• Journal of Pharmaceutical Investigation
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• v.32 no.3
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• pp.215-221
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• 2002

Cephradine is a first generation cephalosporin and has broad spectrum antibacterial activity against gram-positive and gram-negative microorganisms, through inhibition of bacterial cell wall synthesis. Cephradine is useful for treatment of infections of the urinary and respiratory tract, skin and soft tissues. The purpose of the present study was to evaluate the bioequivalence of two cephradine capsules, Cefradine Yuhan (YuHan Corporation) and Broadcef (Ilsung Pharmaceuticals Co. Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). The cephradine release from the two cephradine capsules in vitro was tested using KP VII Apparatus II method with various different kinds of dissolution media (pH 1.2, 4.0, 6.8 buffer solution and water). Twenty normal male volunteers, $23.10{\pm}2.90$ years in age and $67.69{\pm}8.04\;kg$ in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After one capsule containing 500 mg as cephradine was orally administered, blood was taken at predetermined time intervals and the concentrations of cephradine in serum were determined using HPLC method with UV detector. The dissolution profiles of two cephradine capsules were very similar at all dissolution media. Besides, the pharmacokinetic parameters such as $AVC_t,\;C_{max}\;and\;T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AVC_t\;and\;C_{max}$ and untransformed $T_{max}$. The results showed that the differences in $AVC_t,\;C_{max}\;and\;T_{max}$ between two capsules based on the Cefradine Yuhan were -2.87%, -0.96% and -4.85%, respectively. There were no sequence effects between two capsules in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of 1og(0.8) to log(1.25) $(e.g.,\;log(0.93){\sim}log(1.02)\;and\;log(0.88){\sim}log(1.13)\;for \;AVC_t\;and\;C_{max},\;respectively)$. The 90% confidence interval using untransformed data was within ${\pm}20%$ $(e.g., \;-17.54{\sim}7.78\;for\;T_{max})$. All parameters met the criteria of KFDA guideline for bioequivalence, indicating that Broadcef capsule is bioequivalent to Cefradine Yuhan capsule.

• The Journal of the Korea Contents Association
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• v.18 no.9
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• pp.294-307
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• 2018

The aim of this study is to find out how married women who had had an abortions experience a change through Family Constellation. The consequent changes will occur in the perception of an abortion experience and in the relation between married women themselves and their family. The participants in the study were 9 married women aged 40~60 who have experienced an abortion, and data collection was carried out over 3 periods which were before, right after and one month after the Family Constellation experience through individual in-depth interviews. The chief methodology of this study is based on the one by Colaizzi's phenomenological research, and by using the methodology to analyze the data 15 theme collections and 3 categories were deducted. According to the result of the analysis, the experience of abortion was having negative influence on the whole spectrum of the life of married women who experienced an abortion even though they did not consciously recall the relevant experiences. In the married women's Family Constellation, the agent visualizes the restrained relation which is hidden in unconsciousness and thereby offers an opportunity for married women to untie "knot". Moreover through this opportunity, married women are able to have new perception of their abortion experience and the relation between their family. Furthermore, not only will they be able to recover the relationship with their family, but also emotional stability.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.12
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• pp.5931-5936
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• 2012

This study was to evaluate the clinical usefulness of the PRESS technique based on the correlation between PRESS technique and biopsy results by applying 3.0T high magnetic field MRS technique for evaluation of non-alcoholic fatty liver disease patients. This experiment were carried out using a 3.0T magnetic resonance imaging equipment. The part data of each spectrum is taken by peak area integration. The part data of resonance peak was used to calculate relative ratio. MR spectral peak in patients with non-alcoholic fatty liver disease is from 0.9 to 1.6 ppm. According to MRS method study result, Patients with NAFLD were obtained with 94% sensitivity and 80% specificity(p=0.000). When compared to normal based on MRS and Biopsy results was valid correlation(r=0.79, p=0.04). Results for NAFLD(r=0.89, p=0.002) also showed a correlation. Therefore, PRESS technique to evaluate patients with non-alcoholic fatty liver disease, the distribution difference between normal liver and fatty liver part is significantly distinguished. Biopsy and MRS fatty liver peak ratio(%) proves high lipid over grade(r = 0.7).

• Geophysics and Geophysical Exploration
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• v.16 no.4
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• pp.211-216
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• 2013

In general, smoothing filters regularize functions by reducing differences between adjacent values. The smoothing filters, therefore, can regularize inverse solutions and produce more accurate subsurface structure when we apply it to full waveform inversion. If we apply a smoothing filter with a constant coefficient to subsurface image or velocity model, it will make layer interfaces and fault structures vague because it does not consider any information of geologic structures and variations of velocity. In this study, we develop a selective smoothing regularization technique, which adapts smoothing coefficients according to inversion iteration, to solve the weakness of smoothing regularization with a constant coefficient. First, we determine appropriate frequencies and analyze the corresponding wavenumber coverage. Then, we define effective maximum wavenumber as 99 percentile of wavenumber spectrum in order to choose smoothing coefficients which can effectively limit the wavenumber coverage. By adapting the chosen smoothing coefficients according to the iteration, we can implement multi-scale full waveform inversion while inverting multi-frequency components simultaneously. Through the successful inversion example on a salt model with high-contrast velocity structures, we can note that our method effectively regularizes the inverse solution. We also verify that our scheme is applicable to field data through the numerical example to the synthetic data containing random noise.

• Food Science and Preservation
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• v.16 no.3
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• pp.392-399
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• 2009

Recent studies indicate that green tea may have anticancer, antioxidant, and antihypertensive effects, and aids body weight control and the promotion of various desirable physiological functions. However, few studies have investigated the antimicrobial effects of green tea. We sought to determine the antimicrobial activity of green tea extract against food spoilage microorganisms. The extract showed remarkable antimicrobial effects against a wide spectrum of putrefactive and food spoilage microorganisms when used at concentrations greater than $500{\mu}g/ml$. The extract showed thermal and pH stability in the range of $40{\sim}150^{\circ}C$ and pH 3.11, respectively. Green tea extract seems to be an ideal natural antimicrobial, considering both efficacy and thermal and pH stabilities. Antimicrobial substances in green tea extract were investigated using electron microscopy and a $\beta$-galactosidase assay. The data showed that the extract contains several efficacious materials, and that their activities are not synergistic but are instead independent. Our data indicate that hydrophilic antimicrobial substances in green tea extract might control food spoilage microorganisms owing to perturbation of the microbial cell membrane.

• 한국지구물리탐사학회:학술대회논문집
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• 2005.05a
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• pp.87-92
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• 2005

The ground-motion (GM) attenuation relations available in Korea has required the validation process for large earthquakes since most of them were developed based on small earthquake database, The Fukuoka earthquake (M=7.0) that occurred near the Korean Peninsula provides invaluable data to indirectly evaluate the attenuation characteristics of the strong GM in Korea. The GM levels (PGA, SA) obtained from the KIK-net downhole stations near the epicenter (R<100km) are reasonably predicted by the GM attenuation relation developed by KEPRI in 2003 for the Kori NPP site, the result of which validates the use of KEPRI GM attenuation relation for predicting GM induced by future large earthquakes. Also, the comparison between the Osaki spectra and response spectra of KIK-net downhole data reveals that the amplitude levels of Osaki spectra are higher than the spectra from KIK-net stations which are believed to be installed at the seismic basement.

• Journal of the Korean Geophysical Society
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• v.8 no.3
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• pp.109-113
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• 2005

The ground-motion (GM) attenuation relations available in Korea has required the validation process for large earthquakes since most of them were developed based on small earthquake database. The Fukuoka earthquake (M=7.0) that occurred near the Korean Peninsula provides invaluable data to indirectly evaluate the attenuation characteristics of the strong GM in Korea. The GM levels (PGA, SA) obtained from the KIK-net downhole stations near the epicenter (R<100km) are reasonably predicted by the GM attenuation relation developed by KEPRI in 2003 for the Kori NPP site, the result of which validates the use of KEPRI GM attenuation relation for predicting GM induced by future large earthquakes. Also, the comparison between the Osaki spectra and response spectra of KIK-net downhole data reveals that the amplitude levels of Osaki spectra are higher than the spectra from KIK-net stations which are believed to be installed at the seismic basement.

• The Journal of the Petrological Society of Korea
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• v.10 no.3
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• pp.190-201
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• 2001

Isotope Dilution Mass Spectrometry(IDMS) is one of the analytical method which uses enriched isotope spikes and analyzes the abundance of element by comparison of the spectrum between spiked mass and non-spike mass. Especially, the Thermal Ion Mass Spectrometry with isotope dilution technique (in general ID-TIMS) is the most accurate method of the chemical analysis, which enables us to obtain the data better than 1% in accuracy and precision. In IDMS, enriched isotope spike is one of the most important factor in order to obtain the best data. For rare earth elements, in general, a mixture of /sup 138/La, /sup 142/Ce, /sup 145/Nd, /sup 149/Sm, /sup 151/Sm, /sup 151/Eu, /sup 157/Gd, /sup 163/Dy, /sup 167/Er, /sup 171/Yb, and /sup 176/Lu is used as composite spike. IDMS is very useful in geochronology and REE geochemistry. Especially, it is very effective in studying the “tetrad effect” of rare earth elements in natural samples.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.36 no.3
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• pp.349-359
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• 2016

In order to analytically evaluate buffeting responses, the analysis of wind characteristics such as turbulence intensity, turbulence length, gust, roughness coefficient, etc must be a priority. Static aerodynamic force coefficients, flutter coefficients, structural damping ratios, aerodynamic damping ratios and natural frequencies affect the analytical responses. The bridge interested in this paper has being been used for 32 years. As the time passes, current terrain conditions around the bridge are different markedly from the conditions it was built 32 years ago. Also, wind environments were considerably varied by the climate change. For this reason, it is necessary to evaluate the turbulence intensity, length, spectrum and roughness coefficient of the bridge site from full-scale measurements using the structural health monitoring system. The evaluation results indicate that wind characteristics of bridge site is analogous to that of open terrain although the bridge is located on the coastal area. To calculate buffeting responses, the analysis variables such as damping ratios, static aerodynamic force coefficients and natural frequency were evaluated from measured data. The analysis was performed with regard to 4 cases. The evaluated variables from measured data are applied to the first and second analysis cases. And the other analysis cases were performed based on Design Guidelines for Steel Cable Supported Bridges. The calculated responses of each analysis cases are compared with the buffeting response measured at less than 25m/s wind speed. It is verified that the responses by the numerical analysis applying the estimated variables based on full-scale measurements are well agreed with the measured actual buffeting responses under wind speed 25m/s. Also, the extreme wind speed corresponding to a recurrence interval 200 years is derived from Gumbel distribution. The derived wind speed for return period of 200 years is 45m/s. Therefore the buffeting responses at wind speed 45m/s is determined by the analysis applying the estimated variables.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.19 no.2
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• pp.151-161
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• 2007

Statistical characteristic analysis was carried out using the non-tidal components computed by the harmonic analysis of the tidal elevation data in East coast. The tide gauging stations included in this study are the Sokcho, Mukho, Hupo, Pohang, Ulsan and Ulreungdo stations. In this study, the variance and skewness coefficient (SC) information changes, i.e., the max. value, min. value, mean and standard deviation of the variance and SC, are compared and analysed in detail by the various analysis periods increased from one year to the maximum available period. Based on the result of the statistical information (SI) range analysis, the minimum analysis period required in order to satisfy the confidence interval of the ${\pm}5%$ range of the variance and the ${\pm}0.1$ range of the SC is suggested as the 12 years, except the Ulreungdo stations. The auto-correlation and spectral density change patterns show the very similar shapes in every stations even though the absolute values are a little bit different each other.