• Journal of Yeungnam Medical Science
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• 제22권1호
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• pp.1-12
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• 2005

Normal growth and development is of prime concern during childhood. The treatment of children with growth hormone deficiency has been revolutionized by growth hormone therapy. An improved height outcome with a final height within the target height range has been achieved. However, close follow-up with regular clinical and laboratory monitoring is essential for achieving the desirable height outcome. The theoretical unlimited supply of growth hormone has led to its wide spread use in a variety of disorders other than a growth hormone deficiency. Initially used in children with Turner syndrome, growth hormone is now used to treat chronic renal failure, an idiopathic short stature and intrauterine growth restrictions in addition to a wide array of newly emerging indications. This review summarizes the basics for a proper growth assessment, the differentiation of normal and abnormal growth causes of a short stature, and the indications for growth hormone treatment.

• 대한인간공학회지
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• 제31권1호
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• pp.255-259
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• 2012

Objective: This study aims to investigate relationship between representative anthropometric dimensions and income levels for Korean from 1958 to 1989. The anthropometric dimensions include stature and body weight, and GNP per head was used as an index of income level. Background: Although anthropometric dimensions were affected by varying factors such as genetic, environmental and socioeconomic factors, most studies on anthropometry have focused on measurement methods, providing data and their characteristics. Method: Anthropometric data were retrieved from homepages of Korean Agency for Technology and Standards, and Ministry of Culture, Sports & Tourism, and GNPs per head by year from Korean Statistical Information Service. Results: During analysis period, statures and body weights for males and females increased by 6.4cm and 6.1cm, 10.7kg and 4.0kg, respectively. Infants' stature and body weight nearly linearly increased with GNPs per head. Anthropometric dimensions of stature and body weight were very positively correlated with GNPs per head. Conclusion: This study revealed that income levels significantly affect stature and body weight. Application: The results would be used as a valuable basic data when establishing government policies related to anthropometry.

• 대한한방내과학회지
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• 제22권4호
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• pp.513-517
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• 2001

Objective : Recently many studies of herbal medication to promote growth have been implemented. The purpose of this study was to identify the feasibility and safety of herbal medication on short stature. Methods : 143 patients(87 males, 56 Females)who visited with short stature at Kangnam CHA Oriental Hospital From February 1999 to January 2000 and were treated during 6 months, were available for this study. We treated with 5 herbal medications.(Soeumin hyangbujapalmultang-gagambang, Soyangin yukmijihwangtang-gagambang, Taeumin chungsimyunjatang-gagambang, Boa-tang, Boikyangwi tang) At the begining of the treatment and after 6 months treatment, We measured height, weight and body mass index(BMI). And we investigated changes of aspartate aminotransferase(AST), alanine aminotransferase(ALT), blood urea nitrogen(BUN), alkaline phosphatase(ALP), creatinine. Results: The distribution of ages was from 5 years old to 17 years old. After herbal treatment, mean height, mean weight, mean BMI and mean percentile grade increased $138.5{\pm}15.6$ to $141.9{\pm}15.1$, from $36.9{\pm}13.2$ to $38.9{\pm}13.2$, from $18.5{\pm}3.29$ to $18.7{\pm}3.21$, from $3.2{\pm}1.2$ to $3.4{\pm}1.2$. The contents of AST, ALT, BUN, ALP and Creatinine were not showed any significant change. Conclusions : In the results We recognized Short stature was showed prominent feasibility and safety of herbal medication. Herbal Medication in patients with short stature will improve height velocity without liver and kidney function disorders.

• Journal of Preventive Medicine and Public Health
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• 제39권6호
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• pp.447-454
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• 2006

Objectives : To determine obesity for the screening of individuals at high risk of coronary heart disease in urban areas. Methods : Data were obtained from 4,137 adults between 19 and 85 years of age (2,372 males, 1,765 females), not recognized as taking medicines for cardiovascular diseases, who underwent a health check-up at the health promotion center of university hospitals in cities between Jan. 2003 and Dec. 2004. The variables studied were divided into two broad categories, and their relationships examined. obesity indices and risk factors for coronary heart disease. To reveal the relation between each of the obesity indices and the proportion of individuals at risk of coronary heart disease, the obesity indices were stratified and odds ratios obtained after age adjustment. Results : From a gender comparison of anthropometric measures, men were found to have significantly greater heights, weights, and waist and hip circumferences than women. From a gender comparison by the obesity indices, women were found to have significantly higher BMI, %Fat, waist to hip and waist to stature ratios than men. As obesity indices, the waist to stature ratio and the waist circumference were strongly correlated with coronary risk factors, both in men and women. The age-adjusted odds ratio of coronary risk factors increased significantly with increasing waist circumference, BMI, %fat, waist to hip and waist to stature ratios, and were highest specifically for the waist to stature ratio and the waist circumference. Conclusions : The study results showed that the waist to stature ratio and the waist circumference, as obesity indices, were most closely correlated with coronary risk factors. It is suggested that the waist to stature ratio and, specifically, the waist circumference can be effectively used in the field of health management for screening those with high levels of coronary risk factors.

• 한국의류학회지
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• 제10권3호
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• pp.37-48
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• 1986

The purpose of this study was to analyze 'the natural groupings' of subjects in order to classify highly similar somatotype for clothing construction. The sample for the study was drawn randomly out of senior high school boys in Seoul urban area. The sample size was 425 boys between age 16 and 18. Cluster analysis was more concerned with finding the hierarchical structure of subjects by three dimensional distance of stature. bust girth and sleeve length. The groups forming a partition can be subdivided into 5 and 6 sets by the hierarchical tree of the given subjects. Ward's Minimum Variance Method was applied after extraction of distance matrix by the Standardized Euclidean Distance. All of the above data was analyzed by the computer installed at Korea Advanced Institute of Science and Technology. The major findings, take for instance, of 16 age group can be summarized as follows. The results of cluster analysis of this study: 1. Cluster 1 (32 persons means $18.29\%$ of the total) is characterized with smaller bust girth than that of cluster 5, but stature and sleeve length of the cluster 1 are the largest group. 2. Cluster 2 (18 Persons means $10.29\%$ of the total) is characterized with the group of the smallest stature and sleeve length, but bust girth larger than that of cluster 3. 3. Cluster 3(35persons means $20\%$ of the total) is classified with the smallest group of all the stature, bust girth and sleeve length. 4. Cluster 4(60 persons means $34.29\%$ of the total) is grouped with the same value of sleeve length with the mean value of 16 age group, but the stature and bust girth is smaller than the mean value of this age group. 5. Cluster 5(30 persons means $17.14\%$ of the total) is characterized with smaller stature than that of cluster 1, and with larger bust girth than that of cluster 1, but with the same value of the sleeve length with the mean value of the 16 age group.

• 한국융합학회논문지
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• 제12권6호
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• pp.39-47
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• 2021

이 연구는 치아발육단계에서 성장호르몬 결핍의 영향을 알아보기 위해서 성장호르몬 결핍이나 특발성 저신장 소아와 정상 소아 간의 차이를 분석하는 것을 목적으로 한다. 영남대학교 의과대학 부속병원 소아청소년과에서 저신장으로 진단받은 소아들을 성장호르몬 결핍인 대상자와 특발성 저신장 소아로 분류하였다. 구강 파노라마와 신체지수를 계측하여 치아발육과의 관계를 분석하였다. 성장호르몬 결핍성 저신장 소아와 특발성 저신장 소아 간의 유의한 차이는 측절치에서만 나타났다. 성장호르몬 결핍성 저신장 소아와 정상 소아 간에는 모든 치아에서 성장호르몬 결핍성 저신장 소아의 발육이 유의하게 늦은 것으로 나타났다. 결론적으로 저신장 소아에서 성장호르몬 결핍성 저신장 소아나 특발성 저신장 소아 모두 신장뿐만 아니라 치아 발육 역시 영향을 받은 것으로 나타났다. 이 연구는 향후 저신장 소아의 교정치료 프로토콜의 기초자료를 제시할 수 있을 것으로 기대한다.

• Clinical and Experimental Pediatrics
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• 제46권4호
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• pp.363-369
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• 2003

목 적 : 본 연구는 저신장 소아 중 성장호르몬 약물자극검사에서는 정상반응을 나타낸 특발성 저신장 소아들을 대상으로 야간의 수면 양상과 성장호르몬 분비가 정상 신장의 아동과 차이가 있는지 알아보고자 하였다. 방 법 : 성장호르몬 약물자극검사에서 정상반응을 보인 신장이 3 백분위수 이하인 특발성 저신장 아동 12명과 정상 신장 아동 9명을 대상으로 30분 간격으로 야간수면 동안의 자발적 성장호르몬 분비를 측정하고 동시에 polysomnography로 수면양상을 비교 분석하였다. 결 과 : 1) 야간 수면 중 분비된 성장호르몬의 평균농도는 저신장 아동군이 정상 아동군에 비해 유의하게 낮았으며($2.8{\pm}0.2 ng/mL$ vs $4.7{\pm}0.6 ng/mL$), 특히 수면개시 후 서파 수면과 동반되는 성장호르몬 최대 분비치가 저신장 아동군이 낮았다. 2) 수면 중 성장호르몬 농도가 5 ng/mL 이상인 성장호르몬 분비 최대치의 횟수는 각각 $4.1{\pm}0.5$회, $5.8{\pm}0.6$회로 저신장군이 유의하게 적었다. 3) 전체 수면 시간에 대한 서파 수면 시간의 백분율도 저신장 아동군이 정상 아동군에 비해 감소되어 있었다($16.4{\pm}1.3%$ vs $20.8{\pm}1.2%$). 결 론 : 야간 수면 동안의 자발적인 성장호르몬 분비 검사가 약물자극검사에서 정상반응을 보이는 특발성 저신장 아동의 추가적인 진단에 도움을 줄 수 있으며 이들 저신장 아동에서 보이는 야간 성장호르몬 분비 감소는 수면구조의 차이와 일부 관련이 있는 것으로 생각된다.

• 대한치과교정학회지
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• 제37권1호통권120호
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• pp.16-28
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• 2007

본 연구는 청소년의 교정 치료 시 중요한 교정 환자의 성장 평가 및 잔여 성장량 예측 방법을 개발하기 위하여 시행되었다. 이를 위하여 한국인의 전국적 표본 자료 중에서 $2\;{\sim}\;20$세 남자 4,893명, 여자 4,987명의 키 자료를 이용하여 성별 연령별 키에 대한 성장 곡선을 3차 스플라인 함수(NCSF)로 구현하였다. 이후 성장 예측 알고리즘을 개발하고 이를 임의로 선택된 200명의 종단 성장 자료를 이용하여 검증하였다. 검증에는 최종 키 예측 정확성과 검증 표본의 모든 연령에 대한 키 예측 오차 분석 및 NCSF 성장 곡선의 적합성 검사가 포함되었다. 그 결과 NCSF 성장 곡선은 기준 성장 곡선을 표현하는데 매우 적합한 것으로 나타났으며 최종 키 예측 정확성도 높았다. 또한 예측 정확성은 남자 보다 여자가 유의하게 높았다. 이러한 결과에도 불구하고 검증 표본의 모든 연령에 대한 키 예측 오차의 양상이 독립성과 정규성이 부족한 단점도 나타났다. 결론적으로 본 연구 결과 도출된 NCSF 성장 곡선을 이용한 성장 예측 방법의 높은 정확성에도 불구하고 개인의 종단 성장에 좀 더 적합한 성장 모형의 개발이 필요할 것으로 생각되었다.

• 한방비만학회지
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• 제5권1호
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• pp.97-107
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• 2005

Objectives The purpose of this study was to investigate correlation between short stature and obese degree. And we also wanted to know the characteristics of patients visited clinic in the name of 'short stature'. Methods Height, body weight, BMI, fat mass, lean body mass, percent body fat were taken intended for 236 patients in the name of short stature. To all the patient questionnaire for growth clinic was drawn up, and ultrasound scan was taken through calcaneous of the right foot. The patients were classified to three groups - short, average, tall group - according to relative position of mid-parental height. It was analysed that the differences between groups in obese degree. Also was investigated correlation between position of short stature and obese degree, and between obese degree and bony maturity. Results & Conclusion 1. The average ages of patients in the name of 'short stature' were $12.69{\pm}3.93$ years old in boys, $10.66{\pm}3.67$ years old in girls. And it seemed to be just before second rapid maturing period. 2. The average BMI were $20.58{\pm}4.07kg/m^2$ in boys, $18.65{\pm}2.85kg/m^2$ in girls, and average percent body fat were $21.99{\pm}7.35%$ in boys, $26.01{\pm}6.35%$ in girls. 3. The numbers of obese children were 34(31.2%) in boys, 19(14.9%) in girls on the basis of BMI. And the numbers were 39(35.8%) in boys, 53(41.7%) in girls on the basis of percent body fat. There was a big difference in case of girls. 4. The numbers of AG(average group) were 48(44.0%) in boys, 60(47.2%) in girls, the numbers of SG(short group) were 35(32.1%) in boys, 31(24.4%) in girls, and numbers of TG(tall group) were 26(23.9%) in boys, 35(27.6%) in girls. 5. There were no significant differences among the groups in BMI, lean body mass, fat mass, percent body fat. Only significant difference in DI(disease index). 6. There were no significant correlation between PH(percent height) and BMI, leanbody mass, fat mass, percent body fat. Only significant correlation in DI(disease index). 7. There were no significant differences between DA(difference between bone age and chronorogical age) and BMI, leanbody mass, percent body fat. Only significant correlation in fat mass.

• Clinical and Experimental Pediatrics
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• 제53권5호
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• pp.661-665
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• 2010

Anemia caused by vitamin B12 deficiency resulting from inadequate dietary intake is rare in children in the modern era because of improvements in nutritional status. However, such anemia can be caused by decreased ingestion or impaired absorption and/or utilization of vitamin B12. We report the case of an 18-year-old man with short stature, prepubertal sexual maturation, exertional dyspnea, and severe anemia with a hemoglobin level of 3.3 g/dL. He had a history of small bowel resection from 50 cm below the Treitz ligament to 5 cm above the ileocecal valve necessitated by midgut volvulus in the neonatal period. Laboratory tests showed deficiencies of both vitamin B12 and iron. A bone marrow examination revealed dyserythropoiesis and low levels of hemosiderin particles, and a cytogenetic study disclosed a normal karyotype. After treatment with parenteral vitamin B12 and elemental iron, both anemia and growth showed gradual improvement. This is a rare case that presented with short stature and delayed puberty caused by nutritional deficiency anemia in Korea.