Objectives : The moxibustion is the method using the heat stimulation done by attached and burned a moxa on a healing point or acupuncture point with chemical stimulation of a resin made from burning them. The purpose of this study is to find the physical and thermal characteristics of moxibustion in order to standardize the moxa therapy method. Methods : In this study, the thermal changes were observed by means of a testo 845 device, which is an infra-red thermometer to measure the thermal changes. Results & Conclusions : 1. The thermal changes on the external surface of moxibustion did not depend on the weight of the moxa; the external surface temperature was about $500^{\circ}C$. 2. The central thermal changes depend on the weight of moxa; the central temperatures ranged from $500^{\circ}C$ to $700^{\circ}C$. 3. The burning duration of moxibustion depend on the weight of moxa but that of external surface temperature did not depend on the weight of moxa in high degree : about $400^{\circ}C$. 4. The integral values of central and external temperature curves were proportional to the weight of moxa; that is central temperature curves were higher than that of external.

Effect of a dual trigger on oocyte maturation in young women with decreased ovarian reserve for the purpose of elective oocyte cryopreservation

  • Kim, Se Jeong;Kim, Tae Hyung;Park, Jae Kyun;Eum, Jin Hee;Lee, Woo Sik;Lyu, Sang Woo
    • Clinical and Experimental Reproductive Medicine
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    • v.47 no.4
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    • pp.306-311
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    • 2020
  • Objective: The aim of this study was to determine whether co-administration of a gonadotropin-releasing hormone (GnRH) agonist and human chorionic gonadotropin (hCG) for final oocyte maturation improved mature oocyte cryopreservation outcomes in young women with decreased ovarian reserve (DOR) compared with hCG alone. Methods: Between January 2016 and August 2019, controlled ovarian stimulation (COS) cycles in women (aged ≤35 years, anti-Müllerian hormone [AMH] <1.2 ng/mL) who underwent elective oocyte cryopreservation for fertility preservation were retrospectively analyzed. Results: A total of 76 COS cycles were triggered with a GnRH agonist and hCG (the dual group) or hCG alone (the hCG group). The mean age and serum AMH levels were comparable between the two groups. The duration of stimulation, total dose of follicle-stimulating hormone used, and total number of oocytes retrieved were similar. However, the number of mature oocytes retrieved and the oocyte maturation rate were significantly higher in the dual group than in the hCG group (p=0.010 and p<0.001). After controlling for confounders, the dual-trigger method remained a significant factor related to the number of mature oocytes retrieved (p=0.016). Conclusion: We showed improved mature oocyte collection and maturation rate with the dual triggering of oocyte maturation in young women with DOR. A dual trigger appears to be more beneficial than hCG alone in terms of mature oocyte cryopreservation for young women with DOR.

Enhancing Multiple Steady-State Visual Evoked Potential Responses Using Dual-frequency tACS (이중 주파수 tACS를 이용한 안정상태 시각 유발 전위 반응 향상)

  • Jeonghui Kim;Sang-Su Kim;Young-Jin Jung;Do-Won Kim
    • Journal of Biomedical Engineering Research
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    • v.45 no.2
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    • pp.101-107
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    • 2024
  • Steady-state visual evoked potential-based brain-computer interface (SSVEP-BCI) is one of the promising systems that can serve as an alternative input device due to its stable and fast performance. However, one of the major bottlenecks is that some individuals exhibit no or very low SSVEP responses to flickering stimulation, known as SSVEP illiteracy, resulting in low performance on SSVEP-BCIs. However, a lengthy duration is required to enhance multiple SSVEP responses using traditional single-frequency transcranial alternating current stimulation (tACS). This research proposes a novel approach using dual-frequency tACS (df-tACS) to potentially enhance SSVEP by targeting the two frequencies with the lowest signal-to-noise ratio (SNR) for each participant. Seven participants (five males, average age: 24.42) were exposed to flickering checkerboard stimuli at six frequencies to determine the weakest SNR frequencies. These frequencies were then simultaneously stimulated using df-tACS for 20 minutes, and the experiment was repeated to evaluate changes in SSVEP responses. The results showed that df-tACS effectively enhances the SNR at each targeted frequency, suggesting it can selectively improve target frequency responses. The study supports df-tACS as a more efficient solution for SSVEP illiteracy, proposing further exploration into multi-frequency tACS that could stimulate more than two frequencies, thereby expanding the potential of SSVEP-BCIs.

Effect of Stimulus Waveform of Biphasic Current Pulse on Retinal Ganglion Cell Responses in Retinal Degeneration (rd1) mice

  • Ahn, Kun No;Ahn, Jeong Yeol;Kim, Jae-Hyung;Cho, Kyoungrok;Koo, Kyo-In;Senok, Solomon S.;Goo, Yong Sook
    • The Korean Journal of Physiology and Pharmacology
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    • v.19 no.2
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    • pp.167-175
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    • 2015
  • A retinal prosthesis is being developed for the restoration of vision in patients with retinitis pigmentosa (RP) and age-related macular degeneration (AMD). Determining optimal electrical stimulation parameters for the prosthesis is one of the most important elements for the development of a viable retinal prosthesis. Here, we investigated the effects of different charge-balanced biphasic pulses with regard to their effectiveness in evoking retinal ganglion cell (RGC) responses. Retinal degeneration (rd1) mice were used (n=17). From the ex-vivo retinal preparation, retinal patches were placed ganglion cell layer down onto an $8{\times}8$ multielectrode array (MEA) and RGC responses were recorded while applying electrical stimuli. For asymmetric pulses, 1st phase of the pulse is the same with symmetric pulse but the amplitude of 2nd phase of the pulse is less than $10{\mu}A$ and charge balanced condition is satisfied by lengthening the duration of the pulse. For intensities (or duration) modulation, duration (or amplitude) of the pulse was fixed to $500{\mu}s$($30{\mu}A$), changing the intensities (or duration) from 2 to $60{\mu}A$(60 to $1000{\mu}s$). RGCs were classified as response-positive when PSTH showed multiple (3~4) peaks within 400 ms post stimulus and the number of spikes was at least 30% more than that for the immediate pre-stimulus 400 ms period. RGC responses were well modulated both with anodic and cathodic phase-1st biphasic pulses. Cathodic phase-1st pulses produced significantly better modulation of RGC activity than anodic phase-1st pulses regardless of symmetry of the pulse.

The Pharmacological Studies on the Origin of Calcium ion in Myocardial Contraction (심근 수축에 있어서 Calcium 이온의 기원에 관한 약리학적 연구)

  • Ko, Chang-Mann;Kim, Kyung-Hwan
    • The Korean Journal of Pharmacology
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    • v.30 no.1
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    • pp.67-73
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    • 1994
  • Na-Ca exchange transports calcium ion either into (reverse mode Na-Ca exchange) or out of the cell (forward mode Na-Ca exchange) according to the direction of driving force produced by the changes in ratio of intra- and extra-cellular Na concentrations. Thus, Na-Ca exchange is regarded as the regulator of myocardial contraction. However, the existence of reverse mode Na-Ca exchange and its role in myocardial contraction is still questioned. Present study was performed to identify the presence of reverse mode Na-Ca exchange and its possible involvement in the regulation of myocardial contraction in rat heart. Using the left atria of rat, contraction was induced by electrical field stimulation (EFS, 0.5 msec duration and supramaximal voltage). Changing of the stimulation frequencies from resting 4 Hz to 0.4, 1 or 8 Hz caused typical negative staircase effect in twitch tension, but $^{45}Ca$ uptake showed bimodal increase. When the stimulation frequency was abruptly changed from 4 Hz to 0.4 Hz the atrial twitch tension showed three phased-enhancement, that is, the initial rapid increase (the first phase) followed by rapid decrease (the second phase) and stabilization (the third phase). $^{45}Ca$ uptake was equivalent to tension, i.e. initial significant increase in first 30 second and then decrease. Benzamil treatment abolished the first phase of increase in a dose dependent manner from $10^{-5}\;to\;3{\times}10^{-4}M.$ Bay k 8644 $(3{\times}10^{-5}M)$ treatment enhanced the inotropy induced by frequency reduction and abolished the second and third phase decreases. Benzamil treatment also suppressed the contraction stimulated by Bay K 8644. Although the contraction at 4 Hz stimulation was completely abolished by verapamil $3{\times}10^{-5}\;M$ pretreatment, the contraction reappeared as soon as the stimulation frequency was changed into 0.4 or 1 Hz and interstingly,$^{45}Ca$ uptake were significantly higher than no treatment. From these results, it is concluded that reduction of stimulation frequency causes calcium influx by the reverse mode Na-Ca exchange, resulting in initial rapid increase of twitch tension. then it turns into forward mode exchange to efflux the calcium, resulting in decrease of the twitch tension in left atria of rat.

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Feeding Desaturation and Effects of Orocutaneous Stimulation in Extremely Low Birth Weight Infants (초극소 저체중 출생아에서 수유 시 산소포화도 저하와 구강자극 요법의 효과)

  • Choi, Hae-Won;Park, Hye-Won;Kim, Hee-Young;Lim, Gi-Na;Koo, So-Eun;Lee, Byong-Sop;Kim, Ai-Rhan;Kim, Ki-Soo;Pi, Soo-Young
    • Neonatal Medicine
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    • v.17 no.2
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    • pp.193-200
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    • 2010
  • Purpose: Feeding desaturation is a common problem among preterm infants which can result in prolonged hospital stays, longterm feeding difficulties and growth delay. The purpose of this study was to identify the characteristics of premature infants with feeding desaturation and to examine the effect of orocutaneous stimulation on oral feeding. Methods: During the first phase of this study, 125 extremely low birth weight infants were reviewed retrospectively. Characteristics between infants with feeding desaturation (n=34) and those without feeding desaturation (n=91) were examined. During the second phase, 29 infants recruited from March, 2009 to May, 2010 were subjected to orocutaneous stimulation. The results of orocutaneous stimulation were compared to a control group (n=81). Results: The first phase of the study revealed that extremely low birth weight infants with feeding desaturation were significantly lower in gestational ages at birth, and had lower 5 minute apgar scores, more gastroesophageal refluxes and bronchopulmonary dysplasia. Infants without feeding desaturation reached full enteral feeding significantly earlier and showed shorter duration of hospital stay. At the second phase, infants in the intervention group showed shorter days to achieve initiation of bottle feeding, shorter days in achievement of full bottle feeding, last episodes of feeding desaturation and length of hospital stay compared to the control group of similar characteristics. Conclusion: Orocutaneous stimulation among extremely low birth weight infants results in earlier achievement of full bottle feedings without episodes of feeding desaturation hence shortens the length of hospital stay.

Radiofrequency C2 Ganglionotomy in Atlantoaxial Subluxation: Short Term Follow up (환축추 전방아탈구 환자에서 제 2 경추신경절 열응고술 후의 예후에 대한 단기적 추적관찰)

  • Shim, Jae-Hang;Shim, Jae-Chul
    • The Korean Journal of Pain
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    • v.14 no.2
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    • pp.193-198
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    • 2001
  • Background: Anterior atlantoaxial subluxation (AAS) is a frequent phenomenon in rheumatoid arthritis (RA). AAS compresses the C2 ganglion or nerve and is a cause of posterior neck pain or occipital headache. Methods: We selected RA patients that had developed posterior neck pain or occipital headache caused by AAS. AAS was diagnosed by an increase of ADI (atlantodental interval). A distance of 3 mm or more was considered significant. Patients with vertical subluxation or symptoms suggestive of myelopathy were excluded. Before C2 RF ganglionotomy, we proceeded with a C2 ganglion block or greater occipital nerve block used by local anesthetics. For C2 RF ganglionotomy, the patient was placed in the supine position on a fluoroscopic table. A 100 mm, 4 mm active tip electrode was chosen. Following sensory stimulation at 0.2 to 0.6 V, the lesion was performed at a temperature of $60^{\circ}C$ to $65^{\circ}C$ for 60 sec. We followed up the patient after 6 months later. Results: All cases were female and the average duration of RA was 8.5 years. The duration of posterior neck pain or occipital headache was 1-8 months. The average ADI was 4.2 mm and the McGregor index was 3.3 mm on the average. In all cases, the score on the 4 point Likert scale was 4 (pain free) during the follow-up period. Conclusions: We found that the occipital headache or posterior neck pain caused by AAS in rheumatoid arthritis patients was alleviated over a short term follow up. C2 RF ganglionotomy is suggested as an effective palliative treatment for AAS in RA patients.

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