• 제목/요약/키워드: Song Kun-Ho

검색결과 414건 처리시간 0.038초

A novel HDAC6 inhibitor, CKD-504, is effective in treating preclinical models of huntington's disease

  • Endan Li;Jiwoo Choi;Hye-Ri Sim;Jiyeon Kim;Jae Hyun Jun;Jangbeen Kyung;Nina Ha;Semi Kim;Keun Ho Ryu;Seung Soo Chung;Hyun Sook Kim;Sungsu Lee;Wongi Seol;Jihwan Song
    • BMB Reports
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    • 제56권3호
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    • pp.178-183
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    • 2023

  • Huntington's disease (HD) is a neurodegenerative disorder, of which pathogenesis is caused by a polyglutamine expansion in the amino-terminus of huntingtin gene that resulted in the aggregation of mutant HTT proteins. HD is characterized by progressive motor dysfunction, cognitive impairment and neuropsychiatric disturbances. Histone deacetylase 6 (HDAC6), a microtubule-associated deacetylase, has been shown to induce transport- and release-defect phenotypes in HD models, whilst treatment with HDAC6 inhibitors ameliorates the phenotypic effects of HD by increasing the levels of α-tubulin acetylation, as well as decreasing the accumulation of mutant huntingtin (mHTT) aggregates, suggesting HDAC6 inhibitor as a HD therapeutics. In this study, we employed in vitro neural stem cell (NSC) model and in vivo YAC128 transgenic (TG) mouse model of HD to test the effect of a novel HDAC6 selective inhibitor, CKD-504, developed by Chong Kun Dang (CKD Pharmaceutical Corp., Korea). We found that treatment of CKD-504 increased tubulin acetylation, microtubule stabilization, axonal transport, and the decrease of mutant huntingtin protein in vitro. From in vivo study, we observed CKD-504 improved the pathology of Huntington's disease: alleviated behavioral deficits, increased axonal transport and number of neurons, restored synaptic function in corticostriatal (CS) circuit, reduced mHTT accumulation, inflammation and tau hyperphosphorylation in YAC128 TG mouse model. These novel results highlight CKD-504 as a potential therapeutic strategy in HD.

  • https://doi.org/10.5483/BMBRep.2022-0157 인용 PDF

모바일 앱을 이용한 스노보드 채점관리 시스템의 구현 (The Implementation of Snowboard Scoring Management System using Mobile Apps)

  • 박명철;정현철;박영남
    • 한국컴퓨터정보학회:학술대회논문집
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    • 한국컴퓨터정보학회 2013년도 제48차 하계학술발표논문집 21권2호
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    • pp.223-224
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    • 2013

  • 본 논문에서는 모바일 앱을 이용한 스노보드 경기의 채점 시스템 개발을 소개한다. 이 시스템은 오프라인 형식으로 진행하는 기존 채점시스템의 문제점을 극복하기 위하여 심판용 모바일 앱과 전광판 출력을 위한 관리 시스템으로 구성된다. 심판들의 채점상황은 모바일 앱을 통하여 실시간으로 원격 데이터베이스에 적재되고 관리시스템에서 자동 합산 및 점수화되어 전광판으로 해당 점수가 출력되게 된다. 이를 통하여 신속하고 정확한 채점 관리를 수행할 수 있으며 모바일 환경이 지원되는 대부분의 스노보드 경기장에서 활용될 수 있다. 본 연구결과는 국내 다양한 스노보드 경기에 적용하여 동계 스포츠분야의 열악한 정보화 환경을 개선할 수 있음을 보였다.

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폴리설폰 UF막에 의한 부식산 분리 (Separation of Humic Acid Using Polysulfone Ultrafiltration Membrane)

  • 송근호;이광래
    • 산업기술연구
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    • 제19권
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    • pp.343-350
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    • 1999

  • The separation of humic acid by ultrafiltration was most influenced by pressure difference. when pressure difference increased from latm to 3atm, permeate flux increased from 40% to 60% but rejection rate reduced from 97% to 91% because of adsorption of molecules of humic acid at membrane surface. Since physical adsorption was more dominant than chemical adsorption, adsorption of membrane surface was reduced 50% when slow rate increased at same conditions.

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