• International Journal of Oral Biology
• /
• v.36 no.1
• /
• pp.31-35
• /
• 2011

Teeth develop via a reciprocal induction between the ectomesenchyme originating from the neural crest and the ectodermal epithelium. During complete formation of the tooth morphology and structure, many cells proliferate, differentiate, and can be replaced with other structures. Apoptosis is a type of genetically-controlled cell death and a biological process arising at the cellular level during development. To determine if apoptosis is an effective mechanism for eliminating cells during tooth development, this process was examined in the rat mandible including the developing molar teeth using the transferase-mediated dUTP-biotin nick labeling (TUNEL) method. The tooth germ of the mandibular first molar in the postnatal rat showed a variety of morphological appearances from the bell stage to the crown stage. Strong TUNEL-positive reactivity was observed in the ameloblasts and cells of the stellate reticulum. Odontoblasts near the prospective cusp area also showed a TUNEL positive reaction and several cells in the dental papilla, which are the forming pulp, were also stained intensively in this assay. Our results thus show that apoptosis may take place not only in epithelial-derived dental organs but also in the mesenchyme-derived dental papilla. Hence, apoptosis may be an essential biological process in tooth development.

• Journal of the Korean Society of School Health
• /
• v.17 no.1
• /
• pp.55-69
• /
• 2004

Purpose ： To describe epidemiological characteristics and related factors in school personnel with hypertension. Method ： 5,384 school personnel (2,638 males and 2,746 females) received physical examination at the Seoul School Health Center in 2002. blood pressure(BP) was classified by JNC 7th report. Normal BP is systolic BP <120 and diastolic BP<80, prehypertension BP is 120-139 or 80-89mmHg, stage 1 hypertension BP is 140-159 or 90-99, and stage 2 hypertension >=160 or >=100 mmHg. each group was evaluated by gender. We used multiple regression and logistic regression. Results ： Normotension was 20.13% in males and 48.65% in female, prehypertension 43.4% in males and 38.06% in females, stage 1 hypertension 26.38% in males and 10.99% in females, stage2 hypertension 9.59% in males and 3.2% in females. the older age group had higher distribution of stage 1 hypertension and stage 2 hypertension. The means and abnormal rates of BMI, blood sugar, total cholesterol, GOT, GPT, and GTP was higher when their blood pressure was higher. However, an alcohol habit among lifestyle factors had an inverse effect. Higher Bp was correlated to a higher BMI, FBS, and cholesterol-like dose response. In stage 1 hypertension, the related factors of hypertension for males were BMI, amount of cigarettes smoked, exercise, blood sugar, total cholesterol, and GTP. In stage 1 hypertension, age, BMI, exercise, blood sugar, total cholesterol were related factors in female. In stage 2 hypertension, age and smoking were related factors in male, and age, BMI, and cholesterol in female. Conclusions ： It is possible to intervene in all related factors of hypertension except age through life-style modification and appropriate medical management. Active health promotion is needed in School personnel.

• Membrane Journal
• /
• v.26 no.2
• /
• pp.159-165
• /
• 2016

Polyimide hollow fiber membrane modules were prepared in order to investigate the process of multi stage gas separation. The modules performance was carried out using 50/50 of $N_2/SF_6$ mixed gas. The membrane modules has been tested for measuring gas flow rate and concentration under various stage cut at 0.5 MPa. The membrane modules showed a high recovery ratio at the same stage cut as $N_2/SF_6$ selectivity increased. Two stage process was fulfilled for improving $SF_6$ recovery ratio and $SF_6$ concentration. Eventually, two stage process showed higher performance of $SF_6$ recovery ratio and concentration ($SF_6$ recovery ratio = 95%, $SF_6$ conc. = 98%).

• Journal of Animal Science and Technology
• /
• v.52 no.6
• /
• pp.467-473
• /
• 2010

A total of 4,323,781 records for informal 16 primary linear descriptive traits of dairy cows in Holstein breed from 1988 to 2007 in USA were analyzed to estimate adjustment factors for lactation number and stage. While all factors in the model were highly significant (P < 0.01), major influences on linear type traits were due to lactation number and stage. The frequencies of lactation number 1 through 6 were 58.6, 22.0, 11.8, 4.8, 2.1, and 0.8%, respectively. Further, the frequencies of lactation stage were 0.7, 76.9, 15.3, 4.9, and 2.1%, respectively, for springing, early, medium, late, and dry. To adjust 16 linear traits (stature, dairy form, strength, body depth, rump width, rump angle, legs rear view, leg set, foot angle, fore udder, rear udder height, rear udder width, udder support, udder depth, and front teat placement), additive and multiplicative adjustment factors of lactation number (lactations 2 to 4) and stage (springing, medium, late and dry) were estimated with the solutions in the generalized linear model, assigning lactation 1 and stage early as base class. Additive adjustment factors of lactation number ranged from -1.23 to 2.908, while multiplicative factors ranged from 0.853 to 2.207. Further, additive and multiplicative adjustment factors for lactation stage ranged from -0.668 to 0.785, and from 0.891 to 1.154. Application of adjustment factors to 20 randomly sampled sub-data sets produced the results that additive adjustment factors for both lactation number and stage reduced more mean square of lactation number and stage over 16 linear traits than any combination of adjustments, and leaded additive adjustment factors for both lactation number and stage as a choice of methods for adjustment of informal 16 primary linear type traits collected by classifiers of AI studs.

• Korean Journal of Microbiology
• /
• v.16 no.3
• /
• pp.122-130
• /
• 1978

During the sporulation stage in Saccharomyces cerevisiae J170, the incorporation of $D^{14}$ C-glucose into starved cells of sporulation stage as well as the vegetative one is appeared higher at pH 6.0. Glucose transport system, in both the vegetative and sporulation stage, is associated with "energy dependent" as the result of repression by such a respiratory inhibitor as 2, 4-dinitrophenol. The Km value of glucose uptake in vegetative stage and sporulation stage was 2.1 mM and 2.5 mM respectively, indicating that the glucose is considerably reuqired for vegetative growth. Competition and countertranspoer of glucose by frutose and galactose are more distinct in vegetative stage, comparing with sporulation stage. The main sugar components of yeast cells consists of ribose, mannose, and ${\alpha}, \;{\beta}-glucose$. Amounts of mannose is lower in the aporulation stage than that in the vegetative stage.

• Industrial Engineering and Management Systems
• /
• v.14 no.1
• /
• pp.22-31
• /
• 2015

In this paper, a two-stage hybrid flow shop problem is considered. Specifically, there exist identical parallel machines at stage 1 and two dedicated machines at stage 2, and the objective of the problem is to minimize makespan. After being processed by any machine at stage 1, a job must be processed by a specific machine at stage 2 depending on the job type, and one type of jobs can have different processing times on each machine. First, we introduce the problem and establish complexity of several variations of the problem. For some special cases, we develop optimal polynomial time solution procedures. Then, we establish some simple lower bounds for the problem. In order to solve this NP-hard problem, three heuristics based on simple rules such as the Johnson's rule and the LPT (Longest Processing Time first) rule are developed. For each of the heuristics, we provide some theoretical analysis and find some worst case bound on relative error. Finally, we empirically evaluate the heuristics.

• Proceedings of the Korean Society of Precision Engineering Conference
• /
• 2003.06a
• /
• pp.1207-1210
• /
• 2003

This paper deals with experiments for dynamic characteristics and performance evaluation of the 3-axis fine positioning stage developed in [1]. The features of the developed fine positioning stage are the long stroke due to the magnetically preloaded PZT actuators, the minimum motion crosstalk due to the use of a ball contact mechanism and the compact design. The dynamic characteristics of the actuator and the stage are tested with the preload changed in order to validate the actuator and the stage design. Performance evaluation is also made for the PZT actuators as well as the stage positioning accuracy. Experimental results show that the developed stage is accurate enough to be used for nanometer positioning.

• Journal of the Korean Operations Research and Management Science Society
• /
• v.4 no.1
• /
• pp.51-67
• /
• 1979

This paper considers the problem of determining an optimal dynamic operating policy for a two-stage tandem queueing service system in which the service facilities (or stages) can be operated at more than one service rate. At each period of the system's operation, the system manager must specify which of the available service rates is to be employed at each stage. The cost structure includes an operating cost for running each stage and a service facility profit earned when a service completion occurs at Stage 2. We assume that the system has a finite waiting capacity in front of each station and each customer requires two services which must be done in sequence, that is, customers must pass through Stage 1 and Stage 2 in that order. Processing must be in the order of arrival at each station. The objective is to minimize the total discounted expected cost in a two-stage tandem queueing service system, which we formulate as a Discrete-Time Markov Decision Process. We present analytical and numerical results that specify the form of the optimal dynamic operating policy for a two-stage tandem queueing service system.

• Proceedings of the Korea Crystallographic Association Conference
• /
• 2002.11a
• /
• pp.36-36
• /
• 2002

To Establish of standard technique of length measurent in 2D plane, we develope AFM system. The XY scanner scans the sample only in XY plane, while the Z scanner scans the specimen only in Z-direction. Cantilever tip is controlled to has constant height relative to speciman surface by feedback of PSPD signal. To acquire high accuracy, Z-axis measuring sensor will be added.(COXI or others). In this paper we design XYZ stage suitable for this AEM system. For XY stage, single module parallel-kinnematic flexure stage is used which has high orthogonality and minimum out-of-plane motion. To obtain best performance optimal design is performed. For XY stage, to be robust about parasitic motion optimal design of maximizing Z and tilt stiffness is performed under the constraint of motion range and stage size. And for Z stage, optimal design of maximizing 1st resonant frequency is performed. Because if resonant frequency is get higher, scan speed is improved. So it makes reduce the error by sensor drift. Resultly XYZ stage each have 1st natural frequency of 115㎐, 201㎐, 2.66㎑ and range 109㎛, 110㎛, 12㎛.

• Journal of the Korean Society for Precision Engineering
• /
• v.21 no.3
• /
• pp.155-162
• /
• 2004

This paper presents the fabrication procedure and the experiments for the 3-axis fine positioning stage proposed in［1］. First, the dynamic characteristics of the actuator and the stage are tested with the preload changed in order to validate the stage design specifications. Secondly, the performance of the stage is also evaluated on the accuracy associated with linear positioning, angular error, and straightness error. Experimental results show that the developed stage is accurate enough to be used for nanometer positioning. Through the analysis and experiment, the developed fine positioning stage are found to have a long stroke due to the magnetically preloaded PZT actuators, the minimum motion crosstalk due to the use of a ball contact mechanism and the compact design.