• The Korean Journal of Pain
• /
• 제7권2호
• /
• pp.231-237
• /
• 1994

Epidural steroid injection is a treatment for low back pain which allows smaller doses with less risk of side effects and longer duration of relief than systemic administration. From 1 June 1992 to 31 January, 1994, 1 mg/kg of triamcinolone diacetate in 8 ml of lidocaine 1% was administered 56 times to 33 patients who complained of low back pain. Results of epidural steroid injection provided effectiveness in treating various low back pain diseases except postlaminectomy syndrome. However there are no gains about repeated epidural steroid injection.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• 제31권3호
• /
• pp.161-164
• /
• 2020

Crohn's disease is a chronic inflammatory disease that involves the upper and lower gastrointestinal tracts, including the oral cavity. For the conventional treatment of inflammatory bowel diseases, steroids are usually used as induction therapy, and azathioprine is used as maintenance therapy. Steroids are associated with various side effects. Under rare circumstances, they can even cause psychotic symptoms, and reports on steroid-induced psychosis in the pediatric population are few. Here, we report the first case of steroid-induced psychosis in a 16-year-old female with Crohn's disease administered with steroids as induction therapy in South Korea. She showed psychotic symptoms, including auditory hallucination, loosening of association, and idea of reference, after 2 weeks of administering prednisolone 60 mg/day. One week after steroid discontinuation, the patient gradually recovered and was treated with quetiapine. Therefore, pediatricians should be aware of serious psychiatric adverse effects when administering corticosteroids for various indications.

• 대한후두음성언어의학회지
• /
• 제20권1호
• /
• pp.21-24
• /
• 2009

Various laryngeal injection techniques andmaterials have been introduced and widelyused. In this section, office-base laryngeal injection with Cidofovir, Steroid and Botulinum toxin will be described including a suitable approach for the injection, treatment efficacy, side effects and its pitfalls.

• The Korean Journal of Pain
• /
• 제4권2호
• /
• pp.152-156
• /
• 1991

경부 신경근병이 의심되는 31예의 환자에 경막외강 스테로이드 주입으로 치료하여 다음과 같은 결과를 얻었다. 1) 총 31예중 10예에서는 1회만을 주입하였다. 2) 최소한 1주일 간격으로 2회이상 주입한 21예중 15예에서 증상의 호전을 보였고 6예에서는 효과가 없었다. 3) 총 88회 주업중 2회의 지주막 천자외에는 합병증이 없었다. 이상의 결과로 보아 cervical radiculopathy가 의심되는 환자는 수술적 치료를 적용하기 전에 다른 종류의 대중적 치료와 더불어 경막외 스테로이드률 주입하는 것이 안전하고 효과적인 것으로 사료된다.

• 한국산학기술학회논문지
• /
• 제20권10호
• /
• pp.62-67
• /
• 2019

본 연구는 rotifer Brachionus rotundiformis의 유성생식을 유도하기 위해 효과적인 매개물질로 몇 가지 성 steroid hormone (serotonin, progesterone 및 ${\beta}$-estradiol)을 선정하여 농도별(Low, 30 mg/L 및 High, 300 mg/L)로 내구란 생산효과를 6일 동안 배양하면서 조사하였다. 배양 3일째 ${\beta}$-estradiol ($E_2$) 처리구가 다른 실험구에 비해 유성생식률이 20.6%로 가장 높게 나타났다. 배양 6일째 내구란 생산수(106 개)도 동일한 결과를 보였으며 다음으로는 serotonin이 높게 나타났다. 더하여, 위 스테로이드 호르몬이 몇 가지 유성생식관련 유전자의 발현에 미치는 영향에 대해 조사한 결과, NrbP, SRY, Cyclin 및 MrpmB 유전자가 처리한 모든 hormone에 대해 up-regulation되는 경향을 보였다. 결과를 종합해보면, B. rotundiformis의 내구란 생산에 가장 효과적인 steroid hormone은 ${\beta}$-estradiol인 것으로 판단되며 유성생식 관련 유전자로 NrbP, SRY, MrpmrB 및 Cyclin을 제안할 수 있다. 차후 효과적인 내구란 생산을 위한 $E_2$의 최적 처리농도규명에 관한 추가 연구가 필요할 것으로 판단된다.

• Journal of Audiology & Otology
• /
• 제25권1호
• /
• pp.27-35
• /
• 2021

Background and Objectives: This study aimed to evaluate the clinical features and the clinical factors associated with prognosis of sudden sensorineural hearing loss (SSNHL) in diabetic patients. Subjects and Methods: Forty-nine diabetic with unilateral SSNHL were retrospectively included. All patients received systemic high dose steroid therapy within one month after onset and had more than one month of follow-up audiogram. The basic characteristics of the patients, initial and follow-up audiograms, laboratory data, and methods of steroid treatment were collected. Results: Compared to reference values in healthy subjects, 79%, 55%, and 45% of the patients had higher values of mean neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and lymphocyte-monocyte ratio (LMR), respectively. Older patients had significantly less degree of hearing loss, but they also had significantly worse hearing thresholds in the unaffected ear. After steroid treatment, less than half patients (47%) showed hearing recovery. Simultaneous intratympanic dexamethasone (ITD) injections with systemic steroid did not confer an additional hearing gain or an earlier recovery rate in diabetic patients with SSNHL. In the multivariate analysis, initial hearing thresholds of affected ear and timing of steroid treatment were significantly associated with hearing prognosis in diabetic patients with SSNHL. Conclusions: Diabetic patients with SSNHL tended to have increased NLR, LMR, and PLR, which are reported to be associated with microvascular angiopathy. Simultaneous ITD injections to improve hearing recovery in diabetic patients with SSNHL seems unnecessary.

• 대한청각학회지
• /
• 제25권1호
• /
• pp.27-35
• /
• 2021

Background and Objectives: This study aimed to evaluate the clinical features and the clinical factors associated with prognosis of sudden sensorineural hearing loss (SSNHL) in diabetic patients. Subjects and Methods: Forty-nine diabetic with unilateral SSNHL were retrospectively included. All patients received systemic high dose steroid therapy within one month after onset and had more than one month of follow-up audiogram. The basic characteristics of the patients, initial and follow-up audiograms, laboratory data, and methods of steroid treatment were collected. Results: Compared to reference values in healthy subjects, 79%, 55%, and 45% of the patients had higher values of mean neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and lymphocyte-monocyte ratio (LMR), respectively. Older patients had significantly less degree of hearing loss, but they also had significantly worse hearing thresholds in the unaffected ear. After steroid treatment, less than half patients (47%) showed hearing recovery. Simultaneous intratympanic dexamethasone (ITD) injections with systemic steroid did not confer an additional hearing gain or an earlier recovery rate in diabetic patients with SSNHL. In the multivariate analysis, initial hearing thresholds of affected ear and timing of steroid treatment were significantly associated with hearing prognosis in diabetic patients with SSNHL. Conclusions: Diabetic patients with SSNHL tended to have increased NLR, LMR, and PLR, which are reported to be associated with microvascular angiopathy. Simultaneous ITD injections to improve hearing recovery in diabetic patients with SSNHL seems unnecessary.

• Tuberculosis and Respiratory Diseases
• /
• 제55권6호
• /
• pp.631-635
• /
• 2003

비특이성 간질성 폐렴에서 대개의 경우 스테로이드 치료로 호전지만 스테로이드 저항성 인 경우 여러 가지 면역 억제제가 이차 약제로 치료에 시도되고 있으며 본 증례에서는 cyclosprin을 이차약제로 사용해서 좋은 치료 효과를 얻었기에 문헌 고찰과 함께 보고 하는 바이다.

• 한국임상약학회지
• /
• 제14권1호
• /
• pp.11-23
• /
• 2004

Although most children with idiopathic nephrotic syndrome respond to corticosteroid therapy, many responders show steroid dependency and frequent relapse. In these children, one of the major problems is the serious side effects resulting from continuous steroid therapy. Thus, this study was conducted to assess the therapeutic efficacy and safety of six-month cyclosporine treatment with the low-dose deflazacort therapy in children with nephrotic syndrome. Thirty children with steroid dependence (SD), frequent relapse (FR) and steroid resistance (SR) were enrolled in this study. They were treated with 6-month oral cyclosporine $(Cypol-N^{(R)})$ plus the low-dose deflazacort $(Calcort^{(R)})$ therapy at Samsung Medical Center from September 2002. The dosage of cyclosporine was started at 5 mg/kg/day and was monthly adjusted to maintain clinical remission and/or a trough blood level, while deflazacort dosage was reduced gradually. Clinical evaluation and monitoring of cyclosporine toxicity were performed every $2\sim4$ weeks. Outcomes were compared to the latest sir-month period of steroid only therapy before cyclosporine treatment. Student's t-test and ANOVA were used for statistical analysis. Out of 28 children with SD and FR, 23 $(82.1\%)$ sustained remission, and 5 $(17.9\%)$ experienced 1 or 2 relapses during therapy. Out of 2 children with SR, 1 child sustained remission, and 1 child showed no response. The mean duration of remission and occurrence of relapse were significantly improved (p <.0001). In addition, the mean dosage of steroid was significantly reduced (p=.003). Although a number of adverse effects occurred in this study, they were not so serious as to necessitate discontinuation of the therapy. No nephrotoxicity was observed. Twenty out of the 28 children who had been in remission relapsed after withdrawal of cyclosporine. Fifteen of these children showed relapse within a month. These results demonstrated that the combination of cyclosporine with the low-dose deflazacort was efficient and safe in children with SD and FR during the six-month treatment. However, further studies are necessary in order to resolve the problem of high relapse rate after discontinuation of cyclosporine.

• Archives of Plastic Surgery
• /
• 제33권6호
• /
• pp.700-705
• /
• 2006

Purpose: For hypertrophic scars and keloids no universally effective treatment modality exists. Surgical revision, intralesional steroid injection, silicone gel sheeting, pressure, laser, and others have been used with variable success, but many treatments are associated with high recurrence rates. Although optimal treatment remains undefined, successful treatment can be obtained through a combined therapeutic approach. Methods: We used three therapeutic modalities in combination, which are intralesional injection of triamcinolone acetonide, silicone gel sheeting, and 585 nm flashlamp-pumped pulsed dye laser. Fifty-eight cases of hypertrophic or keloid scar were treated by combined therapeutic regimen for mean period of 18 months. The changes of thickness, color, and pliability of scars were evaluated with clinical photographs by grading scale. Results: As summing the grades and categorizing the result into three group, we obtained 28% good, 67% fair, and 5% poor results. There was a desirable improvement of scars with insignificant adverse effects. Conclusion: Combination of intralesional steroid injection, silicone gel sheeting, and pulsed dye laser can lead to successful treatment of hypertrophic scar and keloid.