• Tuberculosis and Respiratory Diseases
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• 제84권4호
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• pp.299-316
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• 2021

Background: The lack of effective medications for coronavirus disease 2019 (COVID-19) has led to a trend of drug repurposing such as the case of azithromycin which shows immunomodulatory and anti-viral effect. Several clinical trials have shown conflicting results. It is currently unclear whether the available evidence is in favor or against the use of azithromycin in COVID-19 patients. Thus, the aim of this study was to investigate the efficacy and safety of azithromycin in COVID-19 patients. Methods: Four independent reviewers selected relevant studies from PubMed, ScienceDirect, EBSCO, and ProQuest published prior to March 2021. The protocol used in this study has been registered in PROSPERO (CRD42020224967). Results: We included 17 studies and found that the mortality rate (odds ratio [OR], 0.95; 95% confidence interval [CI], 0.76-1.19), need of respiratory support (OR, 1.30; 95% CI, 0.98-1.73), hospitalization rate (standardized mean difference, 0.12; 95% CI, -0.02 to 0.27), and intensive care unit transfer (OR, 1.21; 95% CI, 0.79-1.86) of azithromycin-treated group did not differ significantly (p>0.05) from those of the control group. Azithromycin treatment did not significantly increase the risk of getting secondary infection (OR, 1.23; 95% CI, 0.83-1.82), hypoglycemia (OR, 0.73; 95% CI, 0.38-1.40), gastrointestinal problems (OR, 1.03; 95% CI, 0.73-1.45) or electrocardiogram abnormalities (OR, 1.16; 95% CI, 0.94-1.42). The overall quality of evidence ranged from low to very low. Conclusion: Azithromycin did not result in a superior clinical improvement in COVID-19 patients, although it was well-tolerated and safe to use.

• 대한조현병학회지
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• 제21권2호
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• pp.74-80
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• 2018

Objectives : This study investigated whether long-acting injectable (LAI) paliperidone is different from its oral form in terms of the effect on cognitive function in schizophrenia spectrum and other psychotic disorders. Methods : We reviewed the medical records of patients in Seoul National University Bundang Hospital who were diagnosed as having schizophrenia and/or other psychotic disorders based on DSM-5 from 2016 to 2017. Seven patients were treated with oral paliperidone and 11 were treated with paliperidone palmitate. All patients underwent clinical and neuropsychological assessment, including the Korean version of the MATRICS Consensus Cognitive Battery (MCCB) at their first visit or within one month of their initial treatment. MCCB was repeated within three to 12 months after the initial assessment. Results : There was no significant difference between the two groups in most cognitive domains including speed of processing, attention and vigilance, working memory, verbal learning, visual learning and reasoning and problem solving domain. However, patients treated with paliperidone palmitate showed better improvement in social cognition domain than those taking oral paliperidone. The standardized values of social cognition domain scores had significantly improved over time in patients under paliperidone palmitate, demonstrating a significant time-by-group interaction. Conclusion : Our results show that long-acting injectable paliperidone could be helpful in some aspects of improving cognitive function in schizophrenia spectrum and other psychotic disorders. Further studies with other antipsychotics are necessary to generalize the results.

• 대한한방내과학회지
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• 제44권4호
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• pp.675-702
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• 2023

Objective: This study assessed the effectiveness of using Yijung-tang to treat chronic gastritis through a systematic review and meta-analysis of randomized controlled trials (RCTs). Methods: The search was conducted using keywords such as "gastritis", "Lizhong", "Yijung", and "Chronic gastritis" on July 31, 2023. A meta-analysis was conducted according to outcome measurements, such as total effective rate (TER), Traditional chinese medicine symptom score (TSS), gastric hormones, and symptom relief time, using the Review Manager website. Results: A total of 11 RCT studies were selected. The treatment group (Yijung-tang-gagam or Yijung-tang-gagam+Western medicine) showed significant improvement effects in terms of TER, TSS, serum gastrointestinal hormones (motilin (MTL), gastrin (GAS), and somatostatin (SS)), and symptom relief time compared to the control group (Western medicine). TER-RR : 1.20, 95% CI : 1.11 to 1.30, P≤0.00001, RR : 1.21, 95% CI : 1.14 to 1.28, P≤0.00001; MTL-MD : 35.99, 95% CI : 30.79 to 41.20, P≤0.00001); GAS-MD : 103.33, 95% CI : 97.62 to 109.04, P≤0.00001); SS : MD : -37.19, 95% CI : -41.75 to -32.64, P≤0.00001; symptom relief time (nausea)-MD : -1.96, 95% CI : -2.47 to -1.45, P≤0.00001; symptom relief time (colic)-MD : -1.75, 95% CI : -2.31 to -1.18, P≤0.00001. Conclusion: This study suggests that Yijung-tang is effective against chronic gastritis. However, the number of studies was insufficient, and the diagnosis and evaluation criteria were not standardized. Furthermore, because of the low quality of the included studies, more clinical studies need to be conducted to increase the possibility of clinical use.

• 한국식품영양학회지
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• 제26권1호
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• pp.137-145
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• 2013

동아(冬瓜, wax gourd, Benincase hispida) 추출물과 프로바이오틱 유산균(Lactobacillus casei와 Bifidobacterium bifidum)(이하 유산균이라 한다)의 생리활성을 분석하였다. 동아 추출물은 안기오텐신전환효소의 활성을 47.9%, 티로시나제의 활성을 13.2% 저해하였고, 항산화 활성을 23.4% 나타냈다. 설사 증세자 120명에게 동아 추출물 제제를 72시간 복용시킨 결과 117명이 개선되었고, 6~12시간째에 개선율이 가장 높았다. 개선율은 80%가 치료되는 상태를 기준하였다. 유산균 제제는 안기오텐신전환효소의 활성을 21.4% 저해하였다. 설사 증세자 120명에게 유산균 제제를 72시간 복용시킨 결과 108명이 개선되었고, 24시간째에 개선율이 가장 높았다. 이들 결과를 바탕으로, 과민성대장증후군 개선을 위한 동아 추출물과 유산균을 함유한 제제(tablet)를 개발하였다. 이 제품은 안기오텐신전환효소의 활성을 27.1% 저해하였고, 항산화 활성을 20.3% 나타냈다. 인체폐암 A549 세포에 100 ${\mu}g/m{\ell}$ 및 250 ${\mu}g/m{\ell}$ 농도로 이 제제를 가하여 24시간 반응시킨 결과, 세포 증식을 67% 억제하였고, 동아 추출물 제제나 프로바이오틱 유산균 제제 단독으로 작용시킨 것보다 억제율이 높았다. 또 이 제제를 인체대장암 HCT116 세포에 100 ${\mu}g/m{\ell}$ 농도로 가한 결과, 24시간 후 세포 증식이 70% 억제되었고, 동아 추출물 제제나 유산균 제제 단독으로 작용시킨 것보다 개선율과 개선 속도가 높았다. 이 제제를 설사형, 변비형, 일반형의 과민성대장증후군 증세자 164명에게 72시간 복용시킨 결과 100% 개선시켰으며, 개선율은 3~6시간째에 가장 높았고, 동아 추출물 제제나 유산균 제제 단독으로 사용한 것보다 개선율과 개선속도가 높았다.

• Asian Journal of Business Environment
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• 제1권1호
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• pp.13-20
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• 2011

This study is conducted to verify existing differences in consumer attitude according to distributor type and PB product type. Pre-test was conducted for this study in order to select the distributor and to classify the product type, FGI was conducted with 10 graduate students of K university in Kyong-gi. This study survey housewives, office workers, and university students excluding the participants in the pre-test. In the final analysis, research hypothesis is verified through the data of 280 answers in Korea. This research is conducted with a factor design of 3 types of distributors -department store, discount store, convenience store-and 2 types of product -utilitarian product, hedonic product. To verify the hypotheses, ANOVA is carried out. Reliability test of each measurement variables, Cronbach α coefficient is used. For each analysis, SPSS Windows 15.0 statistical program is used. The findings suggest that First, according to the size and characteristics, distributors are classified into department stores, discount stores, and convenience stores and it is verified whether if there are differences in consumers' attitude (product attitude, brand attitude and purchase intention) by the effect of different distributors. Results showed that product attitude is statistically significant. Second, product type is classified by two categories according to whether the product seeks for practicality or emotional pleasure - Utilitarian product and Hedonic product. In this context, the result after verifying whether if there is difference in the attitudes -product attitude, brand attitude, and purchase intention - in accordance with the product types is shown that utilitarian products makes bigger difference compared to hedonic products. Third, it is confirmed that there is interaction effect between product attitude and purchase intention according to the distributer type and product type. However, we find that in terms of brand attitude, there is no interaction effect. The implications of this research is as the following. First, we propose the need of PB product development and marketing strategy, which considers the product types in accordance with the scale and features of each distributor. Second, PB products should break away from the simplicity of standardized products and consider the different features of distributors. Distributors will be in need of a strategy to build a compelling brand that can differentiate itself from other distributors. This will contribute to the improvement in reliability and formation of product value.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2014년도 추계학술대회
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• pp.233-236
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• 2014

본 연구의 목적은 가드너의 다중지능이론을 활용한 개별화수업이 다양한 성향과 개인차를 갖고 있는 대안학교 학생들의 컴퓨터교과의 학업성취도향상과 학습흥미도향상에 미치는 영향을 알아보는 것이다. 본 연구의 목적을 달성하기 위해서 다중지능이론을 적용한 컴퓨터교과 수업프로그램을 화성시에 소재하고 있는 특성화 대안학교 2학년 2개 학급을 연구대상으로 진행하였다. 다중지능이론에 기초한 기존 연구결과를 토대로 수업에 적용 가능한 교수학습 활동 전략을 실시한 1개 학급 20명과 기존의 전통식 교육방식으로 수업을 실시한 1개 학급 19명의 학생을 대상으로 주 2시간씩 10차시 수업을 진행하였다. 자료 분석은 실험집단과 비교집단의 사전 사후 검사의 차이를 독립 t-test를 이용하여 분석하였다. 이에 대한 자료통계 분석결과 다음과 같은 결론을 얻을 수 있었다. 첫째, 다중지능이론을 활용해서 수업을 실시한 실험집단이 전통적 강의식 수업을 실시한 비교 집단에 비해서 학업성취도가 더 높은 것으로 나왔다. 둘째, 다중지능이론을 활용해서 수업을 실시한 실험집단이 전통적 강의식 수업을 실시한 비교집단에 비해서 학습흥미가 더 높은 것으로 나왔다. 셋째, 사회성발달은 실험집단과 비교집단 둘 다 별 차이를 보이지 않았다.

• 대한한방내과학회지
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• 제43권4호
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• pp.542-558
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• 2022

Objectives: The purpose of this study was to assess the effect of Yigong-san on anorexia in children by conducting a systematic review and meta-analysis of randomized controlled trials (RCTs). Methods: Eleven electronic databases were searched on May 30, 2022 to collect relevant studies. All studies published up to the search date were considered. RCTs reporting the effect of Yigong-san on the treatment of anorexia in children were included. The primary outcome was an improvement in clinical anorexia symptoms after treatment. In this meta-analysis, continuous and binary outcomes were assessed, and the data were presented as the mean difference and risk ratio with their 95% confidence intervals. The risk of bias was assessed using the Cochrane Collaboration's risk of bias tool. Results: A total of nine studies were included in this systematic review. The treatment group (Yigong-san only or Yigong-san plus conventional treatment) showed a statistically significant effect compared to the control group (conventional treatment only) in total effective rate (Yigong-san only: RR 1.26, 95% CI 1.17, 1.36, I²=0%; Yigong-san plus conventional treatment: RR 1.32, 95% CI 1.18, 1.47, I²=0%), clinical symptoms, some of the anthropometric outcomes, and biological markers related to appetite and growth in children with anorexia. No serious adverse events related to Yigong-san were reported. Conclusions: Yigong-san showed statistically significant effects as a treatment for anorexia in children. However, the number of studies included in the meta-analysis was insufficient, and the herbs contained in the Yigong-san used in the included studies were not standardized. Future research should focus on the implementation of methodologically robust clinical research.

• Asian Pacific Journal of Cancer Prevention
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• 제17권11호
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• pp.4999-5003
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• 2016

The testicular cancer (TCa) incidence is increasing in many countries, with age-standardized incidence rates up to 7.8/100,000 men in the Western world, although reductions in mortality and increasingly high cure rates are being witnessed at the same time. In Africa, where rates are lower, presentation is often late and morbidity and mortality high. Given this scenario, awareness of testicular cancer and practice of testicular self-examination among future first response doctors is very important. This study was conducted to determine knowledge and attitude to testicular cancer, and practice of testicular self-examination (TSE) among final (6th) year medical students. In addition, the effect of an intervention in the form of a single PowerPoint(R) lecture, lasting 40 minutes with image content on testicular cancer and testicular self examination was assessed. Pre and post intervention administration of a self-administered structured pre tested questionnaire was performed on 151 medical students, 101 of whom returned answers (response rate of 66.8%). In the TC domain, there was a high level of awareness of testicular cancer, but poor knowledge of the age group most affected, with significant improvement post intervention (p<0.001). Notable also was the poor awareness of the potential curability of TC, this also being improved following the intervention (p<0.001). A poor level of awareness and practice of testicular self-examination pre-intervention was found considering the nature of the study group..Respondents had surprisingly weak/poor responses to the question "How important to men's health is regular testicular self-examination?" Answers to the questions "Do you think it is worthwhile to examine your testis regularly?" and "Would you be interested in more information on testicular cancer and testicular self-examination?" were also suboptimal, but improved post intervention p<0.001, p<0.001 and p=0.037. Age, gender and marital status were without specific influence. In conclusion, this study showed poor levels of knowledge regarding epidemiology of TCa and its potential curability when detected early. There was also a poor awareness of, practice of, and poor attitudes to TSE. The significant improvement in these parameters post intervention indicates value in educational intervention. We recommend inclusion of TCa coverage and TSE teaching in the secondary school curriculum (targeting adolescents). Greater emphasis should also be given to testicular cancer in the curricula of medical schools and other training institutions for health care personnel.

• 산업진흥연구
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• 제4권2호
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• pp.9-18
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• 2019

본 연구는 "ICT환경과 경영성과의 관계분석"에 대하여 연구하였다. 한국의 주력산업의 경우 대기업들은 이미 상당한 수준의 스마트공장을 구축, 운영함으로써 세계시장을 선도하고 있으나 전체 기업의 95%를 차지하는 중소 중견기업은 자체적으로 스마트공장을 구축하지 못하고 있는 실정이다. 스마트공장 구축 정부지원 기업수는 총 4,891개 기업(구축완료는 3,984개 기업, 구축중인 기업은 907개)으로 구축가능 공장수의 2.9%, 미 구축기업은 97.1%(166,344개 기업)로 매우 미약한 실정으로 개선해야 할 커다란 문제점 있다. 연구결과, 급변하는 환경에 대응하여, 도전적이고 지속적인 경쟁력을 갖추기 위한 기업혁신의 일부분인 스마트공장의 성공적인 구축을 위해서는 경영자의 의지가 가장 중요하다는 이론적 체계를 제시하는 본 연구의 첫 번째 연구목적이 달성 되었다고 할 수 있다. 둘째, 스마트공장을 구축하기 위한 자금조달은 자체자금 충당뿐만 아니라 정부의 자금지원이 스마트공장 구축의 핵심요인임을 알 수 있었다. 셋째, 스마트구축에 필요한 기술은 자체기술 이외에 정부의 기술지원, 외부기술 컨설팅 지원이 매우 중요함을 알 수 있었다. 넷째, 내부 조직원의 조직참여도는 협조적이고 원활한 긍정적인 참여도 또한 성공요인임을 알 수 있었다. 후속 연구로는 기업의 운영 현황을 파악하고 문제점을 도출하여 4M1E 기법으로 원인을 분석하고 대책을 수립하여 실시해본 결과, 개선전후를 비교하고 개선된 사항을 표준화하고, 보다 깊이 있는 연구가 필요하다. 논연구는 기업의 ICT환경과 경영성과의 관계분석을 통하여 스마트공장을 구축을 위한 기초자료를 제공 하였다는데 그 의미가 있다.

• 핵의학기술
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• 제21권1호
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• pp.76-82
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• 2017

전신 뼈 스캔은 핵의학에서 가장 많은 비중을 차지하는 검사 중 하나이다. 기본적으로 전면상과 후면상을 동시에 획득하는데, 때때로 전면상과 후면상만으로는 병소를 분간하기 어려울 때가 있다. 이러한 경우 SPECT/CT나 추가 정적 영상을 통한 병소의 정확한 위치 확인이 중요하며, 추가 촬영 여부에 대한 최초 판단은 주로 방사선사에 의해 이루어진다. 이에 본원에서는 방사선사의 업무 능력 함양을 위한 다양한 개선활동이 이루어져 왔고, 본 연구에서는 방사선사의 교육 및 표준화된 업무 프로세스 적용이 전신 뼈 스캔 오류 감소에 어떠한 영향을 미치는지 확인하고자 한다. 새로운 프로세스 적용을 위해 몇 가지 시스템이 순차적으로 도입되었다. 첫 번째는 의국 교육 및 테스트의 시행, 두 번째는 추가 촬영이 예상되는 환자를 분류하여 촬영 전에 방사선사가 미리 확인할 수 있는 사전 여과 시스템 도입, 마지막으로 판독의가 방사선사에게 직접 촬영 영상에 대해 피드백 할 수 있는 NMQA라는 커뮤니케이션 시스템을 적용하였다. 결과 확인을 위해 2014년 1월부터 2016년 12월까지 서울아산병원 핵의학과를 내원한 전신 뼈 스캔 환자를 대상으로 조사하였다. 조사 기간 동안 전체 전신 뼈 스캔 대비 NMQA가 전송된 검사 건수를 백분율로 산출하였다. 연간 발생량은 2014년 141건, 2015년 88건, 2016년 86건으로 집계되었고 NMQA 발생률은 2014년 0.88%, 2015년 0.53%, 2016년 0.45%로 감소하였다. 새로운 프로세스가 적용된 2014년 이후 NMQA 발생률이 감소하는 경향을 보였다. 다만 통계적으로 유용성을 확인하기까지는 데이터가 부족하여 향후에도 지속적인 데이터 축적이 필요할 것으로 생각한다. 본 연구를 통해 전신 뼈 스캔 영상 질 향상을 위해 표준화된 업무와 교육의 필요성을 확인하였고 향후에도 지속적인 연구와 관심으로 업데이트가 필요하다고 사료된다.