• Journal of the Korea Society of Computer and Information
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• v.12 no.4
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• pp.191-200
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• 2007

This study was identify web interface design factors for increasing information processing and attention for mentally disabled men. Gaining information via the internet is becoming pivotal in today"s society as the internet is becoming the center of knowledge and information. The goal of this study is to present the guideline of web interface design for the disabled men who are alienated in gaining information from the Internet. If the internet were more user friendly to the disabled men, they would be able to spend more time in doing what they enjoy and also in self development, with the information gained on the internet. This study investigated current portal sites to understand the present situation, surveyed and interviewed the disabled men, and researched literatures on how the disabled men perceive various stimulants and also researched documents for previous guidelines on interface design for them. This study investigated internet sites which the disabled men use to gather information about products and which entice their purchasing desires. The conclusion is that the usability can be improved by eliminating visual dizzy elements in the pages, simplifying the layout and the menu designs which represent the information architecture.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.1
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• pp.222-225
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• 2008

Hiccup is one of common symptoms that remains poorly understood. The hiccups coordinating center is located in the brain-stem reticular formation. Hiccups may be derived from 400 medical origins. Stroke is an infrequent cause of intractable hiccups. Intractable hiccups in pontine infarction remain poorly understood. As for treatments of hiccups, physical stimulating methods, pharmacological therapies and surgery are occidental conventional methods. In Pharmacological therapies, antidepressants, gastric motility stimulants, antispastic drugs are commonly used. Oriental medicines and acupuncture are also used frequently to treat hiccups. We have treated a case of intractable hiccup induced by pontine infarction with herbal medication; Gwakhyangjeonggi-san gami, acupuncture and moxibustion, and successfully improved. This case showed oriental medicine therapy is effective in intractable hiccup induced by pontine infarction.

• Archives of Pharmacal Research
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• v.26 no.12
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• pp.1067-1073
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• 2003

Ursodeoxycholic acid (UDCA) is a non-toxic, hydrophilic bile acid in widespread clinical use mainly for acute and chronic liver disease. Recently, treatment with UDCA in hepatic graft-versus-host disease has been given in immunosuppressive therapy for improvement of the biochemical markers of cholestasis. Moreover, it has been reported that UDCA possesses immunomodulatory effects by the suppression of cytokine production. In the present study, we hypothesized that UDCA may inhibit the production of the pro-inflammatory cytokine, IL-1$\beta$, and nitric oxide (NO) in microglia. In the study, we found that 100 $\mu$ g/mL UDCA effectively inhibited these two pro-inflammatory factors at 24 hand 48 h, compared to the $A\beta$42-pretreated groups. These results were compared with the LPS+UDCA group to confirm the UDCA effect. As microglia can be activated by several stimulants, such as $A\beta$42, in Alzheimers brain and can release those inflammatory factors, the ability to inhibit or at least decrease the production of IL-1$\beta$ and NO in Alzheimers disease (AD) is essential. Using RT-PCR, ELISA and the Griess Reagent System, we therefore found that UDCA in $A\beta$42 pre-treated cultures played a significant role in suppressing the expression or the production of IL-1$\beta$ and NO. Similarly, lipopolysaccharide (LPS) did not activate microglia in the presence of UDCA. Moreover, we found that UDCA exhibits a prolonged effect on microglial cells (up to 48 h), which suggests that UDCA may play an important role in chronic cell damage due to this long effect. These results further imply that UDCA could be an important cue in suppressing the microglial activation stimulated by massive AD peptides in the AD progressing brain.

• The Journal of Korean Orthopaedic Ultrasound Society
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• v.1 no.2
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• pp.117-121
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• 2008

Prolotherapy can be defined as the injection of growth factors or growth factor production stimulants to grow normal cells or tissue. Even though it has been a controversal procedure for decades, it is currently gaining in popularity among many physicians. The term prolotherapy was coined by Hacket in the 1950s to imply proliferation of normal tissue at ligamentous and tendinous entheses. The procedure has been described by other terms, such as sclerotherapy, regenerative injection therapy, and stimulated ligament repair. Incomplete healing from sprains or strains is common and can lead to chronic pain, joint instability and laxity, and is a risk factor for the development of osteoarthritis. Prolotherapy is commonly used for these musculoskeletal conditions which are refractory to usual care therapies. The proliferant solution and technique varies according to physicial training and preferance. Commonly reported proliferants include 10% to 25% dextrose, P2G and sodium morrhuate. High resolution ultrasound imaging of musculoskeletal tissue is increasing in popularity because of patient tolerability, low cost, ability to visualize tissue in real time motion and superior resolution of highly organized tissue such as a tendon. This procedure can be introduced by ultrasound imaging and tissue growth and repair after this procedure in a tendon or a ligament can be documented with ultrasound.

• Journal of Korean Academy of Nursing
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• v.23 no.3
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• pp.487-503
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• 1993

This study was designed to investigate the situation of adolescent drug use in Seoul, and to com-pare this with the 1991 survey in order to better understand the present situation. The subject for this study were 1000 students in High School and Middle School. The data were collected during the period from september 1, 1992 to December 30, 1992. The guestionnaire developed by Kim So Ya Ja (1991) to survey adolescent drug use was used. The data was analyzed using descriptive statistics, 1-test and ANOVA with the SPSS program. The results of this study can be summarized as follows 1. Prevalence of Substance use : Antihistamines were used by 0.3% of adolescent, Sedatives 0.6%, Stimulants 8.1%, Hallucinogens 0.9%, Inhalants 3.2%, Narcotics 1.7%, and Analgetics 154.3%. 2. Trend in substance use compared to the 1991 surbey : Alcohol use increased from 52.8% to 63.7% and narcotics from 0.6% to 1.7%, while Smeking, Analgetics, Antihistamines, Sedatives, and Inhalants showed a decrease. 3. Smoking and Alcohol use : Twenty five percent of school adolescent had experienced cigarette smoking and 63.7% of school adolescent had experienced alcohol use. 4. Motives for drug use : The highest was avoidence of sleep at 49.4% and the next highest was adventure seeking at 27.7%. As to feeling after drug use, 34.3％ felt apathy, 22.8% had feelings of sleepiness and unconsciousness. 5. Places were dreg were purchased : The most frequent was the drug store (78.3%) and 84.4% of the respondents answered that drug purchase was easy and 86.7% that drug use was mainly at home. 6. Related Variables : There was a statistically significent high score for drug and alcohol use by adolescents whose fathers used drugs. (PC.05) In conclusion, adolescents in Seoul showed in decrease in the tendency to use drugs compared to the 1991 survey, however drugs which are habit-forming and lead to dependency are still being abused. Therefore, counter-plans and preventive stratiges are important.

• Korean Journal of Health Education and Promotion
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• v.17 no.2
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• pp.57-73
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• 2000

A study on drug abuse of young people who failed in college entrance examinations and preparing the next examination and those enrolled at colleges but trying to transfer to other colleges was conducted from February 3 to May 31, 1999 in order to determine current drug abuse status of them and factors affecting their behavior related to drug abuse. A total of 1,771 people were selected from college entrance preparation institutes in Seoul, Pusan, Taegu, Taejon and Kwangju and interviewed by using questionnaires. The results are summarized as follows; 1. 49.78％ of them experienced drinking, 22.8％ smoking, and 6.7％ drug previously. More males smoked cigarettes than females. The young in the age group of 25 to 29 years old, and the young living in small towns, and subjects who finished junior colleges and those without religions drank more than those in other categories. The subjects in the age group of 20 to 24 years old and those with one parent, and those living in small towns used more drugs than those in other categories. 2. 60.1％ of those with drug using experience used the drug in their or friends' homes. 53.6％ of them used drugs with their friends, junior or senior classmates. 36.6％ of them purchased drugs from drug stores. 76.0％ of them spent their pocket money for buying drugs. 3. The drugs (excluding alcohol and tobacco) they used were bond and butane gas (29.6％), stimulants (20.6％), marijuana 02.0％) LSD (4.8％), cocaine, heroine and opium (4.2％), and others (28.8％). 4. 21.5％ of those with drug using experience had detoxification treatment previously. The ajmor sufferings they experienced were distraction (42.6％), fear 01.7％), and others. 5. 51.0％ of the subjects experienced drug related health education in schools, and 14.6％ had that kind of education through social program. 6. 64.3％ of the subjects got information about drug abuse through mass media, 16.4％ through printed materials, and 11.4％ through public health professionals. 7. The knowledge level of drug abuse was 16.48:1:2.76 points out of 24 (68.6 points out of 100).

• The Korean Journal of Zoology
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• v.32 no.1
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• pp.34-39
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• 1989

Ouabain, strychnine sulfate, caffeine sodium benzoate and chlorpromazine hydrochloride were introduced intraperitoneally into male mice for 7, 14 and 21 days to induce the changes in the relative percentages of lactate dehydrogenase isozymes. The five isozymes in brain, heart and kidney tissues were electrophoresed on cellulose acetate strip and subjected to densitometry. Ouabain caused a drastic increase of B$_4$isozymes only in brain tissues. The two stimulants altered the relative percentages of $A_4$and B$_4$isozymes conspicuously in brain tissues, whereas virtually no redistributions of five isozymes were occurred by the depressant except B$_4$isozymes in brain and heart tissues. On the basis of these observations, it might be suggested that the changes in intracellular concentration of sodium and calcium ions are not the cause of the isozyme redistributions and that Organization of plasma membrane could be one of the factors involved in the tissue specificity of lactate dehydrogenase isozymes in vertebrates.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.27 no.1
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• pp.31-38
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• 2016

Pharmacotherapy is considered the first line therapy in attention-deficit hyperactivity disorder (ADHD). Many patients also choose complementary medicine such as dietary supplements. Omega-3 has shown some efficacy for improving ADHD symptoms in several studies. The goal of this review is to integrate the previous research findings on omega-3 and understand the issues worth considering in the treatment of ADHD. The terms "attention deficit disorder with hyperactivity", "omega-3", and "dietary supplements" were searched on PubMed, Cochrane, and Google scholar. The search was further limited to clinical trials, reviews, and meta-analyses. Trials that examined treatments for ADHD, used randomized design, and placebo-controlled trials were included. Eighteen clinical trials with a total of 1,141 participants were included in this review. Fifteen trials had parallel designs, comparing an omega-3/6 polyunsaturated fatty acid (PUFAs) or a combination of both to a placebo and three compared omega-3/6 PUFAs to a placebo and psycho-stimulants. Seven of the included trials showed significant improvements in groups receiving omega-3/6 PUFAs compared to placebo groups, however, 11 trials showed no significant differences. Evidence that PUFAs supplementation provides benefits for ADHD was yet limited. Mixed results were due to selection variability criteria, variability of supplementation, and short follow-up intervals.

• Journal of the Society of Disaster Information
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• v.5 no.1
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• pp.48-62
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• 2009

Bodyguards always perform their duty with psychological burdens in their mind, not only because security situations are developed in various forms dependent on the surrounding environments or circumstances, but because bodyguards only take follow-up actions while the criminal decides time, place, and style of every attack. Thus, in the security situation, it is not uncommon for bodyguards to experience muscle rigidity, uncontrollable emotional elevation, difficulty in concentration, negative perception, frustration and enervation, which are caused by continuous physical/mental burdens, stimulations by various interpersonal behaviors or minute environmental stimulants. In conclusion, the result of performing security duties is related in the first place with the degree of the bodyguard's potential, in the second place with the degree of training and efficiency. And the result can also be changed by the way they control their negative psychological state of the moment when they carry out the skills they acquired. Maximizing the performance of the bodyguards by helping them overcome these psychological factors may be facilitated by detecting their psychological factors, understanding the causes, and training them in applying appropriate measures for overcoming these factors. When these measures are applied, the positive perception is indispensable that duties of protecting clients can be carried out successfully. No single measure can be declared to be more effective than the other because the effect of each measure is expressed differently by the individual characteristics of the bodyguards. However, it is important to select and apply the measures most appropriate to the bodyguard. Besides, they should devote themselves to the training with persistence because efficient implement of the measures for overcoming psychological factors takes a lot of time.

• Journal of Korean Society of Water and Wastewater
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• v.33 no.5
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• pp.367-377
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• 2019

In this study, the fate and removal of 15 pharmaceuticals (including stimulants, non-steroidal anti-inflammatory drugs, antibiotics, etc.) in unit processes of a sewage treatment plant (STP) were investigated. Mass loads of pharmaceuticals were 2,598 g/d in the influent, 2,745 g/d in the primary effluent, 143 g/d in the secondary effluent, and 134 g/d in the effluent. The mass loads were reduced by 95% in the biological treatment process, but total phosphorous treatment did not show a significant effect on the removal of most pharmaceuticals. Also, mass balance analysis was performed to evaluate removal characteristics of pharmaceuticals in the biological treatment process. Acetaminophen, caffeine, acetylsalicylic acid, cefradine, and naproxen were efficiently removed in the biological treatment process mainly due to biodegradation. Removal efficiencies of gemfibrozil, ofloxacin, and ciprofloxacin were not high, but their removal was related to sorption onto sludge. This study provides useful information on understanding removal characteristics of pharmaceuticals in unit processes in the STP.