• Journal of the Korean Society for Precision Engineering
• /
• v.23 no.8 s.185
• /
• pp.72-79
• /
• 2006

We measured grating pitch standards using optical diffractometry and analyzed measurement uncertainty. Grating pitch standards have been used widely as a magnification standard for a scanning electron microscope (SEM) and a scanning probe microscope (SPM). Thus, to establish the meter-traceability in nano-metrology using SPM and SEM, it is important to certify grating pitch standards accurately. The optical diffractometer consists of two laser sources, argon ion laser (488 nm) and He-Cd laser (325 nm), optics to make an incident beam, a precision rotary table and a quadrant photo-diode to detect the position of diffraction beam. The precision rotary table incorporates a calibrated angle encoder, enabling the precise and accurate measurement of diffraction angle. Applying the measured diffraction angle to the grating equation, the mean pitch of grating specimen can be obtained very accurately. The pitch and orthogonality of two-dimensional grating pitch standards were measured, and the measurement uncertainty was analyzed according to the Guide to the Expression of Uncertainty in Measurement. The expanded uncertainties (k = 2) in pitch measurement were less than 0.015 nm and 0.03 nm for the specimen with the nominal pitch of 300 nm and 1000 nm. In the case of orthogonality measurement, the expanded uncertainties were less than $0.006^{\circ}$. In the pitch measurement, the main uncertainty source was the variation of measured pitch values according to the diffraction order. The measurement results show that the optical diffractometry can be used as an effective calibration tool for grating pitch standards.

• Journal of Preventive Medicine and Public Health
• /
• v.42 no.6
• /
• pp.392-402
• /
• 2009

Objectives : The aims of this paper were to develop the composite deprivation index (CDI) for the sub-district (Eup-Myen-Dong) levels based on the theory of social exclusion and to explore the relationship between the CDI and the standardized mortality ratio (SMR). Methods : The paper calculated the age adjusted SMR and we included five dimensions of social exclusion for CDI; unemployment, poverty, housing, labor and social network. The proxy variables of the five dimensions were the proportion of unemployed males, the percent of recipients receiving National Basic Livelihood Security Act benefits, the proportion of households under the minimum housing standard, the proportion of people with a low social class and the proportion of single-parent household. All the variables were standardized using geometric transformation and then we summed up them for a single index. The paper utilized the 2004-2006 National Death Registry data, the 2003-2006 national residents' registration data, the 2005 Population Census data and the 2005-2006 means-tested benefit recipients' data. Results : The figures were 115.6, 105.8 and 105.1 for the CDI of metropolitan areas (big cities), middle size cities and rural areas, respectively. The distributional variation of the CDI was the highest in metropolitan areas (8.9 - 353.7) and the lowest was in the rural areas (26.8 - 209.7). The extent and relative differences of deprivation increased with urbanization. Compared to the Townsend and Carstairs index, the CDI better represented the characteristics of rural deprivation. The correlation with the SMR was statistically significant and the direction of the CDI effects on the SMR was in accordance with that of the previous studies. Conclusions : The study findings indicated mortality inequalities due to the difference in the CDI. Despite the attempt to improve deprivation measures, further research is warranted for the consensus development of a deprivation index.

• Transactions of the Korean Society of Mechanical Engineers
• /
• v.12 no.5
• /
• pp.1150-1157
• /
• 1988

Two-dimensional turbulent plane jet which is under the pressure gradient in the transverse direction is studied numerically. Full Navier-Stokes equations are used to correctly account for the pressure variation in the transverse direction. Using the standard k-.epsilon. turbulence model as a closure relationship, a time marching procedure gives the velocity field. The temperature fields are obtained for two different cases : (1) Hot jet is issued into the cold still air, and (2) Hot jet is issued into the surrounding across which exists a temperature difference. The velocity and temperature fields along with other flow and heat-transfer characteristics for two different pressure gradients are presented. A simple formula that relates the jet trajectory to the pressure gradient is also proposed. The mass flux in the longitudinal direction and the jet halfwidth seem insensitive to the pressure gradient. However, the pressure gradient increases the heat flux in the longitudinal direction as well as in the transverse direction.

• Journal of Genetic Medicine
• /
• v.17 no.1
• /
• pp.21-26
• /
• 2020

Purpose: To evaluate the additive value of prenatal chromosomal microarray analysis (CMA) in assessing increased nuchal translucency (NT) (≥3.5 mm) with normal karyotype and the possibility of detecting clinically significant genomic imbalance, based on specific indications. Materials and Methods: Invasive samples from 494 pregnancies with NT ≥3.5 mm, obtained from the Research Center of Fertility & Genetics of Hamchoon Women's Clinic between January 2019 and February 2020, were included in this study and CMA was performed in addition to a standard karyotype. Results: In total, 494 cases were subjected to both karyotype and CMA analyses. Among these, 199 cases of aneuploidy were excluded. CMA was performed on the remaining 295 cases (59.7%), which showed normal (231/295, 78.3%) or non-significant copy number variation (CNV), such as benign CNV or variants of uncertain clinical significance likely benign (53/295, 18.0%). Clinically significant CNVs were detected in 11 cases (11/295, 3.7%). Conclusion: Prenatal CMA resulted in a 3% to 4% higher CNV diagnosis rate in fetuses exhibiting increased NT (≥3.5 mm) without other ultrasound detected anomalies and normal karyotype. Therefore, we suggest using high resolution, non- targeting CMA to provide valuable additional information for prenatal diagnosis. Further, we recommend that a genetics specialist should be consulted to interpret the information appropriately and provide counseling and follow-up services after prenatal CMA.

• Journal of the Korean Society of Fisheries and Ocean Technology
• /
• v.50 no.3
• /
• pp.244-251
• /
• 2014

This paper describes a prototype mechanical white noise generator has a source level of more than 170.0 dB (re $1{\mu}Pa$ at 1 m) at the frequency range of 10 Hz to 100 kHz. The results of performance evaluation of the generator are as follows. The average source level of the generator measured by a step of $15^{\circ}$ in horizontal (0 to $360^{\circ}$, 25 points) was 185.2 (SD (standard deviation): 2.3) dB (re $1{\mu}Pa$ at 1 m). The maximum and minimum source levels were appeared at the frequency range of 2.5 to 5.0 kHz and around 100 kHz, respectively. The average source levels at $0^{\circ}$, $90^{\circ}$, $180^{\circ}$ and $270^{\circ}$ were 162.9 (SD: 10.6), 168.4 (SD: 10.0), 162.1 (SD: 9.1) and 166.5 (SD: 11.1) dB (re $1{\mu}Pa$ at 1 m). The average source level measured by a step of $30^{\circ}$ in vertical was 184.9 (SD: 2.2) dB (re $1{\mu}Pa$ at 1 m). The relative maximum variation width of the source levels in horizontal and in vertical measurement were less than 7.0 dB and 1.0 dB, respectively.

• Fire Science and Engineering
• /
• v.24 no.1
• /
• pp.40-45
• /
• 2010

Asymmetric Slimflor Beam had been unveiled with Thor beam (Hat beam) in Sweden since the late 1970s and had been developed by British Steen and SCI. In the major advanced countries in Europe after the early 1990s have interested in and developed this method, it has been concrened as the absence of hot-rolled section steel in the United Kingdom and welded of asymmetric section steel in Finland in the 2000s. It can be increase total floor area about 10%, save the interior and exterior materials, reduce the waste through reduction of the floor height. And it has more excellent fire resistance performance because less exposed than a regular composite steel beam in fire. This study is purpose that, a fire resistance performance of the Asymmetric Slimflor Beam in fire, it compared the temperature range with deflection of structure by fire behavior and load ratio of structure through change the shape of the steel cross-section in standard fire condition.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.12 no.9
• /
• pp.4095-4100
• /
• 2011

In this paper, a log periodic bow-tie dipole array (LPBDA) antenna for UWB communications is investigated. Bow-tie shaped dipole elements are used instead of general dipole elements for LPDA antennas and the input reflection coefficient and realized gain characteristics of the LPBDA as a function of a flare angle are analyzed. It turns out that as the flare angle of the bow-tie dipole elements is increased, the lowest operating frequency is shifted toward lower frequency and the operating frequency band is increased, but the average gain is decreased. However, the gain variation of the LPBDA is much decreased and the front-back ratio is improved compared to the LPDA. Standard LPDA and LPBDA with a flare angle of 13 degrees are fabricated on an FR4 substrate with a dielectric constant of 4.4 and a thickness of 1.6 mm. Measured gain for the LPDA ranges from 4 to 6.5 dBi at 3.1 to 10.6 GHz band, while that for the LPBDA is in the range of 4.2 to 5 dBi.

• Journal of Korean Medical Science
• /
• v.33 no.51
• /
• pp.340.1-340.14
• /
• 2018

Background: Various pneumococcal vaccines have been evaluated for immunogenicity by opsonophagocytic assay (OPA). A multiplexed OPA (MOPA) for 13 pneumococcal serotypes was developed by Nahm and Burton, and expanded to 26 serotypes in 2012. The development of new conjugate vaccines with increased valence has necessitated expanded MOPAs to include these additional serotypes. In this study, we validated this expanded MOPA platform and applied to measure antibodies against 11 additional serotypes (2, 8, 9N, 10A, 11A, 12F, 15B, 17F, 20B, 22F, and 33F) in human sera. Methods: All materials, including serum, complement, bacterial master stocks, and HL-60 cells, were evaluated for assay optimization. Following optimization, the assay was validated for accuracy, specificity, and intra- and inter-assay precision with sera from adult donors following standard protocols. The assay was applied to evaluate functional antibodies of 42 sera immunized with 23-valent pneumococcal polysaccharide vaccine (PPV23). Results: The expanded MOPA platform was specific for all serotypes, with the exception of serotype 20. The assay results were highly correlated with those obtained from single-serotype OPA, indicating acceptable accuracy. The coefficients of variation were 7%-24% and 13%-39% in tests of intra- and inter-assay precision, respectively, using three quality-control samples. A MOPA that included 11 additional serotypes in the PPV23 was established and validated with respect to accuracy, specificity, and precision. The opsonic indices of immune sera were obtained using this validated assay. Conclusion: The expanded MOPA will be useful for evaluation of the immunogenicity of PPV23 and future conjugate vaccine formulations.

• Osong Public Health and Research Perspectives
• /
• v.8 no.6
• /
• pp.389-396
• /
• 2017

Objectives: To circumvent the limitations of the current golden standard method, colony-forming unit (CFU) assay, for viability of Bacille Calmette-$Gu{\acute{e}}rin$ (BCG) vaccines, we developed a new method to rapidly and accurately determine the potency of BCG vaccines. Methods: Based on flow cytometry (FACS) and fluorescein diacetate (FDA) as the most appropriate fluorescent staining reagent, 17 lots of BCG vaccines for percutaneous administration and 5 lots of BCG vaccines for intradermal administration were analyzed in this study. The percentage of viable cells measured by flow cytometry along with the total number of organisms in BCG vaccines, as determined on a cell counter, was used to quantify the number of viable cells. Results: Pearson correlation coefficients of FACS and CFU assays for percutaneous and intradermal BCG vaccines were 0.6962 and 0.7428, respectively, indicating a high correlation. The coefficient of variation value of the FACS assay was less than 7%, which was 11 times lower than that of the CFU assay. Conclusion: This study contributes to the evaluation of new potency test method for FACS-based determination of viable cells in BCG vaccines. Accordingly, quality control of BCG vaccines can be significantly improved.

• Cross-Cultural Studies
• /
• v.38
• /
• pp.7-28
• /
• 2015

This article considers Chunhyanjeon written in Japanese by Jang Hyukju in 1938. His Chunhyangjeon was presented from among the collusion and crack of 'things Japanese' and 'things Chosun' discussed in Japanese literary world in the 1930's. This article analyzed the writing method and the meaning of the text. Jang Hyukju(張赫宙, 1905~1997) became known to Japanese literary world by the second grade nomination of the prize contest of the magazine Kaizo in 1932. Since then, he worked actively in the Japanese literary world by writing novels in Japanese and introducing the literature of Chosun. Thanks to his activity, the literature of Chosun drew attraction from the Japanese, which can be called 'boom'. Jang Hyukju was in the middle of this boom. So, his text presented the collusion and crack of empire and colony. We can make sure this issue from his play Chunhyangjeon. When he presented Chunhyangjeon, Jang Hyukju mentioned his purpose of writing. He intended to write modern play in new literary style. Chunhyangjeon was surely the material of things traditional Chosun, which was corresponded to the demand of Japanese literary world. Through the story of Chunhyangjeon, however, he formed the modern text style. He wrote in standard Japanese language, and described things from the perspective style which is often used in modern novel. And he renewed the character characteristically and arranged the structure of the play. His writing style showed clear distinction in the comparison to Chunhyangjeon written by You Chijin which was presented in Korean language 2 years earlier than Jang Hyukuju's. The text Chunhyangjeon written in Japanese by Jang Hyukju reflected specificity as a district of Japan. But on the other hand, a new literary method of modern realism was tried. Chunhyangjeon written by Jang Hyukju shows the cross penetration of empire and colony. And in his Japanese-language literature, the literature of Chosun is coexisting and playing variation.