Background: The human papillomavirus (HPV) and its variants show wide geographical distribution and have been reported to cause cervical lesions. With cervical neoplasia as the leading cancer in Indian women, the aim of the present study was to evaluate the multiple infection HPV type distribution and variant genotypes in cervical samples from the coastal Karnataka region, India. Materials and Methods: A total of 212 samples were screened by nested polymerase chain reaction using PGMY9/11 and GP5+/6+ primers. HPV positive samples were sequenced to identify the types and a phylogenetic tree was constructed using the neighbor-joining method. Results: Sequence analysis identified a total of 14 HPV types distributed in 20%, 73.3% and 82.5% of non-malignant, pre-malignant [low grade squamous intraepithelial lesion (LSIL) and high grade squamous intraepithelial lesion (HSIL)] and cervical cancer samples. The distribution of high risk HPV in cancer samples was HPV 16, 76.4%, HPV18, 11.7%, HPV81, 2.9%, HPV31, 1.4%, HPV35, 1.4% and HPV 45, 1.4%. Multiple infections were observed in 11.8% of tumor samples with HPV 16 contributing to 62.5% of cases. In non-malignant samples, 20% of HPV positive samples were detected with HPV16, 82.3%, HPV33, 5.8% and HPV58, 5.8% and very low incidence of multiple infections. Comparative phylogenetic analysis of HPV variants identified 9 HPV sequences as new papillomavirus species, predominantly classified as European lineage type. Conclusions: The findings for HPV infections associated with progression of cervical cancer in coastal Karnataka region and HPV variant analysis provide baseline data for prevention and HPV vaccination programs.
Raju, Kalyani;Punnayanapalya, Shruthi Suresh;Mariyappa, Narayanaswamy;Eshwarappa, Sumathi Mayagondanahalli;Anjaneya, Chandramouli;Kai, Lee Jun
Asian Pacific Journal of Cancer Prevention
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v.15
no.8
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pp.3779-3784
/
2014
Aims: To study alterations of plasma lipid profiles in carcinoma cervix and to assess significance comparedwith controls in different histological grades and stages. Materials and Methods: Totals of 99 histopathologically diagnosed cases and 35 controls from a tertiary hospital situated in the southern part of India which caters the rural and semi-urban populations were considered for the study. Fasting blood samples were taken to analyze total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoproteins cholesterol (LDL-C), for comparison of cases, grouped according to histological grades and stages, and controls. One way ANOVA was used for multiple group comparisons and the Student's t test (unpaired) for group wise comparisons. For all tests a 'p' value of 0.05 or less was considered as significant. Results: Out of 99 cases, most (n-39) were seen in the 40-49 year age group followed by 60-69 years (n-22). Serum TG significantly differed between cases and controls but without any relation to differentiation grade. The lipid profile parameters in various grades of cervical cancer were not statistically significant. Statistically significant increase of TC and LDL-C values was observed with increase in stage of the disease. Conclusions: The study showed TG is elevated in cervical cancer, and that TC and LDL-C are proportional to the spread of cancer as it increases from stage I to stage IV. An in-depth study of molecular changes in lipid metabolism in cervical cancer patients, enzymes/genes responsible and alterations in LDL receptors is necessary to provide information to decide whether the lipid profile has any diagnostic/prognostic role in cervical cancer.
I have researched in the field the religious and performance culture of Indonesia through the musical iconography of Borobudur. There are many kinds of musical instruments which belong to India or Indonesia, performers being either court or folk musicians. Contemporary south-east Asian Indonesia has a broad religious heritage. Most of the population is Muslim, but the culture and customs are rooted in Indian Ramayana. I discovered, for example, the same percussion instruments played on a person's knees. I also came across similar string instruments with long and elliptical resonance casks on the iconography of the Incense Burner and Byam temple stone pagoda of Beakje dynasty in Korea and in Borobudur in Indonesia. The two musical instruments can not be found in other countries, such as Silla, Koguryŏ, China or the silk road area, but only Indonesia or India. This suggests that Beakje Buddhism is from the southern regions rather than China. I also discovered the same dancing motion with the court performers on the iconography of Borobudur, and the same musical instrument and performance in the Gamelan in today's Indonesian performance. Despite a disjuncture between the people and their past, the Shailendra Buddhism is alive in people's life and culture in the present day. So we can discover some familiarities between Indonesia's Gamelan and the percussional performance in Korean Buddhist rituals.
Journal of the Korea Academia-Industrial cooperation Society
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v.18
no.8
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pp.34-40
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2017
In recent years, global warming has caused abnormal weather phenomena. Unusually cold climates have occurred all around the world, including cold waves in the Northeastern United States, Beijing, China, Southern India, and Pakistan, as well as floods in Chile, Kazakhstan, and Vietnam. China has been experiencing a nationwide heat wave annually since the year 2013, especially in the southern region. In this study, we used Landsat 8 OLI TIRS sensor images from four periods to analyze the characteristics of abnormal high temperature phenomena in Cixi-si, China. Land cover classification was performed using 10 bands of satellite imagery, and the surface temperature was extracted using the 10th thermal band. The results of the land cover classification of the fourth period show the changes of the time series quantitatively. The results of the surface temperature calculation provided both the average overall temperature and the average temperature of individual items. The temperature was found to be highest for buildings, followed by grassland, forest, agricultural land, water systems, and tidal flats in the same period.
South Korea and Vietnam have been engaged in extensive political, economic and cultural exchanges since the establishment of diplomaticties in 1992. In March 2018, Moon Jae-in, President of South Korea, made an official visit to Vietnam, a key partner of the New Southern Policy and discussed comprehensive cooperation measures, including expanding trade volume and measures to establish peace on the Korean Peninsula. At the defense ministers' meeting held in April 2018, the two countries signed a joint defense and defense cooperation statement, which included promotion of maritime security, defense cooperation, UN PKO activities, excavation of remains, and joint military cooperation. Currently, Vietnam is facing territorial disputes with China over the South China Sea, and is stepping up military modernization and military buildup to counter this. In particular, Vietnam is strengthening its external military cooperation beyond ideology with the U.S., Russia, India and France to strengthen its maritime power. Against this backdrop, the bilateral cooperation between South Korea and Vietnam needs to expand beyond the traditional economic and cultural exchanges to military cooperation. The study aims to review the relationship between South Korea and Vietnam on the 26th anniversary of the normalization of diplomaticties and seek ways to develop military cooperation with Vietnam, which has grown to the next China. To that end, it analyzed Vietnam's security environment and military strategy and presented strategies for promoting military cooperation focusing on defense areas.
Finger millet straw and rice straw are the major source of dry roughage in southern India. They distinctly vary in their morphological and nutritional characters. Hence an effort was made to study the nutrient utilization, milk yield and composition in crossbred dairy cows fed either finger millet (group 1) or rice straw (group 2) as a source of dry roughage. The cows in both the groups were fed as per requirement with concentrate, green fodder and straw in the ratio of 30:45:25 parts (DM). At the end of 50 days of preliminary feeding a digestibility trial was conducted for 7 days and pooled samples of feed, fodder, feces, urine and milk were analysed for macro and micro nutrient content. Finger millet straw contained more CP, Ca, P, Mg, Cu, Zn and Co than rice straw and rice straw contained higher ADF, ash and silica. The intake of DM, CP, EE, NDF, ADF and most micronutrients (Ca, P, Mg, Cu, Zn, Fe, Mn and Co) was significantly higher in cows fed finger millet straw. The digestibility of DM, CP, NDF and ADF was significantly higher in cows fed finger millet straw and the gut absorption of Ca, Cu, Mn and Co was significantly higher in cows fed finger millet straw. The dietary requirement of all micronutrients in both the group of cows could be met irrespective of the type of roughage fed except that of Ca, which was low (0.61 and 0.40%) in rice straw fed cows. The average daily milk yield (L/cow) was also higher (7.0 L) in cows fed finger millet straw as compared to cows fed rice straw (6.3 L). The average milk composition also did not differ except that of milk fat which was significantly (4.7 and 4.5%) low in cows fed rice straw. The overall results of this study have indicated that finger millet straw is a better source of dry fodder than rice straw and while feeding rice straw as the sole roughage to dairy cows there is need to supplement additional calcium as this could be one of the limiting nutrients for milk production.
One of the factors influencing the climate around Korea is the oceanic-atmospheric variability in the tropical region between the eastern Indian and the western Pacific Oceans. Lack of knowledge about the air-sea interaction in the tropical Indo-Pacific region continues to make it problematic forecasting the ocean climate in the East Asia. The 'Tropical Indo-Pacific water transport and ecosystem monitoring EXperiment (TIPEX)' is a program for monitoring the ocean circulation variability between Pacific and Indian Oceans and for improving the accuracy of future climate forecasting. The main goal of the TIPEX program is to quantify the climate and ocean circulation change between the Indian and the Pacific Oceans. The contents of the program are 1) to observe the mixing process of different water masses and water transport in the eastern Indian and the western Pacific, 2) to understand the large-scale oceanic-climatic variation including El Nino-Southern Oscillation (ENSO)/Warm Pool/Pacific Decadal Oscillation (PDO)/Indian Ocean Dipole (IOD), and 3) to monitor the biogeochemical processes, material flux, and biological changes due to the climate change. In order to effectively carry out the monitoring program, close international cooperation and the proper co-work sharing of tasks between China, Japan, Indonesia, and India as well as USA is required.
Background: Although 3D image based brachytherapy is currently the standard of treatment in cervical cancer, most of the centres in developing countries still practice orthogonal intracavitary brachytherapy due to financial constraints. The quest for optimum dose and fractionation schedule in high dose rate (HDR) intracavitary brachytherapy (ICBT) is still ongoing. While the American Brachytherapy Society recommends four to eight fractions of each less than 7.5 Gy, there are some studies demonstrating similar efficacy and comparable toxicity with higher doses per fraction. Objective: To assess the treatment efficacy and late complications of HDR ICBT with 9 Gy per fraction in two fractions. Materials and Methods: This is a prospective institutional study in Southern India carried on from $1^{st}$ June 2012 to $31^{st}$ July 2014. In this period, 76 patients of cervical cancer satisfying our inclusion criteria were treated with concurrent chemo-radiation following ICBT with 9 Gy per fraction in two fractions, five to seven days apart. Results: The median follow-up period in the study was 24 months (range 10.6 - 31.2 months). The 2 year actuarial local control rate, disease-free survival and overall survival were 88.1%, 84.2% and 81.8% respectively. Although 38.2% patients suffered from late toxicity, only 3 patients had grade III late toxicity. Conclusions: In our experience, HDR brachytherapy with 9 Gy per fraction in two fractions is an effective dose fractionation for the treatment of cervical cancer with acceptable toxicity.
Korean Journal of Air-Conditioning and Refrigeration Engineering
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v.27
no.11
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pp.574-580
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2015
Climatic zone in building code is an administrative district classification reflecting regional climatic characteristics. Use of Degree-Days is a fundamental method that can be used in various building design codes, analysis of building energy performance, and establishment of minimum thermal transmittance of building envelopes. Many foreign countries, such as the USA, the EU, Australia, Italy, India, China, etc., have already adapted climatic zone classification with degree-days, precipitation or amount of water vapor based on the characteristics of their own country's climate. In Korea, however, the minimum requirements for regional thermal transmittance are classified separately for the Jungbu area, Nambu area and Jeju Island with no definite criterion. In this study, degree-days of 255 Korean cities were used for climatic zone classification. Outdoor dry-bulb temperature data from the Korea Meteorological Administration for 1981~2010 was used to calculate degree-days. ArcGIS and the calculated degree-days were utilized to analyze and visualize climatic zone classification. As a result, depending on the distribution and distinctive differences in degree-days, four climatic zones were derived : 1) Central area, 2) Mountain area of Gyeonggi and Gangwon provinces, 3) Southern area, and 4) Jeju Island. The climatic zones were suggested per administrative district for easy public understanding and utilization.
Cervical cancer is one of the leading causes of cancer in women worldwide. One way by which the incidence of this malignant disease can be minimized is by imparting knowledge through health education. This study aimed at developing an educational package on cervical cancer (EPCC) and determining its effectiveness in terms of significant increase in knowledge of rural women regarding cervical cancer. A one group pre-test, post-test design was adopted. Thirty rural women were selected using a convenient sampling method. Data were collected using a demographic questionnaire and a structured knowledge questionnaire developed by the researchers. The EPCC was designed for a duration of one hour and 10 minutes. The structured knowledge questionnaire was first administered as the pre-test, following which knowledge on cervical cancer was imparted using the EPCC. On the 8th day, the post-test was administered. Data were analyzed using descriptive and inferential statistics. The mean post-test knowledge score of the women regarding cervical cancer was significantly higher than that of their mean pre-test score, indicating that the EPCC was effective in improving the knowledge of rural women on cervical cancer. The association between pre-test knowledge scores and selected demo-graphic variables were computed using chi-square test showed that pre-test knowledge score of the women regarding cervical cancer was independent of all the socio-demographic variables. It was concluded that the EPCC is effective in improving the knowledge of women, regarding cervical cancer. Since the prevalence of cervical cancer is high, there is an immediate need to educate women on prevention of cervical cancer.
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