• Asian Pacific Journal of Cancer Prevention
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• 제16권15호
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• pp.6545-6548
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• 2015

Background: Synovial sarcoma is a mesenchymal neoplasm that accounts for around 10% of all soft tissue sarcomas. The diagnosis of synovial sarcoma can be a challenging task, particularly with small biopsy specimens. Aim: We investigated transducer-like enhancer of split 1 (TLE1), monoclonal antibody, expression by immunohistochemical analysis in a group of 74 synovial sarcoma cases, 20 cases of MPNST, 12 cases of neurofibroma, 15 cases of schwannoma, 5 cases of MFH, 10 cases of lieomyosarcoma and 10 cases of solitary fibrous tumor. Materials and Methods: Whole tissue sections were examined: (39 biphasic and 35 monophasic). Nuclear immunoreactivity was scored as negative (<5% of cells positive), 1+(mild /5-25%), 2+ (moderate/25-50%), and 3+ (strong >50%). Results: Overall, 71 (96%) of 74 synovial sarcomas were positive for TLE1, including 37 biphasic (95%) and 34 monophasic (97%) tumors. Other spindle cell tumors showed very low or absent staining of TLE1. Conclusions: We conclude that TLE1 is a sensitive marker and can be a useful diagnostic marker for synovial sarcoma, particularly the monophasic forms.

• 대한기관식도과학회:학술대회논문집
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• 대한기관식도과학회 1972년도 춘계종합 학술대회 초록집
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• pp.17.2-17
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• 1972

현재 일반적으로 Neurilemmoma 또는 Schwannoma라고 부르는 일련의 종양들은 1908年 Verocay에 의해 처음으로 기술되었으며, 1910년 그는 이것을 "Neurinoma"라고 명명하였다. Neurilemmoma라는 명칭은 1935년 Stoutdp 의하여 처음으로 소개되었다. Neurilemmoma는 신경초(Newe Sheath)를 소유하고 있는 어떤 신경에서나 발생할 수 있는 종양으로서 비교적 희유한 양성종양이며 연령, 성병, 그리고 발생장소에 따른 어떤 우월성은 없었으나 이 종양의 약 25% 이상이 두경부에 발생한다. 다른 부위로 전이를 일으키지 않으며 완전 제거 후에는 재발되지 않으며 방사선에 대한 감수성은 거의 없었다. 저자들은 과거 5년간 본 병원 이비인후과령역에서 수술제거한 5예의 Neurilemmoma를 문헌고찰과 함께 보고하는 바이다.

• Journal of Korean Neurosurgical Society
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• 제29권4호
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• pp.550-554
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• 2000

Most extracranial schwannomas are solitary, but neurofibromas are frequently associated with other manietations of neurofibromatosis. Schwannomas that occur within the context of neurofibromatosis tend to be multiple, but multiple schwannomas without manifestation of neurofibromatosis type 2 are very rare. The authors report a very rare case of multiple spinal intradural schwannomas in the absence of neurofibromatosis Type 2 maniestations. A 40-year-old man suffered from longstanding low back pain and left side sciatica which was treated with two stage operations. MRI showed multiple intradural mass lesions extending from L1 vertebral segment to S1 vertebral segment. There were no clinical and radiological manifestations of Type 2 neurofibromatosis. Histologically confirmed diagnosis was schwannoma.