• Bulletin of the Korean Chemical Society
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• 제35권9호
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• pp.2870-2872
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• 2014

• Journal of Microbiology and Biotechnology
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• 제20권6호
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• pp.985-987
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• 2010

The biological transformation of the bioactive dihydroisocoumarin, (-)-mellein, isolated from the marinederived fungus Cladosporium sp., was studied. The preparativescale culture of (-)-mellein with a marine isolate of a bacterium Stappia sp. resulted in the isolation of its oxidized metabolite, (3R,4S)-4-hydroxymellein. The stereostructure of the metabolite obtained was assigned on the basis of detailed physicochemical data analyses.