• 대한기계학회논문집B
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• 제36권11호
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• pp.1105-1110
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• 2012

척추는 인간의 근골격계 건강에 큰 영향을 미치는 신체 부위 중 하나이다. 최근에 고령화 사회에 진입하게 되면서 요통과 같은 척추 질환이 급속하게 증가하고 있다. 이러한 척추 질환의 요인에는 선천적인 척추 장애나 스포츠 및 교통사고의 부상뿐만 아니라 일상생활에서 반복적으로 취하는 나쁜 자세도 포함된다. 잘못된 척추 자세는 척추 디스크에 압력을 주어 퇴행성 변화를 가져옴으로써 척추를 변형시키고 척추질환을 일으킨다. 따라서 본 연구에서는 여러 나쁜 자세를 취했을 때 흉추와 요추 관절의 3 차원 관절 각도를 분석하였다. 그 결과로부터 일상생활에서의 나쁜 자세가 굽힘/신전, 측면 굽힘, 축 회전 방향으로 척추 관절에 각도 변형을 일으키고 정상범위에서 벗어날 수 있음을 알 수 있었다. 향후 연구로써 척추관절의 각도변화가 디스크와 인대 및 근육 등에 미치는 영향에 대한 연구가 필요하다 생각된다.

• Tuberculosis and Respiratory Diseases
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• 제52권6호
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• pp.627-632
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• 2002

폐암 환자에서 척수에 대한 신경학적 증상이 발생할 경우, 척수 수질 내로의 전이를 고려해야 하며, 조기 진단이 예후에 중요한 영향을 미칠 것으로 사료된다. 자기공명영상 검사는 이러한 병변의 진단에 매우 민감한 검사이나, 임상증상과 원발병변, 타 장기로의 전이 등을 함께 고려하여야 하며, 가능하다면 조직검사를 시행하여 진단할 수 있다. 본 예는 임상양상 및 방사선 검사에 의해 매우 드문 비소세포 폐암의 척수 수질내 전이로 판단된 경우이기에 보고하는 바이다.

• Tuberculosis and Respiratory Diseases
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• 제49권3호
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• pp.372-375
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• 2000

척추 경막외 기종은 드문 질환으로 흉부 CT상 우연히 발견되는 경우가 많고, 고식적 치료로 완치되는 양성 질환이다. 저자들은 기종격동 및 경막외 기종까지 동반된 기관지 천식 1례를 치료하였기에 문헌고찰과 함께 보고하는 바이다.

• 디지털융복합연구
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• 제19권2호
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• pp.307-314
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• 2021

본 연구는 척추·관절질환 환자 만족도와 병원 추천 의향을 분석하고 만족도에 영향을 미치는 요인을 확인하기 위해 수행되었다. 이에 2019년 서울지역 소재 척추·관절 전문병원에서 환자 만족도와 추천 의향을 조사하였고, 인구·사회적 특성과 환자 만족도와의 관련성, 만족도 영향요인 및 추천 의향 등을 분석하였다. 분석 결과 외래의 경우 직원 용모·복장의 단정함과 청결도, 직원 친절도, 시설환경 쾌적성에서 환자 만족도가 높게 나타났고, 대기시간 관련 문항에서 환자 만족도가 낮게 나타났다. 입원의 경우 간호 영역과 병원환경 영역에서 여성의 만족도가 높았다. 하위 영역별로는 간호 영역 중 고객 존중 및 예의, 고객 경청, 담당 간호사에서 환자 만족도가 높게 나타났고, 병원환경 영역은 전반적인 병원 청결도와 안전 문항에서 만족도가 높았다. 환자 만족도와 주변에 해당 병원을 추천할 의향이 있는지를 묻는 문항 간 상관관계 분석에서는 환자 만족도와 병원 추천 의향은 양의 상관관계가 있는 것으로 나타났다. 척추·관절 질환 환자 만족도와 추천 의향 평가 결과는 척추·관절 전문병원에서 의료서비스 질 향상과 병원경영 전략 수립을 위한 기초 자료로 활용될 수 있을 것이다.

• Hip & pelvis
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• 제35권4호
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• pp.238-245
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• 2023

Purpose: Elderly patients with degenerative diseases undergo treatment for the hip and spine; these patients present with various symptoms. This study focused on patients with residual symptoms, predominantly pain, even after receiving treatment for their spinal lesions. Materials and Methods: Patients who underwent total hip arthroplasty (THA) between 2016 and 2022 at a single tertiary hospital were included in the study. Of the 417 patients who underwent primary THA, a retrospective review of 40 patients with previous lesions of the spine was conducted. Patients were stratified to two cohorts: Patients with symptoms related to the spine (Group A), and those with hip-related symptoms (Group B). Preand postoperative comparisons of groups A and B were performed. Results: Improvements in patients' symptoms were observed in groups A and B after THA. In Group A, the mean preoperative visual analog scale (VAS) score was 5.10±0.876, which showed a postoperative decrease to 2.70±1.767. In Group B, the mean preoperative VAS score was 5.10±1.539, which showed a postoperative decrease to 2.67±1.493. Conclusion: According to the findings, promising results were achieved with THA in treatment of debilitating diseases of the hip for both the prognosis of the disease, as well as the patients' symptoms. In addition, in some cases elderly patients with dual pathologies underwent treatment for spinal lesions without performance of any evaluation related to the hip. Thus, evaluation of a patient's hip must be performed and performance of THA in patients with symptoms even after treatment of spinal lesions is recommended.

• The Korean Journal of Pain
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• 제33권4호
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• pp.318-325
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• 2020

Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a major side effect of anti-cancer drugs. Neurotensin receptors (NTSRs) are widely distributed within the pain circuits in the central nervous system. The purpose of this study was to determine the role of NTSR1 by examining the effects of an NTSR1 agonist in rats with CIPN and investigate the contribution of spinal serotonin receptors to the antinociceptive effect. Methods: Sprague-Dawley rats (weight 150-180 g) were used in this study. CIPN was induced by injecting cisplatin (2 mg/kg) once a day for 4 days. Intrathecal catheters were placed into the subarachnoid space of the CIPN rats. The antiallodynic effects of intrathecally or intraperitoneally administered PD 149163, an NTSR1 agonist, were evaluated. Furthermore, the levels of serotonin in the spinal cord were measured by high-performance liquid chromatography. Results: Intrathecal or intraperitoneal PD 149163 increased the paw withdrawal threshold in CIPN rats. Intrathecal administration of the NTSR1 antagonist SR 48692 suppressed the antinociceptive effect of PD 149163 given via the intrathecal route, but not the antinociceptive effect of intraperitoneally administered PD 149163. Intrathecal administration of dihydroergocristine, a serotonin receptor antagonist, suppressed the antinociceptive effect of intrathecally administered, but not intraperitoneally administered, PD 149163. Injecting cisplatin diminished the serotonin level in the spinal cord, but intrathecal or intraperitoneal administration of PD 149163 did not affect this reduction. Conclusions: NTSR1 played a critical role in modulating CIPN-related pain. Therefore, NTSR1 agonists may be useful therapeutic agents to treat CIPN. In addition, spinal serotonin receptors may be indirectly involved in the effect of NTSR1 agonist.

• 대한간호학회지
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• 제53권4호
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• pp.371-384
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• 2023

Purpose: With an increase in the aging population, the number of patients with degenerative spinal diseases undergoing surgery has risen, as has the incidence of postoperative delirium. This study aimed to investigate the risk factors affecting postoperative delirium in older adults who had undergone spine surgery and to identify the associated biomarkers. Methods: This study is a prospective study. Data of 100 patients aged ≥ 70 years who underwent spinal surgery were analyzed. Demographic data, medical history, clinical characteristics, cognitive function, depression symptoms, functional status, frailty, and nutritional status were investigated to identify the risk factors for delirium. The Confusion Assessment Method, Delirium Rating Scale-R-98, and Nursing Delirium Scale were also used for diagnosing delirium. To discover the biomarkers, urine extracellular vesicles (EVs) were analyzed for tau, ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), neurofilament light, and glial fibrillary acidic protein using digital immunoassay technology. Results: Nine patients were excluded, and data obtained from the remaining 91 were analyzed. Among them, 18 (19.8%) developed delirium. Differences were observed between participants with and without delirium in the contexts of a history of mental disorder and use of benzodiazepines (p = .005 and p = .026, respectively). Tau and UCH-L1-concentrations of urine EVs-were comparatively higher in participants with severe delirium than that in participants without delirium (p = .002 and p = .001, respectively). Conclusion: These findings can assist clinicians in accurately identifying the risk factors before surgery, classifying high-risk patients, and predicting and detecting delirium in older patients. Moreover, urine EV analysis revealed that postoperative delirium following spinal surgery is most likely associated with brain damage.

• 대한영상의학회지
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• 제82권6호
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• pp.1413-1440
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• 2021

MRI에서 추간판의 이상 신호와 위, 아래 척추체 종판의 파괴, 종판 주변의 골수부종 등은 감염성 척추염의 전형적인 소견으로 여겨지나 퇴행성 척추질환, acute Schmorl's node, 척추관절병증, synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO)/chronic recurrent multifocal osteomyelitis, 척추신경관절병증, calcium pyrophosphate dehydrate 결절침착질환 등 다양한 비감염성 척추질환에서도 나타날 수 있다. MRI에서 이러한 비감염성 척추질환과 감별되는 감염성 척추염의 영상 소견은 추간판의 고신호와 농양, 척추 연부조직의의 농양, 그리고 T1 강조영상에서 저신호로 보이는 종판의 경계가 불명확해지는 점 등이다. 그러나 이러한 감별점이 항상 적용되는 것은 아니며 감염성, 비감염성 질환의 영상 소견에 유사점이 많기 때문에 정확한 진단을 위해서는 감염성 척추염뿐만 아니라 감염과 감별해야 하는 다양한 질환의 병태생리와 연관된 영상학적 특징을 아는 것이 중요하다.

• International Journal of Oral Biology
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• 제32권4호
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• pp.153-160
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• 2007

The superficial dorsal horn, particularly substantia gelatinosa (SG) in the spinal cord, receives inputs from small-diameter primary afferents that predominantly convey noxious sensation. Reactive oxygen species (ROS) are toxic agents that may be involved in various neurodegenerative diseases. Recent studies indicate that ROS are also involved in persistent pain through a spinal mechanism. In the present study, whole cell patch clamp recordings were carried out on SG neurons in spinal cord slice of young rats to investigate the effects of hydrogen peroxide on neuronal excitability and excitatory synaptic transmission. In current clamp condition, tert-buthyl hydroperoxide (t-BuOOH), an ROS donor, depolarized membrane potential of SG neurons and increased the neuronal firing frequencies evoked by depolarizing current pulses. When slices were pretreated with phenyl-N-tert-buthylnitrone (PBN) or ascorbate, ROS scavengers, t-BuOOH did not induce hyperexcitability. In voltage clamp condition, t-BuOOH increased the frequency and amplitude of spontaneous excitatory postsynaptic currents (sEPSCs), and monosynaptically evoked excitatory postsynaptic currents (eEPSCs) by electrical stimulation of the ipsilateral dorsal root. These data suggest that ROS generated by peripheral nerve injury can modulate the excitability of the SG neurons via pre- and postsynaptic actions.

• 대한근전도전기진단의학회지
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• 제20권2호
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• pp.130-134
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• 2018

A 36-year-old male patient developed diffuse low back pain. His past medical history was unremarkable and had no family history of neuromuscular disease. He had no bladder and bowel problems. Creatine kinase was 172 U/L (normal < 170). Other fluid and blood chemistry tests were normal. Manual muscle test grades of extremities and sensory examination were normal. Muscle stretch reflexes were normal. Fasciculations and myotonia were not detected. Straight leg raising test was negative. There was no spinal root compression, spinal stenosis, or signal intensity change of spinal cord on magnetic resonance imaging (MRI). Fatty change and atrophy of the cervical, thoracic and lumbar paraspinal muscles were noted on MRI. Nerve conduction studies were normal. Electromyography showed 1+ positive sharp waves in the lumbar paraspinal muscles. Electromyography of upper and lower extremity muscles revealed no abnormal spontaneous activity. We report a rare case of severe paraspinal muscle atrophy with fatty degeneration in a Young Adult.