• BMB Reports
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• v.54 no.10
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• pp.505-515
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• 2021

Human pluripotent stem cells (hPSCs) include human embryonic stem cells (hESCs) derived from blastocysts and human induced pluripotent stem cells (hiPSCs) generated from somatic cell reprogramming. Due to their self-renewal ability and pluripotent differentiation potential, hPSCs serve as an excellent experimental platform for human development, disease modeling, drug screening, and cell therapy. Traditionally, hPSCs were considered to form a homogenous population. However, recent advances in single cell technologies revealed a high degree of variability between individual cells within a hPSC population. Different types of heterogeneity can arise by genetic and epigenetic abnormalities associated with long-term in vitro culture and somatic cell reprogramming. These variations initially appear in a rare population of cells. However, some cancer-related variations can confer growth advantages to the affected cells and alter cellular phenotypes, which raises significant concerns in hPSC applications. In contrast, other types of heterogeneity are related to intrinsic features of hPSCs such as asynchronous cell cycle and spatial asymmetry in cell adhesion. A growing body of evidence suggests that hPSCs exploit the intrinsic heterogeneity to produce multiple lineages during differentiation. This idea offers a new concept of pluripotency with single cell heterogeneity as an integral element. Collectively, single cell heterogeneity is Janus-faced in hPSC function and application. Harmful heterogeneity has to be minimized by improving culture conditions and screening methods. However, other heterogeneity that is integral for pluripotency can be utilized to control hPSC proliferation and differentiation.

• Journal of the Regional Association of Architectural Institute of Korea
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• v.20 no.6
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• pp.41-46
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• 2018

The context of innovation in which we evolve today, subtracts us in a spacial reality and virtuality (digital) that aimed less and less to interact with natural processes which could converge to new possible relationships in the world. We constantly live in presence of fluctuations and imperceptible natural energies (wind, solar radiation, etc.) defined by flows, their own physicality, which remains without being virtual, elusive. This study first outlines how these energies already exploited within the framework of production, could be thought as interactive of our habitat's space dimension, as a prolongation of a physical and material environment built by men and for men, giving rise to new social, cultural dynamics, and making natural complexity of our space vivid, comprehensible with new visual and physical clues. In recent days, where lifestyles are changing, architecture no longer needs to limit its scope of creation to only built structures. Based on a deeper understanding of human and through new potential advanced technologies (kinetic system, etc), it is time to fundamentally diagnose what environments or devices contribute to our lives. Architecture becomes ${\ll}interface{\gg}$, step up its fundamental role, and newly defines the sturdy image and tectonics of existing environment, establishing a stance to search for a new typology. In the end, building will show two simultaneous and distinctive connections related to its physical existence: reality in its function and irreductibility, in its ability to forge new dynamic connections with its environment, hybridizing the spatial dimension to a new form of physicality, adaptive and incessantly flexible in the dimension time, becoming a vessel for ever changing contemporary lifestyles.

• Journal of the Korea Computer Graphics Society
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• v.25 no.3
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• pp.65-73
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• 2019

Recently commercial mixed-reality devices have be launched and a variety of mixed-reality content has produced, but narrow field of view, which appear to be hardware technical limitations, are mentioned as an important issue for hindering immersion and limiting the scope of use. We propose a new innovative system that cooperate multiple beam projectors and a number of mixed reality devices. Using this technology, users can maximize immersion and minimize frustration of narrow viewing angles through 3D object rendering on background of large 2D screens. This system, named BtS (Beyond the Sight), is implemented on a client-server basis and includes the ability to calibrate between devices, share spatial coordinate systems, and synchronize real-time renderings as core modules. In this paper, each configuration module is described in detail and the possibility of its performance and application is shown through the introduction of mixed reality content case created using BtS system.

• Journal of the Economic Geographical Society of Korea
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• v.22 no.2
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• pp.123-140
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• 2019

Empathy is the ability to feel, understand, and respond to the emotions of others from the standpoint of others. Recently, 'sympathy' has emerged as an important issue not only in emotional empathy in relation to individuals but also in 'social empathy', which sees sympathy as a basic principle for maintaining society. This study focuses on the issue of empathy as a new driving force for modern society and focused on 'urban scene' as a spatial application for cultural empathy in the city. Urban scenes approach the city as a space of consumption, classify it according to its inherent attributes, and analyze its characteristics. This study approaches the existing urban scene theory in terms of empathy. In addition, as a way to consume city images reflected on contents, a concrete example of 'contents tourism'is examined, and a 'contents scene' is proposed as a new urban scene and its meaning and possibility are presented.

• Advances in Computational Design
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• v.4 no.2
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• pp.119-139
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• 2019

Planning and management building projects should tackle the coordination of works and the management of limited spaces, traffic and supplies. Activities cannot be performed without the resources available and resources cannot be used beyond the capacity of workplaces. Otherwise, workspace congestion will negatively affect the flow of works. Better on-site management allows for substantial productivity improvements and cost savings. The procurement system should be able to manage a wider variety of materials and products of the required quality in order to have less stock, in less time, using less space, with less investment and avoiding multiple storage stations. The objective of this paper is to demonstrate the advantages of using the Chronographic modeling, by combining spatiotemporal technical scheduling with the 4D simulations, the Last Planner System and the Takt-time when modeling the construction of building projects. This paper work toward the aforementioned goal by examining the impact that material flow has on site occupancy. The proposed spatiotemporal model promotes efficient site use, defines optimal site-occupancy and workforce-rotation rates, minimizes intermediate stocks, and ensures a suitable procurement process. This paper study the material flow on the site and consider horizontal and vertical paths, traffic flows and appropriate means of transportation to ensure fluidity and safety. This paper contributes to the existing body of knowledge by linking execution and supply to the spatial and temporal aspects. The methodology compare the performance and procurement processes for the proposed Chronographic model with the Gantt-Precedence diagram. Two examples are presented to demonstrate the benefits of the proposed model and to validate the related concepts. This validation is designed to test the model's graphical ability to simulate construction and procurement.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.25 no.10
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• pp.1310-1316
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• 2021

Recently, with the development of artificial intelligence and IoT technology, the importance of video processing such as object tracking, medical imaging, and object recognition is increasing. In particular, the noise reduction technology used in the preprocessing process demands the ability to effectively remove noise and maintain detailed features as the importance of system images increases. In this paper, we provide a modified weight filter based on pixel matching in an AWGN environment. The proposed algorithm uses a pixel matching method to maintain high-frequency components in which the pixel value of the image changes significantly, detects areas with highly relevant patterns in the peripheral area, and matches pixels required for output calculation. Classify the values. The final output is obtained by calculating the weight according to the similarity and spatial distance between the matching pixels with the center pixel in order to consider the edge component in the filtering process.

• Journal of Microbiology and Biotechnology
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• v.31 no.6
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• pp.815-822
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• 2021

Indigenous fungus-feeding nematodes may adversely affect the growth and activity of introduced biocontrol fungi. Alginate pellets of the biocontrol fungus Trichoderma harzianum ThzID1-M3 and sclerotia of the fungal plant pathogen Sclerotinia sclerotiorum were added to nonsterile soil at a soil water potential of -50 or -1,000 kPa. The biomass of ThzID1-M3, nematode populations, and extent of colonization of sclerotia by ThzID1-M3 were monitored over time. The presence of ThzID1-M3 increased the nematode population under both moisture regimes (p < 0.05), and fungivores comprised 69-75% of the nematode population. By day 5, the biomass of ThzID1-M3b and its colonization of sclerotia increased and were strongly correlated (R² = 0.98), followed by a rapid reduction, under both regimes. At -50 kPa (the wetter of the two environments), fungal biomass and colonization by ThzID1-M3 were less, in the period from 5 to 20 days, while fungivores were more abundant. These results indicate that ThzID1-M3 stimulated the population growth of fungivorous nematodes, which in turn, reduced the biocontrol ability of the fungus to mycoparasitize sclerotia. However, colonization incidence reached 100% by day 5 and remained so for the experimental period under both regimes, although hyphal fragments disappeared by day 20. Our results suggest that indigenous fungivores are an important constraint for the biocontrol activity of introduced fungi, and sclerotia can provide spatial refuge for biocontrol fungi from the feeding activity of fungivorous nematodes.

• Proceedings of the Korea Water Resources Association Conference
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• 2023.05a
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• pp.161-161
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• 2023

Bias correction of values is a necessary step in downscaling coarse and systematically biased global climate models for use in local climate change impact studies. In addition to univariate bias correction methods, many multivariate methods which correct multiple variables jointly - each with their own mathematical designs - have been developed recently. While some literature have focused on the inter-comparison of these multivariate bias correction methods, none have focused extensively on the effect of diverse configurations (i.e., different combinations of input variables to be corrected) of climate variables, particularly high-dimensional ones, on the ability of the different methods to remove biases in uni- and multivariate statistics. This study evaluates the impact of three configurations (inter-variable, inter-spatial, and full dimensional dependence configurations) on four state-of-the-art multivariate bias correction methods in a national-scale domain over South Korea using a gridded approach. An inter-comparison framework evaluating the performance of the different combinations of configurations and bias correction methods in adjusting various climate variable statistics was created. Precipitation, maximum, and minimum temperatures were corrected across 306 high-resolution (0.2°) grid cells and were evaluated. Results show improvements in most methods in correcting various statistics when implementing high-dimensional configurations. However, some instabilities were observed, likely tied to the mathematical designs of the methods, informing that some multivariate bias correction methods are incompatible with high-dimensional configurations highlighting the potential for further improvements in the field, as well as the importance of proper selection of the correction method specific to the needs of the user.

• Asian Journal of Business Environment
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• v.13 no.2
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• pp.9-20
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• 2023

Purpose: This study aims to map the spatial distribution of poverty using nighttime light satellite images as a proxy indicator of economic activities and infrastructure distribution in D.I Yogyakarta, Indonesia. Research design, data, and methodology: This study uses official poverty statistics (National Socio-economic Survey (SUSENAS) and Poverty Database 2015) to compare satellite imagery's ability to identify poor urban areas in D.I Yogyakarta. National Socioeconomic Survey (SUSENAS), as poverty statistics at the macro level, uses expenditure to determine the poor in a region. Poverty Database 2015 (BDT 2015), as poverty statistics at the micro-level, uses asset ownership to determine the poor population in an area. Pearson correlation is used to identify the correlation among variables and construct a Support Vector Regression (SVR) model to estimate the poverty level at a granular level of 1 km x 1 km. Results: It is found that macro poverty level and moderate annual nighttime light intensity have a Pearson correlation of 74 percent. It is more significant than micro poverty, with the Pearson correlation being 49 percent in 2015. The SVR prediction model can achieve the root mean squared error (RMSE) of up to 8.48 percent on SUSENAS 2020 poverty data.Conclusion: Nighttime light satellite imagery data has potential benefits as alternative data to support regional poverty mapping, especially in urban areas. Using satellite imagery data is better at predicting regional poverty based on expenditure than asset ownership at the micro-level. Light intensity at night can better describe the use of electricity consumption for economic activities at night, which is captured in spending on electricity financing compared to asset ownership.

• Journal of the Korean Geotechnical Society
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• v.23 no.6
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• pp.67-76
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• 2007

Raining method has been widely used for preparing sand specimen because of its ability to reconstitute the homogeneous specimen with desired relative density and its reliability established by the numerous experiments on diverse influential factors. In conventional raining methods, adjustment of relative density is achieved by controlling the shutter porosity and the whole system is required to be re-adjusted to achieve the target relative density when the granular characteristics are changed. It is also observed from conventional methods that certain degrees of spatial variation in density exist and the limited range of relative density is reproduced. In this paper, raining system with porous plate is proposed. It is shown that the wide range of relative density can be achieved by controlling failing height only. This enhanced system is able to obviate the subtle control of shutter porosity and minimize the effect of falling distance, which in turn ensures the homogeneity of the specimen, especially for low relative density.