• 분석과학
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• 제17권2호
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• pp.184-191
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• 2004

본 연구에서는 HRGC/HRMS에 의한 다이옥신분석에 있어 가장 널리 사용되고 있는 SP-2331 및 DB-5MS 컬럼에 의한 독성 2,3,7,8-다이옥신 동족체 분리의 영향에 대하여 조사하였다. 컬럼분리성능평가 표준용액과 비산재 시료의 분석을 통하여 이들 컬럼에 의한 tetra, penta 및 hexa-2,3,7,8-동족체의 분리에 대한 부분과 I-TEQ값의 영향을 중심으로 설명하였다. 이들 두 컬럼에 의한 분석에서 컬럼분리성능평가 표준용액의 경우 DB-5MS에 의해서는 총 2,3,7,8-치환이성체의 농도는 508.4 ng/mL로 나타났으며, SP-2331에 의해서는 515.8 ng/mL로 나타났다. 이들을 I-TEQ값으로 환산하였을 때 거의 동등하게 나타났다. 비산재 시료의 경우에서도 이들 두 컬럼에 의한 2,3,7,8-치환이성체의 총 농도와 I-TEQ값이 거의 비슷하게 나타났다.

• 국제학술발표논문집
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• The 9th International Conference on Construction Engineering and Project Management
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• pp.25-32
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• 2022

As a project delivery method, Design-Build (DB) has provided owner, architect, and contractor groups with a process of early design and rapid construction for the past three decades. Although there are many benefits to using standard DB, dissatisfaction has arisen due to limitations to innovate, limited owner involvement during design, and often lengthy procurement. Progressive Design-Build (PDB) has become an appealing alternative providing benefits not seen with standard DB. This paper investigates how PDB impacts a project and how it compares against standard DB; it also presents a proposed framework for evaluating the owner's responsibility and assessment of a project, which we named the "Four Pillars of Project Success". The four pillars are defined with respect to an owner's responsibility and assessment of a project, including project predictability, project risk, project schedule, and project cost. We conducted a literature review, examined several public project case studies, analyzed PDB project information collected by the Design-Build Institute of America (DBIA), and held stakeholder interviews with owners, contractors, and architects who have used both PDB and standard DB. This paper offers insight into PDB's structure and outcomes so an owner group can make an informed decision when considering PDB as their next construction contracting method.

• Nutritional Sciences
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• 제7권1호
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• pp.8-16
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• 2004

The purpose of this study was to investigate the gene profiles that were up- or down-regulated in the livers of high-fat diet-induced obese mice and $db_-/db_-$ mice with deficient leptin receptor. C57/BL6 normal mice and $db_-/db_-$ mice, respectively, were divided into two groups and fed a standard or high-fat diet for four weeks. Liver weight was unchanged in the normal mice but the high-fat diet led to a 10% weight increase in the $db_-/db_-$mice. Adipose tissue mass increased by about 88% in the normal mice that were fed a high-fat diet and by about 17% in the $db_-/db_-$mice on the high-fat diet. In terms of serum lipids, total cholesterol significantly increased in mice on the high-fat diet. Microarray analysis was carried out using total RNA isolated from the livers of standard or high-fat diet-fed mice of the normal and $db_-/db_-$ strains. The change of gene expression was confirmed by RT-PCR. About 1.6% and 6.8% of total genes, respectively, showed different expression patterns in the normal mice fed the high-fat diet and $db_-/db_-$ mice. As a result of microarray, many genes involved in metabolism and signal pathways were shown to have different expression patterns. Expression of Mgst3 gene increased in the livers of normal and $db_-/db_-$ mice that were fed a high-fat diet. Wnt7b and Ptk9l were down-regulated in the livers of the normal mice and $db_-/db_-$ mice that were fed a high-fat diet. In conclusion, a high-fat diet induced obesity and affected gene expression involved in metabolism and signal pathway.

• 말소리와 음성과학
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• 제9권2호
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• pp.9-22
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• 2017

The purpose of this paper is to report the whole process of developing Korean Standard Speech Database (KSS DB). This project is supported by SPO (Supreme Prosecutors' Office) research grant for three years from 2014 to 2016. KSS DB is designed to provide speech data for acoustic-phonetic and phonological studies and speaker recognition system. For the samples to represent the spoken Korean, sociolinguistic factors, such as region (9 regional dialects), age (5 age groups over 20) and gender (male and female) were considered. The goal of the project is to collect over 3,000 male and female speakers of nine regional dialects and five age groups employing direct and indirect methods. Speech samples of 3,191 speakers (2,829 speakers and 362 speakers using direct and indirect methods, respectively) are collected and databased. KSS DB designs to collect read and spontaneous speech samples from each speaker carrying out 5 speech tasks: three (pseudo-)spontaneous speech tasks (producing prolonged simple vowels, 28 blanked sentences and spontaneous talk) and two read speech tasks (reading 55 phonetically and phonologically rich sentences and reading three short passages). KSS DB includes a 16-bit, 44.1kHz speech waveform file and a orthographic file for each speech task.

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 2002년도 춘계공동학술발표회요약집
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• pp.175.1-175
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• 2002

• Biomolecules & Therapeutics
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• 제7권4호
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• pp.335-341
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• 1999

Antidiabetic activity and mechanism of Supungsungihyan(SPSGH) were examined in db/db mice, which is a spontaneously hyperglycemic, hyperinsulinemic and obese animal model. SPSGH and acarbose were administered orally for 4 weeks. Fasting and non-fasting serum glucose, glycated hemoglobin and trig-lyceride of SPSGH treated group were all reduced when compared with those of db/db control group. At 12th week after birth, SPSGH increased an insulin secretion although statistic significance was not seen. Total activities of sucrose, maltase and lactase in SPSGH treated group were not significantly different from those in db/db control. On the other hand, sucrase and maltase activities in acarbose treated groups were increased. Effect of SPSGH on mRNA expression of glucose transporter(GLUT-4) was also examined by RT-PCR and in vitro transcription with co-amplification of rat $\beta$-actin gene as an internal standard. Muscular GLUT-4 mRNA expression in SPSGH treated group was increased significantly. These results may suggest that SPSGH lowered blood glucose ascribing to upregulation of muscular GLUT-4 mRNA expression.

• 한국지리정보학회지
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• 제23권4호
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• pp.68-82
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• 2020

최근 기후변화로 인해 대규모의 풍수해가 다수 발생하고 있다. 이를 대비하기 위해 정부에서는 국가재난관리정보시스템을 운영하고 있으나, 실제 재난 현장 정보를 공유하기 위한 데이터의 일원화와 표준화는 미흡한 상황이다. 본 연구에서는 재난 상황 인지 및 모니터링 목적의 재난정보 표출시스템을 구축하기 위한 DB 정보를 확보하고 품질기준을 제시하였으며 이를 바탕으로 현재 제공되고 있는 공간정보의 품질을 점검하였다. 점검 결과, 기관별로 다른 기준에 의해 공간정보가 구축되어 통합 사용에 어려움이 있으며, 이를 보완하기 위한 공통 기준을 마련해야 할 필요가 있는 것으로 사료된다.

• 디자인학연구
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• 제13권1호
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• pp.67-74
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• 2000

오늘날 컴퓨터의 사용이 일반화되어 인터넷을 이용한 정보의 교환 시스템이 보편화되면서 필요한 정보를 신속하게 이용하고 공유할 수 있는 데이터 베이스 환경을 구축하는 일은 디자인 분야에서도 신속히 추진해야 할 과제 중의 하나로 떠오르게 되었다. 이러한 디자인 데이터 베이스(DB)의 체계적 구축은 디자인 정보화 산업의 추진과 더 나아가 지식기반 산업으로서의 디자인 분야 발전의 토대가 된다. 이러한 체계적 구축은 디자인 분야 발전의 토대가 된다. 이러한 체계적이고 표준화된 디자인 DB의 구축을 위하여 선행되어 져야 할 것이 사용자들이 쉽게 접근하고 이용할 수 있는, 사용자 중심의 보편화된 분류체계를 수립하는 것이다. 본 연구에서는 분류체계에 대한 연구를 통하여 사용자 중심의 표준화된 분류체계의 구축과 이러한 분류체계가 오늘날의 기술환경에 적용되어 실행될 수 잇는 가능성을 제시하는데 목적이 있다.

• 약학회지
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• 제43권6호
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• pp.818-826
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• 1999

Antidiabetic activity and mechanism of Sangbackpitang (SBPT) was examined in db/db mice, which is a spontaneously hyperglycemic, hyperinsulinemic and obese animal model. SBPT and acarbose were administered orally for 4 weeks. Fasting and non-fasting serum glucose, glycated hemoglobin and triglyceride were all reduced when compared between db/db control group and SBPT treated group. At 12th week after birth, SBPT increased an insulin secretion although statistic significance was not seen. Total activities of sucrase, maltase and lactase in SBPT treated group were all decreased when compared to db/db control. On the other hand, sucrase and maltase activities in acarbose treated groups were increased. Effect of SBPT on mRNA expression of glucose transporter(GLUT-4) was also examined. Quantitation of glucose transporter was performed by RT-PCR and in vitro transcription with co-amplification of rat-action gene as an internal standard. Muscular GLUT-4 mRNA expression in SBPT treated group was increased significantly. These results may suggest that SBPT lowered blood glucose ascribing to inhibition of glycosidase-catalyzed reaction and upregulation of muscular GLUT-4 mRNA expression.

• 한국지리정보학회지
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• 제12권3호
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• pp.143-151
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• 2009

임상도는 산림자원이 어디에 어떻게 얼마나 분포하고 있는가를 보여주는 대표적인 산림지도로 전국 산림에 대해 임상, 영급, 경급, 소밀도 등 다양한 산림정보를 제공하여 산림정책 수립의 주요한 자료로 활용될 뿐만 아니라 토지적성평가, 생태자연도 제작 등 다양한 분야의 기초 자료로 활용되고 있다. 최초의 수치임상도는 1차 NGIS 사업을 통해 제작되었는데 당시 수치임상도제작 표준의 부재로 도엽 간 경계 및 속성 불일치 등 여러 가지 유형의 오류가 발생하였다. 또한 임상도의 제작시기, 항공사진 촬영시기, 속성 설명 등 임상도에 관한 보다 자세한 정보를 알기 어려웠다. 이러한 문제점을 해결하기 위해 본 연구에서는 수치임상도 DB 설계부터 수치화, 메타데이터 입력, 품질관리 등의 수치임상도 전 제작과정을 3단계 33개 단위 공정으로 구조화하고 이를 최적화하여 표준화한 수치임상도 표준제작체계를 개발하였다. 본 수치임상도 표준제작체계를 토대로 전국 수치임상도를 일관된 품질로 제작하고 수치임상도에 대한 보다 상세한 정보를 표준메타데이터를 통해 제공할 수 있게 되었다.