• Polymer(Korea)
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• v.38 no.1
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• pp.93-97
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• 2014

Biodegradable drug-eluting stent has dual functions of supporting the lumen and treating internal tumor preventing the restenosis by releasing drug. In this study, the polycaprolactone (PCL) based three dimensional (3D) mesh loaded with paclitaxel (PTX) was presented by rapid prototyping (RP) technique of solid freeform fabrication (SFF) for biodegradable drug-eluting stent application. PCL has many advantageous properties such as good biocompatibility, good mechanical properties, and good drug permeability. PTX is widely used in the cancer treatment by inhibiting tumor cell proliferation. Analytical methods of HPLC and NMR were used for simultaneous quantification of PTX. Scanning electron microscopy (SEM) was performed to observe the architecture and morphologies of 3D mesh. The cytotoxicity assay results indicated released PTX's biological activity. This study provided that PCL based 3D mesh loaded with PTX by RP technique has great potential for biodegradable drug-eluting stent application.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2007.11a
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• pp.533-534
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• 2007

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2007.11a
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• pp.543-544
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• 2007

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2007.11a
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• pp.529-530
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• 2007

• Proceedings of the KSME Conference
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• 2005.11a
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• pp.211.2-211.2
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• 2005

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2006.10a
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• pp.15-16
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• 2006

• Proceedings of the IEEK Conference
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• 2002.07c
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• pp.2027-2030
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• 2002

SFFS(Solid Freeform Fabrication System) is commercializing to rapid prototyping concept in world- wide some corporations including the U.S.A, have much technological problems yet and need new mode for agile solid freeform fabrication as well as prototyping. In this paper, we design an algorithm that the cutting path of laser beam, on the SFFS, is controlled with constant speed. The designed algorithm fer constant-speed path control is implemented and experimented in the CAFL$\^$VM/ (Computer Aided Fabrication of Lamination for Various Material) system, the new SffS which is developed in this paper. Finally, the ceramic, new material developed in this paper, cut and fabricated. The dimensional accuracy and mechanical stability of the 3D object is confirmed through the experiment, also.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.18 no.2
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• pp.44-51
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• 2019

With the goal of tissue regeneration for organs damaged through an accident or a disease, research on tissue engineering has been conducted to produce 3-D scaffolds that can support the cells in the attachment and growth for the cell proliferation and differentiation. A scaffold requires a suitable pore size and porosity to increase the nutrient circulation or oxygen supply for the attachment and growth of cells. The existing production methods such as solvent-casting particulate leaching, phase separation, and fiber bonding have certain disadvantages. With these methods, it is difficult to obtain a free desired shape. In addition, certain pore sizes and interconnectivities among the pores may not be guaranteed. To solve these problems, this study has fabricated a scaffold with a 3-D shaped nose using Alginate, which is a natural polymer obtained through Fused Deposition Modeling (FDM), one of the CAD/CAM-based Solid Freeform Fabrication (SFF) methods.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2004.10a
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• pp.1299-1302
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• 2004

A real object duplication system (RODS), including three dimensional (3D) scanner and solid freeform fabrication system (SFFS), is a device to make three-dimensional objects directly from the drawing or photo data. A Selective Multi-Laser Sintering (SMLS) process designed in this paper is by which computer images received using 3D scanner are built up from polymer powder on building room of large size using dual laser at industrial type SFF system. Using the process can rapidly produce real object duplication components of industrial type such as cylinder, engine block, chassis of automobile, etc. In this paper, the industrial type SFF system using SMLS process is manufactured and the system is satisfied with high precision and high speed processing technique. To research characteristics of each part for theindustrial type SFF system, a structure and thermal analysis and test of each part is carried out. Also, to achievement of high performance for industrial type SFF system, design and fabrication for the structure, heater, nitrogen supply, laser and control part are carried out.

• Proceedings of the KSME Conference
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• 2007.05a
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• pp.1404-1409
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• 2007

Polymers for laser sintering were needed in order to fabricate the articles with the three-dimensional duplication equipment of SLS (selective laser sintering) process. The thermal properties, particle size, distribution, and shape of polymer powder had a close relation with the processibility of laser sintering. In this study, we prepared new polymer powders with uniform size and higher bulk density by wet process. Wet process consists of several finely-controlled steps such as dissolution, nucleation, propagation and crystallization. Several additives were added to improve the thermal, rheological, and flow properties.