• Proceedings of the Korean Society of Developmental Biology Conference
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• 2003.10a
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• pp.78-78
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• 2003

Adult stem cells can make identical copies of themselves for long periods of time. They also give rise to many differentiated mature cell types that have characteristic morphology and specialized function. Human adult stem cells are the attractive raw materials for the cell/tissue therapy, however, it is not easy to get from the adult tissues. In the present study, we tried to isolate a cell population derived from human umbilical cord vein which has been discarded after birth. The cells were isolated after treatment of the umbilical vein with collagenase or trypsin. After 3 days of culture, two kinds of cell populations were found consisting of adherent cells with endothelial cell-like and fibroblast-like morphology, respectively. When these cells were subcultured 12 times over a period of 3 months, almost cells appeared uniformly to exhibit fibroblastoid morphology which was different from that of mesenchymal stem cells obtained from human bone marrow The results of RT-PCR analyses showed distinct expression of BMP-4, oct-4, and SCF genes but not of GATA, PAX-6 and Brachyury genes. On immunohistochemical staining, the cells were negative for the von Willebrand factor(vWF), alpha-smooth muscle actin and placental alkaline phosphatase. From these observations, it is suggested that stem-like cells might be present in human umbilical cord vein.

• Journal of The Korean Society of Clinical Toxicology
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• v.2 no.2
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• pp.90-95
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• 2004

Purpose: The purpose of this study is to compare the toxicologic characteristics of two groups of patients with acute intoxication for two different time periods and to make recommendations based on the results of this study. Methods: We reviewed retrospectively the medical records of patients with acute intoxication in our emergency center from June 1997 to May 1998 (group A) and from June 2000 to May 2003 (group B), and we evaluated differences in the epidemiologic and the toxicologic characteristics between the two groups. Results: The ratios of the number of patients with acute intoxication to the total numbers of patients who visited our emergency department were $0.49\%$ and $0.52\%$ for groups A and B, respectively. In both groups many poisoned patients visited our emergency center from 4:00 pm to midnight. The interval between the time of intoxication and arrival at the hospital was significantly shorter in group B. The number of patients transferred to our emergency center was larger in group B. Attempted suicide was the major cause of acute intoxication in both groups. Major toxic substances in both groups were centrally active drugs and insecticides. The number of comatose and mechanically ventilated patients was larger in group B. However, there was no statistically significant difference in the mortality rates. Conclusion: Emergency physicians who manage intoxicated patients should recognize regional characteristics and differences in the toxicologic characteristics of poisoning. In addition, the establishment of a poisoning control center in the regional emergency center is necessary to integrate data control and to enhance specialized management of intoxicated patients.

• Journal of Distribution Science
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• v.14 no.10
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• pp.153-164
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• 2016

Purpose - In general, large companies have larger organizations, funds, and systems to provide more effective and efficient services in the market. However, development needs to support the livelihood of ordinary citizens who work for small businesses as well. This research suggests that a new distribution channel, called a "foothold style Kosa mart," that cooperates jointly with a distribution center and a large discount mart can provide direct solutions to small and mid-size distributors. This new distribution channel can achieve a limited type of "Nadle shop (small supermarket) foster project" related to building a joint distribution center and improvement in wholesale supply. Research design, data, and methodology - Data about the Korea distribution situation, the Nadle stores, and the logistics centers were collected from literature, Statistics Korea, journals, and reports. Specifically, we investigated information about Kosa Mart and Nadle stores. We focused on the redesign of the distribution center for the Nadle store. Results - The Kosa Mart distribution center now includes 18 warehouses, and has been handling 2000-3000 items. Most of the warehouses have been simply designed and items loaded and stored without refrigeration; thus, it is possible to store only products of certain manufactured goods. The current logistics center has no wholesale function because it failed to resolve the joint purchasing and product supply issues of competitively priced products. Conclusions - This study aimed to identify ways to strengthen the competitiveness of small- and medium-sized retailers. A Kosa Mart redesign aims to unifying the logistics center, stores, and customers. First, the joint wholesale logistics system, equipped with an integrated ordering system, needs to process customer orders and store orders at the same time. Second, excellent small business product development has to connect with production. Third, the store composition needs to support a shipping hub. Fourth, the Mart differentiates itself from convenience store goods by supplying regional and specialized products to customers. Fifth, a service buying agent and direct transactions between producers and consumers need to be established, and exhibits and displays of goods need to be improved.

• Genomics & Informatics
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• v.7 no.1
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• pp.38-40
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• 2009

The EST Knowledge Integrated System, EKIS (http://ekis.kribb.re.kr), was established as a part of Korea's Ministry of Education, Science and Technology initiative for genome sequencing and application research of the biological model organisms (GEAR) project. The goals of the EKIS are to collect EST information from GEAR projects and make an integrated database to provide transcriptomic and metabolomic information for biological scientists. The EKIS constitutes five independent categories and several retrieval systems in each category for incorporating massive EST data from high-throughput sequencing of 65 different species. Through the EKIS database, scientists can freely access information including BLAST functional annotation as well as Genechip and pathway information for KEGG. By integrating complex data into a framework of existing EST knowledge information, the EKIS provides new insights into specialized metabolic pathway information for an applied industrial material.

• Lingua Humanitatis
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• v.1 no.1
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• pp.235-251
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• 2001

According to Chomskyan grammar, humans can generate and understand an unbounded number of grammatical sentences. Against the background of pure and idealized linguistic competence, this linguistic productivity is argued and understood. In actual utterances, however, there are many limitations of productivity but they are said to come from the general constraints on performances such as capacity of short term memory or attention. In this paper I discuss a problem raised against idealized productivity. I argue that linguistic productivity idealizes our linguistic competence too much. By separating idealized competence from the various constraints of performance, Chomskyan theorists can argue for unlimited productivity. However, the absolute distinction between grammar (pure competence) and parser (actual psychological processes) makes little sense when we explain the low acceptability(intelligibility) of center embedded sentences. Usually, the problem of center embedded sentence is explained in terms of memory shortage or other performance constraints. To explain the low acceptability, however, we need to assume specialized memory structure because the low acceptability occurs only with a specific type of syntactic pattern. 1 argue that this special memory structure should not be considered as a general performance constraint. It is a domain specific (specifically linguistic) constraints and an intrinsic part of human language processing. Recent development of Chomskyan grammar, i.e., minimalist approach seems to close the gap between pure competence and this type of specialized constraints. Chomsky's earlier approach of generative grammar focuses on end result of the generative derivation. However, economy principle (of minimalist approach) focuses on actual derivational processes. By having less mathematical or less idealized grammar, we can come closer to the actual computational processes that build syntactic structure of a sentence. In this way, we can have a more concrete picture of our linguistic competence, competence that is not detached from actual computational processes.

• Journal of Korea Water Resources Association
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• v.48 no.6
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• pp.463-477
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• 2015

The recent unusual climate and extreme weather events have frequently given unexpected disaster and damages, facing difficulties in the management of water resources. In particular, climate change could result in intensified typhoons, and this would be the worst case scenario that can happen. The primary objective of this study is to identify the patterns of typhoon-induced precipitation and the associated synoptic pattern. This study focused on analyzing precipitation patterns over the South Korea using historic records as opposed to a specified season or duration, and further investigates the potential connection with heavy rainfall to synoptic patterns. In this study, we used the best track data provided by the Regional Specialized Meteorological Center of Japan for 40 years from 1973 to 2012. The patterns of the typhoon-induced precipitation were categorized into four groups according to a given typhoon track information, and then the associated synoptic climatology patterns were further investigated. The results demonstrate that the typhoon-induced precipitation patterns could be grouped and potentially simulated according to the identified synoptic patterns. Our future work will focus on developing a short-term forecasting model of typhoon-induced precipitation considering the identified climate patterns as inputs.

• The Journal of Korean Society for School & Community Health Education
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• v.2 no.1
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• pp.41-52
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• 2001

The purpose of this research is to plan the activation of university health business through the appraisal of the function and role of university health centers. To be more specific: Firstly, analyze the facility, personnel, health service of the health centers, Secondly, appraise the role and function of the health centers, and Thirdly, consider the activation plans of health centers. The research method taken was the study of surveys conducted and written research materials on 5 women's universities in Seoul. These materials where descriptively analyzed by converting the surveys, facility and usage of health center and current personnel status in to percentage. The major results of the research are as follows: Unlike as stated in each university's additional clause on the number of personnel were working. This lack of specialized personnel resulted into lack of specialized and various services. Medicine for external application were stocked well whereas only simple medicine for internal application were on shelf and were issued only with a doctor's prescription. Universities with a full-time doctor had various available equipments. One university conducting dental treatment was equipped with indirect chest camera, dental X-ray, unit, chair(dental treatment chair) and even supersonic, electrocardiogram were available. In the case of D women's university, the number of beds compared to the number of students was lower than that of the other 3 universities, to the total size of the university was smaller than that of the other 3 universities. Among health prevention and care matters, health consultation was the only matter practised by all universities. Uniquely, there was one university that hosted epidemic prevention business. There are various tests given by each university, with each showing many differences, but some universities did not even conduct these tests. Vaccinations were usually being conducted through commission. All universities provided basic treatment, therefore matters concerning treatment at health centers were being conducted well. Concerning the management of equipment and documents, all the matters were being conducted except one university where instead of a student medical record, they were using a daily record. Because these were women's universities, most of the educations were on women's health. The subjects of these educations included: sex, contraception, prevention and control of tuberculosis, obesity, mouth hygiene, alcohol, geriatric disease, mental health and first-aid. The rate of health center usage is growing. Being women's universities, the service and treatment practised were mostly concerning sex education.

• Clinical and Experimental Reproductive Medicine
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• v.43 no.3
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• pp.146-151
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• 2016

Objective: This study was conducted to compare the effects of static culture, dynamic culture, and the combination of dynamic culture with specialized surfaces involving co-culture on human embryonic development. Embryos cultured using conventional static culture (SC) techniques served as a control group. We compared dynamic culture using micro-vibration culture (MVC) and micro-vibration with co-culture (MCoC), in which autologous cumulus cells were used as a specialized surface. Methods: We conducted a chart review of patients who were treated between January 2011 and November 2014 in order to compare embryonic development rates and pregnancy rates among the groups. Zygotes were cultured in micro-droplets, and embryos were subsequently selected for transfer. Some surplus embryos were cryopreserved, and the others were cultured for blastocyst development. A micro-vibrator was set at the frequency of 42 Hz for duration of 5 seconds per 60 minutes to facilitate embryo development. Results: No significant differences among the groups were present in patient's characteristics. However, the clinical pregnancy rates were significantly higher in the MVC group and the MCoC group than in the SC group. No significant differences were found in the blastocyst development rate between the SC group and the MVC group, but the blastocyst development rate in the MCoC group was significantly higher than in the SC and MVC groups. Conclusion: The clinical pregnancy rate was significantly increased by the application of micro-vibration to the embryonic cultures of poor responders. The blastocyst development rate was significantly increased by the application of MCoC to surplus embryos.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.7
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• pp.4641-4650
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• 2015

This study aims to further strengthen the medical expertise to offer specialized medical care specialization strategies to gain a competitive edge through the customer segmentation of the Regional Public Hospital. Investigation period was selected to study the inpatients 26,658 people January to December 2013. The method of analysis are Cluster analysis and Decision Tree Analysis. In conclusion, female, age over 60, and diseases in musculoskeletal system and connective tissue were commonly selected as identifiers of the target market of Regional Public Hospital. Customers in this target market are loyal to specialized medical service and keeping continuous relationship with these customers through communication and monitoring of results of provided medical service would be important because the effect of word of mouth propagated to other group of customers having equivalent scale of consumption is expected. And the concentration of the scope of medical service of Regional Public Hospital and the collaboration and mutual reliance of medical service under the strategic alliance with other institutions and private hospitals are also needed.

• Journal of Korean Society on Water Environment
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• v.26 no.6
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• pp.1034-1039
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• 2010

Variation of formation potential of THM (THMFP) by chlorination of humic acid and characteristics of water quality with ${\gamma}$-ray irradiation were investigated, which were divided into two categories by the order of ${\gamma}$-ray irradiation and chlorination in water treatment process. The group A consisted of the ${\gamma}$-ray irradiation followed by chlorination process of humic acid, and the group B consisted of the chlorination followed by ${\gamma}$-ray irradiation process. The pH, ORP, $UV_{254}$, and DOC decreased rapidly with an increase in ${\gamma}$-ray irradiation of 3 kGy. while conductivity was little changed. Maximum degradation ratio of chloroform in THMs of group A was 82%, while that in group B was 69%. No brominated THMs were detected at high irradiation (>3 kGy). We found that group A water treatment process was more effective in lowering the THMFP than that of group B.