• 대한기계학회:학술대회논문집
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• 대한기계학회 2004년도 추계학술대회
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• pp.1323-1328
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• 2004

This paper shows the study on the design of the spray-freeze dryer for the production of the pulmonary inhalation powders. Powder production and handling has been an integral part of pharmaceutical processing because of the wide use of oral dosage forms. There are a few commonly used powder preparation methods including mechanical milling, precipitaion, spray drying, freeze drying, and so on. In general, methods available for preparing inhalation powders are limited due to certain inhalation powder's sensitive nature to the processing environments. This is particularly true for preparing dry powder aerosols where the aerodynamic particle size$(<5{\mu}m)$ and the size distribution are pivotal. Supercritical fluid antisolvent and spray freeze drying have recently emerged as promising techniques for producing powders for use in microcapsulation. However, the aerosol applications of these powders are yet to be explored. The purpose of this study is to test the feasibility of using spray freeze-dried pulmonary inhalation powders for aerosolization.

• 한국해양공학회:학술대회논문집
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• 한국해양공학회 2004년도 학술대회지
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• pp.1-6
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• 2004

This paper shows the study on the design and another applications of the spray-freeze dryer for the production of valuable material powders. Powder production and handling has been an integral part of material extracting processing and pharmaceutical processing because of the wide use of oral dosage forms. There are a few commonly used powder preparation methods including mechanical milling, precipitaion, spray drying, freeze drying, and so on. In general, methods available for preparing inhalation powders are limited due to certain inhalation powder's sensitive nature to the processing environments. This is particularly true for preparing dry powder aerosols where the aerodynamic particle size($<5{\mu}m$) and the size distribution are pivotal. Supercritical fluid antisolvent and spray freeze drying have recently emerged as promising techniques for producing powders for use in microcapsulation. However, the aerosol applications of these powders are yet to be explored. The purpose of this study is to test the feasibility of using spray freeze-dried valuable material powders for aerosolization.

• International Journal of Industrial Entomology and Biomaterials
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• 제6권2호
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• pp.151-155
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• 2003

Using gel filtration chromatography, high molecular silk fibroin with high purity was obtained and silk flbroin microsphere particles (SFMP) could be simply made by spray dryer method. Also, some of the physicochemical properties of SFMP and morphology were investigated. The average molecular weight of pure silk fibroin protein dissolved in calcium chloride is about 61,500g/㏖ as measured by gel permeation chromatography. SFMP was spherical in shape, and particles, sized average of 2 ${\pm}$ 10 ${\mu}$, were observed by SEM and particle analyzer, respectively. Obtaining microspheres particles by spray dryer method accelerated the transition from the random coil to the $\beta$-sheet structure during spray dryer treatment. It was identified by the basic fourier transform infrared spectroscopy of SFMP. The swelling ratio of SFMP is majorly dependent on the pH of the solution, not on the occurred gelation. The characteristic structure, which might be applicable to immobilization of drugs is superior to other matrix materials for the use of biomaterials with skin affinity.

• 한국해양공학회:학술대회논문집
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• 한국해양공학회 2003년도 추계학술대회 논문집
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• pp.24-29
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• 2003

Deep sea water has cold temperature, abundant nutrients and minerals, and good water quality that is pathogen-free and stable. Compared with surface water, deep sea water contains more nutrition salt, such as nitrogen and phosphor. Moreover, if has the good balance of minerals. Because of the ability of the spray drying process to produce a free-flowing power considering of spherical particles with a well-defined size distribution and the rapid drying times for heat-sensitive material, spray drying is attractive for a wide range of applications spray drying is a unique unit operation in which powders are produced from a liquid feed in a single processing step. Key component of the process are atomizer, spray chamber. Design of spray chamber should be based on the atomizer type, the production rate, and the particle size required. Because of the complex processes taking place during spray drying, traditional design method are based on pilot-plant tests and empirical scale-up rules. Modern technique such as CFD have a role to play in design and troubleshooting.

• 기술사
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• 제1권3호
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• pp.27-32
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• 1968

• 청정기술
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• 제2권1호
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• pp.80-95
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• 1996

반건식 배연탈황공정에서 사용되는 spray dryer absorber(SDA)에 대한 수치모사를 행하였다. 기본 방정식으로는 기체와 액적의 각 성분들의 물질수지식, 에너지수지식과 액적의 운동 방정식등이 포함되었다. 만들어진 모델은 대부분이 기존의 SPRAYMOD-M보다 실제의 pilot plant data를 더 잘 모사하였다. 실제 pilot plant에서 사용되는 값의 범위 내에서 선정된 공정변수가 SDA의 성능에 미치는 효과를 계산하고, 이를 $SO_2$의 흡수속도, 배연기체의 체류시간, 그리고 액적의 건조시간 및 속도 등에 의해 검토하였다. 또 $SO_2$ 제거율을 두 개의 독립된 공정 변수의 함수로 구하였으며, 그 결과를 3차원 또는 2차원의 등가선으로 표시하여 SDA의 설계에 쉽게 적용될 수 있도록 하였다.

• Journal of Pharmaceutical Investigation
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• 제38권4호
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• pp.249-254
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• 2008

Solid dispersions of poorly water-soluble drug, atorvastatin, were prepared with Eudragit L100 to improve the solubility by spray dryer. To investigate the correlation between physicochemical properties and dissolution rate of solid dispersions, the samples were characterized by scanning electron microscopy (SEM), differential scanning calorimeter (DSC) and fourier transform infrared spectroscopy (FT-IR). SEM and DSC were found that atorvastatin is amorphous in the Eudragit L100 solid dispersion. FT-IR was used to analyze the salt formation by interaction between atorvastatin and Eudragit L100. The dissolution rate of solid dispersed atorvastatin was markedly increased compared to drug powder in stimulated intestinal juice (pH 6.8). Thus, the solid dispersed atorvastatin using the spray drying method with Eudragit L100 may be effective for the bioavailability.

• 한국축산식품학회지
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• 제38권6호
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• pp.1273-1285
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• 2018

The aim of this study is to determine the some physicochemical (proximate composition, pH and $a_w$ values) and reconstitution (wettability, dispersibility and solubility index (SI)) properties of spray-dried bone broth powder (BBP) along with the effects of the addition of different carrier agents. Subsequently, the powdered products were stored to determine the storage stability (pH, lipid oxidation, color, browning index) for 3 mon at $-18^{\circ}C$. For this purpose, firstly marrow-containing bones (Os femur and Os humerus) have been boiled to get the bone broth. Three different emulsions were respectively prepared (1) 20% maltodextrin (MD) added BBP, (2) 20% whey powder isolate (WPI) added BBP and (3) 10% MD and 10% WPI added BBP and the emulsions were dried using a spray-dryer with $185^{\circ}C$ inlet and $95^{\circ}C$ outlet temperature. The proximate composition and reconstitution properties of BBP were found statistically different (p<0.05) depending on the use of different carrier agents. MD added BBP showed uniform and smooth morphology. The color, browning index, thiobarbituric acid reactive substances (TBARS) and pH values of BBP significantly changed (p<0.05) during storage. In conclusion, both the results of physicochemical and storage period analyses showed that the most suitable encapsulation material in the production of the bone broth powder is MD.

• 한국식품과학회지
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• 제41권1호
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• pp.27-31
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• 2009

식품의 원료인 참기름을 캡슐화하기 위해 전보(11)에서 최적화한 model system을 기초로 피복물질을 선정하고 이에 3%의 gellan gum을 첨가한 후 유화압력을 20.7 MPa로 하여 유화액을 제조하였다. 이를 top spray dryer와 fluidized bed granulator에 의한 공정으로 캡슐을 제조하여 캡슐화 수율, surface oil, 수분함량, 입자 크기, 캡슐의 저장 안정성 및 제품 응용성을 비교하였다. Fluidized bed granulator에 의한 캡슐은 top spray dryer에 의한 캡슐보다 상대적으로 surface oil 함량이 낮고 수율이 높으며 입자 크기가 컸다. 제조한 캡슐을 $37^{\circ}C$에서 저장하면서 flavor retention을 측정한 결과 참기름 원료 자체를 저장한 경우 향기 성분은 1% 이하의 잔존 함량을 나타내어 대부분의 향기 성분이 소실되었다고 보았으나, top spray dryer와 fluidized bed granulator에 의한 캡슐은 각각 37%, 42%의 향기성분을 보유하여 향기 성분 포집성 및 보존성이 우수하였다. 또한 쇠고기 죽 제품에 응용한 후 관능검사 결과에서도 참기름 캡슐을 사용한 제품들이 모두 참기름 원료 자체를 사용한 제품보다 풍미의 강도 및 기호도면에서 모두 높았고 특히 fluidized bed granulator를 이용하여 제조한 캡슐을 사용한 제품이 가장 우수하게 평가되었다. 따라서 참기름 원료와 같이 향기 성분이 소실 되기 쉬운 소재를 fluidized bed granulator를 이용하여 저온 미세 캡슐화하면 풍미의 안정성 증대에 효과가 있을 것으로 판단된다.

• 대한기계학회논문집B
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• 제22권8호
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• pp.1064-1072
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• 1998

The evaporation of sludge particles in a sludge dryer has been numerically investigated with commercial CFX4.1 code. Gas flow field, gas temperature field, sludge particle trajectories, and the moisture content variation of sludge particles are calculated fort various influencing factors, i. e., gas swirl velocity, initial particle distribution, gas temperature. Evaporation of sludge particles increases with gas swirl velocity, several supplying positions, and gas temperature, respectively due to increased residence time, increased contacting surface area, and increased temperature difference between gas and particle.