• Journal of Pharmaceutical Investigation
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• v.30 no.4
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• pp.235-239
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• 2000

Ipriflavone (3-phenyl-7-isopropoxy-4H-1-benzopyran-4-one, IP) is a well-known antiosteoporotic drug with poor bioavailability. In the previous study, we reported that the IP formulation prepared by spray-drying method with polyvinylpyrrolidone (PVP) (SIP) was very effective in improving the bioavailability of IP. In this study, we examined the effects of molecular weight and mixture ratios of PVP to IP on the systemic absorption of IP following oral administration of SIP at a dose of 50 mg/kg to rats. In the effect of molecular weight, the Cmax of spray-dried IP with PVP K30 (SIP-K30) was significantly higher than those of spray-dried IP with PVP 360 (SIP-360), spray-dried IP with PVP K90 (SIP-K90), and spray-dried IP with PVP K17 (SIP-K17) (p<0.05). The AUC of SIP-K30 was about 2, 3, and 5.5 times higher than those of SIP-360, SIP-K90, and SIP-K17, respectively. The AUC value of SIP-K30 was significantly greater than those of SIP-K17 and SIP-K90 (p<0.05) except for SIP-360. In the ratio of PVP K30 to drug, the $C_{max}$ and the AUC value of 3 : 7 IP-PVP solid dispersion were similar to those of 5 : 5 IP-PVP and significantly higher than those of the other solid dispersions (p<0.05). It was concluded that the spray-dried IP with PVP K30 at the ratio of 3:7 (w/w) was the best formulation for improving the bioavailability of IP.

• Journal of the Korea Organic Resources Recycling Association
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• v.9 no.2
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• pp.58-65
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• 2001

To produce the substitute for farmland were mixed concrete waste and organic wastes. To estirnate the application of the mixture for farmland components in the solid and the leachate from the mixture were analyzed according to the ordinance of the Waste Society in Germany. Plants were cultivated in the mixture and its harvests were measured. The results showed that the mixture from waste may be used for the reclamation of landfill and landscaping according to circumstances, and the best mixture was from 85% of concrete waste, 10% of sewage sludge and 5% of paper mill sludge.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.29 no.8
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• pp.63-69
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• 2015

This paper presents the surface flashover characteristics to simulate the poor contact between an anode and a solid dielectric in a $N_2/O_2$ mixture gas (8/2) under a non-uniform field. The surface flashover voltage of the $N_2/O_2$ mixture gas revealed the irregular tendency that was not in accordance with the Paschen's law with an increasing gap of the poor contact. In addition, the insulation performance of the $N_2/O_2$ mixture gas at 0.6MPa was comparable to that of $SF_6$ gas of 0.1MPa based on the insulation performance on the poor contact. These results are able to apply the insulation design of eco-friendly gas insulation switchgear considering the internal faults.

• Korean Journal of Soil Science and Fertilizer
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• v.47 no.6
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• pp.480-485
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• 2014

In satsuma mandarin (C. unshiu Marc. cv. Miyagawa), alternate bearing is frequently occurred. It is very difficult to control and maintain the optimum production because satsuma mandarin is a very sensitive citrus cultivar. We carried out the experiment to find out the effects of foliar application of gibberellic acid ($GA_3$) and machine oil emulsion mixture on flowering and fruit quality of satsuma mandarin grown on open field. The treatments were composed of control (no application), $GA_3$ (25, 50 and $100mg{\cdot}L^{-1}$), machine oil emulsion 100 times and mixture of $GA_3$ (25 and $50mg{\cdot}L^{-1}$) with machine oil emulsion 100 times on 16 year-old 'Miyagawa' satsuma mandarin on December 30, 2012. Foliar application of $GA_3$ during winter season led to a reduction of the flowering in the following year. $GA_3$ decreased flowering in dose dependant manner. However, application of $GA_3$ and machine oil emulsion (100 times-diluted mixture) inhibited effectively the flowering compared to $GA_3$ only. Also, flower-leaf ratio was significantly decreased by the application of $GA_3$ 25 (0.54) and $50(0.41)mg{\cdot}L^{-1}$ with machine oil emulsion mixture in comparison to $GA_3$ 25 (0.86) and $50(0.60)mg{\cdot}L^{-1}$ only. The number of leaves per fruit increased in application of $GA_3$ and machine oil emulsion mixture as concentration of $GA_3$ increased. Fruit weight and sugar-acid ratio also increased in comparison to the control whereas fruit size, soluble solid content and acidity remained unchanged. From the results, it was suggested that $GA_3$ application can reduce the number of flowers on the alternate bearing of satsuma mandarin. Moreover, application of $GA_3$ (25 and $50mg{\cdot}L^{-1}$) with machine oil emulsion 100 times mixture can reduce the flowering effectively without altering fruit maturity and soluble solid contents. Therefore, it can be concluded that the application of $GA_3$ 25 and $50mg{\cdot}L^{-1}$ with machine oil emulsion 100 times might be useful in controlling alternate bearing in satsuma mandarin.

• Preventive Nutrition and Food Science
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• v.5 no.1
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• pp.32-36
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• 2000

Prickly pear juice(PPJ) extracted from prickly pear fruit (Opuntia ficus-indica)was used as raw material for the production of alcoholic beverages. Prickly pear juice (PPJ) had 0.88 oBrix of soluble solid, pH 3.96 and 0.14% of total acidity. Alcohol fermentation of 25% PPJ including 22 oBrix of sugar and 1$\times$106 of inoculum was suitable for alcohol fermentation indicating the rapid decrease of sugar content. The 22 oBrix of sugar in PPJ (25%)GJ (50%) mixture was changed to 6.5 oBrix after fermentation at 3$0^{\circ}C$ for 7 days. The alcohol content was 9.2% (w/v). PPJ (70%)/GJ (30%) mixture produced alcoholic beverage with 6.9% alcohol content resulting in the gradual decrease of soluble for 7 days. On the other hand, PPJ (50%)/GJ(50%) mixture carried out completely the alcohol fermentation at 22$^{\circ}C$ for 6 days and enhanced the red color of alcoholic beverages.

• KSBB Journal
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• v.18 no.1
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• pp.65-69
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• 2003

Two molecular imprinted polymers (MIPs) were prepared by using pentoxifylline and a mixture of caffeine-theophylline (2:1, mole ratio) as the templates, MAA as the monomer, and EDMA as the crosslinker The obtained polymer particles (particle size 25-35 $\mu\textrm{m}$) were packed into a HPLC column (150$\times$3.9mm). The selectivity and chromatographic characterization of the imprinted polymers were studied using pentoxifylline, caffeine, theophylline, theobromine as samples and acetonitrile as the mobile phase, Both imprinted polymers showed increased affinity for structural analogues. By using a mixture of caffeine-theophylline templates MIPs, good separations of caffeine, theobromine and theophylline were obtained, and pentoxifylline and caffeine were partly separated.

• Journal of Pharmaceutical Investigation
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• v.21 no.1
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• pp.11-22
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• 1991

The purpose of this study was for the enhancement of dissolution rate of ketoprofen. The solid dispersions composed of ketoprofen(KP) and polyethylene glycol(PEG) 4000 or 6000 were prepared by fusion method at various ratios of KP to PEG (0.5 : 10, 1 : 10, 2 : 10, 3 : 10 and 4 : 10(w/w)) and their physical mixtures were also prepared at the above ratios. Dissolution tests, X-ray diffraction study and differential scanning calorimetry study were carried out. It was found that the dissolution rates of solid dispersion and physical mixture at any ratio of the two components discribed above were greater than that of the pure ketoprofen. X-ray diffraction studies of ketoprofen suggested that less than 1 to 10 ratio of ketoprofen to PEG4000 (or 6000) was required to dispersion amorphous state in the carrier. In addition, the studies of DSC showed that ketoprofen had a sharp endothermic peak at $94^{\circ}C$ but not for the solid dispersion at the same temperature.

• Journal of Environmental Science International
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• v.13 no.1
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• pp.79-87
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• 2004

Esterification of soybean oil with methanol was investigated. First of all, liquid-liquid equilibriums for systems of soybean oil and methanol were measured at temperatures ranging from 40 to 65$^{\circ}C$. Profiles of conversion of soybean oil with time were determined from the glycerine content in reaction mixtures for the different kinds of catalysts, such as NaOH, CaO, Ca(OH)$_2$, MgO, Mg(OH)$_2$, and Ba(OH)$_2$. The effects of dose of catalyst, cosolvent and reaction temperature on final conversion were examined. Esterification of waste vegetable oil with methanol was investigated and compared to the case of soybean oil. Solubility of methanol in soybean oil was substantially greater than that of soybean oil in methanol. When the esterification reaction of soybean oil was catalyzed by solid catalyst, final conversion was strongly dependent on the alkalinity of the solid catalyst, and increased with the alkalinity of the metal. Hydroxides from the alkali metals were more effective than oxides. When Ca(OH)$_2$ was used for the esterification catalyst, maximum value of final conversion was measured at dose of 4％. When CHCl$_3$ as a cosolvent, was added into the reaction mixture of soybean oil which catalyzed by Ba(OH)$_2$, maximum value of final conversion was appeared at dose of 3％. When waste vegetable oil was catalyzed by NaOH and solid catalysts, high final conversion, over 90％, and fast reaction rate were obtained.

• BMB Reports
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• v.38 no.5
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• pp.517-525
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• 2005

Solid phase peptide synthesis method, which was introduced by Merrifield in 1963, has spawned the concept of combinatorial chemistry. In this review, we summarize the present technologies of solid phase peptide synthesis (SPPS) that are related to combinatorial chemistry. The conventional methods of peptide library synthesis on polymer support are parallel synthesis, split and mix synthesis and reagent mixture synthesis. Combining surface chemistry with the recent technology of microelectronic semiconductor fabrication system, the peptide microarray synthesis methods on a planar solid support are developed, which leads to spatially addressable peptide library. There are two kinds of peptide microarray synthesis methodologies: pre-synthesized peptide immobilization onto a glass or membrane substrate and in situ peptide synthesis by a photolithography or the SPOT method. This review also discusses the application of peptide libraries for high-throughput bioassays, for example, peptide ligand screening for antibody or cell signaling, enzyme substrate and inhibitor screening as well as other applications.

• Journal of the Korean Ceramic Society
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• v.37 no.8
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• pp.817-823
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• 2000

A solid-state electrochemicall cell for sensing CO2 gas was fabricated using a solid electrolyte of Li2CO3-Li3PO4-Al2O3 mixture and a reference electrode of LiMn2O4. The e.m.f. (electromotive force) of sensor showed a good accordance with theoretical Nernst slope (n=2) for CO2 gas concentration range of 100-10000 ppm above 35$0^{\circ}C$. The e.m.f. of sensor was constant regardless of oxygen partial pressure at the high temperature above 0.1 atm. It was, however, a little depended on oxygen partial pressure as the pressure decreased below 0.1 atm. The oxygen-dependency of our sensor gradually disappeared as the operating temperature increased. The sensing behavior of our CO2 sensor was affected by the presence of water vapor, but its effect was small comparing with other sensors.