• Archives of Pharmacal Research
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• 제29권9호
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• pp.735-740
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• 2006

Lactic acid bacteria (LAB) quickly attenuate or are killed during the freeze-drying process and storage. The effect of some natural polysaccharides, which are known as potent antitumor and immunomodulating substances, on the viability of the LAB, Lactobacillus acidophilus and Bifidobacterium breve, on freeze-drying and storage were investigated. Among the polysaccharides tested, red ginseng polysaccharide (RGP) and chitosan significantly inhibited the cell death of the LAB during freeze-drying, and fucoidan and RGP most potently protected the cell death of the LAB during storage. The stabilities of the LAB on the addition of RGP and fucoidan were comparable to that of skimmed milk. However, white ginseng polysaccharide (WGP) did not promote storage stability. When 5% skimmed milk/5% RGP treated LAB were freeze-dried and stored, their viabilities were found to be significantly higher those treated with 5% or 10% RGP. The stabilizing effect of 5% RGP/5% skimmed milk during LAB freeze-drying and storage stability was comparable to that of treatment with 10% skimmed milk. Based on these findings, we believe that RGP beneficially improves the stability of LAB during the freeze-dry process and storage.

• 한국환경과학회지
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• 제11권11호
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• pp.1173-1181
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• 2002

The present study was undertaken to investigate the effect of low temperature and salicylic acid(SA) on the chilling tolerance of acclimated and nonacclimated cucumber(Cucurmis sativus L.) seedlings. The acclimation phenomenon was characterized in chilling-sensitive cucumber seedlings and found to have a significant effect on the survival and shoot dry weights. The injuries experienced by the acclimated seedlings in the third leaf stage were on average smaller by half than those experienced by the nonacclimated seedlings. Chilling also caused a large increase in the free proline levels, regardless of the acclimation status. Exogenous treatment with SA(0.5mM) resulted in improved growth and survival of the nonacclimated chilled seedlings, indicating that SA induced chilling tolerance and SA and acclimation had common effects. The application of cycloheximide in the presence of SA restored the acclimation-induced chilling tolerance. The elevated proline level observed in the cold-treated and SA-treated plants was more pronounced in the light than in the dark at a chilled temperature, indicating that endogenous proline may play a role in chilling tolerance by stabilizing the water status in response to chilling. From these results it is suggested that SA provided protection against low-temperature stress by increasing the proline accumulation, and pre-treatment with SA may induce antioxidant enzymes leading to increased chilling tolerance.

• 대한기계학회논문집
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• 제14권2호
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• pp.440-452
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• 1990

Comprehensive numberical computations have been made for four turbulent swirling jets with and without recirculation to critically evaluate the accuracy and universality of several exising turbulence models as well as of the modified k-.epsilon. model proposed in the present study. A numerical scheme based on the full Navier-Stoke equations ha been developed and used for this purpose. Inlet conditions are given by experiments, whenever possible, to minimize the error due to incorrect initial conditions. The standard k-.epsilon. model performs well for the strongly swirling jets with recirculation while it underpredicts the influence of swirl for weakly swirling jets. Rodi's swirl correction and algebraic stress model do not exhibit universality for the swirling jets. The present modified k-.epsilon. model derived from algebraic stress model accounts for anisotropy and streamline curvature effect on turbulence. This model performs consistently better than others for all cases. It may be because these flows have a strong dependence of stresses on the local strain of the mean flow. The predictions of truculence intensities indicate that this model successfully reflect the curvature effect in swirling jets, i.e. the stabilizing and destabilizing effects of swirl on turbulence transport.

• Nuclear Engineering and Technology
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• 제48권3호
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• pp.608-612
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• 2016

D-(+)-glucose (Glc) was added to the original Fricke polyvinyl alcohol-glutaraldehyde-xylenol orange (FPGX) hydrogel dosimeter system to make a more stable FPGX hydrogel three-dimensional dosimeter in this paper. Polyvinyl alcohol was used as a substrate, which was combined with Fricke solution. Various concentrations of Glc were tested with linear relevant fitting for optimal hydrogel production conditions. The effects of various formulations on the stability and sensitivity of dosimeters were evaluated. The results indicated that D-(+)-Glc, as a free radical scavenger, had a great effect on stabilizing the dose response related to absorbency and reducing the auto-oxidization of ferrous ions. A careful doping with Glc could slow down the color change of the dosimeter before and after radiation without any effect on the sensitivity of the dosimeter.

• The Journal of Asian Finance, Economics and Business
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• 제7권9호
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• pp.329-340
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• 2020

This study investigates the effect of capital structure on the financial performance of pharmaceutical enterprises which are listing on Vietnam's stock market. The study builds the regression using ROE as dependent variable and four independent variables, including self-financing, financial leverage, long-term asset and debt to assets ratios. In addition, we use other variables as controlling ones, such as firm size, fixed asset rate and growth. We collect data for the period from 2015 to 2019 of all 30 pharmaceutical enterprises which are currently listing on Vietnam's stock market. The least square regression (OLS) is used to test the effect of capital structure to the firms' financial performance. The analysis results show that the financial leverage ratio (LR), long-term asset ratio (LAR) and debt-to-assets ratio (DR) have positive relationship with firm performance, meanwhile the self-financing (E/C) affects negatively to the return on equity (ROE). Upon the findings we suggest that the Vietnamese government should focus on stabilizing macro environment to create favorable environment for enterprises. And the pharmaceutical enterprises should build more reasonable capital structure with higher debt proportion than equity, diversifying loan mobilization channels such as issuing long-term bonds. Additionally, the firms should expand the scale appropriately to maintain development and ability to pay debts.

• Preventive Nutrition and Food Science
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• 제3권1호
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• pp.56-61
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• 1998

This study was conducted to investigate the effect of dietary supplementation of vitamin A on the membrane property and ultrastructure in ethanol-administered rat livers. Male Sprague-Dawley rats weighing of 130 ~150g were fed with experimental diets for 7 weeks. The diets contained different types of vitamin A which were $\beta$-carotene, retinyl acetate and retinoic acid. After feeding theexperimental diets for 7 weeks, a dose of 3.0g ethanol (30%, W/V)/kg B.W was injected to rats intraperitoneally. Control rats received 0.9% saline containing isocaloric sucrose instead of ethanol. Plasma membrane fluidity of liver decreased in rats fed with vitamin a -Deficient diet with ethanol as compared to that of control rats. Fluidity change of liver plasma membrane that ethanol had induced was influenced by dietary supplementation of vitamin A, but not influenced by the type of supplemented vitamin. A . The ultrastructural changed of hepatic mitrochondria were observed in some rats such as vitamin A-deficient rats with ethanol. Inadequate consumptionof vitamin A contributed to ultrastructural changes such as swelled mitochondria occurred by ethanol-induced hepatotoxicity. Although accurate mechanism involved in the plasma membrane-stabilizing effect of vitamin A is still unclear, dietary supplementation of vitamin A such as retinyl acetate is neede to modulate this change. The direct involvement of membrane property on the cell damage caused by ethanol treatment remains to be established.

• 통합자연과학논문집
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• 제15권4호
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• pp.137-144
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• 2022

This paper presents the effect of the supramolecular complex of GA (Glycyrrhizic acid) and Mt(menthol) and GA: Mt (4: 1) obtained on their basis can restore functional dysfunction of the liver mitochondria in alloxan diabetes, ie, inhibit lipid peroxidation. The hypoglycemic activity and mitochondrial membrane stabilizing properties of the supramolecular compound GA: Mt (4: 1) in alloxan diabetes were more pronounced than those of menthol, GA and its GK: Mt (2: 1) and GA: Mt (9: 1) compounds. According to the results obtained, the concentration of GA did not affect the peroxidation of lipid membranes of the liver mitochondria. However, a concentration of 15 μM of GA was found to reduce LPO (lipid peroxidation) formed by the effect of Fe²+ / ascorbate on the mitochondrial membrane by 58.0 ± 5.0% relative to control. The inhibitory effect of GA and its supramolecular compounds in different proportions with menthol on the peroxidation of lipids in rat heart and brain tissue has been studied

• 한국결정성장학회지
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• 제20권4호
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• pp.173-177
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• 2010

Sol-gel method로 합성한 anatase상의 $TiO_2$와 Yb와 Er을 codoping한 $TiO_2:Yb^{3+},\;Er^{3+}$ 파우더의 열적안정성과 이에 따른 광촉매 특성의 변화를 비교하였다. XRD 분석을 통하여 $TiO_2$ 결정성 및 상변화에 $Yb^{3+},\;Er^{3+}$ ions이 미치는 영향을 온도에 따라 비교하였으며 anatase $TiO_2$와 rutile $TiO_2$의 광학적 성질을 UV-Vis을 통하여 비교하였다. UV-Vis 분석결과 anatase $TiO_2:Yb^{3+},\;Er^{3+}$ ions도핑에 의하여 $TiO_2$의 밴드갭이 미세하게 감소함을 확인하였고 이를 통해 광촉매 작용을 향상시킬 수 있음을 확인하였다. $Yb^{3+}$ 이온과 $Er^{3+}$ 이온이 도핑된 $TiO_2:Yb^{3+},\;Er^{3+}$ 파우더를 980 nm에서 PL 분석하여 녹색 및 적색 형광을 하는 up-converting 형광특성을 분석하였다.

• 한국식품과학회지
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• 제19권1호
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• pp.61-65
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• 1987

k-casein은 유단백질 분획으로 GMP를 포함하고있으떠 GMP는 sialic acid를 포함하고 있으므로 k-casein index로 sialic acid 가 사용될 수 있다. 탈지분유 분리 단백질 용해도는 칼슘카페인 보다 일반적으로 낮으므로 용매처리시 야기되는 k-casein의 손실과 저용해도와의 관계를 규명하고자 하였다. 특히 용매처리시 주요 stabilizing fraction k-casein의 손실 혹은 손상을 고려해야만 한다. 용매처리시 sialic acid 는 제1차 추출용매에 16.5%, 제2차 추출용매에 4.0%손실되어 전체 20.5%가 용매처리시 손실되었다. 또 사용한 메탄올의 농도가 증가할수록 sialic acid손실이 감소하여 sialic acid 손실은 메탄을분획보다 물분획에따라 좌우된 것 같다. 따라서 sialic acid를 함유한 분말 extracted solid의 feed back 실험 결과 10%첨 가시최대 용해도를 나타냈으며 유당은 용해도 변화에 기여하지 못하였다 결론적으로 탈지분유 단백의 저용해도 헌상은 용매처리시 k-casein의 가용성 물질 손실에도 일부 기인한 것으로 사료된다.

• Preventive Nutrition and Food Science
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• 제3권4호
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• pp.382-386
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• 1998

A soluble dietary fiber, $\beta$-glucan, contained in oat and barley has nutritional benefits such as hypocholesterolemic effects and influences blood glucose regulation. The contents of $\beta$-glucan in both cereals range from 3 to 7% with the exception of a certain barley genotype which contains up to 16% $\beta$-glucan. $\beta$-Glucan is distributed mainly in the cell walls of endosperm and the distal (bran) portion of kernel. Various procedures have been developed for increasing the extraction yield of $\beta$-glucan. Oat gum prepared with weak alkali extractionand alcohol proecipitation following protein removal usually contains 80% $\beta$-glucan.The most commonly used method for $\beta$-glucan quantitiation is an enzymatic procedure combining lichenase plus $\beta$-glucosidase followed by measuring the amount of glucos released by glucose oxidase-peroxidase treatment. The increase in foam-and emulsion-stabilizing capacity of $\beta$-glucan is due to the increase in viscosity of the aqueous phase. Therefore, $\beta$-glucan shows great potentials as a thickener and a stabilizer.