• Journal of Chest Surgery
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• 제38권2호
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• pp.175-179
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• 2005

흉강입구를 침범한 종양을 근골보존 경흉골병 접근술을 이용하여 수술한 증례를 보고하고자 한다. 우측 상지의 근력 약화를 주소로 69세의 남자 환자가 내원하였다. 단순 흉부 방사선 사진에서 우측 폐 상엽에 기관지 확장증, 만성 결핵과 진균덩이가 관찰되었다. 전산화단층촬영에서 종양이 제 6, 7번 경추와 제 1번 흉추의 척추강내 경막외에 위치하며 우측 흉곽 첨부에까지 연장되어 있었다 신경외과에서 먼저 후궁절제술을 시행하여 척추강 안의 종양을 절제한 후, 흉부외과에서 근골보존 경흉골병 접근술을 통하여 흉강입구를 침범한 종양을 제거하였다. 종양은 혈관외피세포종으로 진단되었으며, 환자는 수술 후 합병증 없이 회복되었다.

• Investigative Magnetic Resonance Imaging
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• 제13권2호
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• pp.207-212
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• 2009

척수내 신경집종은 드문 척수내 종양으로 추적 자기공명영상 소견에서 악화된 증례는 보고된 바가 없다. 우리는 신경섬유종이 없는 환자에서 생긴 흉추 척수내 신경집종의 초기 영상소견과 추적 자기공명영상을 보고하고자 한다. 추적 자기공명영상에서 척수내 종양의 크기가 커지고, 동반된 부종의 범위가 증가하여 악성처럼 보여도, 척수내 종양의 감별진단에 척수내 신경집종을 반드시 포함하여야 하겠다.

• 대한골관절종양학회지
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• 제5권3호
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• pp.183-189
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• 1999

Ewing's sarcoma is an uncommon malignant neoplasm of the long bone and it has a poor prognosis due to its early metastasis and aggressive local spread. It is mostly found before the age of 30 and it is rare in extraskeletal sites. Extraskeletal Ewing's sarcoma has been reported to occur in various sites including the larynx, scalp, nasal fossa, neck, chest wall, lung, pelvis, perineum, arm, finger, leg and toe, but it is extremely rare as a primary epidural tumor of the spine. We experienced a case of extraosseous epidural Ewing's sarcoma arising in the lumbar spinal canal at L3-L5 level in a 9-year-old boy. Following total laminectomy from L3 to L5 with a lumbar vertebrae and mass excision, he received chemotherapy with complete remission.

• Journal of Korean Neurosurgical Society
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• 제56권2호
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• pp.152-156
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• 2014

Intracisternal accessory nerve schwannomas are very rare; only 18 cases have been reported in the literature. In the majority of cases, the tumor origin was the spinal root of the accessory nerve and the tumors usually presented with symptoms and signs of intracranial hypertension, cerebellar ataxia, and myelopathy. Here, we report a unique case of an intracisternal schwannoma arising from the cranial root of the accessory nerve in a 58-year-old woman. The patient presented with the atypical symptom of hoarseness associated with recurrent laryngeal neuropathy which is noted by needle electromyography, and mild hypesthesia on the left side of her body. The tumor was completely removed with sacrifice of the originating nerve rootlet, but no additional neurological deficits. In this report, we describe the anatomical basis for the patient's unusual clinical symptoms and discuss the feasibility and safety of sacrificing the cranial rootlet of the accessory nerve in an effort to achieve total tumor resection. To our knowledge, this is the first case of schwannoma originating from the cranial root of the accessory nerve that has been associated with the symptoms of recurrent laryngeal neuropathy.

• Journal of Korean Neurosurgical Society
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• 제58권6호
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• pp.550-553
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• 2015

A 67-year-old male presented with left temporal hemianopsia and left hemiparesis. A contrast-enhanced magnetic resonance image revealed a $4.5{\times}3.5{\times}5.0cm$ rim-enhancing mass with central necrosis and associated edema located in the left occipital lobe. Of positron emission tomography and abdominal computed tomography, a 9-cm mass with poor enhancement was found in the right hepatic lobe. Craniotomy and right hemihepatectomy was performed. The resected specimen showed histological features and immunochemical staining consistent with a metastatic neuroendocrine tumor (NET). Four months later, the tumors recurred in the brain, liverand spinal cord. Palliative chemotherapy with etoposide and cisplatin led to complete remission of recurred lesions, but the patient died for pneumonia. This is the first case of a metastatic brain NET originating from the liver. If the metastatic NET of brain is suspicious, investigation for primary lesion should be considered including liver.

• Journal of Korean Neurosurgical Society
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• 제47권1호
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• pp.51-54
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• 2010

Surgery has a key role in the treatment of malignant peripheral nerve sheath tumors (MPNSTs), but the resectability of paraspinal MPNSTs is only 20%. Therefore, spinal MPNSTs show frequent recurrence and poor prognosis. Local recurrence is much more common than metastasis for MPNSTs, and surgery still has a key role in the treatment of local recurrence. Therefore, it is important that recurrence must be detected before resectability is lost. However, no evidence-based follow-up protocol has been established for MPNST. The authors performed gross total resection in a 34-year-old woman presented with thoracic MPNST. Adjuvant radiotherapy and chemotherapy were not administered since these adjuvant therapies generally do not improve survival in MPNST and may cause additional neurovascular damage. Instead, the authors monitored the primary site every 3 months using magnetic resonance imaging to detect local recurrence at the earliest opportunity. The tumor recurred locally on two occasions without overt symptoms at 21 and 24 months postoperatively. These recurrences were treated successfully by gross total removal.

• Journal of Korean Neurosurgical Society
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• 제30권10호
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• pp.1241-1244
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• 2001

The authors report a very rare case of tuberculous spondylitis combined with a schwannoma of spinal cord. A 39- year-old man was admitted because of paraparesis(G1/G2). MRI showed severe cord compression at two different levels. One was by the bulged soft tissue and subligamentous abscess extending from T7 to T9 and the other was by an intradural extramedullary cord tumor at the level of T1-2. At first operation, T8 corpectomy and T7-9 plate fixation with autogenous iliac bone graft were performed. After then, Paraparesis was improved(G2/G3) postoperatively. The second operation underwent two weeks later. The tumor was totally removed and shortly after second operation, paraparesis was markedly improved(G3/G4). Histological diagnosis were tuberculous spondylitis and schwannoma, respectively. The authors reviewed this case where good surgical outcome was obtained by two stage operation.

• 대한골관절종양학회지
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• 제12권1호
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• pp.57-62
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• 2006

척추의 거대 세포종은 진단이 어려운 경우가 많고, 고도의 악성도로 인해서 수술이 불가능한 경우가 많다. 척추의 거대 세포종은 높은 재발율과 함께 척수의 기계적 압박 가능성으로 인해 방사선 치료가 근간이었으나, 최근에는 근치적 절제술과 함께 기구를 이용한 전후방 고정술을 시행 하여 좋은 결과를 보고 하고있다. 본 정형외과학교실에서는 경부 동통을 유발하며 제3경추를 침범한 거대세포종에 대해서 근치적 절제술과 함께 후방 기기술을 통한 융합을 시행 하였으며, 추시 관찰상 우수한 치료 결과를 보였기에 문헌 고찰과 함께 보고하는 바이다.

• 한국콘텐츠학회논문지
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• 제13권10호
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• pp.419-426
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• 2013

본 연구에서는 간암 치료시 Body fix를 이용하여 4DRT를 실시할 경우 종양의 체적, 위치의 변화정도, 종양 및 정상조직의 선량흡수정도를 파악하여 Body fix의 유용성을 평가하였다. 사전 연구에 동의한 23명의 환자를 대상으로 Body fix의 착용 유무에 따라 각기 다른 4차원 모의치료영상을 획득하여 영상을 바탕으로 종양조직 및 정상조직을 설정하고 분석하였다. 종양의 용적을 분석해본 결과 Body fix의 사용이 GTV는 0.17%, CTV와 PTV는 3.2% 정도 체적을 줄일 수 있었으며, 종양의 운동성은 AP방향에서 29.8%, UL방향에서 5.31%의 움직임을 감소시킬 수 있었다. 종양의 흡수선량 값은 Body fix를 사용한 경우가 다소(1.3%) 높았으며 정상조직(정상간, 위, 우측신장, 척수)의 흡수선량은 5% 정도 줄일 수 있었다. 따라서 간암의 4DRT시 Body fix는 유용하게 사용할 수 있을 것으로 생각된다.

• Animal cells and systems
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• 제7권3호
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• pp.265-269
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• 2003

Vascular endothelial growth factor (VEGF) is a potent regulator of normal and abnormal angiogenesis. Recent literature suggests that VEGF has several activities that may amplify acute inflammation reactions. Dysregulated VEGF expression has been implicated as a major contributor to the development of a number of common disease pathologies. One of common mutations in the 3'- untranslated region of the VEGF gene, a C\longrightarrowT exchange at nucleotide position 936, has been found to be significantly associated with VEGF expression levels in the plasma from a previous Austrian study. The frequency of this mutation could be important genetic information regarding tumor growth and angiogenesis related diseases. The aim of this study was to investigate the frequency distribution of this mutation in general Korean population. We examined the statistical data from 207 healthy Korean subjects. Observed numbers (%) of 936T were 28.5 (CT) and 3.9 (TT), respectively. The mutant allele frequency of 936T in Korean subjects was 0.18, which appeared somewhat higher than that in Austrian subjects.