• Journal of Biomedical Engineering Research
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• v.28 no.1
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• pp.95-101
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• 2007

Recently, small-animal imaging technology has been rapidly developed for longitudinal screening of laboratory animals such as mice and rats. One of newly developed imaging modalities for small animals is an x-ray micro-CT (computed tomography). We have developed two types of x-ray micro-CT systems for small animal imaging. Both systems use flat-panel x-ray detectors and micro-focus x-ray sources to obtain high spatial resolution of $10{\mu}m$. In spite of the relatively large field-of-view (FOV) of flat-panel detectors, the spatial resolution in the whole-body imaging of rats should be sacrificed down to the order of $100{\mu}m$ due to the limited number of x-ray detector pixels. Though the spatial resolution of cone-beam CTs can be improved by moving an object toward an x-ray source, the FOV should be reduced and the object size is also limited. To overcome the limitation of the object size and resolution, we introduce zoom-in micro-tomography for high-resolution imaging of a local region-of-interest (ROI) inside a large object. For zoom-in imaging, we use two kinds of projection data in combination, one from a full FOV scan of the whole object and the other from a limited FOV scan of the ROI. Both of our micro-CT systems have zoom-in micro-tomography capability. One of both is a micro-CT system with a fixed gantry mounted with an x-ray source and a detector. An imaged object is laid on a rotating table between a source and a detector. The other micro-CT system has a rotating gantry with a fixed object table, which makes whole scans without rotating an object. In this paper, we report the results of in vivo small animal study using the developed micro-CTs.

• 한국정보디스플레이학회:학술대회논문집
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• 2009.10a
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• pp.1254-1257
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• 2009

A 360-degree viewable three-dimensional display based on integral imaging is proposed. The cylindrically arranged point light source array which is generated by electroluminescent (EL) pinhole film reconstructs 360-degree viewable virtual 3D image at the center of the cylinder. In this paper, the principle of operation and experimental results are presented.

• 한국정보디스플레이학회:학술대회논문집
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• 2009.10a
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• pp.1330-1333
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• 2009

A 360-degree viewable three-dimensional display based on integral imaging is proposed. The cylindrically arranged point light source array which is generated by electroluminescent (EL) pinhole film reconstructs 360-degree viewable virtual 3D image at the center of the cylinder. In this paper, the principle of operation and experimental results are presented.

• Korean Journal of Optics and Photonics
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• v.19 no.2
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• pp.116-121
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• 2008

A two dimensional point light source array can replace both the viewing zone forming optics and the back light panel in the contact-type 3 dimensional imaging systems based on LC panels. This replacement can make the system structure of the 3 dimensional imaging systems no different from that of the conventional LCD and can reduce undesirable visual effects caused by the viewing zone forming optics. The problem with the point light source array is the visual quality deterioration of the system due to the non-ideal nature of the array.

• Medical Lasers
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• v.10 no.3
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• pp.123-131
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• 2021

Optical imaging modalities with properties of real-time, non-invasive, in vivo, and high resolution for image-guided surgery have been widely studied. In this review, we introduce two optical imaging systems, that could be the core of image-guided surgery and introduce the system configuration, implementation, and operation methods. First, we introduce the optical coherence tomography (OCT) system implemented by our research group. This system is implemented based on a swept-source, and the system has an axial resolution of 11 ㎛ and a lateral resolution of 22 ㎛. Second, we introduce a fluorescence imaging system. The fluorescence imaging system was implemented based on the absorption and fluorescence wavelength of indocyanine green (ICG), with a light-emitting diode (LED) light source. To confirm the performance of the two imaging systems, human malignant melanoma cells were injected into BALB/c nude mice to create a xenograft model and using this, OCT images of cancer and pathological slide images were compared. In addition, in a mouse model, an intravenous injection of indocyanine green was used with a fluorescence imaging system to detect real-time images moving along blood vessels and to detect sentinel lymph nodes, which could be very important for cancer staging. Finally, polarization-sensitive OCT to find the boundaries of cancer in real-time and real-time image-guided surgery using a developed contrast agent and fluorescence imaging system were introduced.

• Nuclear Engineering and Technology
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• v.56 no.10
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• pp.4247-4253
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• 2024

We propose a new method of X-ray backscatter imaging which is a significant development of the well known flying spot approach. Instead of sweeping the imaged object by pencil X-ray beam, and recording the amplitude of backscattered radiation in order to form the raster image, the object is irradiated with a fan beam of X-rays, forming a line on the imaging plane. By properly chosen motion of the collimating slit, a set of lines, which makes up a 2D sinogram of the original object, can be collected. The backscatter image can then be obtained using one of the tomographic reconstruction algorithms, such as the filtered backprojection, which is well known in computed tomography or nuclear medicine. The feasibility of the method has been demonstrated experimentally using a prototype scanner with an industrial X-ray source. The main advantage of our method is the essentially more efficient use of the available X-ray source beam, by illuminating the object with a substantially larger photon flux at each time point. As a result, the image can be obtained at much shorter acquisition time and/or at much lower source power.

• Journal of Korean Neurosurgical Society
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• v.64 no.6
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• pp.933-943
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• 2021

Objective : Percutaneous pedicle screw (PPS) fixation is a needle based procedure that requires fluoroscopic image guidance. Consequently, radiation exposure is inevitable for patients, surgeons, and operation room staff. We hypothesize that reducing the production of radiation emission will result in reduced radiation exposure for everyone in the operation room. Research was performed to evaluate reduction of radiation exposure by modifying imaging manner and mode of radiation source. Methods : A total of 170 patients (680 screws) who underwent fusion surgery with PPS fixation from September 2019 to March 2020 were analyzed in this study. Personal dosimeters (Polimaster Ltd.) were worn at the collar outside a lead apron to measure radiation exposure. Patients were assigned to four groups based on imaging manner of fluoroscopy and radiation modification (pulse mode with reduced dose) : continuous use without radiation modification (group 1, n=34), intermittent use without radiation modification (group 2, n=54), continuous use with radiation modification (group 3, n=26), and intermittent use with radiation modification (group 4, n=56). Post hoc Tukey Honest significant difference test was used for individual comparisons of radiation exposure/screw and fluoroscopic time/screw. Results : The average radiation exposure/screw was 71.45±45.75 µSv/screw for group 1, 18.77±11.51 µSv/screw for group 2, 19.58±7.00 µSv/screw for group 3, and 4.26±2.89 µSv/screw for group 4. By changing imaging manner from continuous multiple shot to intermittent single shot, 73.7% radiation reduction was achieved in the no radiation modification groups (groups 1, 2), and 78.2% radiation reduction was achieved in the radiation modification groups (groups 3, 4). Radiation source modification from continuous mode with standard dose to pulse mode with reduced dose resulted in 72.6% radiation reduction in continuous imaging groups (groups 1, 3) and 77.3% radiation reduction in intermittent imaging groups (groups 2, 4). The average radiation exposure/screw was reduced 94.1% by changing imaging manner and modifying radiation source from continuous imaging with standard fluoroscopy setting (group 1) to intermittent imaging with modified fluoroscopy setting (group 4). A total of 680 screws were reviewed postoperatively, and 99.3% (675) were evaluated as pedicle breach grade 0 (<2 mm). Conclusion : The average radiation exposure/screw for a spinal surgeon can be reduced 94.1% by changing imaging manner and modifying radiation source from real-time imaging with standard dose to intermittent imaging with modified dose. These modifications can be instantly applied to any procedure using fluoroscopic guidance and may reduce the overall radiation exposure of spine surgeons.

• Korean Journal of Optics and Photonics
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• v.16 no.6
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• pp.481-484
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• 2005

Quantum ghost imaging uses quantum mechanically entangled photons to form an image of an object. The quantum ghost image is also obtained by means of classical coincidence measurements with a classically correlated light source[1,2]. In this work we performed classical coincidence imaging experiments with classically correlated beams in their direction of propagation. We observed the ghost interference patterns which were usually made by quantum mechanically entangled states and we also analyze in detail the mechanism of the ghost imaging with classically correlated lights. We made? the classically correlated source with an Ar laser and controlled the direction of the light by a mirror? mounted on a small speaker.

• Nuclear Engineering and Technology
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• v.55 no.9
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• pp.3133-3139
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• 2023

Neutron imaging technology as a means of non-destructive detection of materials is complementary to X-ray imaging. Silicon photomultiplier (SiPM), a new type of optical readout device, has overcome some shortcomings of traditional photomultiplier tube (PMT), such as high-power consumption, large volume, high price, uneven gain response, and inability to work in strong magnetic fields. Its application in the field of neutron detection will be an irresistible general trend. In this paper, a thermal neutron imaging detector based on ⁶LiF/ZnS scintillation screen and SiPM array readout was developed. The design of the detector geometry was optimized by geant4 Monte Carlo simulation software. The optimized detector was evaluated with a step wedge sample. The results show that the detector prototype with a 48 mm × 48 mm sensitive area can achieve about 38% detection efficiency and 0.26 mm position resolution when using a 300 ㎛ thick ⁶LiF/ZnS scintillation screen and a 2 mm thick Bk7 optical guide coupled with SiPM array, and has good neutron imaging capability. It provides effective data support for developing high-performance imaging detectors applied to the China Spallation Neutron Source (CSNS).

• Proceedings of the Optical Society of Korea Conference
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• 2006.02a
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• pp.309-310
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• 2006