• Journal of Korean Society of Transportation
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• v.25 no.3
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• pp.29-43
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• 2007

An automobile black box can provide sufficient and accurate information for investigating the causes of vehicle accidents as well as preventing them in the future. The database of accident information from stored data in the black box can provide a variety of services to the general public when it is accessed in a reasonable manner. minimizing intrusion into drivers' privacy. Therefore, the black box could become the main intelligent automobile Part, with extensive benefits for all associated industries as well as government agencies and insurance companies. While the introduction and spread of the black box are imminent in Korea, this paper reviews technology and product trends of the black box. In particular, this paper presents findings on the investigation of black box-related patent applications and an in-depth study of core patents from several leading counties, including the United States. In addition, this paper describes trends of standardization and legislation in leading countries and presents methods of standardization with suggestions for some development topics related to black box technology.

• Korean Journal of Pharmacognosy
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• v.39 no.4
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• pp.316-323
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• 2008

In this study, we have investigated the HPLC analysis methods and quantitative analysis of standard compounds for quality standardization of a medicinal crude drug GCSB-5, a herbal formulation consisting of 6 medicinal plants (Acanthopanacis Cortex, Achyranthis Radix, Ledebouriellae Radix, Cibotii Rhizoma, Glycine Semen, Eucommiae Cortex) which are used in traditional medicine to treat various bone disorders. HPLC analysis methods of acanthoside D(Acanthopanacis Cortex), 20-hydroxyecdysone(Achyranthis Radix) which were known standard compounds among 6 medicinal plants were developed on crude material and product. And validation of HPLC analysis methods were conformed for verification of HPLC methods by check to specificity, linearity, intra-day precision, inter-day precision and accuracy following ICH guideline. Content of acanthoside D and 20-hydroxyecdysone on raw material of GCSB-5 were decided at 0.577-0.578 mg/g and 0.311-0.312 mg/g. And we confirmed that content of acanthoside D and 20-hydroxyecdysone on GCSB-5 preparation were 0.302-0.303 mg/capsule and 0.113-0.115 mg/capsule.

• Journal of Ginseng Research
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• v.46 no.2
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• pp.255-265
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• 2022

Background: Ginsenoside Rb1, a bioactive component isolated from the Panax ginseng, acts as a remedy to prevent myocardial injury. However, it is obscure whether the cardioprotective functions of Rb1 are related to the regulation of endogenous metabolites, and its potential molecular mechanism still needs further clarification, especially from a comprehensive metabolomics profiling perspective. Methods: The mice model of acute myocardial ischemia (AMI) and oxygen glucose deprivation (OGD)-induced cardiomyocytes injury were applied to explore the protective effect and mechanism of Rb1. Meanwhile, the comprehensive metabolomics profiling was conducted by high-performance liquid chromatography and quadrupole time-of-flight mass spectrometry (HPLC-Q/TOF-MS) and a tandem liquid chromatography and mass spectrometry (LC-MS). Results: Rb1 treatment profoundly reduced the infarct size and attenuated myocardial injury. The metabolic network map of 65 differential endogenous metabolites was constructed and provided a new inspiration for the treatment of AMI by Rb1, which was mainly associated with mitophagy. In vivo and in vitro experiments, Rb1 was found to improve mitochondrial morphology, mitochondrial function and promote mitophagy. Interestingly, the mitophagy inhibitor partly attenuated the cardioprotective effect of Rb1. Additionally, Rb1 markedly facilitated the phosphorylation of AMP-activated protein kinase α (AMPKα), and AMPK inhibition partially weakened the role of Rb1 in promoting mitophagy. Conclusions: Ginsenoside Rb1 protects acute myocardial ischemia injury through promoting mitophagy via AMPKα phosphorylation, which might lay the foundation for the further application of Rb1 in cardiovascular diseases.

• Anxiety and mood
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• v.12 no.2
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• pp.86-96
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• 2016

Paraphilia and paraphilic disorder is one of mental disorders making it difficult to assess and treat. Recently, a number of methods for assessing the paraphilia are being developed gradually outside south Korea. And the reliability and validity of various assessment tools are being reported. The standardization of the assessments and questionnaires was not made yet. For assessment of paraphilia that has been reported from abroad, the author comprehensively organized clinical interview, physical examination, psycho-physiological methods, self-reporting scale of sexual thoughts, fantasies and attitudes and multiple self-reporting scale of sexual interests and described the clinical significance of the assessment tools. The national standardization of both self-reported questionnaire and physical evaluations is expected to be completed later.

• Korean Journal of Pharmacognosy
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• v.40 no.2
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• pp.103-108
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• 2009

GCSB-5 preparation is a purified extract from a mixture of 6 medicinal plants(Acanthopanacis Cortex, Achyranthis Radix, Saposhnikoviae Radix, Cibotii Rhizoma, Glycine Semen Nigra, Eucommiae Cortex) that have been widely used for the treatment of various bone disorders. The aim of this study was to investigate HPLC analysis method and screening of standard compound on Saposhnikoviae Radix for quality standardization of a medicinal crude drug GCSB-5. Standard compound of Saposhnikoviae Radix was decided with cimifugin by isolation and instrumental analysis such as NMR. HPLC analysis method for the simultaneous determination of cimifugin was established for the quality control of the medicinal plants of Saposhnikoviae Radix species, GCSB-5 raw material and preparation. And validation of HPLC analysis methods were conformed for verification of HPLC methods by check to specificity, linearity, intra-day precision, inter-day precision and accuracy following ICH guideline.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2014.10a
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• pp.572-574
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• 2014

Researches on three-dimensional multimedia has been performed actively in recent years. Virtual sound technology corresponding to virtual image should be provided to implement 3D multimedia with high quality. Head-related transfer function (HRTF) plays a key role in this research area. HRTFs measured in changing azimuth, elevation, and distance for each and every subject is necessary for ideal solution. However, it is practically impossible to measure all subjects' HRTFs, so various HRTF databases have been built by many researchers. Because HRTF displays quite different aspects from subject to subject, HRTF of dummy head has been used for generic usage. However, mannequin's HRTF showed much worse performance comparing with individual case so this solution should be improved. From previous work, standardization of HRTF based on tensor-singular value decomposition method has been proposed. For effective extraction of standard HRTF, three different decomposition methods are compared in this paper.

• Journal of Ginseng Research
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• v.45 no.1
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• pp.1-21
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• 2021

Panax species have gained numerous attentions because of their various biological effects on cardiovascular, kidney, reproductive diseases known for a long time. Recently, advanced analytical methods including thin layer chromatography, high-performance thin layer chromatography, gas chromatography, high-performance liquid chromatography, ultra-high performance liquid chromatography with tandem ultraviolet, diode array detector, evaporative light scattering detector, and mass detector, two-dimensional high-performance liquid chromatography, high speed counter-current chromatography, high speed centrifugal partition chromatography, micellar electrokinetic chromatography, high-performance anion-exchange chromatography, ambient ionization mass spectrometry, molecularly imprinted polymer, enzyme immunoassay, 1H-NMR, and infrared spectroscopy have been used to identify and evaluate chemical constituents in Panax species. Moreover, Soxhlet extraction, heat reflux extraction, ultrasonic extraction, solid phase extraction, microwave-assisted extraction, pressurized liquid extraction, enzyme-assisted extraction, acceleration solvent extraction, matrix solid phase dispersion extraction, and pulsed electric field are discussed. In this review, a total of 219 articles published from 1980 to 2018 are investigated. Panax species including P. notoginseng, P. quinquefolius, sand P. ginseng in the raw and processed forms from different parts, geographical origins, and growing times are studied. Furthermore, the potential biomarkers are screened through the previous articles. It is expected that the review can provide a fundamental for further studies.

• Journal of Korean Society for Quality Management
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• v.43 no.3
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• pp.253-272
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• 2015

Purpose: The purpose of this study is to enhance the reliability of quality inspection by standardize the fineness test method of the thermal insulator of military textiles Methods: We have measured the thermal insulator of military textiles by microscope with three different ways and the effectiveness of their difference were analyzed by one-way layout design. Results: We have suggest the standardized the fineness test method of the thermal insulator of military textiles through advanced research. As a result we have verified hollow ratio of heat insulating fiber affect fineness test methods. The fineness test method for the thermal insulator applied with different methods following hollow ratio. We have verified that when the hollow ratio over 90%, the fineness of the thermal insulator measured from fiber-length, if it has over 80%, the cross-section length of hollow and if it has less 80%, the cross-section area of hollow is applied, respectively. Conclusion: This study indicated that the test method of fineness shows high reliability. Heat insulating fibers which have high evenness shows narrow variations(5/% or less, only CV 25%) irrespectively under different testing equipment or institute. Based ons the results, we have suggest the standardization of test methods for fineness by microscope method and produced the registration of Group Standard in Korean Standards Association.

• Korean Journal of Pharmacognosy
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• v.40 no.1
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• pp.18-24
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• 2009

GCSB-5 preparation is a purified extract from a mixture six herbal medicines (Acanthopanacis Cortex, Achyranthis Radix, Saposhnikoviae Radix, Cibotii Rhizoma, Glycine Semen Nigra, Eucommiae Cortex) that have been widely used in traditional medicine to treat various bone disorders. This study was carried out to obtain the HPLC analysis method that can be used to establish quantitative analysis of Glycine Semen Nigra and Eucommiae Cortex for standardization of GCSB-5 preparation. HPLC analysis methods for the simultaneous determination of genistin (Glycine Semen Nigra) and geniposide (Eucommiae Cortex) were established for the quality control of herbal medicinal raw material and preparation. And validation of HPLC analysis methods were conformed for verification of HPLC methods by check to specificity, linearity, intra-day precision, inter-day precision and accuracy following ICH guideline. As the result of quantitative analysis, the contents of genistin and geniposide in the raw material of GCSB-5 preparation were 0.0426-0.0427 mg/g and 0.431-0.432 mg/g. And GCSB-5 preparation contained genistin of 0.0202-0.0203 mg/capsule and geniposide of 0.211-0.212 mg/capsule, respectively.

• 한국환경농학회:학술대회논문집
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• 2011.07a
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• pp.471-471
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• 2011