• Title/Summary/Keyword: Southwest Pacific

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Antitumor Constituents from Anthriscus Sylvestris (L.) Hoffm

  • Chen, Hui;Jiang, He-Zhong;Li, Yong-Chao;Wei, Guo-Qing;Geng, Yun;Ma, Chao-Ying
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.6
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    • pp.2803-2807
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    • 2014
  • Bioassay-guided chemical investigation of the roots of Anthriscus sylvestris (L.) Hoffm. resulted in the isolation of nine compounds, whose structures were determined by spectroscopic methods. Compound 1 was isolated from this plant for the first time and compounds 3 and 9 were first found from this genus. Different polar fractions of A. sylvestris extract and compounds 1, 6-8 and 9 were evaluated for antitumor activities against HepG2 (human hepatocellular carcinoma), MG-63 (human osteosarcoma cells), B16 (melanoma cells) and HeLa (human cervical carcinoma cells) lines by the MTT method. The petroleum ether fraction of A. sylvestris extract exhibited excellent inhibitory activity with an $IC_{50}$ value of $18.3{\mu}g/ml$. Among the isolates from the petroleum ether fraction, compound 7 showed significant inhibition against the growth of the four tumor cells with $IC_{50}$ values ranging from $12.2-43.3{\mu}g/ml$.

Occurrence of sea lice, Caligus undulatus Shen and Li, 1959 (Copepoda: Siphonostomatoida: Caligidae) in plankton samples collected from Korea

  • Moon, Seong Yong;Park, Jong Sick
    • Journal of Species Research
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    • v.8 no.4
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    • pp.365-372
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    • 2019
  • We have conducted faunistic study of sea lice collected from marine plankton samples of western and southern coasts of Korea. These specimens were identified as Caligus undulatus Shen and Li, 1959, belonging to family Caligidae and order Siphonostomatoida with worldwide distribution. The range extension of C. undulatus is reported in addition to the previously known distributional range from the Northwest Pacific (China, Japan, and Korea), India, Brazil, and Mexico. This species can be distinguished from all previous reports with characteristics such as overall body proportions of both sexes, structure details of mouth appendages, armature of legs, and some variation in body size. The distributional range of C. undulatus is now given with its northern and south hemisphere limit being 40 to $10^{\circ}N$ in the Indo-Pacific and $30^{\circ}S$ in the Southwest Atlantic. This is the first record of its female occurring in Korea.

Expression of Lamininγ2 in Extrahepatic Cholangiocarcinoma Tissues and its Influence on Tumor Invasion and Metastasis

  • Li, Yong;Li, Da-Jiang;Chen, Jian;Liu, Wei;Li, Jian-Wei;Jiang, Peng;Zhao, Xin;Guo, Fei;Li, Xiao-Wu;Wang, Shu-Guang
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.5
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    • pp.2099-2102
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    • 2015
  • Objective: To explore the expression of $laminin{\gamma}2$ in extrahepatic cholangiocarcinoma (EHCC) tissues and its influence on tumor invasion and metastasis. Materials and Methods: Paraffin embedding samples of cancer, para-cancer, lymph node metastatic and hepatic metastatic tissues from 79 patients undergoing EHCC resection were collected. Expression of $laminin{\gamma}2$ was detected by immunohistochemistry and its relationship with clinical pathological characteristics and the prognosis of EHCC patients were analyzed. Results: $Laminin{\gamma}2$ showed negative staining in para-cancer tissues, but demonstrated a 51.9% (41/79) positive expression rate in extracellular matrix (ECM) or cytoplasm of EHCC tissues. In lymph node metastatic and distant metastatic nidi, expression of $laminin{\gamma}2$ was significantly higher than in the primary nidi (${\chi}^2=7.4173$, P=0.0065; ${\chi}^2=4.0077$, P=0.0453). The expression was in obvious association with lymph node metastasis (P<0.01), but had no relevance with age, gender, tumor location, tumor stage, differentiation and distant metastasis in ECM (P>0.05), whereas it was in marked connection with lymph node and distant metastasis (P<0.05 or P<0.01), but had no relationship with age, gender, tumor location, tumor stage and differentiation in cytoplasm (P>0.05). However, the median survival time and median recurrent period of patients with positive expression of $laminin{\gamma}2$ in both cytoplasm and ECM of tumor cells, only in ECM and only in cytoplasm, were evidently lower than with negative expression of $laminin{\gamma}2$ in RCM and cytoplasm (P<0.05 or P<0.01). Further Cox regression analysis showed that the positive expression of $laminin{\gamma}2$ and the tumor differentiation were independent risk factors influencing the prognosis of EHCC patients. Conclusions: Abnormal expression of $laminin{\gamma}2$ may be closely associated with invasion and metastasis of tumor cells, and thus a potential molecular marker for prognosis of EHCC patients.

Application of Joint Detection of AFP, CA19-9, CA125 and CEA in Identification and Diagnosis of Cholangiocarcinoma

  • Li, Yong;Li, Da-Jiang;Chen, Jian;Liu, Wei;Li, Jian-Wei;Jiang, Peng;Zhao, Xin;Guo, Fei;Li, Xiao-Wu;Wang, Shu-Guang
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.8
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    • pp.3451-3455
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    • 2015
  • Objective: To explore the application of joint detection of serum AFP, CA19-9, CA125 and CEA in identification and diagnosis of cholangiocarcinoma (CC). Materials and Methods: The levels of serum AFP, CA19-9, CA125 and CEA of both 30 patients with CC and 30 patients with hepatocellular carcinoma (HCC) were assessed. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic effects of single and joint detection of those 4 kinds of tumor markers for CC. Results: The levels of serum CA19-9, CA125 and CEA in CC patients were higher than that in HCC patients,whereas that of serum AFP was significantly lower s. The area under ROC curve of single detection of serum AFP, CA19-9, CA125 and CEA were 0.05, 0.86, 0.84 and 0.83, with the optimal cutoff values of 15.4 ng/ml, 125.1 U/ml, 95.7 U/ml and 25.9 ng/ml, correspondingly, and the percentage correct single diagnosis was <79%. With joint detection, the diagnostic effect of combined AFP, CA19-9, CA125 and CEA was the highest, with an area under the ROC curve of 0.94 (95%CI 0.88~0.99). Conclusions: Single detection of serum CA19-9, CA125 and EA is not meaningful. The sensitivity, specificity, the rate of correct diagnosis and the area under ROC curve of joint detection of AFP, CA19-9, CA125 and CEA are highest, indicating that the joint detection of these 4 tumor markers is of great importance in the diagnosis of CC.

Growth characteristic of Pacific cod, Gadus macrocephalus in theWest Sea of Korea (한국 서해 대구, Gadus macrocephalus (Tilesius)의 성장특성)

  • Kim, Heeyong;Kim, Sanghwa;Im, Yangjae;Hwang, Hak Jin;Huh, Sunjung
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.49 no.3
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    • pp.261-269
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    • 2013
  • The age and growth of the Pacific cod, Gadus macrocephalus were investigated using left sagittal otoliths of 682 individuals collected in the West Sea of Korea from January to December 2007. The seasonal changes in the ratio of an opaque zone to interval between annular rings revealed that the narrow translucent parts of the otolith were annual growth rings formed between February and March once a year. The spawning period was December to January and therefore the duration from fertilization to the complete formation of the opaque zone became thirteen months. From the parameters calculated using the average length when the year ring was formed, the estimated von Bertalanffy growth equations were $L_t=100.0(1-e^{-0.1640(t+0.5247)})$ for females and $L_t=64.6(1-e^{-0.3335 (t+0.3342)})$ for males when is total length in age t.

Long-Term Analysis of Tropical Cyclones in the Southwest Pacific and Influences on Tuvalu from 2000 to 2021

  • Sree Juwel Kumar Chowdhury;Chan-Su Yang
    • Korean Journal of Remote Sensing
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    • v.39 no.4
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    • pp.441-458
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    • 2023
  • Tropical cyclones frequently occur in the Southwest Pacific Ocean and are considered one of the driving forces for coastal alterations. Therefore, this study investigates the frequency and intensity of tropical cyclonesfrom 2000 to 2021 and their influence on the surface winds and wave conditions around the atoll nation Tuvalu. Cyclone best-track and ERA5 single-level reanalysis data are utilized to analyze the condition of the surface winds, significant wave heights, mean wave direction, and mean wave period. Additionally, the scatterometer-derived wind information was employed to compare wind conditions with the ERA5 data. On average, nine cyclones per year originated here, and the frequency increased to 11 cyclones during the last three years while the intensity decreased by 25 m/s (maximum sustained wind speed). Besides, a total of 14 cyclones were observed around Tuvalu during the period from 2015 to 2021, which showed an increase of 3 cyclones compared to the preceding period of 2001 to 2007. During cyclones, the significant wave height reached the highest 4.8 m near Tuvalu, and the waves propagated in the east-southeast direction during most of the cyclone events (52%). In addition, prolonged swells with a mean wave period of 7 to 11 seconds were generated in the vicinity of Tuvalu, for which coastal alteration can occur. After this preliminary analysis, it was found that the waves generated by cyclones have a crucial impact in altering the coastal area of Tuvalu. In the future, remotely sensed high-resolution satellite data with this wave information will be used to find out the degree of alterations that happened in the coastal area of Tuvalu before and after the cyclone events.

The Exploitation of World Fishery Resources for 10 Years under the New Regime in the Sea (신해양질서 10년후 세계어업자원 이용동향)

  • 이장욱;허영희
    • The Journal of Fisheries Business Administration
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    • v.23 no.1
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    • pp.43-87
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    • 1992
  • In this paper, state of exploitation of world fishery resources after 10 years under the new regime in the sea, called the era of exclusive economic zone (EEZ) expending up to a 200 nautical miles from coastal line, was reviewed to determine effect from establishing EEZ in the world fishery production and its export/import volume based on the fishery statistics annually published by the Food and Agriculture Organization (FAO) of United Nation. The world total production from marine living resources had a trend showing a waned increase during 1970's when most of coastal states were translated into the reality of EEZ. From mid-1980's onwards, it increased rapidly, reaching about 85 million tons . Such increase in production was basically from the Pacific Ocean, accounting for more than 60% of the world total production. Fishing areas where showed increase in the production after the new regime in the sea were the southwestern Atlantic (FAO area 41) , the eastern Indian (FAO area 57) and the whole fishing areas in the Pacific except the eastern central Pacific (FAO area 77). Increase in the production from distant-water fishing countries came from the regions of the southwest Atlantic (FAO area 41) and the southwest Pacific (FAO area 81) . The production from coastal states was up from the regions of the eastern Indian (FAO area 57) , the northwest and northeast Pacific (FAO areas 61 and 67) and the southeast Pacific (FAO area 87) . It was likely that the exploitation of the fishable stocks was well monitored in the areas of the northwest Atlantic (FAO area 21) , the eastern central Atlantic (FAO area 34) and the northeast Pacific (FAO area 67) through appropriate management measures such as annual harvest level, establishment of total allowable catch etc. The marine fisheries resources that have made contribution to the world production, despite expansion of 200 EEZ by coastal states, were sardinellas, Atlantic cod, blue whiting and squids in the Atlantic Ocean : tunas which mainly include skipjack, yellowfin and bigeye tuna, croakers and pony fishes in the Indian Ocean : and sardine, Chilean pilchard, Alaska pollock, tunas (skipjack and yellowfin tuna) , blue grenadier and blue whiting including anchoveta in the Pacific Ocean. It was identified that both fishery production and its export since introduction of the new regime in the sea were dominated by such coastal states as USA, Canada, Indonesia, Thailand, Mexico, South Africa and Newzealand. But difficulties have been experienced in the European countries including Norway, Spain, Japan and Rep. of Korea. Therefore, majority of coastal states are unlikely to have yet undertaken proper utilization as well as rational management of marine living resources in their jurisdiction during the last two decades. The main target species groups which led the world fishery production to go up were Alaska pollock, cods, tunas, sardinellas, chub and jack mackerel and anchoveta. These stocks are largely expected to continue to contribute to the production. The fisheries resources which are unexploited, underexploited and/or lightly exploited at present and which will be contributed to the world production in future are identified with cephalopods, Pacific jack mackerel and Atlantic mackerel, silver hake including anchovies. These resources mainly distribute in the Pacific regions, especially FAO statistical fishing areas 67, 77 and 87. It was likely to premature to conclude that the new regime in the sea was only in favour of coastal states in fishey production.

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Regional Occurrence and Sedimentary Environment of Manganese Nodule in KODOS area, C-C zone of NE Pacific (북동태평양 한국 심해저 연구지역 망간단괴의 지역적 분포와 퇴적환경)

  • Chi, Sang-Bum;Kang, Jung-Keuk;Oh, Jae-Kyung;Son, Seung-Kyu;Park, Cheong-Kee
    • Ocean and Polar Research
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    • v.25 no.3
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    • pp.257-267
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    • 2003
  • Deep-sea bottom photographs acquired in the Clarion-Clipperton fracture zone of the northeast equatorial Pacific were analyzed to reveal the controlling processes for the spatial variation of manganese nodule. The results show that regional-scale occurrence variations of manganese nodule are mainly controlled by primary productivity of surface water, sedimentation rate, and water depth (or carbonate compensation depth). As a result, the diagenetic accretion on nodules increases toward southwest while hydrogenetic accretion increases toward northeast. Considering the northwestward movement of Pacific Plate, this regional-scale variation of manganese nodule occurrence seems to be affected by oceanic environment during the active growth period (Oligocene-Miocene) of Pacific Plate.

Antiproliferative Activity of the Methanolic Extract of Withania Somnifera Leaves from Faifa Mountains, Southwest Saudi Arabia, against Several Human Cancer Cell Lines

  • Alfaifi, Mohammad Yahya;Saleh, Kamel Ahmed;El-Boushnak, Mohammed Atallah;Elbehairi, Serag Eldin I;Alshehri, Mohammed Ali;Shati, Ali Abdullah
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.5
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    • pp.2723-2726
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    • 2016
  • Cancer represent one of the most serious health problems and major causes of death around the world. Many anticancer drugs in clinical use today are natural products or derived from natural sources. Withania somnifera (L.) Dunal is a small shrub widely distributed in many parts of the world including Saudi Arabia. The antiproliferative activities of the methanolic extract of W. somnifera leaves collected from Faifa mountains, southwest Saudi Arabia against MCF-7, HCT116 and HepH2 cell lines were investigated. The extract showed a strong antiproliferative activity against all cell lines with $IC_{50}$ values of 3.35, 2.19 and $1.89{\mu}g/ml$, respectively. Flow cytometry results showed that the extract arrested the cell cycle at S phase, and the increase in the caspase 3 activity suggested that the extract could induce cell apoptosis by a caspase mediated pathway. These results demonstrated that the methanolic extract of W. somnifera leaves collected from Faifa mountains has comparable strong antiproliferative activities to samples collected from different locations.

Prevalence and Pathogenesis of Barrett's Esophagus in Luoyang, China

  • Zhang, Ru-Gang;Wang, Chang-Song;Gao, Cun-Fang
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.5
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    • pp.2185-2191
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    • 2012
  • Background: Prevalence of Barrett's esophagus (BE) in Luoyang, China, has not been reported, and its pathogenesis is controversial. The aim of this study was therefore to investigate the prevalence of BE and its underlying factors in the city of Luoyang. Method: This was a prospective study in one center. Many patients were analyzed using endoscopy who showed upper gastrointestinal symptoms between August 2006 and June 2007. In addition, the effect of apoptosis-related proteins and heat shock proteins upon BE's pathogenesis were also investigated by an immunohistochemical protocol. Results: Prevalence of BE was at 4.55% and the mean age of those affected was about 10 years older than for esophagitis. Typical reflux symptoms were significantly lower than with esophagitis, whereas signs of caspase-3 and HSP105 elevation were significantly higher. Expression of TERT, HSP70 and $HSP90{\alpha}$ in BE cases was significantly lower than in esophagitis. However, there was no statistical difference between the two groups in expression of HSP27. Conclusions: The prevalence of BE is high in Luoyang, which could result from esophagitis despite typical reflux symptoms being relatively uncommon. Initiation and development of BE might be the result of accelerated proliferation, apoptosis and differentiation of original cells to intestinal epithelium.