• Journal of the Korean Geographical Society
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• v.32
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• pp.58-73
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• 1985

• Research in Mathematical Education
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• v.17 no.2
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• pp.99-118
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• 2013

The present study focuses on the contribution of a teaching unit to the development of spatial ability of third graders in general and from a gender point of view in particular. The research population consisted of seventy-four pupils: thirty-seven pupils in the experimental group who attended the teaching unit and thirty-seven pupils in the control group. The spatial ability of all the pupils was examined by means of common tests which checked cognitive capabilities of spatial ability. The research findings illustrate an improvement in the spatial ability of the experimental group pupils following the participation in the teaching unit. Moreover, regarding the gender aspect, the findings show that there was no significant differentiation between the spatial ability of third grade boys and the spatial ability of girls of the same age group.

• Journal of The Geomorphological Association of Korea
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• v.24 no.2
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• pp.41-49
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• 2017

From the results of the CIA analysis (A-CN-K and A-CNK-FM ternary diagram), we concluded that granitic grus experienced low chemical alteration and contains plenty of sandy material The chemical alteration of Geochang and Gajo Basin advanced further than that of Yeongju-Bonghwa basin, but does not come to spatial differentiation as Chuncheon Basin. The weathered mantles of inner hills in the basin exhibit very weak alteration, and there is little spatial differentiation of chemical alteration between footslope of mountains, footslope hills. Most of hills are still in incipient weathering stage and have plenty of sandy materials. Therefore the chemical characteristics of granitic hills in Geochang and Gajo basin show that granitic weathered mantles are not saprolite formed by alteration but may be just grus (sandy weathered mantles).

• Journal of the Korean Geographical Society
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• v.32 no.1
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• pp.47-68
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• 1997

The purpose of this study is to clarify both the characteristics of the spatial variations and structure and the logic of spatial differentiation of the renter farming in Korea. The renter farming has transformed its spatial structure from zonal to Thunen's rings-like pattern. This study also suggests that the spatial characteristics of the renter farming has been changed from the ecological and the tenantable to the economical and commercial. Although there is no single logic full explanation the order of such spatial differentiations, the logic of industrialization or neoclassical economics seems to be most effective.

• Nuclear Engineering and Technology
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• v.43 no.6
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• pp.531-546
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• 2011

The backward differentiation formula (BDF) method is applied to a three-dimensional reactor kinetics calculation for efficient yet accurate transient analysis with adaptive time step control. The coarse mesh finite difference (CMFD) formulation is used for an efficient implementation of the BDF method that does not require excessive memory to store old information from previous time steps. An iterative scheme to update the nodal coupling coefficients through higher order local nodal solutions is established in order to make it possible to store only node average fluxes of the previous five time points. An adaptive time step control method is derived using two order solutions, the fifth and the fourth order BDF solutions, which provide an estimate of the solution error at the current time point. The performance of the BDF- and CMFD-based spatial kinetics calculation and the adaptive time step control scheme is examined with the NEACRP control rod ejection and rod withdrawal benchmark problems. The accuracy is first assessed by comparing the BDF-based results with those of the Crank-Nicholson method with an exponential transform. The effectiveness of the adaptive time step control is then assessed in terms of the possible computing time reduction in producing sufficiently accurate solutions that meet the desired solution fidelity.

• International Journal of Stem Cells
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• v.7 no.2
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• pp.108-117
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• 2014

Background and Objectives: Genomic imprinting is an inheritance phenomenon by which a subset of genes are expressed from one allele of two homologous chromosomes in a parent of origin-specific manner. Even though fine-tuned regulation of genomic imprinting process is essential for normal development, no other means are available to study genomic imprinting in human during embryonic development. In relation with this bottleneck, differentiation of human embryonic stem cells (hESCs) into specialized lineages may be considered as an alternative to mimic human development. Methods and Results: In this study, hESCs were differentiated into three lineage cell types to analyze temporal and spatial expression of imprinted genes. Of 19 imprinted genes examined, 15 imprinted genes showed similar transcriptional level among two hESC lines and two human induced pluripotent stem cell (hiPSC) lines. Expressional patterns of most imprinted genes were varied in progenitors and fully differentiated cells which were derived from hESCs. Also, no consistence was observed in the expression pattern of imprinted genes within an imprinting domain during in vitro differentiation of hESCs into three lineage cell types. Conclusions: Transcriptional expression of imprinted genes is regulated in a cell type- specific manner in hESCs during in vitro differentiation.

• BMB Reports
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• v.53 no.12
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• pp.646-651
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• 2020

Bone resorption is linked to bone formation via temporal and spatial coupling within the remodeling cycle. Several lines of evidence point to the critical role of coupling factors derived from pre-osteoclasts (POCs) during the regulation of bone marrow-derived mesenchymal stem cells (BMMSCs). However, the role of glial cell-derived neurotrophic factor (GDNF) in BMMSCs is not completely understood. Herein, we demonstrate the role of POC-derived GDNF in regulating the migration and osteogenic differentiation of BMMSCs. RNA sequencing revealed GDNF upregulation in POCs compared with monocytes/macrophages. Specifically, BMMSC migration was inhibited by a neutralizing antibody against GDNF in pre-osteoclast-conditioned medium (POC-CM), whereas treatment with a recombinant GDNF enhanced migration and osteogenic differentiation. In addition, POC-CM derived from GDNF knock-downed bone marrow macrophages suppressed BMMSC migration and osteogenic differentiation. SPP86, a small molecule inhibitor, inhibits BMMSC migration and osteogenic differentiation by targeting the receptor tyrosine kinase RET, which is recruited by GDNF into the GFRα1 complex. Overall, this study highlights the role of POC-derived GDNF in BMMSC migration and osteogenic differentiation, suggesting that GDNF regulates bone metabolism.

• Genomics & Informatics
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• v.15 no.4
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• pp.114-122
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• 2017

It is becoming increasingly clear that eukaryotic genomes are subjected to higher-order chromatin organization by the CCCTC-binding factor/cohesin complex. Their dynamic interactions in three dimensions within the nucleus regulate gene transcription by changing the chromatin architecture. Such spatial genomic organization is functionally important for the spatial disposition of chromosomes to control cell fate during development and differentiation. Thus, the dysregulation of proper long-range chromatin interactions may influence the development of tumorigenesis and cancer progression.

• The Journal of Asian Finance, Economics and Business
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• v.5 no.3
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• pp.169-178
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• 2018

This study aims is to explore of the theoretical concepts of regional imbalances and spatial inequality, analysis of spatial distribution of economic growth and identifying of "growth poles" for sustainable development in the regions of Kazakhstan. Based on the theoretical views, we conclude that the key direction of regional policy is the search and development of "growth poles", which will distribute their potential equally to backward regions. The authors propose the methodological tools for presenting a standard form of evaluation of spatial distribution and inequality of the regions of Kazakhstan. This study confirms the importance of using of proposed methods and its application for objectively and realistically defines "growth poles" for sustainable development. Further, the obtained results showed the distribution of Kazakhstan's regions by economic growth and specialization with using modified index of KDI. According to the results of this theoretical and empirical study proved that distribution of the regions of Kazakhstan and results of KDI indexes shows that the spatial differentiation of economic development, but its level and dynamics are different in different respects. In addition, according to the conducted survey, we conclude that one of the most important tasks is sustainable growth based on "growth poles" for sustainable development.

• Journal of the Korean housing association
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• v.17 no.5
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• pp.147-157
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• 2006

A study on Composing Unit Spaces of Apartment Houses according to the Differentiation in Lifestyle by survey on preferences. The purpose of this study is to propose composition models of unit spaces for 85m2 net area apartment houses by lifestyle types. This study set up a hypothesis that there is a critical divergence of preferences in composition types of unit spaces according to lifestyle. To prove the hypothesis, investigation on variable floor plans of apartments to extract spatial composition types of units and questionnaire survey on lifestyleand preferences for composition types were implemented. To extract several factors regarding, characteristics of lifestyle, factor analysis, was implemented for each variable. Cluster analysis was conducted to cluster interviewees by similarity of lifestyle. To identify and define how each factor reacts, ANOVA and cross tabulation analysis between factors and clusters were used. The type of spatial composition was analyzed by plane characteristic, spatial relation and spatial usability on the basis of apartment plate type. As a result, lifestyle was divided into three types: reasonable lifestyle, trend-seeking lifestyle and conservative lifestyle. As, the result of investigating characteristics for the type of spatial composition according to the type of lifestyle, preferred types and main districts were different. Therefore, the hypothesis was proved.