• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.24 no.11
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• pp.907-918
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• 2014

In this study for the prediction of 3D underwater radiated noise pattern, a comparison between the proposed method(DHIE, Discrete Helmholtz Integral Equation) and the 3D underwater radiated noise calculation results using the measurement of near-field acoustic pressure data is performed. The near-field acoustic pressure in water is measured for the calculation of the far-field radiated noise pattern and the far-field acoustic power. Also the vibration field of the underwater structure is measured in simultaneously. Using the total far-field acoustic power and the vibration field on the surface of the structure, the proposed method(DHIE) can predict the underwater radiated noise pattern of the far-field The predicted results show the reasonable agreement within about 5dB comparing with the experiment result.

• Molecules and Cells
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• v.40 no.2
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• pp.151-161
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• 2017

Proper synaptic function in neural circuits requires precise pairings between correct pre- and post-synaptic partners. Errors in this process may underlie development of neuropsychiatric disorders, such as autism spectrum disorder (ASD). Development of ASD can be influenced by genetic factors, including copy number variations (CNVs). In this study, we focused on a CNV occurring at the 16p11.2 locus in the human genome and investigated potential defects in synaptic connectivity caused by reduced activities of genes located in this region at Drosophila larval neuromuscular junctions, a well-established model synapse with stereotypic synaptic structures. A mutation of rolled, a Drosophila homolog of human mitogen-activated protein kinase 3 (MAPK3) at the 16p11.2 locus, caused ectopic innervation of axonal branches and their abnormal defasciculation. The specificity of these phenotypes was confirmed by expression of wild-type rolled in the mutant background. Albeit to a lesser extent, we also observed ectopic innervation patterns in mutants defective in Cdk2, Gq, and Gp93, all of which were expected to interact with Rolled MAPK3. A further genetic analysis in double heterozygous combinations revealed a synergistic interaction between rolled and Gp93. In addition, results from RT-qPCR analyses indicated consistently reduced rolled mRNA levels in Cdk2, Gq, and Gp93 mutants. Taken together, these data suggest a central role of MAPK3 in regulating the precise targeting of presynaptic axons to proper postsynaptic targets, a critical step that may be altered significantly in ASD.

• Journal of Genetic Medicine
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• v.7 no.2
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• pp.111-118
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• 2010

Chromosomal microarray analysis (CMA) enables the genome-wide detection of submicroscopic chromosomal imbalances with greater precision and accuracy. In most other countries, CMA is now a commonly used clinical diagnostic test, replacing conventional cytogenetics or targeted detection such as FISH or PCR-based methods. Recently, some consensus statements have proposed utilization of CMA as a first-line test in patients with multiple congenital anomalies not specific to a well-delineated genetic syndrome, developmental delay/intellectual disability, or autism spectrum disorders. CMA can be used as an adjunct to conventional cytogenetics to identify chromosomal abnormalities observed in G-banding analysis in constitutional or acquired cases, leading to a more accurate and comprehensive assessment of chromosomal aberrations. Although CMA has distinct advantages, there are several limitations, including its inability to detect balanced chromosomal rearrangements and low-level mosaicism, its interpretation of copy number variants of uncertain clinical significance, and significantly higher costs. For these reasons, CMA is not currently a replacement for conventional cytogenetics in prenatal diagnosis. In clinical applications of CMA, knowledge and experience based on genetics and cytogenetics are required for data analysis and interpretation, and appropriate follow-up with genetic counseling is recommended.

• Journal of Genetic Medicine
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• v.11 no.2
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• pp.86-90
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• 2014

Smith-Lemli-Opitz syndrome (SLOS) is a rare autosomal recessive disorder caused by 7-dehydrocholesterol reductase deficiency. The characteristic clinical features are syndactyly of the second and third toes, facial dysmorphism, multiple malformations, and intellectual disability. Few cases of SLOS have been reported in Korea. We observed a male patient with SLOS who presented with typical facial features, undescended testes, microcephaly, bilateral syndactyly of the second and third toes, and cardiac defects, including patent ductus arteriosus and atrial septal defect. Mutation analysis of the DHCR7 gene identified compound heterozygous mutations of c.907G>A (p.Gly303Arg) and c.1055G>A (p.Arg352Gln). In a review of the literature, c.1054C>T (p.Arg352Trp) was the most common mutation reported in Far East Asian countries. This report describes the clinical features, biochemical data, molecular characteristics, and clinical outcome of a Korean patient with SLOS.

• Journal of the Korean Society for Nondestructive Testing
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• v.27 no.6
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• pp.531-540
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• 2007

While determination of the solid propellant burning rates by ultrasound, it has been reported that the frequent data scatters were caused by two major factors; 1) variation in the acoustical properties, and 2) non-linear burning of a solid propellant sample under investigation. This work is carried out for the purpose of investigating the effect of non-linear burning of solid propellant samples. Specifically, we propose an ultrasonic measurement model that can predict the reflections from solid propellant surfaces with non-linear burning by the combination of two ingredients; 1) a pulse-echo ultrasonic measurement model for a planar, circular reflector imbedded in the second medium in an immersion set-up, and 2) an efficient model of non-linear burning surfaces with a number of small, planar circles. Then, we demonstrate the capability of the proposed measurement model by simulation of the surface echo signals from four different burning surfaces that have been generated by the combination of two factors; the base shape (flat or paraboloidal) and the surface roughness (perfectly smooth or randomly rough). From the simulation presented here, we can confirm the fact that the non-linear burning of the propellant can cause the waveform change of the burning surface echo and the corresponding spectrum variation.

• Journal of the Korean Institute of Intelligent Systems
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• v.19 no.5
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• pp.629-634
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• 2009

In real-time system application, the feature extraction and scoring algorithm for classification of the passive sonar target has the following problems: it requires an accurate and efficient feature extraction method because it is very difficult to distinguish the features of the propeller shaft rate (PSR) and the blade rate (BR) from the frequency spectrum in real-time, it requires a robust and effective feature scoring method because the classification database (DB) composed of extracted features is noised and incomplete, and further, it requires an easy design procedure in terms of structures and parameters. To solve these problems, an intelligent feature extraction and scoring algorithm using the evolution strategy (ES) and the fuzzy theory is proposed here. To verify the performance of the proposed algorithm, a passive sonar target classification is performed in real-time. Simulation results show that the proposed algorithm effectively solves sonar classification problems in real-time.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.11 no.9
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• pp.1658-1664
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• 2007

The popularity of OFDM systems is being increased because of high speed data transmission capability md the spectral efficiency characteristics. However, since OFDM systems are very sensitive to the Doppler spread, The interference among subcarriers and the total system noise can be increased seriously due to the degree of Doppler effects which can cause the orthogonality problems. Therefore, these Doppler effects were analyzed using the Doppler spectrum models by varying its parameters. Especially in this paper, The degree of system performance degradation was investigated for the OFDM systems applying the relatively simple transmit and receiver diversity. The degree of the system performance degradation depends on the specific diversity structures of transceiver systems. Here, the performances of OFDM systems with two antennas transceiver diversity were analyzed and compared with that of systems with only transmission diversity and without diversity as the Doppler characteristics varied.

• Journal of the Korea Society of Computer and Information
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• v.24 no.11
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• pp.153-161
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• 2019

In this paper, we proposed a method to measure the feed intake of cattle using the cattle's gulp downing sounds. To measure the sound of cattle's gulp downing, the recording is performed through a wearable device attached to the cattle's neck. A lot of noises are recorded according to the ranching environment. This paper proposed a method for spectralizing raw gulping sound data containing white noise and removing white noise through the signal transformation using a filter. This allows the feed intake to be measured. Through the proposed white noise reduction method, it was possible to extract only the cattle's gulp downing sound, and through this, the number of cattle's gulp downing could be measured. The proposed method in this paper makes it possible to measure cattle's feed intake easily, so that estrus prediction, health care for cattle, and feed management can be done efficiently.

• Journal of Advanced Navigation Technology
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• v.23 no.5
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• pp.373-379
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• 2019

AeroMACS spectrum is a national resource internationally allocated by ITU at WRC-07. AeroMACS is an airport broadband mobile communication infrastructure based on WiMAX-based IEEE 802.16e that enables real-time video, graphics, voice, and high-speed data transmission. With the approval of ICAO's development technology standards in 2008, 50 airports in 11 countries have already completed the testing of D-TAXI or A-SMGCS technology using the AeroMACS infrastructure in 2019, starting in the United States in 2009. With many advantages in safety and convenience in terrestrial telecommunications operations, the system is becoming an area of performance improvement for airport operations in accordance with ICAO's ASBU plan. This paper examines the current status of domestic development of AeroMACS and lists service areas applicable to airlines and operators. It also seeks to promote safe and efficient next-generation airport mobile communication system services by presenting feasible partners management in the mobile area and use of aircraft communication systems for active technology development.

• Proceedings of the Korea Water Resources Association Conference
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• 2015.05a
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• pp.244-244
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• 2015

Managed Aquifer Recharge (MAR) in the form of Aquifer Storage and Recovery (ASR) systems are being applied for numerous water augmentation projects both in developed and developing countries. Given the onset of Climate Change and its influence on weather patterns and land use, it has been acknowledged the utilization of this technology will be ever increasing. This technique like all others does have its drawbacks or disadvantages, whereby to overcome these drawbacks or disadvantages it is recommended that logical planning process be followed. In this study, we developed a decision framework known as "Decision framework for the planning, designing, construction/testing and implementation of subsurface water storage system" to further standardize the planning and design process of subsurface water storage system to increase the probability of having a successful ASR/ASTR project. The formulation of this framework was based on earlier frameworks, guidelines, published papers and technical reports which were compiled into a data collection database. The database of which consider both qualitative and quantitative aspect for example recharge objectives, site location, water chemistry of the native, source and recovered water, aquifer characteristics(hydraulic conductivity, transmissivity, porosity), injection/pumping rate, ecological constraints, societal restrictions, regulatory restrictions etc. The assimilation of these factors into a singular framework will benefit the broad spectrum of stakeholder as it maps the chronological order under which ASR project should be undertaken highlighting at each stage the feasibility of the project. The final stage of which should result in fully operational ASR system. The framework was applied to two case studies and through the application of a modified ASR site selection suitability index (Brown et al., 2005) a score was derived to identify the performance of each site. A high score of which meant a maximize chance of success given the reduce presence of project constraints.