• Tuberculosis and Respiratory Diseases
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• v.50 no.5
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• pp.557-567
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• 2001

Background : Tumor angiogenesis is required for tumor growth and metastasis. In this study, we investigated the correlation between the intensity of angiogenesis and stage, nodal status, histologic type, metastasis and survival rate of non-small cell lung cancer. Method : Formalin fixed, paraffin embedded surgical specimens of 45 patients who had surgically resected primary non-small cell lung cancers without pre or post operative adjuvant chemotherapy or radiotherapy were examined. The microvessel count(MVC) was demonstrated by immunohistochemical staining for CD31(platelet endothelial cell adhesion molecule, PECAM). Results : Microvessel counts(MVCs) in stage IIIA and IIIB were higher than in stage I and II(p<0.05). The MVC in patients with lymph node metastasis was higher than that in patients without lymph node metastasis, although the difference was not statistically significant(p>0.05). However, in adenocarcinoma, the MVC in patients with lymph node metastasis was significantly higher than that seen in patients without lymph node metastasis(p<0.05). The MVC in adenocarcinoma was higher than that in squamous cell carcinoma(p<0.05). The difference between the MVCs of adenocarcinoma and squamous cell carcinoma was not statistically significant in stage I and II or N0 stage(p>0.05). However, in stage IIIA and IIIB or N1~3 stage, the MVC in adenocarcinoma was higher than that in squamous cell carcinoma(p<0.05). MVC was more increased when metastasis developed within 12 months. In the same histologic type and stage, the duration of survival time in patients with high MVC was shorter than in patients with low MVC, however the difference was not statistically significant(p>0.05). The survival rate in patients with high MVCs was lower than that in patients with low MVCs(P<0.05). Conclusion : In non-small cell lung cancer, MVC correlated relatively well with pathologic stage, nodal status(limited in patients with adenocarcinoma), histologic type, postoperative metastasis and survival rate. However, in the same histologic type and stage, MVC was not significantly related to the duration of survival. Therefore the assessment of the intensity of angiogenesis in non-small cell lung cancer may be helpful in predicting prognosis and in selecting patients for systemic adjuvant therapy of potential metastasis according to the results.

• Tuberculosis and Respiratory Diseases
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• v.45 no.4
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• pp.776-784
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• 1998

Background: The cyclin D1 gene is one of the most frequently amplified chromosomal regions(11q13) in human carcinomas. In laryngeal and head and neck carcinomas, its overexpression has been shown to be associated with advanced local invasion and presence of lymph node metastases. Cyclin D1 may therefore playa key role in cell growth regulation and tumorigenesis. Lung cancer is a worldwide problem and in many contries it is the most lethal malignancy. As relapse is frequent after resection of early stage non-small cell lung cancer, there is an urgent need to define prognostic factors. Purpose: This study was undertaken to evaluate the prognostic value of the cyclin D1, that is one the G1 cyclins which control cell cycle progression by allowing G1 to S phase transition, on the patients in radically resected non-small cell lung cancer. Method: Total 81 cases of formalin-fixed paraffin-embedded blocks from resected primary non-small cell lung cancer from January 1, 1983 to July 31, 1995 at Hanyang University Hospital were available for both clinical follow-up and immunohistochemical staining using monoclonal antibodies for cyclin D1. Results : The histologic classification of the tumor was based on WHO criteria, and the specimens included 45 squamous cell carcinomas, 25 adenocarcinomas and 11 large cell carcinomas. Cyclin D1 overexpression was noted in 26 cases of 81 cases tested (30.9%). Cyclin D1 expression was not significantly associated with cell types of the tumor, pathological staging and the size of the tumor. But cyclin D1 overexpression was significantly correlated with positive lymph node metastasis(p=0.035). The mean survival duration was $22.76{\pm}3.50$ months in cyclin D1 positive group and $45.38{\pm}5.64$ months in eyclin D1 negative group. There was a nearly significant difference in overall survival between cyclin D1 positive and negative groups(p=0.0515) in radically resected non-small cell lung cancer. Conclusion: Based on this study, cyelin D1 overexpression appears an important poor prognostic indicator in non-small cell lung cancer and may have diagnostic and prognostic importance in the treatment of resectable non-small cell lung cancer.

• Journal of the korean academy of Pediatric Dentistry
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• v.29 no.3
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• pp.389-396
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• 2002

The purpose of this study was to compare the microtensile bonding strength of chemomechanically excavated dentin($Carisolv^{TM}$) to conventional caries removal(bur). The following adhesive systems were used; AB: All-Bond 2(3M, USA), PB: Prime & Bond 2.1(Dentsply, DE), AQ: AQ Bond(sun medical, Japan). 42 human molars with occlusal caries were assigned to 6 groups. Sequential caries removal was controlled with laser fluorescence. Each group was devided as follows; group A, B, C were $Carisolv^{TM}$ applied, group D,E,F were bur used. In group A and D, AB was used as a dentin adhesive. group B,E and group C,F was AQ and AQ was used each. The cavity was filled with composite resin(Z-100). The specimens were sectioned vertically into multiple serial 0.7 mm thick slabs. And then those slabs were sectioned into rectangular parts under 0.7 mm width. Finally 0.7-1.0 mm a right hexahedron shape stick become. Microtensile bonding test was carried out with testing apparatus at cross-head speed of $0.5\;mm/min^{-1}$ and fractured surfaces were observed with scanning electron microscope(JSM-6400, Jeol, Japan). The obtained results were summarized as follows ; 1. In the group of caries removal with $Carisolv^{TM}$, micro-tensile bonding strength decreased to $75.8{\sim}80$ percent of bur used group. 2. In the group of caries removal with $Carisolv^{TM}$, decreased degree of micro-tensile bonding strength is not so different in 3 kinds of dentin adhesives(p<0.05). 3. In the group of caries removal with $Carisolv^{TM}$, microtensile bonding strength of AB, PB, AQ was 32.6MPa(2.4), 30.1Mpa (1.8), 21.2Mpa(1.9). 4. In the group of caries removal with Bur and $Carisolv^{TM}$, microtensile bonding strength of AQ was significantly lower than that of AB and PB(p<0.01).

• Journal of the korean academy of Pediatric Dentistry
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• v.29 no.3
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• pp.376-381
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• 2002

The purpose of this study was to analyse the color of natural deciduous teeth in Korean children and to compare with that of composite resin specimens. The subjects were 148 children (80 boys and 68 girls) with good general condition and normal teeth color, aged between 3 and 6 years. The color of middle third of maxillary central incisor in deciduous teeth was examined with shade guide and then measured by means of the colorimeter CV300 which can be measured by CIELAB system. The data were analyzed statistically by SPSS program. The results were summerized as follows; 1. Over 90% of the color for the deciduous anterior teeth was in A1, A2, B1, B2 and P shade. 2. The means of deciduous teeth color were $L^*=58.72,\;a^*=-1.18,\;b^*=-0.63$ by colorimeter CV300. 3. $L^*,\;a^*\;and\;b^*$ prices for A1, A2, B1, B2, P were $L^*=52.52,\;a^*=-1.90,\;b^*=1.18$ in A1 specimen, $L^*=54.90,\;a^*=-1.87,\;b^*=1.60$ in A2 specimen, $L^*=59.80,\;a^*=-2.70,\;b^*=-0.63$ in B1 specimen, $L^*=56.90,\;a^*=-1.70,\;b^*=1.63$ in B2 specimen, $L^*=52.93,\;a^*=-2.33,\;b^*=1.10$ in P specimen. The means of B1 color specimen were most similar to those of deciduous teeth color. The A1 color values were similar to the P color values. 4. The standard deviation of $L^*,\;a^*$ was small among colors, but that of $b^*$, in the yellowish color, was large.

• Journal of the Korean Institute of Landscape Architecture
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• v.38 no.1
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• pp.119-128
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• 2010

The purpose of this study was to find a basic theory about Korean traditional planting pattern by analyzing a characteristic of planting and planted species in Haein, Tongdo and Songkwang Temples. The results are as follows. The planted species in three-treasure temples were 129 taxa; 57 families, 96 genera, 110 species, 12 varieties and 7 forma. The species related in Buddhism were Viburnum sargentii for. sterile, Hydrangea macrophylla for. otaksa and Musa basjoo. They are related in plant form and Buddhist ceremony. The results of forms were 34.1% in trees, 33.3% in shrubs, 3.9% in vine and 28.7% in herbage. The results of leaf fall were 56 taxa in broad-leaved deciduous trees, 27 taxa in broad-leaved evergreen trees and 14 taxa in needle-leaved evergreen trees. The native species were 32 taxa in Haein Temple, 27 taxa in Tongdo Temple and 44 taxa in Songkwang Temple. And the exotic species were 20 taxa, 28 taxa and 44 taxain the Haein, Tongdo and Songkwang Temples, respectively. In the results of analyzing the characteristics of planting, in the case of Haein Temple, Abies holophylla was linearly planted in Yiljumun, and Magnolia denudata was single planted in plant stairs of Haetalmun. In the case of plant stairs of Jeokmukdang, Cephalotaxus koreana was planted at regular intervals. In the case of Tongdo Temple, Celtis sinensis, Zelkova serrata and so forth were planted in Yiljumun, and Phyllostachys nigra was planted in form of screen planting in Youngsanjeon. The form of Hwanghwagak was a planting of symmetry in the center of a building, and the one of Daekwangmyyeongjeon was a mixed planting. The regular planting pattern was not shown in Yiljumun of Songkwang Temple. In the case of Dosungdang, Corunus officinalis was linearly planted in the west. In the case of Gwaneumjeon, Juniperus chinensis var. globosa and Camellia japonica were planted in symmetry. The old aged trees were planted in front of specimens planted in front of Daewoongbojeon.

• Journal of dental hygiene science
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• v.10 no.6
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• pp.451-457
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• 2010

It is well known that most of the beverages on sale contain acid. Among these beverages, one of the most typically purchased products is Coca-Cola ($Coke^{(R)}$), which affects the demineralization of the tooth enamel surface. However other beverages also affect the erosion of the tooth enamel surface. Therefore, the aim of this study was to observe the influence that acid containing beverages have upon the tooth enamel surface. In this study, 30 enamel specimens were obtained from extracted maxillary third molars without cracks. The study measured the pH concentrations and the Ca and P concentration levels of the acidic beverages. The control without exposure was kept in distilled water, and each enamel specimen was stored for 30-min, 60-min, and 120-min. The erosion effect of the enamel surface was observed by SEM. The results obtained from this study can be summarized as follows: 1. The pH concentration of acidic beverages, without milk, was 3.105 on average. The beverages eroded the enamel surface and the erosion degree was determined by the pH concentration of beverages. 2. The erosion degree significantly increased by as the exposure time increased. The difference in the erosion degree between the 30-min group and the 60-min and the 120-min group was significant, but the erosion degree of the 120-min group was significantly less than that of the initial group. 3. When compared with the beverages containing similar pH concentrations, the demineralization degree of the beverages containing higher concentrations of Ca and P was lower.

• Journal of Korean Tunnelling and Underground Space Association
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• v.19 no.6
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• pp.1059-1075
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• 2017

The objective of this study was to evaluate the freezing and thawing resistance of the existing drainage system for leakage treatment of underground concrete structures operating in cold regions. The freezing and thawing test was conducted on 4 types of drainage system specimens to evaluate the freezing and thawing resistance of the drainage system. The freezing and thawing resistance was evaluated on 4 types of Hotty-gel, as a waterproofing material, connection methods and on two methods to fix the drainage board with Hotty-gel on the surface of cement concrete specimen. One cycle of the freeze-thaw testing was 48 hours (24 hours of freezing and 24 hours of thawing), and the temperatures of freezing and thawing were at $-18^{\circ}C$ and $10^{\circ}C$, respectively. Among the 4 types of Hotty-gel connection methods, leakage occurred after 28 cycles (8 weeks) of freeze-thawing only in the Hotty-gel connection method with the 'V' groove applied to the corner of the drainage board. No leakage occurred in the 3 types of Hotty-gel connection methods. In two fixing methods, leakage occurred in the method of fixing the drainage board on the cement concrete specimen using the washer, screw and plastic wall plug. Leakage occurred at one point after 10 cycles (3 weeks) of freezing and thawing. After 28 cycles (8 weeks) of freezing and thawing, leakage point increased to 5 points. As time passed, the leak point was not increased, but the amount of leakage was increased at each leak point. The Hotty-gel connection method with cross-sectional diagonal shape was evaluated to be the highest in the production efficiency considering the production time and manufacturing method of the Hotty-gel connection shape. In the construction efficiency considering the construction time and construction method, the fixing method of air nailer, fixed nail and washer was superior to that of the washer, screw and plastic wall plug.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.31 no.2
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• pp.136-142
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• 2009

Bone density in the recipient implant site seems to be an important factor for long term success of endosseous implants. Preoperative evaluation of bone density is very helpful to assist the clinician with the treatment planning of implant therapy. Accurate information on bone density will help the surgeon identify suitable implant sites, thereby improving the success rate of the procedure. Purpose; The aim of this study was to evaluate a correlation between bone density measured preoperatively with computerized tomography and histologically measured bone density by bone biopsy. Patients and methods; Twenty seven patients were selected. All the patients were in good health, with no systemic disorder and additional bone graft. Preoperatively the patients underwent CT scanning to evaluate Houmsfield Unit(HU). Each patients wore a surgical template for implant placement. During surgery 2mm in diameter and 6mm in length specimens were taken. Histomorphometric analysis was performed using digitalized image analysis software Axiovision 4.3. Also, the Resonance frequency analysis(RFA) and insertion torque values were recorded. Results; The highest histomorphometric values was found in the posterior mandible $32.3{\pm}3.8$, followed by $29.9{\pm}2.6$ for the posterior maxilla, $29.4{\pm}2.6$ for the anterior maxilla, $28.6{\pm}2.3$ for the anterior mandible(p=0.214). The hounsfield unit was $989.2{\pm}258.1$ in the posterior mandible, $845.0{\pm}241.5$ in the anterior maxilla, $744.5{\pm}92.6$ in the anterior mandible, $697.3{\pm}136.9$ in the posterior maxilla(p=0.045). This results may suggest that there are strong correlation between the histomorphometric values and hounsfield unit(r=0.760, p<0.05). The RF measurements were $81.9{\pm}2.4$ ISQ in the posterior mandible, $79.0{\pm}1.4$ ISQ in the anterior mandible, $78.3{\pm}4.6$ ISQ in the posterior maxilla, $76.5{\pm}5.0$ ISQ in the anterior maxilla(p=0.048). The insertion torque values was $43.2{\pm}4.2\;Ncm$ in the posterior mandible, $42.0{\pm}0.0\;Ncm$ in the anterior mandible, $41.3{\pm}4.1\;Ncm$ in the posterior maxilla, $40.8{\pm}3.8\;Ncm$ in the anterior maxilla(p=0.612). This results may suggest that there are statistical significance between the hounsfield unit and the insertion torque values(r=0.494, p<0.05), the histomorphometric values and the insertion torque values(r=0.689, p<0.05). But there was no correlation between histomorphometric values and ISQ. There was no statistical significance in age and gender effect on parameters. Conclusions; There was significant correlations between bone density and implant stability parameters. The bone density measurements using preoperative CT may help clinicians to predict primary stability before implant insertion, which is associated with implant survival rates.

• Journal of dental hygiene science
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• v.12 no.5
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• pp.477-485
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• 2012

This study evaluate the influence of food staining food and bleaching on the color (CIELAB) and reflectivity of two-way (anterior & posterior) composite resin and flowable composite resin. There were 6 immersion media: kimchi, red pepper paste, blueberry, tea, curry and distilled water. A total of 36 specimens ($11{\times}11{\times}2$ mm) were prepared and immersed in each immersion media for 8 days at $37^{\circ}C$. Their color and reflectivity measured with the spectrophotometer at baseline and every 24 hours. Data from the color change and reflectivity were collected and subjected to statistical analysis by ANOVA, ANCOVA and RM-ANOVA. Curry showed the highest influence on color change and blueberry on brightness (p<0.001) on both resins. Bleaching after polishing made color change more than polishing or bleaching independently on two-way (anterior & posterior) composite resin, but not on flowable composite resin. It was suggested cleaning the mouth after taking curry and blueberry be needed to maintain the original color of composite resin.

• Korean Journal of Ichthyology
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• v.6 no.2
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• pp.132-159
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• 1994

The taxonomic revision of the family Congridae was made based on the specimens collected from the south-western coasts of the Korea from June 1988 to Oct. 1993. The family Congridae was classified into 8 species belonging to 6 genera. based on the external and internal morphological characters : Anago anago, Ariosoma anagodies, Ariosoma shiroanago shiroanago, Conger myriaster, Conger japonicus, Gnathophis nystromi nystromi, Rhechias retrotincta and Uroconger lepturus. Among the species reported as the congrid eels from Korea until now, four species were transferred into different generic or specific name Conger flavirostris into Ariosoma anagoides ; Astroconger myriaster into Conger myriaster ; Congrina retrotincta into Rhechias retrotincta and Rhynchocymba nystromi into Gnathophis nystromi nystromi. A Korean congrid eel, Ariosoma shiroanago shiroanago, was reported for first time in Korea. Intergeneric characters of the family Congridae were the form of the lateralline scales, the state of the tip of tail, the segmented state of the dorsal and anal fin rays, the existance of the supraoccipital bone and of lateral ethmoid process of the skull, the origin of dorsal fin and the forms of upper labial flange. The interspecific classification was made according to the characters such as the numbers of sensory pores of head part and in front of vent, teeth rows and numbers of upper and lower jaw, the numbers of vertebrae, the body color, the shapes of the head part, the color of intestine, the size of eye, the structure of air bladder and the number of branchiostegal rays. A new key on the taxonomical characteristics to the genera and species of the family Congridae has been estabilished and their distribution in Korea is described.