• Title/Summary/Keyword: Standard variation

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Evaluation of Variation Method to Improve the Sensitivity of Immunoradiometric Assay (면역방사계수측정법의 민감도 향상을 위한 변법의 평가)

  • Won-Hyun Kwon;Mi-Ji Kang;;Ji-Sol Park;Jung-In Kim;Kyung-Jae Lee
    • The Korean Journal of Nuclear Medicine Technology
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    • v.27 no.1
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    • pp.29-35
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    • 2023
  • Purpose The concentration of PSA (Prostate Specific Antigen) after radical prostatectomy in prostate cancer patients is a predictor of biochemical recurrence, and the AUA (American Urological Association) is defined as biochemical recurrence when the concentration of PSA is measured at 0.2 ng/mL or more, and when the concentration is measured at 0.2 ng/mL or more at the retest. This standard is also applied our hospital. In this laboratory, the PSA reagent using IRMA (Immunoradiometric Assay) is used, and the sensitivity at a very low value was not as good as the reagent used in the department of laboratory medicine. This study aims to increase the reliability of the results by improving the precision and sensitivity of very low values. Materials and Methods As a reagent for the study, PSA reagent using IRMA was used. As a method to improve the precision and sensitivity of very low values, a variation method on the serum volume(25 uL, 50 uL, 100 uL, 200 uL) was studied, and variation usefulness evaluation was conducted. The evaluation items were compared the results of precision, analytical sensitivity, recovery rate, dilution test, high-dose hook effect test, parallel test and very low concentration values(n = 20). Results The validation results were displayed in the order of 25 uL, 50 uL, 100 uL, 200 uL. As the serum volume increased, it was confirmed that CV (Coefficient of Variation)(%) improved. Analytical sensitivity(ng/mL) was 0.038, 0.041, 0.017, 0.015 and recovery rate(%) was 101±3, 101±3, 99±2, 97±4. very low concentration values(ng/mL) between each volume(n=20) were 0.135±0.068, 0.076±0.050, 0.048±0.034, 0.046±0.034. and high dose hook effect appeared as the serum volume increased. Conclusion Through the variation usefulness evaluation, it was confirmed that as the serum volume increased, the precision and sensitivity improved at very low concentration values. However, it is necessary to pay special attention to the occurrence of high-dose hook effect as the serum volume increases. In the case of tests that requires very low concentration values, it is thought that the reliability of the result will be increased if the variation method is properly used after the variation usefulness evaluation.

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ANALYSIS OF ASTRONOMICAL ALMANAC DATA FOR NATIONAL STANDARD REFERENCE DATA (참조표준 등록을 위한 천문역법 자료 분석)

  • Yang, Hong-Jin;Ahn, Young-Sook;Lee, Ki-Won
    • Publications of The Korean Astronomical Society
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    • v.23 no.2
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    • pp.53-63
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    • 2008
  • Korea Astronomy and Space Science Institute (KASI), direct decendant of Korea National Astronomy Observatory, has been publishing Korean Astronomical Almanac since in 1976. The almanac contains essential data in our daily lives such as the times of sunrise, sunset, moonrise, and moonset, conversion tables between luni-solar and solar calendars, and so forth. So, we are planning to register Korean astronomical almanac data for national Standard Reference Data(SRD), which is a scientific/technical data whose the reliablity and the accuracy are authorized by scientific analysis and evalution. To be certificated as national SRD, reference data has to satisfy several criteria such as traceability, consistency, uncertainty, and so on. Based on similarity among calculation processes, we classified astronomical almanac data into three groups: Class I, II, and III. We are planning to register them for national SRD in consecutive order. In this study, we analyzed Class I data which is aimed to register in 2009, and presented the results. Firstly, we found that the traceability and the consistency can be ensured by the usage of NASA/JPL DE405 ephemeris and by the comparsion with international data, respectively. To evaluate uncertainty in Class I data, we solved the mathematical model and determined the factors influencing the calculations. As a result, we found that the atmospheric refraction is the main factor and leads to a variation of ${\pm}16$ seconds in the times of sunrise and sunset. We also briefly review the histories of astronomical almanac data and of standard reference data in Korea.

Comparative Studies on Heating and Cooling Loads' of a Building Varied by Annual Weather Data (연도별 기상데이터를 활용한 건물의 냉.난방부하 특성 비교)

  • Lee, Ji-Hoon;Hwang, Kwang-Il
    • Journal of Navigation and Port Research
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    • v.35 no.3
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    • pp.265-270
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    • 2011
  • The purpose of this study is to compare and analyze the differences of a building's heating and cooling loads depending on the weather variation. Followings are the results. The temperature, humidity and wind speeds of standard year are bigger than those of 2006~2009. The 2006~2009's total horizontal solar irradiance is greater than that of standard year, and the direct solar irradiance of standard year is bigger in winter and vice versa in summer. As results of simulation on heating and cooling loads, it is difficult to find out the bilateral influences between maximum thermal loads and annual's. The equivalent-time operating ratio(EOR) is defined on this study to estimate the differences between year and year, and the EOR of standard year shows low value comparing to 2006~2009 years'.

Comparative Analysis of TOA and TDOA method for position estimation of mobile station (이동국 위치 추정을 위한 TOA와 TDOA방법의 비교 분석)

  • 윤현성;이창호;변건식
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.4 no.3
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    • pp.595-602
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    • 2000
  • This paper is aimed at developing an location tracking system of mobile station based on currently available mobile communication network or mobile Phone and PCS(Personal Communication System). When the location tracking of mobile stations is in services, Emergency-119, all of crime investigation, effective urban traffic management and the safety protection of Alzheimer's patients can be available. In order to track the location of the mobile and base station, assumption in this paper is to use the statistic characteristics of LOS when modeling the standard noise in case that radio path is LNOS environment. The standard variation of the standard noise is $\pm150$. First, location is estimated by the positioning algorithms of TOA and TDOA and compared each other. Second, after canceling the standard noise by Kalman filter, location is estimated by the above two positioning algorithms. Finally, the location by the Kalman filter and two positioning algorithms is estimated by smoothing method. As a result, 2 dimensional average location error is imvoved by 51.2m in TOA and 34.8m in TDOA when Kalman filer and two positioning algorithms are used, compared with the two positioning algorithm used. And there is 3 more meter improvement after smoothing than Kalman filer and two positioning algorithms used.

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Inelastic Seismic Behavior of Low-story Standard School Buildings according to Characteristics of Earthquake Loads and Hysteresis Models (지진하중의 특성과 이력모델에 따른 저층 표준학교건물의 비탄성 지진거동)

  • Kim, Jin-Sang;Yoon, Tae-Ho
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.13 no.9
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    • pp.4294-4301
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    • 2012
  • The inelastic response characteristics of the standard school buildings depending on selection of hysteresis models and variable earthquakes are studied. Three earthquake records of El-centro, Santa-Monica, Taft in accordance with KBC2009 standard and four inelastic hysteresis models such as Degrading tri-linear model, Clough model, Takeda model, and Modified Takeda model are used. The inelastic response characteristics such as story shear force, story drift ratio, story displacement are reviewed. As results, El-centro earthquake shows large response in transverse direction and Santa Monica earthquake shows larger response in longitudinal direction on the contrary. Taft earthquake shows less variation of story drift ratio and story displacement for all hysteresis models and stable response.

A Study on Worker Exposure Level and Variation to Asbestos in some Asbestos Industries (일부 석면취급사업장의 석면폭로 농도 및 작업환경관리 기준에 관한 연구)

  • Oh, Se Min;Shin, Yong Chul;Park, Doo Yong;Park, Dong Uk;Chung, Kyou Chull
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.3 no.1
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    • pp.100-109
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    • 1993
  • This study was performed to evaluate the asbestos exposure levels and variations in textile, brake lining manufacturing and slate manufacturing industries. For this study, fifteen plants of brake lining manufacturing industry, 7 plants of textile industry, and 2 plants of slate manufacturing industry were selected and surveyed. Geometric means (GMs) of airborne asbestos concentrations in textile, brake lining manufacturing, and slate manufacturing industries were 1.42 f/cc(0.07-6.1O f/cc), 0.19 f/cc(<0.01-2.67 f/cc) and 0.08 f/cc(0.02-0.67 f/cc), respectively. In textile industry overall GMs of airborne asbestos concentrations in plants with less than 50 workers and in plants with more than 50 workers were 1.60 f/cc and 0.3 f/cc, respectively. Therefore, the size of plant showed some difference in the airborne asbestos concentrations. Three out of 7(42.9%) exceed the Korean standard, 2 f/cc, and every plant exceed the USA standard, 0.2 f/cc of the OSHA-Permissible Exposure Level(OSHA-PEL). Especially, one plant showed the highest average concentration of 2.87 f/cc. In brake lining manufacturing industry, the plants with less than 50 workers showed 0.22 f/cc. The plants with more than 50 workers showed 0.18 f/cc. All plants showed the exposure level below the Korean standard. Five of 15 (33.3%) were above the OSHA-PEL. One plant showed the highest average concentraton of 0.84 f/cc. In slate manufacturing industry, the average exposure level was 0.08 f/cc, and all of the plants were below the Korean standard and the OSHA-PEL.

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Effects of the Phase Noise in the Frequency Synthesizer on the SFH/M-NCFSK System (주파수 합성기의 위상 잡음이 SFH/M-NCFSK 시스템에 미치는 영향)

  • 손종원;이준서;유흥균;박진수
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.14 no.7
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    • pp.685-691
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    • 2003
  • This paper newly analyzes the effect of the phase noise in the frequency synthesizer on the performance of SFH/M-NCFSK system by standard frequency deviation(equation omitted) when noncoherent FSK demodulation of the square-law detector is considered. We derive the SER in the SFH system and analyze the effect of phase noise on the SFH/M-NCFSK system performance according to the hopping frequency spacing (1/T$\_$h/) and the variation of the standard frequency deviation (equation omitted). The required SNR is about 13.4 dB to meet Ps=10$\^$-3/ when the standard frequency deviation is about 4.0 Hz and the hopping frequency spacing (1/T$\_$h/) in the SFH/2-NCFSK system is 30. So, there is about 2.4 dB power penalty than the phase noise-free system. If the hopping frequency spacing 1/T$\_$h/ is under 30, the error floor may happen and SER considerably grows up. We show that the analytic results closely match with the simulation results.

Stress Analysis and Fatigue limit Evaluation of Plate with Notch by Lock-In Thermography (Lock-In Thermography를 이용한 노치시험편의 응력해석 및 피로한계치 평가)

  • Kim, Won-Tae;Kang, Ki-Soo;Choi, Man-Yong;Park, Jeong-Hak;Huh, Yong-Hak
    • Journal of the Korean Society for Nondestructive Testing
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    • v.26 no.5
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    • pp.315-320
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    • 2006
  • This paper describes stress analysis and fatigue limit evaluation of plate with V-notch and hole-notch by lock-in infrared thermography. Temperature variation of a specimen under cyclic loading is negatively proportional to the sum of principle stress change and the surface temperature measured by infrared camera is calculated to the stress of notch specimens, based on thermoelastic equation. And also, fatigue limitation can be evaluated by the change of intrinsic energy dissipation. Fatigue limitation of two notch specimens is evaluated as 164 MPa and 185 MPa, respectively and the stress measured by Lock-in infrared Thermography show good agreement within 10% error.

A Comparison of Two Kinds of Markers Applied in Analysis of Genetic Diversity in Sheep and Goat Populations

  • Yang, Z.P.;Chang, H.;Sun, W.;Gen, R.Q.;Mao, Y.J.;Tsunoda, K.
    • Asian-Australasian Journal of Animal Sciences
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    • v.17 no.7
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    • pp.892-896
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    • 2004
  • A genetic examination using 14 structural loci and 7 microsatellite markers was carried out among random samples of Hu sheep (Hu), Tong sheep (Tong) and Yantse River Delta White goat (YRD); The mean heterozygosity (H), mean polymorphism information contents (PIC) and mean effective numbers of alleles (Ne) calculated based on the data from the above two types of genetic markers were compared. The standard genetic distances among the three populations based on two types of gene frequencies were calculated and compared. The results show that the mean heterozygosity (H), mean polymorphism information contents (PIC) and mean effective numbers of alleles (Ne) based on 7 microsatellite markers are greater than those based on the structural loci. The standard genetic distances based on structural loci among the three populations are: 0.0268-0.2487, the standard genetic distances based on microsatellite markers are: 0.2321-1.2313. The study indicates that structural and microsatellite markers reflect the genetic variation of the three populations consistently: Tong>Hu>YRD. The differentiation between related species or interpopulations can be expressed more effectively by microsatellite markers than structural markers. Oar FCB11, MAF33, Oar AE101, Oar FCB128 and OarFCB304 can be used as representative loci for research on genetic differentiation between sheep and goat.

Development of the Index for Estimating the Arc Status in the Short-circuiting Transfer Region of GMA Welding (GMA용접의 단락이행영역에 있어서 아크 상태 평가를 위한 모델 개발)

  • 강문진;이세헌;엄기원
    • Journal of Welding and Joining
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    • v.17 no.4
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    • pp.85-92
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    • 1999
  • In GMAW, the spatter is generated because of the variation of the arc state. If the arc state is quantitatively assessed, the control method to make the spatter be reduced is able to develop. This study was attempted to develop the optimal model that could estimate the arc state quantitatively. To do this, the generated spatters was captured under the limited welding conditions, and the waveforms of the arc voltage and of the welding current were collected. From the collected waveforms, the waveform factors and their standard deviations were produced, and the linear and non-linear regression models constituted using the factors and their standard deviations are proposed to estimate the arc state. the performance test to the proposed models was practiced. Obtained results are as follow. From the results of correlation analysis between the factors and the amount of the generated spatters, the standard deviations of the waveform factors have more the multiple regression coefficients than the waveform factors. Because the correlation coefficient between T and {TEX}$T_{a}${/TEX}, and s[T] and s[{TEX}$T_{a}${/TEX}] was nearly one, it was found that these factors have the same effect to the spatter generation. In the regression models to estimate the arc state, it was fond that the linear and the non linear models were also consisted of similar factors. In addition, the linear regression model was assessed the optimal model for estimating the arc state because the variance of data was narrow and multiple regression coefficient was highest among the models. But in the welding conditions which the amount of the generated spatters were small, it was found that the non linear regression model had better the estimation performance for the spatter generation than the linear.

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