• Proceedings of the Korean Vacuum Society Conference
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• 2008.02a
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• pp.171-171
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• 2008

• Analytical Science and Technology
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• v.5 no.2
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• pp.229-234
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• 1992

Stable Isotope Mass Spectrometric technique was studied for quality assessment of Korean Honey and compared with the current regulation for the feasibility of adaptation to the regulation.

• Archives of Pharmacal Research
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• v.22 no.4
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• pp.414-416
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• 1999

A shkionin derivative was isolated from the roots of Lithospermum erythrorhizon with silica gel column chromatography and preparative TLC. The structure of the isolated pigment was identified as propionylshikonin by NMR and mass spectrometric analysis. The isolation of propionylshiknin was for the first time in the nature.

• Bulletin of the Korean Chemical Society
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• v.30 no.8
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• pp.1864-1866
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• 2009

• Analytical Science and Technology
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• v.24 no.6
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• pp.407-413
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• 2011

Over the last decade sophisticated and powerful microcapillary HPLC for proteomic analysis have been developed increasingly and interfaced with high resolution tandem mass spectrometers. Separation prior to mass spectrometric (MS) analysis removes impurities, and concentrates analytes in the narrow elution peaks, resulting in increased sensitivity of MS analysis. This review will focus on the recent advances of on-line highperformance separation techniques based on microfluidic chips for complex proteomic analysis.

• Mass Spectrometry Letters
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• v.15 no.1
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• pp.26-39
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• 2024

Gold nanostructures (Au NSs) are useful and interesting matrices for mass spectrometric analysis of various biomolecules based on organic matrix-free laser desorption/ionization time-of-flight mass spectrometry (LDI-TOF-MS). Au NSs provide high efficiency and versatility in LDI-TOF-MS analysis based on their well-established synthesis and surface functionalization, large surface area, high laser absorption capacity, and photothermal conversion efficiency. Therefore, Au NSs based LDI-TOF-MS can be a facile, functional, and efficient analytical method for important small biomolecules owing to its simple preparation, rapid analysis, salt-tolerance, signal reproducibility, and quantitative analysis. This review chronologically summarizes the important advance of Au NSs-based LDI-TOF-MS platforms in terms of in-depth mechanism, signal enhancement, quantitative analysis, and disease diagnosis.

• Journal of the Korean Chemical Society
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• v.44 no.4
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• pp.322-327
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• 2000

A new absorption spectrometric method for the determination of the Cr$_2O_7^{2-}$ ionin acidic media has been developed. The new method is based on the oxidation-reduction reaction of the HCr$O_4^-$ ion with H$_2$O$_2$forming a deep blue CrO(O$_2$) $_2$ andis coupled with a technique of flow injection analysis(FIA). The new method provides a linear calibration curve which accurately follows the Beer's law over a wide range of the analytical concentrations(2.0 ${\times}$ $10^{-6}$M~8.0 ${\times}$ $10^{-3}$M) of K$_2$Cr$_2$O$_2$. The sensitivity of the new method is approximately two times greater than the current method and the effects of the interfering substances such as V, Co, Ni, Fe, and Mn are almost negligible except Cu.

• Journal of the Korean Society of Tobacco Science
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• v.30 no.2
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• pp.117-124
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• 2008

A solid phase microextraction (SPME) method in combination with gas chromatography/mass spectrometric techniques was used for the extraction and quantification of 12 selected agrochemical residues in tobacco. The parameters such as the type of SPME fiber, adsorption/desorption time and the extraction temperature affecting the precision and accuracy of the SPME method were investigated and optimized. Among three types of fibers investigated, polyacrylate (PA), polydimethylsiloxane (PDMS) and polydimethylsiloxane-divinylbenzene (PDMS-DVB), PDMS fiber was selected for the extractions of the agrochemicals. The SPME device was automated and on-line coupled to a gas chromatograph with a mass spectrometer. Mass spectrometry (MS) was used and two different instruments, a quadrupole MS and triple quadrupole MS-MS mode, were compared. The performances of the two GC-MS instruments were comparable in terms of linearity (in the range of 0.01$\sim$0.5 $\mu$g/mL) and sensitivity (limits of detection were in the low ng/mL range). The triple quadrupole MS-MS instrument gave better precision than that of quadrupole MS system, but generally the relative standard deviations for replicates were acceptable for both instruments (< 15%). The LODs was fully satisfied the requirements of the CORESTA GRL. Recoveries of 12 selected agrochemicals in tobacco yielded more than 80% and reproducibility was found to be better than 10% RSD so that SPME procedure could be applied to the quantitative analysis of agrochemical residues in tobacco.

• Mass Spectrometry Letters
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• v.12 no.3
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• pp.81-84
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• 2021

Collagen, which accounts for one-third of human protein, is reduced due to human aging, and much attention is focused on making collagen into food to prevent such aging. Gel permeation chromatography with Reflective Index (RI) detection (GPC/RI) was chosen as the most suitable instrument to confirm molecular weight distribution, and we explored the use of this technique for analysis of collagen peptide molecular sizes and distributions. Data reliability was verified by matrix-assisted laser desorption/ionization coupled to time-of-flight (MALDI-TOF) mass spectrometric analysis. The data were considered meaningful for comparative analysis of molecular weight distribution patterns.

• Archives of Pharmacal Research
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• v.7 no.1
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• pp.23-31
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• 1984

An improved mass spectrometric method for multicomponent analysis of metabolites in urine, well-suited for clinical biochemistry, is described. The method involves solvent elution of the metabolites from an adsorbent and the concentration of the eluate on a microadsorption column. This is administered by a direct inlet probe into the ionizing source of field ionization mass spectrometry (FIMS), which yield a molecular weight profile of the metabolites. The procedure provides rapidly (within one hour) reproducible profiles from a small volume of urine. The optimization of the sampling technique and the reproducibility are discussed.