• The Transactions of The Korean Institute of Electrical Engineers
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• v.58 no.7
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• pp.1443-1449
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• 2009

This paper presents a profiling model of a wide-window superscalar microprocessor using multiple branch prediction. The key idea is to apply statistical profiling technique to the superscalar microprocessor with a wide instruction window and a multiple branch predictor. The statistical profiling data are used to obtain a synthetical instruction trace, and the consecutive multiple branch prediction rates are utilized for running trace-driven simulation on the synthesized instruction trace. We describe our design and evaluate it with the SPEC 2000 integer benchmarks. Our performance model can achieve accuracy of 8.5 % on the average.

• Journal of Korea Multimedia Society
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• v.20 no.1
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• pp.66-73
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• 2017

Due to the recent rapid changes in society and wide spread of information devices, diverse digital information is utilized in a variety of economic and social analysis. Information related to the crime statistics by type of crime has been used as a major factor in crime. However, statistical analysis using only the structured data has the difficulty in the investigation by providing limited information to investigators and users. In this paper, structured data and unstructured data are analyzed by applying Korean Natural Language Processing (Ko-NLP) and the Latent Semantic Analysis (LSA) technique. It will provide a crime profile optimum system that can be applied to the crime profiling system or statistical analysis.

• Journal of Digital Convergence
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• v.14 no.6
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• pp.263-270
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• 2016

In this study, it was attempted to develop a grade-customized statistical analysis system that can be operated by a teacher without professional knowledge of statistics by utilizing profiling in the education sector. For this, with the convergence of techniques of profiling into the education sector, it examined the elements necessary for building a customized student multidimensional analysis system. Referring to the overall configuration and the current state to build multidimensional analysis system utilizing practical profiling, it showed the implementation result of the algorithm applied to each statistical method, and presented the differences and superiority to existing systems. Once the system based on the proposed techniques is built, considering differences of students' needs and abilities and clarifying precise objectives and standards, with the improvement of satisfaction in public education, it is possible not only to reduce expense of prior and private learning but also realize self-directed learning suitable to one's learning ability and aptitude.

• Bulletin of the Korean Chemical Society
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• v.34 no.5
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• pp.1467-1472
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• 2013

Metabolomics is a field that studies systematic dynamics and secretion of metabolites from cells to understand biological pathways based on metabolite changes. The metabolic profiling of intact human colorectal tissues was performed using high-resolution magic angle spinning (HR-MAS) NMR spectroscopy, which was unnecessary to extract metabolites from tissues. We used two different groups of samples, which were defined as normal and cancer, from 9 patients with colorectal cancer and investigated the samples in NMR experiments with a water suppression pulse sequence. We applied target profiling and multivariative statistical analysis to the analyzed 1D NMR spectra to identify the metabolites and discriminate between normal and cancer tissues. Cancer tissue showed higher levels of arginine, betaine, glutamate, lysine, taurine and lower levels of glutamine, hypoxanthine, isoleucine, lactate, methionine, pyruvate, tyrosine relative to normal tissue. In the OPLS-DA (orthogonal partial least square discriminant analysis), the score plot showed good separation between the normal and cancer groups. These results suggest that metabolic profiling of colorectal cancer could provide new biomarkers.

• Proceedings of the Korean Society of Applied Pharmacology
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• 2007.11a
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• pp.19-27
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• 2007

An important potential of metabolomics-based approach is the possibility to develop fingerprints of diseases or cellular responses to classes of compounds with known common biological effect. Such fingerprints have the potential to allow classification of disease states or compounds, to provide mechanistic information on cellular perturbations and pathways and to identify biomarkers specific for disease severity and drug efficacy. Metabolic profiles of biological fluids contain a vast array of endogenous metabolites. Changes in those profiles resulting from perturbations of the system can be observed using analytical techniques, such as NMR and MS. $^1H$ NMR was used to generate a molecular fingerprint of serum or urinary sample, and then pattern recognition technique was applied to identity molecular signatures associated with the specific diseases or drug efficiency. Several metabolites that differentiate disease samples from the control were thoroughly characterized by NMR spectroscopy. We investigated the metabolic changes in human normal and clinical samples using $^1H$ NMR. Spectral data were applied to targeted profiling and spectral binning method, and then multivariate statistical data analysis (MVDA) was used to examine in detail the modulation of small molecule candidate biomarkers. We show that targeted profiling produces robust models, generates accurate metabolite concentration data, and provides data that can be used to help understand metabolic differences between healthy and disease population. Such metabolic signatures could provide diagnostic markers for a disease state or biomarkers for drug response phenotypes.

• Journal of Plant Biotechnology
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• v.33 no.3
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• pp.161-169
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• 2006

Plant metabolomics is a plant biology field for identifying all of the metabolites found in a certain plant cell, tissue, organ, or whole plant in a given time and conditions and for studying changes in metabolic profiling as time goes or conditions change. Metabolomics is one of the most recently developed omics for holistic approach to biology and is a kind of systems biology. For holistic approach, metabolomics frequently uses chemometrics or multivariate statistical analysis of metabolic profillings. In plant biology, metabolomics is useful to determine functions of genes often in combination with DHA microarrays by analyzing tagged mutants of the model plants Arabidopsis and rice. This review paper attempted to introduce basic concepts of metabolomics and practical uses of multivariate statistical analysis of metabolic profiling obtained by $^1$H HMR and Fourier transform infrared spectrometry.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.14 no.6
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• pp.259-265
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• 2014

When the trace-driven simulation is used for the performance analysis of widely used multicore processors in the initial design stage, much time and disk space is necessary. In this paper, statistical simulations are performed for a high performance multicore processor with various hardware configurations. For the experiment, SPEC2000 benchmarks programs are used for profiling and synthesizing new instruction traces. As a result, the performance obtained by our statistical simulation is comparable to that of the trace-driven simulation with the benefit of tremendous reduction in the simulation time.

• Journal of the Korean Magnetic Resonance Society
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• v.17 no.1
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• pp.1-10
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• 2013

Metabolomics is the study which detects the changes of metabolites level. Metabolomics is a terminal view of the biological system. The end products of the metabolism, metabolites, reflect the responses to external environment. Therefore metabolomics gives the additional information about understanding the metabolic pathways. These metabolites can be used as biomarkers that indicate the disease or external stresses such as exposure to toxicant. Many kinds of biological samples are used in metabolomics, for example, cell, tissue, and bio fluids. NMR spectroscopy is one of the tools of metabolomics. NMR data are analyzed by multivariate statistical analysis and target profiling technique. Recently, NMR-based metabolomics is a growing field in various studies such as disease diagnosis, forensic science, and toxicity assessment.

• Journal of the Korean Society for information Management
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• v.28 no.2
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• pp.11-36
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• 2011

Since the 1990s, informetrics has grown in popularity among information scientists. Today it is a general discipline that comprises all kinds of metrics, including bibliometrics and scientometrics. To illustrate the dynamic progress of this field, this study aims to identify the structure and infrastructure of the informetrics literature using statistical and profiling methods. Informetrics literature was obtained from the Web of Knowledge for the years 2001-2010. The selected articles contain least one of these keywords: informetrics', bibliometrics', scientometrics', webometrics', and citation analysis.' Noteworthy publication patterns of major countries were identified by a statistical method. Intellectual structure analysis shows major research areas, authors, and journals.

• Journal of the Korean Magnetic Resonance Society
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• v.15 no.1
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• pp.54-68
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• 2011

$^1H$ nuclear magnetic resonance (NMR) spectroscopy of biological samples has been proven to be an effective and nondestructive approach to probe drug toxicity within an organism. In this study, ketoprofen toxicity was investigated using $^1H$-NMR spectroscopy coupled with multivariate statistical analysis. Histopathologic test of ketoprofen-induced acute gastrointestinal damage in rats demonstrated a significant dose-dependent effect. Furthermore, principal component analysis (PCA) derived from $^1H$-NMR spectra of urinary samples showed clear separation between the vehicle-treated control and ketoprofen-treated groups. Moreover, PCA derived from endogenous metabolite concentrations through targeted profiling revealed a dose-dependent metabolic shift between the vehicle-treated control, low-dose ketoprofen-treated (10 mg/kg body weight), and high-dose ketoprofen-treated (50 mg/kg) groups coinciding with their gastric damage scores after ketoprofen administration. The resultant metabolic profiles demonstrated that the ketoprofen-induced gastric damage exhibited energy metabolism perturbations that increased urinary levels of citrate, cis-aconitate, succinate, and phosphocreatine. In addition, ketoprofen administration induced an enhancement of xenobiotic activity in fatty oxidation, which caused increase levels of N-isovalerylglycine, adipate, phenylacetylglycine, dimethylamine, betaine, hippurate, 3-indoxylsulfate, N,N-dimethylglycine, trimethyl-N-oxide, and glycine. These findings demonstrate that $^1H$-NMR-based urinary metabolic profiling can be used for noninvasive and rapid way to diagnose adverse drug effects and is suitable for explaining the possible biological pathways perturbed by nonsteroidal anti-inflammatory drug toxicity.